PT101982A - PROCESSO PARA A PREPARACAO DE S-N, N'-BIS-{2-HIDROXI-(1-HIDROXIMETIL) ETIL}- 5-(2-ACETOXI-PROPIONILAMINO)-2,4,6-TRIIODO-ISOFTALAMIDA E SUA UTILIZACãO NA PREPARACãO DO IOPAMIDOL - Google Patents

PROCESSO PARA A PREPARACAO DE S-N, N'-BIS-{2-HIDROXI-(1-HIDROXIMETIL) ETIL}- 5-(2-ACETOXI-PROPIONILAMINO)-2,4,6-TRIIODO-ISOFTALAMIDA E SUA UTILIZACãO NA PREPARACãO DO IOPAMIDOL Download PDF

Info

Publication number: PT101982A
Authority: PT; Portugal
Prior art keywords: preparation; isoftalamide; triodo; iopamidol; propionylamino
Prior art date: 1996-03-29

Application number

PT101982A

Other languages

English (en)

Other versions

PT101982B (pt

Inventor

Marco Villa

Antonio Nardi

Original Assignee

Zambon Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-03-29

Filing date

1997-03-21

Publication date

1997-11-28

1997-03-21 Application filed by Zambon Spa filed Critical Zambon Spa

1997-11-28 Publication of PT101982A publication Critical patent/PT101982A/pt

1999-06-30 Publication of PT101982B publication Critical patent/PT101982B/pt

Links

-1 1-HYDROXYMETHYL Chemical class 0.000 title 2
QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 title 1
XQZXYNRDCRIARQ-LURJTMIESA-N iopamidol Chemical compound C[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I XQZXYNRDCRIARQ-LURJTMIESA-N 0.000 title 1
229960004647 iopamidol Drugs 0.000 title 1
238000000034 method Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Steroid Compounds (AREA)

PT101982A 1996-03-29 1997-03-21 PROCESSO PARA A PREPARACAO DE S-N, N'-BIS-{2-HIDROXI-(1-HIDROXIMETIL) ETIL}- 5-(2-ACETOXI-PROPIONILAMINO)-2,4,6-TRIIODO-ISOFTALAMIDA E SUA UTILIZACãO NA PREPARACãO DO IOPAMIDOL PT101982B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT96MI000621A IT1283319B1 (it)	1996-03-29	1996-03-29	Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati

Publications (2)

Publication Number	Publication Date
PT101982A true PT101982A (pt)	1997-11-28
PT101982B PT101982B (pt)	1999-06-30

Family

ID=11373817

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT101982A PT101982B (pt)	1996-03-29	1997-03-21	PROCESSO PARA A PREPARACAO DE S-N, N'-BIS-{2-HIDROXI-(1-HIDROXIMETIL) ETIL}- 5-(2-ACETOXI-PROPIONILAMINO)-2,4,6-TRIIODO-ISOFTALAMIDA E SUA UTILIZACãO NA PREPARACãO DO IOPAMIDOL

Country Status (21)

Country	Link
US (1)	US5817861A (pt)
JP (1)	JP4035198B2 (pt)
BE (1)	BE1010961A3 (pt)
CA (1)	CA2201012C (pt)
CH (1)	CH692044A5 (pt)
CZ (1)	CZ96097A3 (pt)
DE (1)	DE19713456B4 (pt)
DK (1)	DK32297A (pt)
ES (1)	ES2136011B1 (pt)
FI (1)	FI971318A7 (pt)
FR (1)	FR2746796B1 (pt)
GB (1)	GB2311524B (pt)
HU (1)	HU225647B1 (pt)
IE (1)	IE970214A1 (pt)
IL (1)	IL120483A (pt)
IT (1)	IT1283319B1 (pt)
NL (1)	NL1005650C2 (pt)
NO (1)	NO322508B1 (pt)
PT (1)	PT101982B (pt)
SE (1)	SE9701145L (pt)
ZA (1)	ZA972627B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1299202B1 (it) *	1998-05-08	2000-02-29	Dibra Spa	Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodo
US6262303B1 (en)	1998-05-08	2001-07-17	Dibra S.P.A.	Process for the preparation of S-N,N′-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)-amino]-2,4,6-triiodo-1,3-benzenedicarboxamide
IT1302200B1 (it) *	1998-09-11	2000-07-31	Dibra Spa	PROCESSO PER LA PREPARAZIONE DELLA S-N,N'-BIS°2-IDROSSI-1-(IDROSSIMETIL)ETILé-5-°(2-IDROSSI-1-
KR20000075115A (ko) *	1999-05-28	2000-12-15	강재헌	불순물 ｃ가 제거된 이오파미돌의 신규 제조방법
PT2365963T (pt) *	2008-11-18	2017-08-22	Bracco Imaging Spa	Processo para a preparação de agente de contraste iodado
CN105272899B (zh) *	2015-11-17	2017-09-22	浙江海洲制药有限公司	一种化合物及其用于合成碘帕醇杂质d、杂质f、杂质g和杂质j的方法
JP7364841B2 (ja) *	2018-02-14	2023-10-19	智彦大和田	酸ハロゲン化物による化合物の製造方法
GB202009917D0 (en) *	2020-06-29	2020-08-12	Ge Healthcare As	Process for the preparation of iopamidol
CN116063195A (zh) *	2023-01-07	2023-05-05	安庆朗坤药业有限公司	一种碘帕醇中间体碘化物的制备方法
CN121620501A (zh)	2023-06-13	2026-03-06	伯拉考成像股份公司	通过反应挤出合成非离子型射线摄影造影剂

