PT70401A - Pyrimido-(6,1-a)-isochinolin-4-one neue bei ihrer herstellung verwendete zwischenprodukte und verfahren zu ihrer herstellung - Google Patents

Pyrimido-(6,1-a)-isochinolin-4-one neue bei ihrer herstellung verwendete zwischenprodukte und verfahren zu ihrer herstellung

Info

Publication number: PT70401A
Authority: PT; Portugal
Prior art keywords: pyrimido; isochinolin; manufacture; production; intermediates used
Prior art date: 1978-11-03

Application number

PT70401A

Other languages

German (de)

English (en)

Portuguese (pt)

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-11-03

Filing date

1979-11-02

Publication date

1979-12-01

1979-11-02 Application filed by Hoechst Ag filed Critical Hoechst Ag

1979-12-01 Publication of PT70401A publication Critical patent/PT70401A/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PT70401A 1978-11-03 1979-11-02 Pyrimido-(6,1-a)-isochinolin-4-one neue bei ihrer herstellung verwendete zwischenprodukte und verfahren zu ihrer herstellung PT70401A (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19782847693 DE2847693A1 (de)	1978-11-03	1978-11-03	Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen

Publications (1)

Publication Number	Publication Date
PT70401A true PT70401A (de)	1979-12-01

Family

ID=6053766

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT70401A PT70401A (de)	1978-11-03	1979-11-02	Pyrimido-(6,1-a)-isochinolin-4-one neue bei ihrer herstellung verwendete zwischenprodukte und verfahren zu ihrer herstellung

Country Status (18)

Country	Link
US (1)	US4400506A (2)
EP (1)	EP0010759B1 (2)
JP (1)	JPS5564587A (2)
AT (1)	ATE21104T1 (2)
AU (1)	AU538039B2 (2)
CA (1)	CA1123434A (2)
DE (2)	DE2847693A1 (2)
DK (1)	DK465879A (2)
ES (2)	ES8102125A1 (2)
FI (1)	FI66865C (2)
GR (1)	GR74082B (2)
HU (1)	HU181884B (2)
IL (1)	IL58609A0 (2)
NO (1)	NO793537L (2)
NZ (1)	NZ191994A (2)
PH (1)	PH15281A (2)
PT (1)	PT70401A (2)
ZA (1)	ZA795888B (2)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI64370C (fi) *	1977-05-05	1983-11-10	Hoechst Ag	Foerfarande foer framstaellning av terapeutiskt anvaendbara pyimido-(6,1-a)isokinolin-2-imino-4-onderivat
DE2847693A1 (de)	1978-11-03	1980-05-22	Hoechst Ag	Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen
FR2470130A2 (fr) *	1979-11-21	1981-05-29	Hoechst Ag	Derives de pyrimido (6,1-a) isoquinoleine-4-one, leur procede de preparation et leur application en therapeutique
DE3126837A1 (de) *	1981-07-08	1983-01-27	Hoechst Ag, 6000 Frankfurt	Triazino-(2,1-a)isochinolinderivate
DE3135831A1 (de) *	1981-09-10	1983-04-28	Hoechst Ag, 6230 Frankfurt	9,10-substituierte 2-mesitylimino-3-alkyl-3,4,6,7-tetrahydro-2h-pyrimido(6,1-a)isochinolin-4-one, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4612376A (en) *	1983-03-25	1986-09-16	Fujisawa Pharmaceutical Co., Ltd.	Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent
ZW6284A1 (en) *	1983-05-05	1985-10-30	Hoffmann La Roche	Novel pyrimidone derivatives
DE60005493T2 (de) *	1999-03-31	2004-07-01	Vernalis Ltd., Wokingham	Pyrimido[6,1-a]isochinolinonderivate
CA2715683A1 (en) *	1999-08-21	2001-03-01	Nycomed Gmbh	Synergistic combination
TWI347845B (en) *	2002-03-06	2011-09-01	Nycomed Gmbh	Pharmaceutical compositions,combinations,and kits for the treatment of respiratory diseases and use of the same
US7772188B2 (en)	2003-01-28	2010-08-10	Ironwood Pharmaceuticals, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
MX354786B (es)	2007-06-04	2018-03-21	Synergy Pharmaceuticals Inc	Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2522968T3 (es)	2008-06-04	2014-11-19	Synergy Pharmaceuticals Inc.	Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
AU2009270833B2 (en)	2008-07-16	2015-02-19	Bausch Health Ireland Limited	Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
DK2681236T3 (en)	2011-03-01	2018-04-16	Synergy Pharmaceuticals Inc	PROCEDURE FOR MANUFACTURING GUANYLATE CYCLASE-C-AGONISTS
WO2014131024A2 (en)	2013-02-25	2014-08-28	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
AU2014235209B2 (en)	2013-03-15	2018-06-14	Bausch Health Ireland Limited	Guanylate cyclase receptor agonists combined with other drugs
AU2014235215A1 (en)	2013-03-15	2015-10-01	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
BR112015030326A2 (pt)	2013-06-05	2017-08-29	Synergy Pharmaceuticals Inc	Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos
AU2014305843B2 (en)	2013-08-09	2019-08-29	Ardelyx, Inc.	Compounds and methods for inhibiting phosphate transport
GB201613054D0 (en)	2016-07-28	2016-09-14	Verona Pharma Plc	New compound and process
EP4706758A3 (en)	2019-05-21	2026-05-06	Ardelyx, Inc.	Methods for inhibiting phosphate transport
GB202202297D0 (en)	2022-02-21	2022-04-06	Verona Pharma Plc	Formulation production process
AU2024309346C1 (en)	2023-06-26	2026-03-12	Verona Pharma Plc	Particulate composition comprising ensifentrine

