PT3652187T - Processo melhorado para a preparação de imetelstat - Google Patents
Processo melhorado para a preparação de imetelstatInfo
- Publication number
- PT3652187T PT3652187T PT187376215T PT18737621T PT3652187T PT 3652187 T PT3652187 T PT 3652187T PT 187376215 T PT187376215 T PT 187376215T PT 18737621 T PT18737621 T PT 18737621T PT 3652187 T PT3652187 T PT 3652187T
- Authority
- PT
- Portugal
- Prior art keywords
- imetelstat
- preparing
- improved process
- improved
- preparing imetelstat
- Prior art date
Links
- LVZYXEALRXBLJZ-ISQYCPACSA-N f60ne4xb53 Chemical compound N1([C@@H]2O[C@@H]([C@H](C2)NP(O)(=S)OC[C@@H]2[C@H](C[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)NP(S)(=O)OC[C@@H]2[C@H](C[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)N)COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)OCC(O)CNC(=O)CCCCCCCCCCCCCCC)N2C(NC(=O)C(C)=C2)=O)N2C3=NC=NC(N)=C3N=C2)N2C3=C(C(NC(N)=N3)=O)N=C2)N2C3=C(C(NC(N)=N3)=O)N=C2)N2C3=C(C(NC(N)=N3)=O)N=C2)N2C(NC(=O)C(C)=C2)=O)N2C(NC(=O)C(C)=C2)=O)N2C3=NC=NC(N)=C3N=C2)N2C3=C(C(NC(N)=N3)=O)N=C2)N2C3=NC=NC(N)=C3N=C2)C=CC(N)=NC1=O LVZYXEALRXBLJZ-ISQYCPACSA-N 0.000 title 1
- 229950004291 imetelstat Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Processes Specially Adapted For Manufacturing Cables (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17180426 | 2017-07-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3652187T true PT3652187T (pt) | 2021-12-16 |
Family
ID=59313083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT187376215T PT3652187T (pt) | 2017-07-10 | 2018-07-09 | Processo melhorado para a preparação de imetelstat |
Country Status (30)
| Country | Link |
|---|---|
| US (4) | US11332489B2 (pt) |
| EP (1) | EP3652187B1 (pt) |
| JP (2) | JP7199410B2 (pt) |
| KR (2) | KR20240144459A (pt) |
| CN (1) | CN110891961B (pt) |
| AU (2) | AU2018298658B2 (pt) |
| BR (1) | BR112020000410A2 (pt) |
| CA (2) | CA3195922A1 (pt) |
| CL (1) | CL2020000054A1 (pt) |
| CO (1) | CO2020000096A2 (pt) |
| CY (1) | CY1125351T1 (pt) |
| DK (1) | DK3652187T3 (pt) |
| EA (1) | EA038579B1 (pt) |
| ES (1) | ES2901099T3 (pt) |
| HR (1) | HRP20211940T1 (pt) |
| HU (1) | HUE056722T2 (pt) |
| IL (1) | IL271388B (pt) |
| LT (1) | LT3652187T (pt) |
| MA (1) | MA49555A (pt) |
| PL (1) | PL3652187T3 (pt) |
| PT (1) | PT3652187T (pt) |
| RS (1) | RS62705B1 (pt) |
| SA (1) | SA520410996B1 (pt) |
| SG (1) | SG11201912385VA (pt) |
| SI (1) | SI3652187T1 (pt) |
| SM (1) | SMT202100701T1 (pt) |
| TW (1) | TWI775895B (pt) |
| UA (1) | UA125185C2 (pt) |
| WO (1) | WO2019011829A1 (pt) |
| ZA (2) | ZA201908452B (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4051252A4 (en) | 2019-10-28 | 2023-12-06 | Geron Corporation | CRYSTALLINE SOLIDS OF 3-PALMITOYL-AMIDO -1,2-PROPANEDIOL AND 3-PALMITOYL-AMIDO-2-HYDROXY-1-DIMETHOXYTRIPHENYLMETHYL ETHER-PROPANE AND METHODS OF MANUFACTURE AND USE THEREOF |
| IL292328B2 (en) | 2019-10-28 | 2025-10-01 | Geron Corp | Succinylate-converted 3-(amido fatty acid)-2-hydroxy-1-(protected hydroxy)-propane salts, amorphous solids and methods for their preparation |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1317291C (zh) | 1999-09-10 | 2007-05-23 | 杰龙公司 | 寡核苷酸n3′→p5′硫代氨基磷酸酯,其合成及应用 |
