PL3615544T3 - Związki przeciwguzowe - Google Patents

Związki przeciwguzowe

Info

Publication number
PL3615544T3
PL3615544T3 PL18720255.1T PL18720255T PL3615544T3 PL 3615544 T3 PL3615544 T3 PL 3615544T3 PL 18720255 T PL18720255 T PL 18720255T PL 3615544 T3 PL3615544 T3 PL 3615544T3
Authority
PL
Poland
Prior art keywords
antitumoral compounds
antitumoral
compounds
Prior art date
Application number
PL18720255.1T
Other languages
English (en)
Inventor
Maria Del Carmen Cuevas Marchante
Andres Francesch Solloso
Valentin MARTINEZ BARRASA
Original Assignee
Pharma Mar S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar S.A. filed Critical Pharma Mar S.A.
Publication of PL3615544T3 publication Critical patent/PL3615544T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL18720255.1T 2017-04-27 2018-04-27 Związki przeciwguzowe PL3615544T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17382228 2017-04-27
EP17382497 2017-07-26
PCT/EP2018/060868 WO2018197663A1 (en) 2017-04-27 2018-04-27 Antitumoral compounds

Publications (1)

Publication Number Publication Date
PL3615544T3 true PL3615544T3 (pl) 2023-07-17

Family

ID=62063080

Family Applications (5)

Application Number Title Priority Date Filing Date
PL18720255.1T PL3615544T3 (pl) 2017-04-27 2018-04-27 Związki przeciwguzowe
PL22166571.4T PL4047002T3 (pl) 2017-04-27 2018-04-27 Związki przeciwguzowe
PL18382287T PL3395820T3 (pl) 2017-04-27 2018-04-27 <sub>Związki przeciwguzowe</sub>
PL18382288T PL3395821T3 (pl) 2017-04-27 2018-04-27 Związki przeciwguzowe
PL22187664.2T PL4101855T3 (pl) 2017-04-27 2018-04-27 Związki przeciwguzowe

Family Applications After (4)

Application Number Title Priority Date Filing Date
PL22166571.4T PL4047002T3 (pl) 2017-04-27 2018-04-27 Związki przeciwguzowe
PL18382287T PL3395820T3 (pl) 2017-04-27 2018-04-27 <sub>Związki przeciwguzowe</sub>
PL18382288T PL3395821T3 (pl) 2017-04-27 2018-04-27 Związki przeciwguzowe
PL22187664.2T PL4101855T3 (pl) 2017-04-27 2018-04-27 Związki przeciwguzowe

Country Status (39)

Country Link
US (5) US11332480B2 (pl)
EP (5) EP3395821B1 (pl)
JP (5) JP6501947B2 (pl)
KR (3) KR102492283B1 (pl)
CN (4) CN110621678B (pl)
AU (4) AU2018260314C1 (pl)
BR (1) BR112019022282A2 (pl)
CA (1) CA3061518A1 (pl)
CL (1) CL2019003057A1 (pl)
CO (1) CO2019011967A2 (pl)
CY (3) CY1121884T1 (pl)
DK (5) DK4047002T3 (pl)
EC (1) ECSP19083967A (pl)
ES (5) ES2740073T3 (pl)
FI (3) FI3615544T3 (pl)
HK (2) HK1255941B (pl)
HR (5) HRP20230433T1 (pl)
HU (5) HUE063736T2 (pl)
IL (3) IL295044B2 (pl)
JO (1) JOP20190254B1 (pl)
LT (5) LT3395820T (pl)
MA (2) MA44021B1 (pl)
MD (5) MD3395820T2 (pl)
ME (2) ME03467B (pl)
MX (3) MX392829B (pl)
MY (1) MY198004A (pl)
PH (1) PH12019550224A1 (pl)
PL (5) PL3615544T3 (pl)
PT (2) PT3395821T (pl)
RS (5) RS59174B1 (pl)
SA (1) SA523440283B1 (pl)
SG (2) SG10201913300YA (pl)
SI (5) SI3615544T1 (pl)
SM (5) SMT202300343T1 (pl)
TN (2) TN2019000211A1 (pl)
TW (3) TWI807411B (pl)
UY (1) UY37706A (pl)
WO (1) WO2018197663A1 (pl)
ZA (1) ZA201907119B (pl)

Families Citing this family (16)

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Publication number Priority date Publication date Assignee Title
TWI807411B (zh) * 2017-04-27 2023-07-01 西班牙商瑪製藥股份有限公司 抗腫瘤化合物
TWI824043B (zh) * 2018-10-25 2023-12-01 西班牙商瑪製藥股份有限公司 藥物抗體共軛物
EP4061372A1 (en) * 2019-11-21 2022-09-28 Pharma Mar, S.A. Methods of treating small cell lung cancer with lurbinectedin formulations
BR112022020823A2 (pt) * 2020-04-21 2022-11-29 Pharma Mar Sa Conjugados de fármaco e anticorpo
TW202144369A (zh) * 2020-04-26 2021-12-01 大陸商江蘇恆瑞醫藥股份有限公司 海鞘素類衍生物及其製備方法與醫藥用途
MX2023013715A (es) * 2021-05-19 2024-03-26 Pharma Mar Sa Regímenes de dosis de ecubectedina.
WO2024186263A1 (en) * 2023-03-07 2024-09-12 Axcynsis Therapeutics Pte. Ltd. Antibody-drug conjugates comprising trabectedin and lurbinectedin derivatives
WO2025077996A1 (en) 2023-10-09 2025-04-17 Pharma Mar, S.A. Synthetic process for the manufacture of ecteinascidin compounds
EP4563149A1 (en) 2023-11-30 2025-06-04 Pharma Mar, S.A. Lurbinectedin, ecubectedin and a related compound for use in the treatment of skin cancers
TW202532075A (zh) * 2024-02-08 2025-08-16 大陸商映恩生物製藥（蘇州）有限公司 海鞘素類化合物及其應用
WO2025228595A1 (en) 2024-04-30 2025-11-06 Pharma Mar, S.A. Use of compound ia in the treatment of cancers including combination therapy with atezolizumab.
WO2025228596A1 (en) 2024-04-30 2025-11-06 Pharma Mar, S.A. Combination of pm14 and a topoisomerase i inhibitor in the treatment of cancer
TW202547488A (zh) 2024-04-30 2025-12-16 西班牙商瑪製藥股份有限公司 於癌症的治療中之化合物Ｉａ和拓樸異構酶Ｉ抑制劑的組合
WO2025228594A1 (en) 2024-04-30 2025-11-06 Pharma Mar, S.A. Use of ecubectedin in the treatment of cancers including combination therapy with atezolizumab
TW202547504A (zh) 2024-05-10 2025-12-16 西班牙商瑪製藥股份有限公司 海鞘素的合成方法
WO2026022359A2 (en) 2024-07-26 2026-01-29 Pharma Mar, S.A. Synthetic process for the manufacture of ecteinascidin compounds

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