CR20170231A - Anticuerpos mejorados contra il-6 - Google Patents

Anticuerpos mejorados contra il-6

Info

Publication number
CR20170231A
CR20170231A CR20170231A CR20170231A CR20170231A CR 20170231 A CR20170231 A CR 20170231A CR 20170231 A CR20170231 A CR 20170231A CR 20170231 A CR20170231 A CR 20170231A CR 20170231 A CR20170231 A CR 20170231A
Authority
CR
Costa Rica
Prior art keywords
antibodies against
improved antibodies
antibodies
improved
treatment
Prior art date
Application number
CR20170231A
Other languages
English (en)
Inventor
Gregory Zarbis-Papastoitsis
Allison Tisdale
Eric Steven Furfine
Michael March Schmidt
Original Assignee
Eleven Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eleven Biotherapeutics Inc filed Critical Eleven Biotherapeutics Inc
Publication of CR20170231A publication Critical patent/CR20170231A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se proporcionan anticuerpos contra IL-6 mejorados. Se describen los usos de los anticuerpos en el tratamiento de enfermedades relacionadas a IL-6, por ejemplo, enfermedades oculares tales como edema macular diabético.
CR20170231A 2014-11-07 2015-11-06 Anticuerpos mejorados contra il-6 CR20170231A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462077105P 2014-11-07 2014-11-07
US201462087448P 2014-12-04 2014-12-04
US201562247705P 2015-10-28 2015-10-28
PCT/US2015/059532 WO2016073890A1 (en) 2014-11-07 2015-11-06 Improved il-6 antibodies

Publications (1)

Publication Number Publication Date
CR20170231A true CR20170231A (es) 2017-09-25

Family

ID=54602042

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20170231A CR20170231A (es) 2014-11-07 2015-11-06 Anticuerpos mejorados contra il-6

Country Status (33)

Country Link
US (3) US11142571B2 (es)
EP (3) EP3215530B9 (es)
JP (1) JP6594438B2 (es)
KR (2) KR102770849B1 (es)
CN (1) CN107249631B (es)
AU (1) AU2015342882B2 (es)
CA (1) CA2965689C (es)
CL (1) CL2017001135A1 (es)
CO (1) CO2017005404A2 (es)
CR (1) CR20170231A (es)
DK (2) DK3215530T3 (es)
EA (1) EA035199B1 (es)
ES (2) ES3051832T3 (es)
FI (1) FI4268843T3 (es)
HR (2) HRP20251312T1 (es)
HU (1) HUE046181T2 (es)
IL (1) IL251858B (es)
LT (1) LT4268843T (es)
MA (2) MA51554A (es)
MX (2) MX385206B (es)
MY (1) MY185114A (es)
PE (1) PE20171107A1 (es)
PH (1) PH12017500809B1 (es)
PL (2) PL3215530T3 (es)
PT (2) PT4268843T (es)
RS (2) RS67353B1 (es)
SA (1) SA517381458B1 (es)
SG (2) SG10202103420PA (es)
SI (2) SI3215530T1 (es)
SM (1) SMT202500415T1 (es)
UA (1) UA122673C2 (es)
WO (1) WO2016073890A1 (es)
ZA (1) ZA201702985B (es)

