PT85386A - Processo para a preparacao de um agente para a terapia da hemofilia a resistente ao factor viii - Google Patents

Processo para a preparacao de um agente para a terapia da hemofilia a resistente ao factor viii

Info

Publication number: PT85386A
Authority: PT; Portugal
Prior art keywords: agent; factor viii; preparing; solution; appropriate
Prior art date: 1986-07-24

Application number

PT85386A

Other languages

English (en)

Other versions

PT85386B (pt

Inventor

Norbert Heimburger

Karl-Heinz Wenz

Wilfried Wormsbacher

Original Assignee

Behringwerke Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-07-24

Filing date

1987-07-23

Publication date

1988-07-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6305910&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT85386(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1987-07-23 Application filed by Behringwerke Ag filed Critical Behringwerke Ag

1988-07-29 Publication of PT85386A publication Critical patent/PT85386A/pt

2001-05-31 Publication of PT85386B publication Critical patent/PT85386B/pt

Links

229960000301 factor viii Drugs 0.000 title abstract 2
208000031220 Hemophilia Diseases 0.000 title 1
208000009292 Hemophilia A Diseases 0.000 title 1
238000000034 method Methods 0.000 title 1
238000002560 therapeutic procedure Methods 0.000 title 1
239000000243 solution Substances 0.000 abstract 3
PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 abstract 1
102000004411 Antithrombin III Human genes 0.000 abstract 1
108090000935 Antithrombin III Proteins 0.000 abstract 1
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract 1
102100022641 Coagulation factor IX Human genes 0.000 abstract 1
108010076282 Factor IX Proteins 0.000 abstract 1
108010054218 Factor VIII Proteins 0.000 abstract 1
102000001690 Factor VIII Human genes 0.000 abstract 1
108010000499 Thromboplastin Proteins 0.000 abstract 1
102000002262 Thromboplastin Human genes 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
229960005348 antithrombin iii Drugs 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
229910001424 calcium ion Inorganic materials 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
238000001035 drying Methods 0.000 abstract 1
229960004222 factor ix Drugs 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
150000003904 phospholipids Chemical class 0.000 abstract 1
229920005862 polyol Polymers 0.000 abstract 1
150000003077 polyols Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Junction Field-Effect Transistors (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PT85386A 1986-07-24 1987-07-23 Processo para a preparacao de um agente para a terapia da hemofilia a resistente ao factor viii PT85386B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19863625090 DE3625090A1 (de)	1986-07-24	1986-07-24	Mittel zur therapie faktor viii-resistenter haemophilie a und verfahren zu seiner herstellung

Publications (2)

Publication Number	Publication Date
PT85386A true PT85386A (pt)	1988-07-29
PT85386B PT85386B (pt)	2001-05-31

Family

ID=6305910

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT85386A PT85386B (pt)	1986-07-24	1987-07-23	Processo para a preparacao de um agente para a terapia da hemofilia a resistente ao factor viii

Country Status (12)

Country	Link
US (1)	US5091363A (pt)
EP (1)	EP0255651B1 (pt)
JP (1)	JP2535547B2 (pt)
AT (1)	ATE73673T1 (pt)
AU (1)	AU607924B2 (pt)
CA (1)	CA1321139C (pt)
DE (2)	DE3625090A1 (pt)
DK (1)	DK166652B1 (pt)
ES (1)	ES2037035T3 (pt)
FI (1)	FI87044C (pt)
GR (1)	GR3004868T3 (pt)
PT (1)	PT85386B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH03215430A (ja) *	1990-01-19	1991-09-20	Kita Kiyoshi	関節腔抗凝固剤
DE3939346A1 (de) *	1989-11-29	1991-06-06	Behringwerke Ag	Arzneimitel zur subkutanen oder intramuskulaeren applikation enthaltend polypeptide
DE4001451A1 (de) *	1990-01-19	1991-08-01	Octapharma Ag	Stabile injizierbare loesungen von faktor viii und faktor ix
AT395597B (de) *	1991-01-25	1993-01-25	Immuno Ag	Reagens zur bestimmung von faktor viii-aktivitaet
CA2090738C (en) *	1993-02-24	1996-05-21	Hema-Quebec	Use of paf
US7582712B1 (en)	2008-05-09	2009-09-01	Formosa Plastics Corporation, U.S.A.	Alpha-olefins polymerization catalyst
CN108226540B (zh) *	2018-02-08	2020-07-03	武汉市长立生物技术有限责任公司	一种鞣花酸试剂及其配制方法与活化部分凝血活酶时间测定试剂、aptt试剂盒

