PH30255A - Enzymatic resolution of endo-bicyclo[2.2.1] heptan-2-ol and derived pharmaceutical agents - Google Patents

Enzymatic resolution of endo-bicyclo[2.2.1] heptan-2-ol and derived pharmaceutical agents

Info

Publication number: PH30255A
Authority: PH; Philippines
Prior art keywords: endo; heptan; bicyclo; pharmaceutical agents; enzymatic resolution
Prior art date: 1989-11-13

Application number

PH47065A

Other languages

English (en)

Inventor

Nicholas A Saccomano

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-13

Filing date

1993-10-12

Publication date

1997-02-05

1993-10-12 Application filed by Pfizer filed Critical Pfizer

1993-10-12 Priority to PH47065A priority Critical patent/PH30255A/en

1997-02-05 Publication of PH30255A publication Critical patent/PH30255A/en

Links

ZQTYQMYDIHMKQB-DSYKOEDSSA-N (1r,3r,4s)-bicyclo[2.2.1]heptan-3-ol Chemical compound C1C[C@@H]2[C@H](O)C[C@H]1C2 ZQTYQMYDIHMKQB-DSYKOEDSSA-N 0.000 title abstract 2
230000002255 enzymatic effect Effects 0.000 title 1
239000008177 pharmaceutical agent Substances 0.000 title 1
102000019280 Pancreatic lipases Human genes 0.000 abstract 1
108050006759 Pancreatic lipases Proteins 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
229940116369 pancreatic lipase Drugs 0.000 abstract 1
238000005809 transesterification reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/10—Oxygen or sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Pulmonology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Dermatology (AREA)
Analytical Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Plant Substances (AREA)

PH47065A 1989-11-13 1993-10-12 Enzymatic resolution of endo-bicyclo[2.2.1] heptan-2-ol and derived pharmaceutical agents PH30255A (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
PH47065A PH30255A (en)	1989-11-13	1993-10-12	Enzymatic resolution of endo-bicyclo[2.2.1] heptan-2-ol and derived pharmaceutical agents

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
PCT/US1989/005228 WO1991007501A1 (en)	1989-11-13	1989-11-13	Enzymatic resolution of endo-bicyclo[2.2.1]heptan-2-ol and derived pharmaceutical agents
PH4150190		1990-11-06
PH47065A PH30255A (en)	1989-11-13	1993-10-12	Enzymatic resolution of endo-bicyclo[2.2.1] heptan-2-ol and derived pharmaceutical agents

Publications (1)

Publication Number	Publication Date
PH30255A true PH30255A (en)	1997-02-05

Family

ID=22215375

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH47065A PH30255A (en)	1989-11-13	1993-10-12	Enzymatic resolution of endo-bicyclo[2.2.1] heptan-2-ol and derived pharmaceutical agents

Country Status (27)

Country	Link
EP (2)	EP0801135A1 (da)
JP (1)	JPH06104661B2 (da)
KR (1)	KR930004654B1 (da)
CN (1)	CN1040423C (da)
AT (1)	ATE158577T1 (da)
AU (3)	AU633157B2 (da)
CA (1)	CA2029705C (da)
CZ (2)	CZ280006B6 (da)
DE (1)	DE69031487T2 (da)
DK (1)	DK0428302T3 (da)
EG (1)	EG19860A (da)
ES (1)	ES2107420T3 (da)
FI (1)	FI105106B (da)
GR (1)	GR3025196T3 (da)
HU (2)	HU215441B (da)
IE (2)	IE980174A1 (da)
IL (5)	IL110568A (da)
MY (1)	MY104517A (da)
NO (1)	NO304838B1 (da)
NZ (1)	NZ236037A (da)
PH (1)	PH30255A (da)
PL (4)	PL164176B1 (da)
PT (1)	PT95855B (da)
RU (1)	RU2104306C1 (da)
WO (1)	WO1991007501A1 (da)
YU (1)	YU48413B (da)
ZA (1)	ZA909044B (da)

