PL372468A1 - Isostructural pseudopolymorphs of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a - Google Patents

Isostructural pseudopolymorphs of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a

Info

Publication number: PL372468A1
Authority: PL; Poland
Prior art keywords: homoerythromycin; deoxo; aza; methyl; pseudopolymorph
Prior art date: 2002-03-18

Application number

PL03372468A

Other languages

English (en)

Polish (pl)

Inventor

Miljenko Dumic

Mladen Vinkovic

Marina Oresic

Ernest Mestrovic

Aleksandar Danilovski

Alojz Dumbovic

Zdravka Knezevic

Gorjana Lazarevski

Dominik Cincic

Darko Filic

Katica Lazaric

Dejan-Kresimir Bucar

Original Assignee

Pliva-Istrazivanje I Razvoj D.O.O.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-18

Filing date

2003-03-18

Publication date

2005-07-25

2003-03-18 Application filed by Pliva-Istrazivanje I Razvoj D.O.O. filed Critical Pliva-Istrazivanje I Razvoj D.O.O.

2005-07-25 Publication of PL372468A1 publication Critical patent/PL372468A1/xx

Links

MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 title abstract 2
239000013078 crystal Substances 0.000 abstract 2
239000003960 organic solvent Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Tropical Medicine & Parasitology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Thermal Transfer Or Thermal Recording In General (AREA)
Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
Finger-Pressure Massage (AREA)
Instructional Devices (AREA)

PL03372468A 2002-03-18 2003-03-18 Isostructural pseudopolymorphs of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a PL372468A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
HR20020231A HRP20020231A2 (en)	2002-03-18	2002-03-18	ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
US39361202P	2002-07-03	2002-07-03
US39470502P	2002-07-08	2002-07-08

Publications (1)

Publication Number	Publication Date
PL372468A1 true PL372468A1 (en)	2005-07-25

Family

ID=28045976

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL03372468A PL372468A1 (en)	2002-03-18	2003-03-18	Isostructural pseudopolymorphs of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a

Country Status (23)

Country	Link
US (1)	US7569549B2 (2)
EP (2)	EP1485393B1 (2)
JP (1)	JP2005529082A (2)
KR (1)	KR20050002872A (2)
CN (1)	CN1642966A (2)
AT (1)	ATE440104T1 (2)
AU (1)	AU2003215779A1 (2)
BG (1)	BG108874A (2)
BR (1)	BR0308644A (2)
CA (1)	CA2479211A1 (2)
DE (1)	DE60328872D1 (2)
EA (1)	EA200401217A1 (2)
ES (1)	ES2331733T3 (2)
HR (2)	HRP20020231A2 (2)
IL (1)	IL163836A0 (2)
IS (1)	IS7449A (2)
MX (1)	MXPA04009009A (2)
NO (1)	NO20044341L (2)
NZ (1)	NZ535477A (2)
PL (1)	PL372468A1 (2)
RS (1)	RS82504A (2)
TN (1)	TNSN04166A1 (2)
WO (1)	WO2003077830A2 (2)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HRP20020231A2 (en)	2002-03-18	2003-12-31	Pliva D D	ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
HRP20020614A2 (en) *	2002-07-22	2004-06-30	PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o.	Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
ATE421882T1 (de) *	2003-07-24	2009-02-15	Pliva Hrvatska D O O	Schnellösliches azithromycin in einzeldosisform
EP1878432A1 (en) *	2003-07-24	2008-01-16	Pliva - Research and Development Ltd.	Single dose fast dissolving azithromycin
ES2600577T3 (es) *	2003-12-04	2017-02-09	Bend Research, Inc.	Procedimiento de pulverización-solidificación que usa un extrusor para preparar composiciones en multipartículas de fármacos cristalinos
US6984403B2 (en) *	2003-12-04	2006-01-10	Pfizer Inc.	Azithromycin dosage forms with reduced side effects
KR100844628B1 (ko) *	2003-12-04	2008-07-07	화이자 프로덕츠 인크.	제약상 다입자의 제조 방법
WO2005053652A1 (en)	2003-12-04	2005-06-16	Pfizer Products Inc.	Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
MXPA06005913A (es) *	2003-12-04	2006-06-27	Pfizer Prod Inc	Formas de dosificacion de multiparticulas de azitromicina por procedimientos basados en liquidos.
CA2547597A1 (en)	2003-12-04	2005-06-16	Pfizer Products Inc.	Multiparticulate compositions with improved stability
US20060116336A1 (en) *	2004-03-17	2006-06-01	American Pharmaceutical Partners, Inc.	Lyophilized azithromycin formulation
US7468428B2 (en) *	2004-03-17	2008-12-23	App Pharmaceuticals, Llc	Lyophilized azithromycin formulation

Family Cites Families (27)