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE590405A (2) *	1959-05-02
US3081306A (en) *	1959-11-04	1963-03-12	Pfizer & Co C	2, 4-dioxo-3-aralkylaza-9, 10-di(lower alkoxy)-1, 2, 3, 4, 6, 7-hexahydro-11b-h-benzopyridocolines
GB1062357A (en) *	1965-03-23	1967-03-22	Pfizer & Co C	Quinazolone derivatives
US3476755A (en) *	1967-01-17	1969-11-04	Edward C Taylor	8,13-diazasteroids
US3594379A (en) *	1968-09-16	1971-07-20	Sandoz Ag	2,3-dihydroimidazo(1,2-c)quinazolines
US3876788A (en) *	1970-08-27	1975-04-08	Burroughs Wellcome Co	Heterocyclic compounds in the treatment of inflammatory of arthritic conditions
DE2720085A1 (de) *	1977-05-05	1978-11-16	Hoechst Ag	Pyrimido(6,1-a)isochinolin-2-on- derivate
IN147624B (2)	1976-12-10	1980-05-03	Hoechst Pharma
FI64370C (fi) *	1977-05-05	1983-11-10	Hoechst Ag	Foerfarande foer framstaellning av terapeutiskt anvaendbara pyimido-(6,1-a)isokinolin-2-imino-4-onderivat
DE2847693A1 (de)	1978-11-03	1980-05-22	Hoechst Ag	Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen

1978
- 1978-11-03 DE DE19782847693 patent/DE2847693A1/de not_active Withdrawn
1979
- 1979-10-29 ES ES485489A patent/ES8102125A1/es not_active Expired
- 1979-10-31 DE DE7979104238T patent/DE2967610D1/de not_active Expired
- 1979-10-31 EP EP79104238A patent/EP0010759B1/de not_active Expired
- 1979-10-31 AT AT79104238T patent/ATE21104T1/de not_active IP Right Cessation
- 1979-11-01 JP JP14053279A patent/JPS5564587A/ja active Pending
- 1979-11-01 GR GR60383A patent/GR74082B/el unknown
- 1979-11-01 NZ NZ191994A patent/NZ191994A/xx unknown
- 1979-11-01 IL IL58609A patent/IL58609A0/xx unknown
- 1979-11-01 FI FI793430A patent/FI66865C/fi not_active IP Right Cessation
- 1979-11-02 AU AU52453/79A patent/AU538039B2/en not_active Ceased
- 1979-11-02 HU HU79HO2195A patent/HU181884B/hu unknown
- 1979-11-02 DK DK465879A patent/DK465879A/da not_active Application Discontinuation
- 1979-11-02 NO NO793537A patent/NO793537L/no unknown
- 1979-11-02 CA CA339,089A patent/CA1123434A/en not_active Expired
- 1979-11-02 PT PT70401A patent/PT70401A/pt unknown
- 1979-11-02 ZA ZA00795888A patent/ZA795888B/xx unknown
- 1979-11-05 PH PH23245A patent/PH15281A/en unknown
1980
- 1980-07-01 ES ES493011A patent/ES8103083A1/es not_active Expired
1981
- 1981-10-26 US US06/314,994 patent/US4400506A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE2847693A1 (de)	1980-05-22
JPS5564587A (en)	1980-05-15
EP0010759B1 (de)	1986-07-30
US4400506A (en)	1983-08-23
ZA795888B (en)	1980-10-29
EP0010759A3 (en)	1981-08-19
ES485489A0 (es)	1980-12-16
FI66865C (fi)	1984-12-10
HU181884B (en)	1983-11-28
FI66865B (fi)	1984-08-31
EP0010759A2 (de)	1980-05-14
NZ191994A (en)	1982-09-07
AU5245379A (en)	1980-05-08
DK465879A (da)	1980-05-04
ES493011A0 (es)	1981-02-16
ES8102125A1 (es)	1980-12-16
FI793430A7 (fi)	1980-05-04
DE2967610D1 (en)	1986-09-04
GR74082B (2)	1984-06-06
ES8103083A1 (es)	1981-02-16
NO793537L (no)	1980-05-06
AU538039B2 (en)	1984-07-26
IL58609A0 (en)	1980-02-29
CA1123434A (en)	1982-05-11
PH15281A (en)	1982-11-02
ATE21104T1 (de)	1986-08-15