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HU215441B (hu) *	1989-11-13	1999-04-28	Pfizer Inc.	Eljárás az endo-biciklo [2.2.1]-heptan-2-ol előállítására és az ebből kapott hatóanyagok enzimatikus úton történő elválasztására
US5124455A (en) *	1990-08-08	1992-06-23	American Home Products Corporation	Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents
IE71647B1 (en)	1991-01-28	1997-02-26	Rhone Poulenc Rorer Ltd	Benzamide derivatives
NZ246087A (en) *	1991-12-06	1995-04-27	Shionogi Seiyaku Kk	Production of optically active norborneol from a racemic ester mixture using a microoganism or treated cells thereof
BR9307570A (pt) *	1992-12-02	1999-05-25	Pfizer	Diéteres de catecol como inibidores seletivos de pdeiv
US5814651A (en) *	1992-12-02	1998-09-29	Pfizer Inc.	Catechol diethers as selective PDEIV inhibitors
JP3431204B2 (ja) *	1993-04-22	2003-07-28	塩野義製薬株式会社	ノルボルナン型エステル・ヒドロラーゼ
CN1041436C (zh) *	1993-05-07	1998-12-30	佛山市制药一厂	一种稳定冯了性风湿跌打药酒的方法
US5482944A (en) *	1993-07-13	1996-01-09	Pfizer Inc.	Pyrimidones and imidazolinones for treatment of shock
JPH1142095A (ja) *	1997-07-25	1999-02-16	Chisso Corp	新規なオキソジシクロペンタジエンの製造方法
KR100479019B1 (ko) *	1998-05-22	2005-08-29	씨제이 주식회사	캐테콜히드라존유도체,이의제조방법및그를함유한약제학적조성물
CA2715683A1 (en)	1999-08-21	2001-03-01	Nycomed Gmbh	Synergistic combination
ES2274854T3 (es) *	2000-05-08	2007-06-01	Pfizer Products Inc.	Resolucion enzimatica de moduladores selectivos del receptor de estrogeno.
KR20040017246A (ko)	2001-06-29	2004-02-26	니켄 가가쿠 가부시키가이샤	사이클로알케논 유도체
ES2194588B1 (es) *	2001-07-13	2004-10-16	Astur Pharma S.A.	Precursores opticamente puros de paroxetina.
US7772188B2 (en)	2003-01-28	2010-08-10	Ironwood Pharmaceuticals, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
EA200501548A1 (ru)	2003-04-01	2006-02-24	Апплайд Резеч Системз Арс Холдинг Н.В.	Ингибиторы фосфодиэстераз при бесплодии
MX2009013293A (es)	2007-06-04	2010-02-15	Synergy Pharmaceuticals Inc	Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos.
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2810951B1 (en)	2008-06-04	2017-03-15	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2730603C (en)	2008-07-16	2019-09-24	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
CA3100941C (en)	2011-03-01	2024-03-05	Synergy Pharmaceuticals Inc.	Process of preparing guanylate cyclase c agonists
EP3718557A3 (en)	2013-02-25	2020-10-21	Bausch Health Ireland Limited	Guanylate cyclase receptor agonist sp-333 for use in colonic cleansing
JP2016514671A (ja)	2013-03-15	2016-05-23	シナジーファーマシューティカルズインコーポレイテッド	グアニル酸シクラーゼのアゴニストおよびその使用
JP2016514670A (ja)	2013-03-15	2016-05-23	シナジーファーマシューティカルズインコーポレイテッド	他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
EA201592263A1 (ru)	2013-06-05	2016-05-31	Синерджи Фармасьютикалз, Инк.	Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования
KR20160042039A (ko)	2013-08-09	2016-04-18	알데릭스, 인코포레이티드	인산염 수송을 억제하기 위한 화합물 및 방법
WO2020237096A1 (en)	2019-05-21	2020-11-26	Ardelyx, Inc.	Combination for lowering serum phosphate in a patient

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Publication number	Priority date	Publication date	Assignee	Title
US4261995A (en) *	1979-08-31	1981-04-14	Syntex (U.S.A.) Inc.	4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives
US4732853A (en) *	1984-11-21	1988-03-22	President And Fellows Of Harvard College	Method of making chiral epoxy alcohols
HU215433B (hu) *	1986-04-29	2000-05-28	Pfizer Inc.	Eljárás új 2-oxo-5-fenil-pirimidin-származékok előállítására
HU215441B (hu) *	1989-11-13	1999-04-28	Pfizer Inc.	Eljárás az endo-biciklo [2.2.1]-heptan-2-ol előállítására és az ebből kapott hatóanyagok enzimatikus úton történő elválasztására