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Publication number	Priority date	Publication date	Assignee	Title
SI8110592A8 (en) *	1981-03-06	1996-06-30	Pliva Pharm & Chem Works	Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
WO1989000576A1 (en) *	1987-07-09	1989-01-26	Pfizer Inc.	Azithromycin dihydrate
HRP20020231A2 (en)	2002-03-18	2003-12-31	Pliva D D	ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
US5686587A (en)	1993-05-19	1997-11-11	Pfizer Inc.	Intermediate for azithromycin
HRP940251B1 (en)	1994-04-15	1998-12-31	Stjepan Mutak	Process for the preparation of azithromycin dihydrochloride
ES2122905B1 (es) *	1996-07-11	1999-11-16	Astur Pharma Sa	Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
PT102130A (pt)	1998-03-13	1999-09-30	Hovione Sociedade Quimica S A	Processo de preparacao de dihidrato de azitromicina
CN1205338A (zh)	1998-05-08	1999-01-20	刘万忠	阿奇霉素水溶性盐的合成新方法及其在医药上的用途
TW546302B (en) *	1998-05-08	2003-08-11	Biochemie Sa	Improvements in macrolide production
CA2245398C (en)	1998-08-21	2002-01-29	Apotex Inc.	Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
SI20639A (sl) *	1998-11-30	2002-02-28	Teva Pharmaceutical Industries Ltd.	Etanolat azitromicina, postopek za njegovo pripravo in njegovi farmacevtski sestavki
AU5820400A (en) *	1999-06-29	2001-01-31	Biochemie S.A.	Macrolides
ES2177373B1 (es) *	1999-11-26	2003-11-01	Astur Pharma Sa	Preparacion de azitromicina en su forma no cristalina
EP1246831B1 (en) *	2000-01-04	2008-03-05	Teva Pharmaceutical Industries Ltd.	Preparation method of azithromycin dihydrate
ES2162764B1 (es) *	2000-05-17	2003-04-01	Ercros Ind Sa	Forma polimorfica del dihidrato de azitromicina, y su procedimiento deobtencion.
DE60026718T2 (de) *	2000-07-25	2006-11-16	Laboratorio Silanes, S.A. De C.V.	Einstufiges verfahren zur herstellung von 7,16-deoxy-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihydroxi-6-ethyl-3,5,9,11,13,15-hexamethylbicycle(11.2.11)hexadeca-1(2)-en-8-ona undeine neue form von 9-desoxo-9a-methyl-9a-aza-9a-homoerythromycin a
JP2004506664A (ja) *	2000-08-23	2004-03-04	ウォックハート・リミテッド	無水アジトロマイシンの製造法
HRP20030430B1 (hr)	2000-11-27	2011-11-30	Biochemie S.A.	Makrolidni solvati
KR100491183B1 (ko)	2001-03-21	2005-05-25	한미약품 주식회사	아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
KR100431431B1 (ko)	2001-04-25	2004-05-14	한미약품 주식회사	아지트로마이신 수화물의 1,2-프로필렌글리콜 내포화합물,그의 제조방법 및 그의 약학적 조성물
HRP20010301A2 (en)	2001-04-27	2001-12-31	Pliva D D	New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
US6861413B2 (en) *	2001-05-22	2005-03-01	Pfizer Inc.	Stable non-dihydrate azithromycin oral suspensions
ES2258142T3 (es) *	2001-05-22	2006-08-16	Pfizer Products Inc.	Nueva forma cristalina.
PL371259A1 (pl) *	2001-12-21	2005-06-13	Pfizer Products Inc.	Bezpośrednio sprasowywalne preparaty azytromycyny
NZ532063A (en) *	2001-12-21	2006-03-31	Pfizer Prod Inc	Methods for wet granulating azithromycin
RU2283092C2 (ru)	2002-02-01	2006-09-10	Пфайзер Продактс Инк.	Сухие гранулированные композиции азитромицина
ITMI20021209A1 (it)	2002-06-04	2003-12-04	Chemi Spa	Processo di preparazione di azitromicina ad elevata purezza