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2550011C2 (de) *	1975-11-07	1982-11-25	Behringwerke Ag, 3550 Marburg	Verfahren zur Herstellung eines antihämophilen Mittels
AT350726B (de) *	1976-08-30	1979-06-11	Immuno Ag	Verfahren zur herstellung einer blut- gerinnungsfoerdernden praeperation aus menschlichem blutplasma
JPS597693B2 (ja) *	1978-01-07	1984-02-20	株式会社ミドリ十字	抗トロンビン製剤及びその製法
DE2916711A1 (de) *	1979-04-25	1980-11-06	Behringwerke Ag	Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
FR2472390A1 (fr) *	1979-05-04	1981-07-03	Merieux Inst	Procede de preparation de concentres de complexe prothrombinique hautement purifies, et concentres obtenus
JPS56127308A (en) *	1980-03-11	1981-10-06	Green Cross Corp:The	Blood-coagulation factor 8 pharmaceutical
US4364861A (en) *	1980-05-27	1982-12-21	Cutter Laboratories, Inc.	Blood-coagulation-promoting products and methods of preparing them
US4404132A (en) *	1980-05-27	1983-09-13	Cutter Laboratories, Inc.	Blood coagulation promoting product
JPS5770814A (en) *	1980-10-17	1982-05-01	Isamu Horikoshi	Oral preparation of blood clotting eighth factor
JPS5874617A (ja) *	1981-10-28	1983-05-06	Green Cross Corp:The	人由来血液凝固第７因子含有水溶液の加熱処理方法
DE3237512A1 (de) *	1982-10-09	1984-04-12	Behringwerke Ag, 3550 Marburg	Verfahren zur pasteurisierung von antihaemophilem kryopraezipitat (ahk) und danach hergestelltes antihaemophiles kryopraezipitat
DE3481109D1 (de) *	1983-05-09	1990-03-01	Novo Nordisk As	Antihaemophilie-faktor-viii-konzentrat und dessen herstellungsverfahren.
AT379510B (de) *	1983-05-20	1986-01-27	Immuno Ag	Verfahren zur herstellung einer faktor viii (ahf) -haeltigen praeparation
US4536392A (en) *	1983-06-27	1985-08-20	Queen's University At Kingston	Method for controlling hemophilia in mammals
US4610880A (en) *	1983-06-27	1986-09-09	Queen's University At Kingston	Composition for controlling hemophilia in mammals
US4710381A (en) *	1984-05-22	1987-12-01	The Blood Center Of Southeastern Wisconsin	Method for maintaining intact, non-degraded factor VIII/von-Willebrand factor during blood processing

1986
- 1986-07-24 DE DE19863625090 patent/DE3625090A1/de not_active Withdrawn
1987
- 1987-07-21 EP EP87110539A patent/EP0255651B1/de not_active Expired - Lifetime
- 1987-07-21 DE DE8787110539T patent/DE3777482D1/de not_active Expired - Lifetime
- 1987-07-21 ES ES198787110539T patent/ES2037035T3/es not_active Expired - Lifetime
- 1987-07-21 AT AT87110539T patent/ATE73673T1/de not_active IP Right Cessation
- 1987-07-22 FI FI873222A patent/FI87044C/fi not_active IP Right Cessation
- 1987-07-23 JP JP62182442A patent/JP2535547B2/ja not_active Expired - Fee Related
- 1987-07-23 DK DK384687A patent/DK166652B1/da not_active IP Right Cessation
- 1987-07-23 AU AU76049/87A patent/AU607924B2/en not_active Ceased
- 1987-07-23 PT PT85386A patent/PT85386B/pt not_active IP Right Cessation
- 1987-07-23 CA CA000542881A patent/CA1321139C/en not_active Expired - Fee Related
1988
- 1988-08-10 US US07/230,717 patent/US5091363A/en not_active Expired - Lifetime
1992
- 1992-06-11 GR GR920401114T patent/GR3004868T3/el unknown

