PL183484B1 - Kompozycja farmaceutyczna do leczenia lub odczulania alergików, oraz sposób jej wytwarzania - Google Patents

Kompozycja farmaceutyczna do leczenia lub odczulania alergików, oraz sposób jej wytwarzania

Info

Publication number: PL183484B1
Authority: PL; Poland
Prior art keywords: allergen; tyrosine; solution; polymerized; composition
Prior art date: 1995-04-29

Application number

PL96323104A

Other languages

English (en)

Polish (pl)

Other versions

PL323104A1 (en

Inventor

Alan W. Wheeler

Iain Taylor

Original Assignee

Allergy Therapeutics Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-29

Filing date

1996-04-25

Publication date

2002-06-28

1996-04-25 Application filed by Allergy Therapeutics Ltd filed Critical Allergy Therapeutics Ltd

1998-03-16 Publication of PL323104A1 publication Critical patent/PL323104A1/xx

2002-06-28 Publication of PL183484B1 publication Critical patent/PL183484B1/pl

Links

239000013566 allergen Substances 0.000 title claims abstract description 44
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 title claims abstract description 21
239000000203 mixture Substances 0.000 title claims abstract description 18
125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 title 1
239000000243 solution Substances 0.000 claims abstract description 31
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims abstract description 24
238000002156 mixing Methods 0.000 claims abstract description 6
239000007864 aqueous solution Substances 0.000 claims abstract description 5
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 5
230000003472 neutralizing effect Effects 0.000 claims abstract description 4
238000000502 dialysis Methods 0.000 claims description 6
238000000034 method Methods 0.000 claims description 6
206010020751 Hypersensitivity Diseases 0.000 claims description 5
239000002253 acid Substances 0.000 claims description 5
208000026935 allergic disease Diseases 0.000 claims description 5
230000007815 allergy Effects 0.000 claims description 5
238000000586 desensitisation Methods 0.000 claims description 5
241000238740 Dermatophagoides pteronyssinus Species 0.000 claims description 4
ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 claims description 3
238000002523 gelfiltration Methods 0.000 claims description 3
238000002360 preparation method Methods 0.000 claims description 3
230000000379 polymerizing effect Effects 0.000 claims description 2
239000011260 aqueous acid Substances 0.000 abstract 1
229960004441 tyrosine Drugs 0.000 description 14
238000006386 neutralization reaction Methods 0.000 description 6
239000000047 product Substances 0.000 description 6
SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 4
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
229960004784 allergens Drugs 0.000 description 3
239000011780 sodium chloride Substances 0.000 description 3
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
239000007975 buffered saline Substances 0.000 description 2
238000004132 cross linking Methods 0.000 description 2
238000001914 filtration Methods 0.000 description 2
238000001556 precipitation Methods 0.000 description 2
102000004169 proteins and genes Human genes 0.000 description 2
108090000623 proteins and genes Proteins 0.000 description 2
239000011541 reaction mixture Substances 0.000 description 2
230000035484 reaction time Effects 0.000 description 2
239000007787 solid Substances 0.000 description 2
239000008223 sterile water Substances 0.000 description 2
238000003756 stirring Methods 0.000 description 2
238000002560 therapeutic procedure Methods 0.000 description 2
238000005406 washing Methods 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
244000036975 Ambrosia artemisiifolia Species 0.000 description 1
235000003129 Ambrosia artemisiifolia var elatior Nutrition 0.000 description 1
235000018185 Betula X alpestris Nutrition 0.000 description 1
235000018212 Betula X uliginosa Nutrition 0.000 description 1
241000238713 Dermatophagoides farinae Species 0.000 description 1
239000004471 Glycine Substances 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
241000238711 Pyroglyphidae Species 0.000 description 1
230000002009 allergenic effect Effects 0.000 description 1
235000003484 annual ragweed Nutrition 0.000 description 1
239000006172 buffering agent Substances 0.000 description 1
235000006263 bur ragweed Nutrition 0.000 description 1
239000000969 carrier Substances 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000000975 co-precipitation Methods 0.000 description 1
235000003488 common ragweed Nutrition 0.000 description 1
239000003431 cross linking reagent Substances 0.000 description 1
238000011026 diafiltration Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
235000013305 food Nutrition 0.000 description 1
238000005194 fractionation Methods 0.000 description 1
229940046533 house dust mites Drugs 0.000 description 1
239000012535 impurity Substances 0.000 description 1
239000007972 injectable composition Substances 0.000 description 1
239000002919 insect venom Substances 0.000 description 1
239000000463 material Substances 0.000 description 1
239000012528 membrane Substances 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
238000006116 polymerization reaction Methods 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
235000009736 ragweed Nutrition 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
239000013049 sediment Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
231100000611 venom Toxicity 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
- A61K39/36—Allergens from pollen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Immunology (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Mycology (AREA)
Microbiology (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pulmonology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PL96323104A 1995-04-29 1996-04-25 Kompozycja farmaceutyczna do leczenia lub odczulania alergików, oraz sposób jej wytwarzania PL183484B1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9508785.4A GB9508785D0 (en)	1995-04-29	1995-04-29	Novel compositions
PCT/EP1996/001733 WO1996034626A1 (en)	1995-04-29	1996-04-25	Composition of tyrosine and polymerised allergen