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KR20180116359A (ko) * 2016-02-23 2018-10-24 세센 바이오, 아이엔씨. 인터루킨-6의 길항제 제제 및 이의 용도
JP2020504105A (ja) * 2016-12-19 2020-02-06 グレンマーク・ファーマシューティカルズ・エスエー 新規なｔｎｆｒアゴニストおよびその使用
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IL269506B2 (en) 2017-03-22 2024-04-01 Genentech Inc Hydrogel cross-linked hyaluronic acid prodrug compositions and methods
CN109867723B (zh) * 2017-12-05 2022-06-17 南京金斯瑞生物科技有限公司 抗人il6单克隆抗体及其制备方法和用途
AU2021236306A1 (en) 2020-03-13 2022-09-15 Genentech, Inc. Anti-interleukin-33 antibodies and uses thereof
WO2021194913A1 (en) 2020-03-24 2021-09-30 Genentech, Inc. Tie2-binding agents and methods of use
JP2023546112A (ja) 2020-10-15 2023-11-01 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 長時間作用型眼送達用非共有結合タンパク質－ヒアルロナンコンジュゲート
CN116554298A (zh) * 2022-02-25 2023-08-08 南京工业大学 一种强化细菌卷曲菌毛提高人表皮生长因子分泌生产效率的方法
CN115343483B (zh) * 2022-08-12 2024-11-26 苏州邦器生物技术有限公司 一种自身免疫性糖尿病检测用试剂盒及其制备方法
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Also Published As

Publication number Publication date
PE20171107A1 (es) 2017-08-07
US20250059270A1 (en) 2025-02-20
MX385206B (es) 2025-03-14
ES2756275T3 (es) 2020-04-27
HK1244008A1 (en) 2018-07-27
ES2756275T9 (es) 2020-10-29
ES3051832T3 (en) 2025-12-30
EA201791005A1 (ru) 2017-09-29
JP2017535285A (ja) 2017-11-30
MA51554A (fr) 2020-11-18
FI4268843T3 (fi) 2025-11-14
RS59805B1 (sr) 2020-02-28
EA035199B1 (ru) 2020-05-14
MX2017005992A (es) 2017-09-15
PL4268843T3 (pl) 2025-12-15
PT4268843T (pt) 2025-10-31
KR20240023450A (ko) 2024-02-21
KR20170077196A (ko) 2017-07-05
KR102770849B1 (ko) 2025-02-20
MA62787B1 (fr) 2025-11-28
US20190194312A1 (en) 2019-06-27
NZ731090A (en) 2024-03-22
HRP20191945T1 (hr) 2020-01-24
EP3632931A1 (en) 2020-04-08
CN107249631A (zh) 2017-10-13
PH12017500809A1 (en) 2017-10-02
AU2015342882A1 (en) 2017-05-18
EP4268843A3 (en) 2023-12-27
IL251858B (en) 2022-09-01
SA517381458B1 (ar) 2020-07-09
UA122673C2 (uk) 2020-12-28
DK3215530T3 (da) 2019-11-25
CN107249631B (zh) 2021-11-23
HUE046181T2 (hu) 2020-02-28
IL251858A0 (en) 2017-06-29
SI3215530T1 (sl) 2020-02-28
JP6594438B2 (ja) 2019-10-23
CO2017005404A2 (es) 2017-10-31
SI4268843T1 (sl) 2026-01-30
RS67353B1 (sr) 2025-11-28
EP3215530A1 (en) 2017-09-13
US20220169719A1 (en) 2022-06-02
AU2015342882B2 (en) 2021-05-20
PT3215530T (pt) 2019-11-21
MX2021008663A (es) 2021-08-19
WO2016073890A1 (en) 2016-05-12
PH12017500809B1 (en) 2023-09-20
CA2965689C (en) 2022-03-22
SG10202103420PA (en) 2021-05-28
LT4268843T (lt) 2025-11-25
CA2965689A1 (en) 2016-05-12
KR102636726B1 (ko) 2024-02-13
ZA201702985B (en) 2019-10-30
US11142571B2 (en) 2021-10-12
EP3215530B1 (en) 2019-08-21
SG11201703574VA (en) 2017-05-30
EP3215530B9 (en) 2020-09-09
PL3215530T3 (pl) 2020-05-18
EP4268843A2 (en) 2023-11-01
BR112017008672A2 (pt) 2018-03-20
SMT202500415T1 (it) 2026-01-12
DK4268843T3 (da) 2025-11-10
EP4268843B1 (en) 2025-09-03
CL2017001135A1 (es) 2017-12-15
MY185114A (en) 2021-04-30
HRP20251312T1 (hr) 2025-12-05

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