Also Published As

Publication number	Publication date
DE3625090A1 (de)	1988-01-28
DK384687A (da)	1988-01-25
FI873222L (fi)	1988-01-25
JP2535547B2 (ja)	1996-09-18
CA1321139C (en)	1993-08-10
EP0255651A3 (en)	1989-10-11
DE3777482D1 (de)	1992-04-23
DK166652B1 (da)	1993-06-28
AU607924B2 (en)	1991-03-21
EP0255651B1 (de)	1992-03-18
ES2037035T3 (es)	1993-06-16
FI87044C (fi)	1992-11-25
GR3004868T3 (pt)	1993-04-28
US5091363A (en)	1992-02-25
ATE73673T1 (de)	1992-04-15
FI87044B (fi)	1992-08-14
EP0255651A2 (de)	1988-02-10
FI873222A0 (fi)	1987-07-22
PT85386B (pt)	2001-05-31
JPS6345224A (ja)	1988-02-26
AU7604987A (en)	1988-01-28
DK384687D0 (da)	1987-07-23

Legal Events

Date	Code	Title	Description
2001-05-31	FG3A	Patent granted, date of granting	Effective date: 20010215
2005-10-31	MM3A	Annulment or lapse	Effective date: 20050816

Publication	Publication Date	Title
ES8603372A1 (es)	1985-12-16	Un procedimiento para la preparacion de oxo-analogos de compuestos del tipo de la mevinolina.
ATE132040T1 (de)	1996-01-15	Verwendung von phospholipiden zur herstellung eines topischen arzneimittels zur beinflussung des serumcholesterinspiegels
ATE114319T1 (de)	1994-12-15	Produktion von proteinen in aktiven formen.
ES524992A0 (es)	1985-08-01	Procedimiento para higienizar o pasterizar fribrinogeno humano
TR26748A (tr)	1995-05-15	SU VE N-METIL-MORFOLIN-N-OKSIT ICINDE SELüLOZ CÖZELTISI.
PT85386A (pt)	1988-07-29	Processo para a preparacao de um agente para a terapia da hemofilia a resistente ao factor viii
MX165470B (es)	1992-11-12	Agentes de carbonatacion de aminoazucares y preparacion
ES2147830T3 (es)	2000-10-01	Procedimiento para la preparacion de pigmentos de diarildicetopirrolopirrol.
PT95456A (pt)	1991-08-14	Processo para a preparacao de preparados de combinacao de acido acetilsalicilico e de derivados de carbaciclina com accao antitrombotica
BR8705927A (pt)	1988-06-14	Processo aperfeicoado para oxidar de maneira substancialmente completa o vapor de alcool e/ou formaldeido contido na mistura de gas de escape aquecida de um motor movido a alcool;e processo para oxidar de maneira substancialmente completa e catalitica uma mistura de vapor de alcool e/ou vapor de formaldeido contida em um gas carreador aquecido
ES2011779B3 (es)	1990-02-16	Procedimiento e instalacion para limpieza de gases de humo con contenido de so2
BR7508676A (pt)	1976-11-09	Aperfeicoamento em processo para tratamento de vapor d'agua gerado na concentracao de uma solucao aquosa de ureia
BR9005230A (pt)	1991-09-17	Composicao aquosa para tratamento de cabelo e processo para distribuicao de um composto nao acido que tem um peso molecular nao acima de 5.000
DE3165050D1 (en)	1984-08-30	Salt of furosemide or piretanide as acid component and penbutolol as base component and pharmaceutical composition containing both of the said components
BR8706782A (pt)	1988-07-19	Banhos para o polimento quimico de superficies de aco inoxidavel e processo para o polimento de uma superficie de aco inoxidavel
ATE111891T1 (de)	1994-10-15	Verfahren zur herstellung von 3- nitrobenzolsulfonsäurechlorid.
PT81908B (pt)	1988-02-17	Processo para a fabricacao de carbonato de sodio anidro denso
ATE1239T1 (de)	1982-07-15	Verfahren zur herstellung von 4-amino-5-chlor-1-phenyl-pyridazon-(6).
BR7703124A (pt)	1978-04-11	Processo para a fabricacao de couro em tripa tratados no caleiro com sulfeto em banhos de tratamento acidos e composicao de descalificacao,purga ou pre-curticao
NO920524D0 (no)	1992-02-10	Kynurensyrederivater, deres fremstilling og farmasoeytiskeblandinger inneholdende disse
DE3376630D1 (en)	1988-06-23	Process for the local and far-reaching influence of chemical and/or physical reactions in the atmosphere
DE3676899D1 (de)	1991-02-21	Verfahren zur herstellung von n-methyl-lysergol.
ZA912829B (en)	1992-01-29	Process for the removal of cholesterol from egg yolk
EP0262063A3 (en)	1989-10-04	Process for stabilizing chlorination mixtures of phenol and/or chlorophenols
ATE70264T1 (de)	1991-12-15	Verfahren zur herstellung von benzylmerkaptan.