CA2479211A1 - 9-dexo-9a-aza-9a-methyl-9a-homoerythromycin a derivatives - Google Patents

9-dexo-9a-aza-9a-methyl-9a-homoerythromycin a derivatives Download PDF

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Publication number: CA2479211A1
Authority: CA; Canada
Prior art keywords: ang; aza; deoxo; homoerythromycin; methyl
Prior art date: 2002-03-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002479211A

Other languages

English (en)

French (fr)

Inventor

Miljenko Dumic

Mladen Vinkovic

Marina Oresic

Ernest Mestrovic

Aleksandar Danilovski

Alojz Dumbovic

Zdravka Knezevic

Gorjana Lazarevski

Dominik Cincic

Darko Filic

Dejan-Kresimir Bucar

Katica Lazaric

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pliva Istrazivanje i Razvoj doo

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-18

Filing date

2003-03-18

Publication date

2003-09-25

2003-03-18 Application filed by Individual filed Critical Individual

2003-09-25 Publication of CA2479211A1 publication Critical patent/CA2479211A1/en

Status Abandoned legal-status Critical Current

Links

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235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 description 1
239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 description 1
229920000136 polysorbate Polymers 0.000 description 1
229940101027 polysorbate 40 Drugs 0.000 description 1
229940068965 polysorbates Drugs 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910000027 potassium carbonate Inorganic materials 0.000 description 1
TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
KWYUFKZDYYNOTN-UHFFFAOYSA-M potassium hydroxide Inorganic materials [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 1
238000000634 powder X-ray diffraction Methods 0.000 description 1
230000002265 prevention Effects 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
OVARTBFNCCXQKS-UHFFFAOYSA-N propan-2-one;hydrate Chemical compound O.CC(C)=O OVARTBFNCCXQKS-UHFFFAOYSA-N 0.000 description 1
FVSKHRXBFJPNKK-UHFFFAOYSA-N propionitrile Chemical compound CCC#N FVSKHRXBFJPNKK-UHFFFAOYSA-N 0.000 description 1
238000000746 purification Methods 0.000 description 1
HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
150000003242 quaternary ammonium salts Chemical class 0.000 description 1
238000001226 reprecipitation Methods 0.000 description 1
239000013557 residual solvent Substances 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
229940081974 saccharin Drugs 0.000 description 1
235000019204 saccharin Nutrition 0.000 description 1
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
229940085605 saccharin sodium Drugs 0.000 description 1
229920002545 silicone oil Polymers 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
229940083542 sodium Drugs 0.000 description 1
CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
229960001462 sodium cyclamate Drugs 0.000 description 1
229910001948 sodium oxide Inorganic materials 0.000 description 1
229920003109 sodium starch glycolate Polymers 0.000 description 1
239000008109 sodium starch glycolate Substances 0.000 description 1
229940079832 sodium starch glycolate Drugs 0.000 description 1
229940045902 sodium stearyl fumarate Drugs 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
241000894007 species Species 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
HXJUTPCZVOIRIF-UHFFFAOYSA-N sulfolane Chemical compound O=S1(=O)CCCC1 HXJUTPCZVOIRIF-UHFFFAOYSA-N 0.000 description 1
125000001174 sulfone group Chemical group 0.000 description 1
239000013589 supplement Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
230000009747 swallowing Effects 0.000 description 1
239000000979 synthetic dye Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
LRGJRHZIDJQFCL-UHFFFAOYSA-M tetraethylazanium;hydroxide Chemical group [OH-].CC[N+](CC)(CC)CC LRGJRHZIDJQFCL-UHFFFAOYSA-M 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
WGTYBPLFGIVFAS-UHFFFAOYSA-M tetramethylammonium hydroxide Chemical group [OH-].C[N+](C)(C)C WGTYBPLFGIVFAS-UHFFFAOYSA-M 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
229960001295 tocopherol Drugs 0.000 description 1
229930003799 tocopherol Natural products 0.000 description 1
235000010384 tocopherol Nutrition 0.000 description 1
239000011732 tocopherol Substances 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
230000009466 transformation Effects 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
238000002424 x-ray crystallography Methods 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Tropical Medicine & Parasitology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Thermal Transfer Or Thermal Recording In General (AREA)
Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
Finger-Pressure Massage (AREA)
Instructional Devices (AREA)