| PL1667522T3 (pl) | 2003-09-09 | 2018-06-29 | Geron Corporation | Zmodyfikowane oligonukleotydy do hamowania telomerazy |
| HRP20171705T1 (hr) | 2004-07-02 | 2017-12-15 | Geron Corporation | Sinteza zaštićenih 3’-amino-nukleozidnih monomera |
| ES2699827T3 (es) | 2009-06-17 | 2019-02-13 | Biogen Ma Inc | Composiciones y métodos para la modulación de corte y empalme de SMN2 en un sujeto |
| JOP20200257A1 (ar) * | 2014-05-01 | 2017-06-16 | Geron Corp | تركيبات أوليجو نوكليوتيد وطرق لتحضيرها |
| CN109689668B (zh) | 2016-06-24 | 2023-02-17 | 比奥根Ma公司 | 无加帽步骤的硫醇化寡核苷酸的合成 |
-
2018
- 2018-07-09 CA CA3195922A patent/CA3195922A1/en active Pending
- 2018-07-09 EA EA202090006A patent/EA038579B1/ru unknown
- 2018-07-09 RS RS20211534A patent/RS62705B1/sr unknown
- 2018-07-09 EP EP18737621.5A patent/EP3652187B1/en active Active
- 2018-07-09 BR BR112020000410-3A patent/BR112020000410A2/pt active Search and Examination
- 2018-07-09 CN CN201880044657.4A patent/CN110891961B/zh active Active
- 2018-07-09 SI SI201830496T patent/SI3652187T1/sl unknown
- 2018-07-09 KR KR1020247031302A patent/KR20240144459A/ko active Pending
- 2018-07-09 SG SG11201912385VA patent/SG11201912385VA/en unknown
- 2018-07-09 SM SM20210701T patent/SMT202100701T1/it unknown
- 2018-07-09 DK DK18737621.5T patent/DK3652187T3/da active
- 2018-07-09 US US16/623,984 patent/US11332489B2/en active Active
- 2018-07-09 PT PT187376215T patent/PT3652187T/pt unknown
- 2018-07-09 TW TW107123644A patent/TWI775895B/zh active
- 2018-07-09 CA CA3066968A patent/CA3066968C/en active Active
- 2018-07-09 ES ES18737621T patent/ES2901099T3/es active Active
- 2018-07-09 WO PCT/EP2018/068485 patent/WO2019011829A1/en not_active Ceased
- 2018-07-09 KR KR1020207003199A patent/KR102709587B1/ko active Active
- 2018-07-09 AU AU2018298658A patent/AU2018298658B2/en active Active
- 2018-07-09 LT LTEPPCT/EP2018/068485T patent/LT3652187T/lt unknown
- 2018-07-09 JP JP2020500591A patent/JP7199410B2/ja active Active
- 2018-07-09 HR HRP20211940TT patent/HRP20211940T1/hr unknown
- 2018-07-09 HU HUE18737621A patent/HUE056722T2/hu unknown
- 2018-07-09 UA UAA201912225A patent/UA125185C2/uk unknown
- 2018-07-09 MA MA049555A patent/MA49555A/fr unknown
- 2018-07-09 PL PL18737621T patent/PL3652187T3/pl unknown
-
2019
- 2019-12-12 IL IL271388A patent/IL271388B/en unknown
- 2019-12-18 ZA ZA2019/08452A patent/ZA201908452B/en unknown
-
2020
- 2020-01-07 CO CONC2020/0000096A patent/CO2020000096A2/es unknown
- 2020-01-08 CL CL2020000054A patent/CL2020000054A1/es unknown
- 2020-01-08 SA SA520410996A patent/SA520410996B1/ar unknown
-
2021
- 2021-12-14 CY CY20211101096T patent/CY1125351T1/el unknown
- 2021-12-17 ZA ZA2021/10555A patent/ZA202110555B/en unknown
-
2022
- 2022-04-12 US US17/718,990 patent/US20230070069A1/en not_active Abandoned
- 2022-10-24 JP JP2022169927A patent/JP2022183382A/ja active Pending
- 2022-12-23 AU AU2022291626A patent/AU2022291626A1/en not_active Abandoned
-
2023
- 2023-10-16 US US18/487,919 patent/US20240199672A1/en not_active Abandoned
-
2024
- 2024-02-07 US US18/435,848 patent/US12264174B2/en active Active
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