Publication	Publication Date	Title
PT70401A (de)	1979-12-01	Pyrimido-(6,1-a)-isochinolin-4-one neue bei ihrer herstellung verwendete zwischenprodukte und verfahren zu ihrer herstellung
ATE1238T1 (de)	1982-07-15	Neue 1,4-dihydropyridinverbindungen, verfahren zu ihrer herstellung, die genannten verbindungen enthaltende arzneimittel und verfahren zur herstellung dieser arzneimittel.
DE19775011I2 (de)	2001-03-22	Chinolinderivate Verfahren zu ihrer Herstellung und ihre Verwendung zur Bekaempfung unerwuenschten Planzenwuchses
ATE26274T1 (de)	1987-04-15	Imidazolylalkylthienyl-tetrahydropyridazine und verfahren zu ihrer herstellung.
AT366039B (de)	1982-03-10	Verfahren zur herstellung von neuen dibenzo(b,d) pyranen und saeureadditionssalzen dieser verbindun-gen
ATE3771T1 (de)	1983-06-15	Dimethylphosphinyl-alkanphosphonsaeuren, ein verfahren zu ihrer herstellung und ihre verwendung als gipsabbindeverzoegerer.
DE3865230D1 (de)	1991-11-07	Beta-d-phenyl-thioxyloside, verfahren zu ihrer herstellung und ihre therapeutische verwendung.
IL58299A (en)	1983-03-31	Fluorine-containing 1,4-dihydropyridine derivatives,their production and their medicinal use
DE3667660D1 (de)	1990-01-25	Chinolylglycinamidderivate, verfahren zu ihrer herstellung und therapeutische verwendung als psychotrope.
ATE30719T1 (de)	1987-11-15	Imino-2-pyrrolidine, verfahren zu ihrer herstellung und ihre therapeutische verwendung.
ATE127512T1 (de)	1995-09-15	Verfahren zur herstellung hydrophilisierter triglyceride.
AT374200B (de)	1984-03-26	Verfahren zur herstellung von neuen halogenvincamonderivaten
ATE31928T1 (de)	1988-01-15	Acylamino-4-aza-1-adamantane, verfahren zu ihrer herstellung und ihre anwendung in der therapeutik.
ATE9330T1 (de)	1984-09-15	Phenethanolamin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
ATE2794T1 (de)	1983-04-15	1-n-alkylsisomicin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
DE69032857D1 (de)	1999-02-04	2-spirocyclopropylcephalosporinderivate und verfahren zu ihrer herstellung
AT377586B (de)	1985-04-10	Verfahren zur herstellung von substituierten pyrrolo-(2,1-b)-chinazolinen und pyrido(2,1-b)chinazolinen
PT68989A (de)	1979-01-01	Verfahren zur herstellung von neuen arylaminoimidazolinderivaten
AT375939B (de)	1984-09-25	Verfahren zur herstellung von neuen 15-halogen-e- homoeburnanderivaten, von deren saeureadditions- salzen, epimeren und optischen antipoden
DD134769A1 (de)	1979-03-21	Verfahren zur herstellung von 3-oxo-oestra-4,9,11-trienen
ATE33837T1 (de)	1988-05-15	Azolylmethylcycloacetale, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
ATA338978A (de)	1979-11-15	Verfahren zur herstellung von 4"-sulfonyl- aminooleandomycinderivaten
ATE25517T1 (de)	1987-03-15	Delta-1-pyrrolin-thiolactimaether und verfahren zu ihrer herstellung.
ATE16186T1 (de)	1985-11-15	Cephalosporinderivate und verfahren zu ihrer herstellung.
ATE23340T1 (de)	1986-11-15	3-alkylthio-2-0-carbamoylpropan-1,2-diol-1-0phosphocholine und verfahren zu ihrer herstellung.