CA002479211A 2002-03-18 2003-03-18 9-dexo-9a-aza-9a-methyl-9a-homoerythromycin a derivatives Abandoned CA2479211A1 (en)

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
HRP20020231A		2002-03-18
HR20020231A HRP20020231A2 (en)	2002-03-18	2002-03-18	ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
US39361202P	2002-07-03	2002-07-03
US60/393,612		2002-07-03
US39470502P	2002-07-08	2002-07-08
US60/394,705		2002-07-08
PCT/IB2003/000987 WO2003077830A2 (en)	2002-03-18	2003-03-18	9-dexo-9a-aza-9a-methyl-9a-homoerythromycin a derivatives

Publications (1)

Publication Number	Publication Date
CA2479211A1 true CA2479211A1 (en)	2003-09-25

Family

ID=28045976

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002479211A Abandoned CA2479211A1 (en)	2002-03-18	2003-03-18	9-dexo-9a-aza-9a-methyl-9a-homoerythromycin a derivatives

Country Status (23)

Country	Link
US (1)	US7569549B2 (2)
EP (2)	EP1485393B1 (2)
JP (1)	JP2005529082A (2)
KR (1)	KR20050002872A (2)
CN (1)	CN1642966A (2)
AT (1)	ATE440104T1 (2)
AU (1)	AU2003215779A1 (2)
BG (1)	BG108874A (2)
BR (1)	BR0308644A (2)
CA (1)	CA2479211A1 (2)
DE (1)	DE60328872D1 (2)
EA (1)	EA200401217A1 (2)
ES (1)	ES2331733T3 (2)
HR (2)	HRP20020231A2 (2)
IL (1)	IL163836A0 (2)
IS (1)	IS7449A (2)
MX (1)	MXPA04009009A (2)
NO (1)	NO20044341L (2)
NZ (1)	NZ535477A (2)
PL (1)	PL372468A1 (2)
RS (1)	RS82504A (2)
TN (1)	TNSN04166A1 (2)
WO (1)	WO2003077830A2 (2)

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US7468428B2 (en) *	2004-03-17	2008-12-23	App Pharmaceuticals, Llc	Lyophilized azithromycin formulation

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JP2004506664A (ja) *	2000-08-23	2004-03-04	ウォックハート・リミテッド	無水アジトロマイシンの製造法
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KR100491183B1 (ko)	2001-03-21	2005-05-25	한미약품 주식회사	아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
KR100431431B1 (ko)	2001-04-25	2004-05-14	한미약품 주식회사	아지트로마이신 수화물의 1,2-프로필렌글리콜 내포화합물,그의 제조방법 및 그의 약학적 조성물
HRP20010301A2 (en)	2001-04-27	2001-12-31	Pliva D D	New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
US6861413B2 (en) *	2001-05-22	2005-03-01	Pfizer Inc.	Stable non-dihydrate azithromycin oral suspensions
ES2258142T3 (es) *	2001-05-22	2006-08-16	Pfizer Products Inc.	Nueva forma cristalina.
PL371259A1 (pl) *	2001-12-21	2005-06-13	Pfizer Products Inc.	Bezpośrednio sprasowywalne preparaty azytromycyny
NZ532063A (en) *	2001-12-21	2006-03-31	Pfizer Prod Inc	Methods for wet granulating azithromycin
RU2283092C2 (ru)	2002-02-01	2006-09-10	Пфайзер Продактс Инк.	Сухие гранулированные композиции азитромицина
ITMI20021209A1 (it)	2002-06-04	2003-12-04	Chemi Spa	Processo di preparazione di azitromicina ad elevata purezza

