PL400413A1 - Methyl-imidazolium ionic liquids with the theophylline anion and a method for their preparation - Google Patents
Methyl-imidazolium ionic liquids with the theophylline anion and a method for their preparationInfo
- Publication number
- PL400413A1 PL400413A1 PL400413A PL40041312A PL400413A1 PL 400413 A1 PL400413 A1 PL 400413A1 PL 400413 A PL400413 A PL 400413A PL 40041312 A PL40041312 A PL 40041312A PL 400413 A1 PL400413 A1 PL 400413A1
- Authority
- PL
- Poland
- Prior art keywords
- theophylline
- general formula
- residue
- anion
- preparation
- Prior art date
Links
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N Theophylline Natural products O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 title abstract 5
- 229960000278 theophylline Drugs 0.000 title abstract 3
- -1 theophylline anion Chemical class 0.000 title abstract 3
- MCTWTZJPVLRJOU-UHFFFAOYSA-O 1-methylimidazole Chemical compound CN1C=C[NH+]=C1 MCTWTZJPVLRJOU-UHFFFAOYSA-O 0.000 title abstract 2
- 239000002608 ionic liquid Substances 0.000 title abstract 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical group [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical group [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical group [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000002603 chloroethyl group Chemical group [H]C([*])([H])C([H])([H])Cl 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910017053 inorganic salt Inorganic materials 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
- 229910052700 potassium Chemical group 0.000 abstract 1
- 239000011591 potassium Chemical group 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 229910052709 silver Chemical group 0.000 abstract 1
- 239000004332 silver Chemical group 0.000 abstract 1
- 229910052708 sodium Chemical group 0.000 abstract 1
- 239000011734 sodium Chemical group 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Przedmiotem wynalazku sa metyloimidazoliowe ciecze jonowe z anionem teofiliniowym o wzorze ogólnym 1, w którym R oznacza prostolancuchowa grupe alkilowa zawierajaca od 1 do 20 atomów wegla lub proton lub grupe arylowa lub allilowa lub winylowa lub chloroetylowa lub hydroksyetylowa lub benzylowa majace zastosowanie jako zwiazki powierzchniowo czynne. W odmianie wynalazku sposób ich wytwarzania polega na tym, ze sól teofiliny o wzorze ogólnym 2, w której M oznacza atom litu, lub sodu, lub potasu, lub srebra lub grupe NH4, poddaje sie reakcji z halogenkiem metyloimidazoliowym o wzorze ogólnym 3, w którym X oznacza chlor, brom, jod, w stosunku molowym 1:0,8-1,5 w rozpuszczalniku organicznym, calosc miesza sie w temperaturze od 273 do 363 K, w czasie co najmniej 15 minut, po czym oddziela roztwór od powstajacego osadu, który stanowi sól nieorganiczna. Nastepnie odparowuje sie rozpuszczalnik organiczny, a pozostalosc przemywa bezwodnym acetonem do usuniecia pozostalosci soli oraz nadmiaru nieprzereagowanej teofiliny, dalej pozostalosc suszy sie pod obnizonym cisnieniem w temperaturze 303 do 343 K, w czasie co najmniej 15 minut.The present invention relates to methylimidazolium ionic liquids with a theophylline anion of general formula 1, wherein R is a straight chain alkyl group containing from 1 to 20 carbon atoms or a proton or aryl or allyl or vinyl or chloroethyl or hydroxyethyl or benzyl group having surfactant compounds. In an embodiment of the invention, the method for their preparation is that the theophylline salt of general formula 2, in which M is lithium, or sodium, or potassium, or silver, or a NH4 group, is reacted with a methylimidazolium halide of general formula 3, in which X is chlorine, bromine, iodine, in a molar ratio of 1: 0.8-1.5 in an organic solvent, the whole is stirred at a temperature of 273 to 363 K for at least 15 minutes, then separates the solution from the resulting precipitate, which is the inorganic salt. The organic solvent is then evaporated and the residue is washed with anhydrous acetone to remove the salt residue and excess unreacted theophylline, then the residue is dried under reduced pressure at 303 to 343 K for at least 15 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL400413A PL223201B1 (en) | 2012-08-16 | 2012-08-16 | Methyl-imidazolium ionic liquids with the theophylline anion and a method for their preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL400413A PL223201B1 (en) | 2012-08-16 | 2012-08-16 | Methyl-imidazolium ionic liquids with the theophylline anion and a method for their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL400413A1 true PL400413A1 (en) | 2014-02-17 |
| PL223201B1 PL223201B1 (en) | 2016-10-31 |
Family
ID=50097355
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL400413A PL223201B1 (en) | 2012-08-16 | 2012-08-16 | Methyl-imidazolium ionic liquids with the theophylline anion and a method for their preparation |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL223201B1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7223406B2 (en) * | 2019-03-08 | 2023-02-16 | 国立大学法人金沢大学 | Method for producing polysaccharide derivative and method for producing lignin derivative |
-
2012
- 2012-08-16 PL PL400413A patent/PL223201B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL223201B1 (en) | 2016-10-31 |
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