PL428742A1 - 4'-Hydroxy-2',5'-dimethoxyflavone and method of preparing 4'-hydroxy-2',5'-dimethoxyflavone - Google Patents

4'-Hydroxy-2',5'-dimethoxyflavone and method of preparing 4'-hydroxy-2',5'-dimethoxyflavone

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Publication number
PL428742A1
PL428742A1 PL428742A PL42874219A PL428742A1 PL 428742 A1 PL428742 A1 PL 428742A1 PL 428742 A PL428742 A PL 428742A PL 42874219 A PL42874219 A PL 42874219A PL 428742 A1 PL428742 A1 PL 428742A1
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PL
Poland
Prior art keywords
dimethoxyflavone
hydroxy
preparing
kch
microorganism
Prior art date
Application number
PL428742A
Other languages
Polish (pl)
Other versions
PL238786B1 (en
Inventor
Mateusz Łużny
Ewa Kozłowska
Marcelina Mazur
Edyta Kostrzewa-Susłow
Tomasz Janeczko
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL428742A priority Critical patent/PL238786B1/en
Publication of PL428742A1 publication Critical patent/PL428742A1/en
Publication of PL238786B1 publication Critical patent/PL238786B1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

Wynalazek dotyczy 4'-hydroksy-2,5'-dimetoksyflawon i sposobu wytwarzania 4'-hydroksy-2',5'-dimetoksyflawonu o wzorze 2. W wyniku działania układu enzymatycznego zawartego w komórkach szczepu Beauveria bassiana KCh J1, następuje regioselektywna hydroksylacja. Uzyskany w ten sposób produkt wydziela się z wodnej kultury mikroorganizmu, znanym sposobem, przez ekstrakcję rozpuszczalnikiem organicznym niemieszającym się z wodą (octan etylu).The invention relates to 4'-hydroxy-2,5'-dimethoxyflavone and a method for the preparation of 4'-hydroxy-2 ', 5'-dimethoxyflavone of formula 2. As a result of the enzyme system contained in the cells of the Beauveria bassiana KCh J1 strain, regioselective hydroxylation occurs. The product obtained in this way is separated from the aqueous culture of the microorganism by a known method by extraction with a water-immiscible organic solvent (ethyl acetate).

PL428742A 2019-01-31 2019-01-31 4'-Hydroxy-2',5'-dimethoxyflavone and method of preparing 4'-hydroxy-2',5'-dimethoxyflavone PL238786B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL428742A PL238786B1 (en) 2019-01-31 2019-01-31 4'-Hydroxy-2',5'-dimethoxyflavone and method of preparing 4'-hydroxy-2',5'-dimethoxyflavone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL428742A PL238786B1 (en) 2019-01-31 2019-01-31 4'-Hydroxy-2',5'-dimethoxyflavone and method of preparing 4'-hydroxy-2',5'-dimethoxyflavone

Publications (2)

Publication Number Publication Date
PL428742A1 true PL428742A1 (en) 2020-08-10
PL238786B1 PL238786B1 (en) 2021-10-04

Family

ID=71943730

Family Applications (1)

Application Number Title Priority Date Filing Date
PL428742A PL238786B1 (en) 2019-01-31 2019-01-31 4'-Hydroxy-2',5'-dimethoxyflavone and method of preparing 4'-hydroxy-2',5'-dimethoxyflavone

Country Status (1)

Country Link
PL (1) PL238786B1 (en)

Also Published As

Publication number Publication date
PL238786B1 (en) 2021-10-04

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