2002
- 2002-03-18 HR HR20020231A patent/HRP20020231A2/hr not_active Application Discontinuation
2003
- 2003-03-17 US US10/390,573 patent/US7569549B2/en not_active Expired - Lifetime
- 2003-03-18 CN CNA038063263A patent/CN1642966A/zh active Pending
- 2003-03-18 ES ES03744475T patent/ES2331733T3/es not_active Expired - Lifetime
- 2003-03-18 PL PL03372468A patent/PL372468A1/xx unknown
- 2003-03-18 AT AT03744475T patent/ATE440104T1/de not_active IP Right Cessation
- 2003-03-18 EP EP03744475A patent/EP1485393B1/en not_active Expired - Lifetime
- 2003-03-18 EA EA200401217A patent/EA200401217A1/ru unknown
- 2003-03-18 JP JP2003575884A patent/JP2005529082A/ja not_active Abandoned
- 2003-03-18 EP EP05023731A patent/EP1627883A1/en not_active Withdrawn
- 2003-03-18 RS YU82504A patent/RS82504A/sr unknown
- 2003-03-18 WO PCT/IB2003/000987 patent/WO2003077830A2/en not_active Ceased
- 2003-03-18 MX MXPA04009009A patent/MXPA04009009A/es not_active Application Discontinuation
- 2003-03-18 DE DE60328872T patent/DE60328872D1/de not_active Expired - Fee Related
- 2003-03-18 NZ NZ535477A patent/NZ535477A/en unknown
- 2003-03-18 AU AU2003215779A patent/AU2003215779A1/en not_active Abandoned
- 2003-03-18 HR HR20040858A patent/HRP20040858A2/xx not_active Application Discontinuation
- 2003-03-18 KR KR10-2004-7014757A patent/KR20050002872A/ko not_active Withdrawn
- 2003-03-18 BR BR0308644-5A patent/BR0308644A/pt not_active Application Discontinuation
- 2003-03-18 CA CA002479211A patent/CA2479211A1/en not_active Abandoned
- 2003-03-18 IL IL16383603A patent/IL163836A0/xx unknown
2004
- 2004-09-03 TN TNP2004000166A patent/TNSN04166A1/en unknown
- 2004-09-14 BG BG108874A patent/BG108874A/xx unknown
- 2004-09-16 IS IS7449A patent/IS7449A/is unknown
- 2004-10-13 NO NO20044341A patent/NO20044341L/no unknown

Also Published As

Publication number	Publication date
TNSN04166A1 (en)	2007-03-12
BG108874A (en)	2005-12-30
EP1485393A2 (en)	2004-12-15
IS7449A (is)	2004-09-16
WO2003077830A2 (en)	2003-09-25
ATE440104T1 (de)	2009-09-15
HRP20040858A2 (en)	2005-06-30
US20040014951A1 (en)	2004-01-22
KR20050002872A (ko)	2005-01-10
BR0308644A (pt)	2005-01-25
WO2003077830A3 (en)	2004-05-13
NZ535477A (en)	2006-11-30
JP2005529082A (ja)	2005-09-29
EP1627883A1 (en)	2006-02-22
EA200401217A1 (ru)	2005-02-24
NO20044341L (no)	2004-11-23
DE60328872D1 (en)	2009-10-01
AU2003215779A1 (en)	2003-09-29
HRP20020231A2 (en)	2003-12-31
RS82504A (sr)	2006-12-15
PL372468A1 (en)	2005-07-25
US7569549B2 (en)	2009-08-04
CN1642966A (zh)	2005-07-20
IL163836A0 (en)	2005-12-18
ES2331733T3 (es)	2010-01-14
EP1485393B1 (en)	2009-08-19
MXPA04009009A (es)	2005-06-17

Legal Events

Date	Code	Title	Description
2008-03-18	FZDE	Discontinued

Publication	Publication Date	Title
EP2181117B1 (en)	2016-11-09	Macrolide solid-state forms
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CA1339215C (en)	1997-08-05	Rifapentine hydrohalides
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EP2882435B1 (en)	2021-03-17	Pharmaceutical formulations containing 3-(4-cinnamyl-L-piperazinyl) amino derivatives of 3-formylrifamycin S
WO2002009640A2 (en)	2002-02-07	Process for the preparation of anhydrous azithromycin
JP2013184902A (ja)	2013-09-19	リファキシミン含有結晶
ZA200406971B (en)	2005-06-20	9-dexo-9a-aza-9a-methyl-9a-homoerythromycin a derivatives.
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DE20321227U1 (de)	2006-12-07	Isostrukturelle Pseudopolymorphe von 9-Deoxo-9a-Aza-9a-Methyl-9a-Homoerythromycin A
HK1187351B (en)	2017-05-19	Optimized synthesis of pure, non-polymorphic, crystalline bile acids with defined particle size
HK1005455B (en)	1999-01-08	Rifapentine hydrohalides