2002
- 2002-03-18 HR HR20020231A patent/HRP20020231A2/hr not_active Application Discontinuation
2003
- 2003-03-17 US US10/390,573 patent/US7569549B2/en not_active Expired - Lifetime
- 2003-03-18 CN CNA038063263A patent/CN1642966A/zh active Pending
- 2003-03-18 ES ES03744475T patent/ES2331733T3/es not_active Expired - Lifetime
- 2003-03-18 PL PL03372468A patent/PL372468A1/xx unknown
- 2003-03-18 AT AT03744475T patent/ATE440104T1/de not_active IP Right Cessation
- 2003-03-18 EP EP03744475A patent/EP1485393B1/en not_active Expired - Lifetime
- 2003-03-18 EA EA200401217A patent/EA200401217A1/ru unknown
- 2003-03-18 JP JP2003575884A patent/JP2005529082A/ja not_active Abandoned
- 2003-03-18 EP EP05023731A patent/EP1627883A1/en not_active Withdrawn
- 2003-03-18 RS YU82504A patent/RS82504A/sr unknown
- 2003-03-18 WO PCT/IB2003/000987 patent/WO2003077830A2/en not_active Ceased
- 2003-03-18 MX MXPA04009009A patent/MXPA04009009A/es not_active Application Discontinuation
- 2003-03-18 DE DE60328872T patent/DE60328872D1/de not_active Expired - Fee Related
- 2003-03-18 NZ NZ535477A patent/NZ535477A/en unknown
- 2003-03-18 AU AU2003215779A patent/AU2003215779A1/en not_active Abandoned
- 2003-03-18 HR HR20040858A patent/HRP20040858A2/xx not_active Application Discontinuation
- 2003-03-18 KR KR10-2004-7014757A patent/KR20050002872A/ko not_active Withdrawn
- 2003-03-18 BR BR0308644-5A patent/BR0308644A/pt not_active Application Discontinuation
- 2003-03-18 CA CA002479211A patent/CA2479211A1/en not_active Abandoned
- 2003-03-18 IL IL16383603A patent/IL163836A0/xx unknown
2004
- 2004-09-03 TN TNP2004000166A patent/TNSN04166A1/en unknown
- 2004-09-14 BG BG108874A patent/BG108874A/xx unknown
- 2004-09-16 IS IS7449A patent/IS7449A/is unknown
- 2004-10-13 NO NO20044341A patent/NO20044341L/no unknown

Also Published As

Publication number	Publication date
TNSN04166A1 (en)	2007-03-12
BG108874A (en)	2005-12-30
EP1485393A2 (en)	2004-12-15
IS7449A (is)	2004-09-16
WO2003077830A2 (en)	2003-09-25
ATE440104T1 (de)	2009-09-15
HRP20040858A2 (en)	2005-06-30
CA2479211A1 (en)	2003-09-25
US20040014951A1 (en)	2004-01-22
KR20050002872A (ko)	2005-01-10
BR0308644A (pt)	2005-01-25
WO2003077830A3 (en)	2004-05-13
NZ535477A (en)	2006-11-30
JP2005529082A (ja)	2005-09-29
EP1627883A1 (en)	2006-02-22
EA200401217A1 (ru)	2005-02-24
NO20044341L (no)	2004-11-23
DE60328872D1 (en)	2009-10-01
AU2003215779A1 (en)	2003-09-29
HRP20020231A2 (en)	2003-12-31
RS82504A (sr)	2006-12-15
US7569549B2 (en)	2009-08-04
CN1642966A (zh)	2005-07-20
IL163836A0 (en)	2005-12-18
ES2331733T3 (es)	2010-01-14
EP1485393B1 (en)	2009-08-19
MXPA04009009A (es)	2005-06-17

Legal Events

Date	Code	Title	Description
2007-06-29	DISC	Decisions on discontinuance of the proceedings (taken after the publication of the particulars of the applications)

Publication	Publication Date	Title
IL163836A0 (en)	2005-12-18	Isostructural pseudopolymorphs of 9-deoxo-9A-aza-9-a-methyl-9A-homoerythromycin a
BR0014274A (pt)	2005-07-19	Composições de intercalação de catodo, métodos de produção e baterias de lìtio recarregáveis contendo as mesmas
EP1457550A3 (en)	2004-11-03	Composition for removing residues from the microstructure of an object
WO2003010138A3 (en)	2003-12-04	Piperidine derivatives as antibacterial agents
EP3738591A3 (en)	2021-03-24	Novel antibacterial agents
NO2012012I2 (no)	2012-07-30	Pasireotide (som diaspartat salt). Det kjemiske navnet er cyclo[(4R)-4-(2-aminoethylcarbamoyloxy)-L-prolyl-L-phenylglycyl-D-tryptophyl-L-lysyl-4-O-benzyl-L-tyrosyl-L-phenylalanyl-)
AU2001236606A1 (en)	2001-08-14	3,4-dihydro-2h-benzo(1,4)oxazine inhibitors of factor xa
IL158485A0 (en)	2004-05-12	Spiropyrazole compounds
PH12009500610A1 (en)	2016-06-13	4-imidazolin-2-one compounds
MXPA03002911A (es)	2003-09-10	Compuestos quimicos.
CA2327679A1 (en)	1999-10-14	Triphendioxazine dyestuffs for dyeing organic substrates
HK1052170A1 (zh)	2003-09-05	新型化合物抑制因子xa活度
WO2003030886A3 (en)	2003-08-07	Allylamides useful in the treatment of alzheimer's disease
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WO2003053971A8 (en)	2004-01-29	Pyridoquinoxaline antivirals
WO2004082629A3 (en)	2005-12-01	Novel cyclosporins
SE9904765D0 (sv)	1999-12-23	Pharmaceutically-useful compounds
AU2002308000A1 (en)	2002-10-21	Antibacterial oxazolidinones with a cyclic sulphilimine or sulphoximine
TW200609228A (en)	2006-03-16	Substituted n-acyl-2-aminothiazoles
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EP2264049A3 (en)	2011-02-16	1-Desamino-8-d-arginyl vasopressin analogs