PL3896091T3 - Chimeryczne receptory antygenowe nakierowane na bcma i sposoby ich zastosowania - Google Patents

Chimeryczne receptory antygenowe nakierowane na bcma i sposoby ich zastosowania

Info

Publication number
PL3896091T3
PL3896091T3 PL21166662.3T PL21166662T PL3896091T3 PL 3896091 T3 PL3896091 T3 PL 3896091T3 PL 21166662 T PL21166662 T PL 21166662T PL 3896091 T3 PL3896091 T3 PL 3896091T3
Authority
PL
Poland
Prior art keywords
methods
chimeric antigen
antigen receptors
targeting bcma
receptors targeting
Prior art date
Application number
PL21166662.3T
Other languages
English (en)
Inventor
Xiaohu FAN
Qiuchuan ZHUANG
Pingyan WANG
Lin Wang
Lei Yang
Jiaying HAO
Dan Zhao
Xian HE
Original Assignee
Legend Biotech Ireland Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CN2016/094408 external-priority patent/WO2017025038A1/en
Application filed by Legend Biotech Ireland Limited filed Critical Legend Biotech Ireland Limited
Publication of PL3896091T3 publication Critical patent/PL3896091T3/pl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001116—Receptors for cytokines
    • A61K39/001117—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR] or CD30
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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PL21166662.3T 2016-08-10 2017-08-10 Chimeryczne receptory antygenowe nakierowane na bcma i sposoby ich zastosowania PL3896091T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2016/094408 WO2017025038A1 (en) 2015-08-11 2016-08-10 Chimeric antigen receptors based on single-domain antibodies and methods of use thereof

Publications (1)

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PL3896091T3 true PL3896091T3 (pl) 2024-04-29

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PL21166662.3T PL3896091T3 (pl) 2016-08-10 2017-08-10 Chimeryczne receptory antygenowe nakierowane na bcma i sposoby ich zastosowania

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Country Link
US (4) US11535677B2 (pl)
EP (4) EP3475307A4 (pl)
JP (4) JP6851461B2 (pl)
KR (5) KR102512934B1 (pl)
CN (1) CN109153731B (pl)
AU (2) AU2017311089B2 (pl)
CA (2) CA3019453C (pl)
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