PL4268843T3 - Ulepszone przeciwciała IL-6 - Google Patents

Ulepszone przeciwciała IL-6

Info

Publication number
PL4268843T3
PL4268843T3 PL23189385.0T PL23189385T PL4268843T3 PL 4268843 T3 PL4268843 T3 PL 4268843T3 PL 23189385 T PL23189385 T PL 23189385T PL 4268843 T3 PL4268843 T3 PL 4268843T3
Authority
PL
Poland
Prior art keywords
antibodies
improved
Prior art date
Application number
PL23189385.0T
Other languages
English (en)
Inventor
Michael March SCHMIDT
Alison TISDALE
Eric Steven Furfine
Grigorios Zarbis-Papastoitsis
Original Assignee
F. Hoffmann-La Roche Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ltd filed Critical F. Hoffmann-La Roche Ltd
Publication of PL4268843T3 publication Critical patent/PL4268843T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PL23189385.0T 2014-11-07 2015-11-06 Ulepszone przeciwciała IL-6 PL4268843T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462077105P 2014-11-07 2014-11-07
US201462087448P 2014-12-04 2014-12-04
US201562247705P 2015-10-28 2015-10-28

Publications (1)

Publication Number Publication Date
PL4268843T3 true PL4268843T3 (pl) 2025-12-15

Family

ID=54602042

Family Applications (2)

Application Number Title Priority Date Filing Date
PL15797538T PL3215530T3 (pl) 2014-11-07 2015-11-06 Ulepszone przeciwciała anty-il-6
PL23189385.0T PL4268843T3 (pl) 2014-11-07 2015-11-06 Ulepszone przeciwciała IL-6

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL15797538T PL3215530T3 (pl) 2014-11-07 2015-11-06 Ulepszone przeciwciała anty-il-6

Country Status (33)

Country Link
US (3) US11142571B2 (pl)
EP (3) EP3632931A1 (pl)
JP (1) JP6594438B2 (pl)
KR (2) KR102636726B1 (pl)
CN (1) CN107249631B (pl)
AU (1) AU2015342882B2 (pl)
CA (1) CA2965689C (pl)
CL (1) CL2017001135A1 (pl)
CO (1) CO2017005404A2 (pl)
CR (1) CR20170231A (pl)
DK (2) DK4268843T3 (pl)
EA (1) EA035199B1 (pl)
ES (2) ES3051832T3 (pl)
FI (1) FI4268843T3 (pl)
HR (2) HRP20191945T1 (pl)
HU (1) HUE046181T2 (pl)
IL (1) IL251858B (pl)
LT (1) LT4268843T (pl)
MA (2) MA51554A (pl)
MX (2) MX385206B (pl)
MY (1) MY185114A (pl)
PE (1) PE20171107A1 (pl)
PH (1) PH12017500809B1 (pl)
PL (2) PL3215530T3 (pl)
PT (2) PT3215530T (pl)
RS (2) RS67353B1 (pl)
SA (1) SA517381458B1 (pl)
SG (2) SG10202103420PA (pl)
SI (2) SI4268843T1 (pl)
SM (1) SMT202500415T1 (pl)
UA (1) UA122673C2 (pl)
WO (1) WO2016073890A1 (pl)
ZA (1) ZA201702985B (pl)

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WO2018115003A2 (en) * 2016-12-19 2018-06-28 Glenmark Pharmaceuticals S.A. Novel tnfr agonists and uses thereof
CA3056248A1 (en) 2017-03-22 2018-09-27 Genentech, Inc. Optimized antibody compositions for treatment of ocular disorders
SG10202107829YA (en) 2017-03-22 2021-08-30 Genentech Inc Hydrogel cross-linked hyaluronic acid prodrug compositions and methods
CN109867723B (zh) * 2017-12-05 2022-06-17 南京金斯瑞生物科技有限公司 抗人il6单克隆抗体及其制备方法和用途
AU2021236306A1 (en) 2020-03-13 2022-09-15 Genentech, Inc. Anti-interleukin-33 antibodies and uses thereof
IL296528A (en) 2020-03-24 2022-11-01 Genentech Inc Tie2-binding agents and methods of use
CA3198668A1 (en) 2020-10-15 2022-04-21 Genentech, Inc. Hyaluronic acid binding derivatives of versican (vg1) for long acting delivery of therapeutics
CN114525235B (zh) * 2022-02-25 2023-07-14 郑州大学 一种提高人表皮生长因子分泌生产效率的方法
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Also Published As

Publication number Publication date
EP4268843A2 (en) 2023-11-01
CN107249631B (zh) 2021-11-23
EP3632931A1 (en) 2020-04-08
SI4268843T1 (sl) 2026-01-30
JP6594438B2 (ja) 2019-10-23
WO2016073890A1 (en) 2016-05-12
HUE046181T2 (hu) 2020-02-28
ZA201702985B (en) 2019-10-30
BR112017008672A2 (pt) 2018-03-20
EP3215530B9 (en) 2020-09-09
SA517381458B1 (ar) 2020-07-09
MX2017005992A (es) 2017-09-15
PT4268843T (pt) 2025-10-31
CL2017001135A1 (es) 2017-12-15
RS67353B1 (sr) 2025-11-28
MA62787B1 (fr) 2025-11-28
PL3215530T3 (pl) 2020-05-18
EP4268843B1 (en) 2025-09-03
RS59805B1 (sr) 2020-02-28
HRP20191945T1 (hr) 2020-01-24
PT3215530T (pt) 2019-11-21
EP4268843A3 (en) 2023-12-27
KR102770849B1 (ko) 2025-02-20
EA201791005A1 (ru) 2017-09-29
US11142571B2 (en) 2021-10-12
EP3215530B1 (en) 2019-08-21
SI3215530T1 (sl) 2020-02-28
DK3215530T3 (da) 2019-11-25
KR20170077196A (ko) 2017-07-05
EA035199B1 (ru) 2020-05-14
HK1244008A1 (en) 2018-07-27
KR102636726B1 (ko) 2024-02-13
US20190194312A1 (en) 2019-06-27
AU2015342882B2 (en) 2021-05-20
SMT202500415T1 (it) 2026-01-12
MX385206B (es) 2025-03-14
PE20171107A1 (es) 2017-08-07
HRP20251312T1 (hr) 2025-12-05
CO2017005404A2 (es) 2017-10-31
CN107249631A (zh) 2017-10-13
UA122673C2 (uk) 2020-12-28
MX2021008663A (es) 2021-08-19
IL251858A0 (en) 2017-06-29
SG10202103420PA (en) 2021-05-28
ES2756275T9 (es) 2020-10-29
US20220169719A1 (en) 2022-06-02
EP3215530A1 (en) 2017-09-13
MA51554A (fr) 2020-11-18
PH12017500809A1 (en) 2017-10-02
JP2017535285A (ja) 2017-11-30
CA2965689C (en) 2022-03-22
ES3051832T3 (en) 2025-12-30
ES2756275T3 (es) 2020-04-27
US20250059270A1 (en) 2025-02-20
KR20240023450A (ko) 2024-02-21
DK4268843T3 (da) 2025-11-10
SG11201703574VA (en) 2017-05-30
FI4268843T3 (fi) 2025-11-14
CA2965689A1 (en) 2016-05-12
CR20170231A (es) 2017-09-25
LT4268843T (lt) 2025-11-25
NZ731090A (en) 2024-03-22
IL251858B (en) 2022-09-01
PH12017500809B1 (en) 2023-09-20
AU2015342882A1 (en) 2017-05-18
MY185114A (en) 2021-04-30

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