Publications (2)

Publication Number	Publication Date
PL323104A1 PL323104A1 (en)	1998-03-16
PL183484B1 true PL183484B1 (pl)	2002-06-28

Family

ID=10773769

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL96323104A PL183484B1 (pl)	1995-04-29	1996-04-25	Kompozycja farmaceutyczna do leczenia lub odczulania alergików, oraz sposób jej wytwarzania

Country Status (19)

Country	Link
EP (1)	EP0825874A1 (cs)
JP (1)	JPH11504338A (cs)
KR (1)	KR19990008120A (cs)
CN (1)	CN1132629C (cs)
AU (1)	AU705873B2 (cs)
BG (1)	BG63990B1 (cs)
BR (1)	BR9608123A (cs)
CA (1)	CA2217388A1 (cs)
CZ (1)	CZ288401B6 (cs)
EA (1)	EA199700271A1 (cs)
GB (1)	GB9508785D0 (cs)
HU (1)	HUP9802237A3 (cs)
NO (1)	NO974893L (cs)
NZ (1)	NZ308080A (cs)
PL (1)	PL183484B1 (cs)
SK (1)	SK281877B6 (cs)
TR (1)	TR199701265T1 (cs)
WO (1)	WO1996034626A1 (cs)
ZA (1)	ZA963340B (cs)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9706957D0 (en) *	1997-04-05	1997-05-21	Smithkline Beecham Plc	Formulation
GB9820525D0 (en)	1998-09-21	1998-11-11	Allergy Therapeutics Ltd	Formulation
GB0000891D0 (en)	2000-01-14	2000-03-08	Allergy Therapeutics Ltd	Formulation
GB201106802D0 (en) *	2011-04-21	2011-06-01	Allergy Therapeutics Ltd	Process for preparing vaccine composition

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1377074A (en) *	1971-07-13	1974-12-11	Beecham Group Ltd	Process for preparing injectable compositions
US4070455A (en) *	1974-02-16	1978-01-24	Beecham Group Limited	Process for preparing injectable desensitizing compositions and products thereof in microparticle form
EP0058021A3 (en) *	1981-02-06	1982-10-27	Beecham Group Plc	Pharmaceutical compositions
ES2013359A6 (es) *	1988-11-04	1990-05-01	Corporacion Biolog Farmaceutic	Procedimiento para la fabricacion de alergenos inmunogenicos polimerizados.