1989
- 1989-11-13 HU HUP9201587A patent/HU215441B/hu not_active IP Right Cessation
- 1989-11-13 CZ CS921240A patent/CZ280006B6/cs not_active IP Right Cessation
- 1989-11-13 HU HU9802988A patent/HU220962B1/hu not_active IP Right Cessation
- 1989-11-13 RU SU5052372A patent/RU2104306C1/ru not_active IP Right Cessation
- 1989-11-13 WO PCT/US1989/005228 patent/WO1991007501A1/en not_active Ceased
1990
- 1990-11-02 AT AT90312019T patent/ATE158577T1/de not_active IP Right Cessation
- 1990-11-02 DK DK90312019.4T patent/DK0428302T3/da active
- 1990-11-02 DE DE69031487T patent/DE69031487T2/de not_active Expired - Fee Related
- 1990-11-02 EP EP97103886A patent/EP0801135A1/en not_active Ceased
- 1990-11-02 ES ES90312019T patent/ES2107420T3/es not_active Expired - Lifetime
- 1990-11-02 EP EP90312019A patent/EP0428302B1/en not_active Expired - Lifetime
- 1990-11-06 IL IL11056890A patent/IL110568A/en active IP Right Grant
- 1990-11-06 IL IL9626190A patent/IL96261A/en active IP Right Grant
- 1990-11-06 IL IL110564A patent/IL110564A/en active IP Right Grant
- 1990-11-09 CA CA002029705A patent/CA2029705C/en not_active Expired - Fee Related
- 1990-11-11 EG EG67090A patent/EG19860A/xx active
- 1990-11-12 AU AU66535/90A patent/AU633157B2/en not_active Ceased
- 1990-11-12 NZ NZ236037A patent/NZ236037A/en unknown
- 1990-11-12 CN CN90109076A patent/CN1040423C/zh not_active Expired - Fee Related
- 1990-11-12 IE IE19980174A patent/IE980174A1/en not_active IP Right Cessation
- 1990-11-12 ZA ZA909044A patent/ZA909044B/xx unknown
- 1990-11-12 YU YU214290A patent/YU48413B/sh unknown
- 1990-11-12 PL PL90287727A patent/PL164176B1/pl unknown
- 1990-11-12 MY MYPI90001992A patent/MY104517A/en unknown
- 1990-11-12 IE IE405990A patent/IE904059A1/en not_active IP Right Cessation
- 1990-11-12 PL PL90301764A patent/PL165132B1/pl unknown
- 1990-11-12 KR KR1019900018244A patent/KR930004654B1/ko not_active Expired - Fee Related
- 1990-11-12 PT PT95855A patent/PT95855B/pt not_active IP Right Cessation
- 1990-11-12 PL PL90292070A patent/PL164457B1/pl unknown
- 1990-11-12 PL PL90292069A patent/PL164202B1/pl unknown
- 1990-11-13 CZ CS905609A patent/CZ280011B6/cs not_active IP Right Cessation
- 1990-11-13 JP JP2306942A patent/JPH06104661B2/ja not_active Expired - Fee Related
1992
- 1992-05-12 NO NO921876A patent/NO304838B1/no unknown
- 1992-05-12 FI FI922142A patent/FI105106B/fi not_active IP Right Cessation
1993
- 1993-01-22 AU AU31979/93A patent/AU645449B2/en not_active Ceased
- 1993-02-09 AU AU32920/93A patent/AU3292093A/en not_active Withdrawn
- 1993-10-12 PH PH47065A patent/PH30255A/en unknown
1994
- 1994-08-04 IL IL11056494A patent/IL110564A0/xx unknown
- 1994-08-04 IL IL11056894A patent/IL110568A0/xx unknown
1997
- 1997-10-29 GR GR970402831T patent/GR3025196T3/el unknown

