PL437713A1 - Method for preparing (-)-isomer of 3-hydroxy-3-butylphthalide - Google Patents

Method for preparing (-)-isomer of 3-hydroxy-3-butylphthalide

Info

Publication number
PL437713A1
PL437713A1 PL437713A PL43771321A PL437713A1 PL 437713 A1 PL437713 A1 PL 437713A1 PL 437713 A PL437713 A PL 437713A PL 43771321 A PL43771321 A PL 43771321A PL 437713 A1 PL437713 A1 PL 437713A1
Authority
PL
Poland
Prior art keywords
butylphthalide
isomer
hydroxy
preparing
water
Prior art date
Application number
PL437713A
Other languages
Polish (pl)
Other versions
PL244219B1 (en
Inventor
Joanna Gach
Teresa Olejniczak
Piotr Krężel
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL437713A priority Critical patent/PL244219B1/en
Publication of PL437713A1 publication Critical patent/PL437713A1/en
Publication of PL244219B1 publication Critical patent/PL244219B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/65—Absidia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Wynalazek dotyczy sposobu wytwarzania (-)-izomeru 3-hydroksy-3-butyloftalidu o wzorze 2.Postępując zgodnie z wynalazkiem, w wyniku działania enzymów pochodzących z komórek szczepu Absidia cylindrospora AM 336, następuje addycja cząsteczki wody do wiązania podwójnego w łańcuchu bocznym 3-n-butylidenoftalidu. Uzyskany w ten sposób produkt wydziela się z wodnej kultury mikroorganizmu, znanym sposobem, przez ekstrakcję rozpuszczalnikiem organicznym niemieszającym się z wodą (octan etylu).The invention relates to a method for the production of the (-)-isomer of 3-hydroxy-3-butylphthalide of the formula 2. Following the invention, as a result of the action of enzymes derived from Absidia cylindrospora AM 336 cells, a water molecule is added to the double bond in the 3- n-butylidenephthalide. The product thus obtained is isolated from the aqueous culture of the micro-organism in a known manner by extraction with a water-immiscible organic solvent (ethyl acetate).

PL437713A 2021-04-27 2021-04-27 Method for preparing the (-)-isomer of 3-hydroxy-3-butylphthalide PL244219B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL437713A PL244219B1 (en) 2021-04-27 2021-04-27 Method for preparing the (-)-isomer of 3-hydroxy-3-butylphthalide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL437713A PL244219B1 (en) 2021-04-27 2021-04-27 Method for preparing the (-)-isomer of 3-hydroxy-3-butylphthalide

Publications (2)

Publication Number Publication Date
PL437713A1 true PL437713A1 (en) 2022-10-31
PL244219B1 PL244219B1 (en) 2023-12-18

Family

ID=83852874

Family Applications (1)

Application Number Title Priority Date Filing Date
PL437713A PL244219B1 (en) 2021-04-27 2021-04-27 Method for preparing the (-)-isomer of 3-hydroxy-3-butylphthalide

Country Status (1)

Country Link
PL (1) PL244219B1 (en)

Also Published As

Publication number Publication date
PL244219B1 (en) 2023-12-18

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