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH608189A5 (pt) *	1974-12-13	1978-12-29	Savac Ag
CH616403A5 (en) *	1975-10-29	1980-03-31	Bracco Ind Chimica Spa	Process for the preparation of 2,4,6-triodoisophthalamides which are readily soluble in water.
FR2656865B1 (fr) *	1990-01-05	1993-03-26	Guerbet Sa	Compose non ionique iode, son procede de preparation et produit de contraste le contenant.
ES2017277A6 (es) *	1989-09-20	1991-01-16	Juste Sa	Un procedimiento para la preparacion de nuevos agentes iodados no ionicos de contraste.
IT1248741B (it) *	1991-02-26	1995-01-26	Bracco Spa	Processo di concentrazione e di purificazione di composti organici
IT1256163B (it) *	1992-10-27	1995-11-29	Zambon Spa	Processo per la preparazione di un intermedio della sintesi organica
DE4320499A1 (de) *	1993-05-14	1994-11-17	Bayer Ag	Verfahren zur Herstellung von 2-Oximinoessigsäurederivaten
IT1274027B (it) *	1994-03-03	1997-07-14	Zambon Spa	Processo per la preparazione e purificazione di mezzi di contrasto iodurati

1996
- 1996-03-29 IT IT96MI000621A patent/IT1283319B1/it active IP Right Grant
1997
- 1997-03-18 IL IL12048397A patent/IL120483A/xx not_active IP Right Cessation
- 1997-03-20 IE IE970214A patent/IE970214A1/en not_active IP Right Cessation
- 1997-03-21 FR FR9703463A patent/FR2746796B1/fr not_active Expired - Lifetime
- 1997-03-21 PT PT101982A patent/PT101982B/pt active IP Right Grant
- 1997-03-21 US US08/822,463 patent/US5817861A/en not_active Expired - Lifetime
- 1997-03-21 DK DK032297A patent/DK32297A/da not_active Application Discontinuation
- 1997-03-24 GB GB9706095A patent/GB2311524B/en not_active Expired - Lifetime
- 1997-03-25 ES ES009700637A patent/ES2136011B1/es not_active Expired - Fee Related
- 1997-03-25 CA CA002201012A patent/CA2201012C/en not_active Expired - Lifetime
- 1997-03-25 CH CH00721/97A patent/CH692044A5/it not_active IP Right Cessation
- 1997-03-25 NO NO19971426A patent/NO322508B1/no not_active IP Right Cessation
- 1997-03-26 ZA ZA9702627A patent/ZA972627B/xx unknown
- 1997-03-26 NL NL1005650A patent/NL1005650C2/nl not_active IP Right Cessation
- 1997-03-27 SE SE9701145A patent/SE9701145L/ not_active Application Discontinuation
- 1997-03-27 FI FI971318A patent/FI971318A7/fi unknown
- 1997-03-27 HU HU9700667A patent/HU225647B1/hu unknown
- 1997-03-28 JP JP07734497A patent/JP4035198B2/ja not_active Expired - Lifetime
- 1997-03-28 BE BE9700288A patent/BE1010961A3/fr not_active IP Right Cessation
- 1997-03-28 CZ CZ97960A patent/CZ96097A3/cs unknown
- 1997-04-01 DE DE19713456A patent/DE19713456B4/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
HU225647B1 (en)	2007-05-29
FI971318L (fi)	1997-09-30
IL120483A0 (en)	1997-07-13
HU9700667D0 (en)	1997-05-28
GB9706095D0 (en)	1997-05-14
NL1005650C2 (nl)	2000-05-31
SE9701145L (sv)	1997-09-30
ZA972627B (en)	1997-10-23
CH692044A5 (it)	2002-01-15
FR2746796B1 (fr)	1998-09-11
NO322508B1 (no)	2006-10-16
ES2136011B1 (es)	2000-07-01
ES2136011A1 (es)	1999-11-01
US5817861A (en)	1998-10-06
DK32297A (da)	1997-09-30
FI971318A0 (fi)	1997-03-27
JPH107636A (ja)	1998-01-13
ITMI960621A0 (pt)	1996-03-29
BE1010961A3 (fr)	1999-03-02
DE19713456A1 (de)	1997-10-30
NL1005650A1 (nl)	1997-09-30
SE9701145D0 (sv)	1997-03-27
ITMI960621A1 (it)	1997-09-29
DE19713456B4 (de)	2007-01-11
FR2746796A1 (fr)	1997-10-03
CA2201012C (en)	2005-07-12
NO971426D0 (no)	1997-03-25
JP4035198B2 (ja)	2008-01-16
GB2311524B (en)	1999-04-07
CA2201012A1 (en)	1997-09-29
GB2311524A (en)	1997-10-01
IT1283319B1 (it)	1998-04-16
NO971426L (no)	1997-09-30
PT101982B (pt)	1999-06-30
HUP9700667A2 (hu)	1999-06-28
IE970214A1 (en)	1997-10-08
IL120483A (en)	2000-07-16
HUP9700667A3 (en)	2001-12-28
FI971318A7 (fi)	1997-09-30
CZ96097A3 (cs)	1998-04-15

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Legal Events

Date

Code

Title

Description

1997-11-28

BB1A

Laying open of patent application

Effective date: 19970627

1999-06-30

FG3A

Patent granted, date of granting

Effective date: 19990301

2004-06-30

PC3A

Transfer or assignment

Free format text: BRACCO IMAGING S.P.A. IT

Effective date: 20040420