Also Published As

Publication number	Publication date
CN1051905A (zh)	1991-06-05
IL110564A0 (en)	1994-11-11
PL287727A1 (en)	1992-02-24
PT95855A (pt)	1991-09-13
CZ124092A3 (en)	1995-04-12
HU220962B1 (hu)	2002-07-29
JPH03173871A (ja)	1991-07-29
ES2107420T3 (es)	1997-12-01
NO921876L (no)	1992-07-10
HU215441B (hu)	1999-04-28
MY104517A (en)	1994-04-30
ATE158577T1 (de)	1997-10-15
PL292070A1 (en)	1992-04-21
YU214290A (sh)	1992-12-21
HU9802988D0 (en)	1999-11-29
GR3025196T3 (en)	1998-02-27
PL292069A1 (en)	1992-04-21
NO921876D0 (no)	1992-05-12
CZ560990A3 (en)	1995-04-12
AU3292093A (en)	1993-04-22
AU6653590A (en)	1991-05-16
IL96261A0 (en)	1991-08-16
NO304838B1 (no)	1999-02-22
DE69031487T2 (de)	1998-02-05
FI105106B (fi)	2000-06-15
PL164202B1 (pl)	1994-06-30
AU3197993A (en)	1993-04-22
IL96261A (en)	1996-12-05
EP0801135A1 (en)	1997-10-15
RU2104306C1 (ru)	1998-02-10
ZA909044B (en)	1992-06-24
WO1991007501A1 (en)	1991-05-30
FI922142L (fi)	1992-05-12
PL165132B1 (pl)	1994-11-30
PL164457B1 (pl)	1994-07-29
CN1040423C (zh)	1998-10-28
YU48413B (sh)	1998-07-10
KR930004654B1 (ko)	1993-06-02
HUT64604A (en)	1994-01-28
FI922142A0 (fi)	1992-05-12
AU645449B2 (en)	1994-01-13
EG19860A (en)	1996-03-31
IL110564A (en)	1998-03-10
CA2029705A1 (en)	1991-05-14
CA2029705C (en)	1998-11-24
KR910009622A (ko)	1991-06-28
JPH06104661B2 (ja)	1994-12-21
EP0428302B1 (en)	1997-09-24
IL110568A (en)	1995-10-31
IE980174A1 (en)	2000-02-23
PT95855B (pt)	1998-01-30
PL164176B1 (pl)	1994-06-30
CZ280011B6 (cs)	1995-09-13
EP0428302A3 (en)	1992-05-13
IL110568A0 (en)	1994-11-11
IE904059A1 (en)	1991-05-22
DE69031487D1 (de)	1997-10-30
AU633157B2 (en)	1993-01-21
NZ236037A (en)	1992-08-26
DK0428302T3 (da)	1997-10-13
EP0428302A2 (en)	1991-05-22
CZ280006B6 (cs)	1995-09-13

Publication	Publication Date	Title
EG19860A (en)	1996-03-31	Enzymatic resolution of endo - bicyclo (2,2,1) heptan -2-ol and derived pharmaceutical agents
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AU3824089A (en)	1990-01-25	Process for the lactonization of mevinic acids and analogs thereof
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AU4061289A (en)	1990-03-05	An amplification assay for hydrolase enzymes
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AU4705389A (en)	1990-07-05	Method for cultivation of bacteria of the genus pseudomonas
AU4058589A (en)	1990-02-05	Synthetic hiv protease gene and method for its expression
AU5364390A (en)	1990-10-25	Method for the production of amidase enzyme
AU7468894A (en)	1995-02-20	Process for the enzymatic preparation of optically active n-substituted-3-pyrrolidinol
FI954650A7 (fi)	1995-09-29	Menetelmä kolesteroliestereiden hydrolysoimiseksi Pseudomonas fragin e steraasin avulla
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AU5632590A (en)	1990-11-29	Method of inactivating lipase
AU1376588A (en)	1988-09-29	Derivative of a fibrinolytic enzyme
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AU1077688A (en)	1988-08-04	Modified fibrinolytic enzymes
PL272177A1 (en)	1989-10-30	The method of enzymes fixing