1995
- 1995-04-29 GB GBGB9508785.4A patent/GB9508785D0/en active Pending
1996
- 1996-04-25 NZ NZ308080A patent/NZ308080A/xx not_active IP Right Cessation
- 1996-04-25 CA CA002217388A patent/CA2217388A1/en not_active Abandoned
- 1996-04-25 AU AU57616/96A patent/AU705873B2/en not_active Expired
- 1996-04-25 BR BR9608123A patent/BR9608123A/pt not_active Application Discontinuation
- 1996-04-25 PL PL96323104A patent/PL183484B1/pl unknown
- 1996-04-25 WO PCT/EP1996/001733 patent/WO1996034626A1/en not_active Ceased
- 1996-04-25 SK SK1461-97A patent/SK281877B6/sk not_active IP Right Cessation
- 1996-04-25 KR KR1019970707645A patent/KR19990008120A/ko not_active Ceased
- 1996-04-25 CZ CZ19973429A patent/CZ288401B6/cs not_active IP Right Cessation
- 1996-04-25 EP EP96914124A patent/EP0825874A1/en not_active Withdrawn
- 1996-04-25 CN CN96193592A patent/CN1132629C/zh not_active Expired - Lifetime
- 1996-04-25 EA EA199700271A patent/EA199700271A1/ru unknown
- 1996-04-25 JP JP8532981A patent/JPH11504338A/ja active Pending
- 1996-04-25 TR TR97/01265T patent/TR199701265T1/xx unknown
- 1996-04-25 HU HU9802237A patent/HUP9802237A3/hu unknown
- 1996-04-26 ZA ZA963340A patent/ZA963340B/xx unknown
1997
- 1997-10-23 NO NO974893A patent/NO974893L/no not_active Application Discontinuation
- 1997-10-29 BG BG102004A patent/BG63990B1/bg unknown

Also Published As

Publication number	Publication date
GB9508785D0 (en)	1995-06-21
NO974893D0 (no)	1997-10-23
BG102004A (en)	1998-11-30
ZA963340B (en)	1997-03-27
EA199700271A1 (ru)	1998-04-30
EP0825874A1 (en)	1998-03-04
AU5761696A (en)	1996-11-21
JPH11504338A (ja)	1999-04-20
CN1132629C (zh)	2003-12-31
HK1010834A1 (en)	1999-07-02
SK146197A3 (en)	1998-05-06
HUP9802237A3 (en)	2000-06-28
CA2217388A1 (en)	1996-11-07
KR19990008120A (ko)	1999-01-25
CN1183046A (zh)	1998-05-27
WO1996034626A1 (en)	1996-11-07
AU705873B2 (en)	1999-06-03
SK281877B6 (sk)	2001-08-06
CZ342997A3 (cs)	1998-03-18
TR199701265T1 (xx)	1998-02-21
HUP9802237A2 (hu)	1999-02-01
PL323104A1 (en)	1998-03-16
NO974893L (no)	1997-10-23
CZ288401B6 (en)	2001-06-13
BR9608123A (pt)	1999-02-09
BG63990B1 (bg)	2003-09-30
NZ308080A (en)	1999-05-28

Publication	Publication Date	Title
AU706746B2 (en)	1999-06-24	Polyaminoacid-based particles for use as active principle vectors, and methods for preparing same
JP3168215B2 (ja)	2001-05-21	微粒子形態のポリ電解質コンプレックスおよび少くとも一つの活性物質を含む薬学的組成物
JP4927256B2 (ja)	2012-05-09	ポリアミノ酸ベースの粒子およびその製造方法
DE2404041A1 (de)	1974-08-01	Blut-fraktionierungsverfahren
EP1564220A1 (en)	2005-08-17	Sustained release drug carrier
WO1987002679A1 (en)	1987-05-07	Immunotherapeutic treatment
US4070455A (en)	1978-01-24	Process for preparing injectable desensitizing compositions and products thereof in microparticle form
CA1171356A (en)	1984-07-24	Modified allergens
PL183484B1 (pl)	2002-06-28	Kompozycja farmaceutyczna do leczenia lub odczulania alergików, oraz sposób jej wytwarzania
US6313103B1 (en)	2001-11-06	Pectic substance as a growth factor stabilizer
EA032855B1 (ru)	2019-07-31	Способ получения глатирамера ацетата
JPH02138130A (ja)	1990-05-28	重合されたアレルゲンの製造方法
RU2198900C2 (ru)	2003-02-20	Усовершенствованный сополимер-1 и способ его получения
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JP4331798B2 (ja)	2009-09-16	アレルゲン処方
MXPA97008336A (en)	1998-01-01	Composition of tyrosine and allergen polymerize
HK1010834B (en)	2004-05-28	Composition of tyrosine and polymerised allergen
JP3263857B2 (ja)	2002-03-11	抗体産生組成物および抗体産生法
JPS62292731A (ja)	1987-12-19	低温殺菌された免疫グロブリン製剤の製法
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Tsung	2000	Development and characterization of a novel drug delivery system with an affinity for fibronectin in vitro