PT97409A - Processo para a preparacao de mutantes beta-lactama-acilases por expressao genetica - Google Patents

Processo para a preparacao de mutantes beta-lactama-acilases por expressao genetica

Info

Publication number
PT97409A
PT97409A PT97409A PT9740991A PT97409A PT 97409 A PT97409 A PT 97409A PT 97409 A PT97409 A PT 97409A PT 9740991 A PT9740991 A PT 9740991A PT 97409 A PT97409 A PT 97409A
Authority
PT
Portugal
Prior art keywords
beta
ailases
lactama
mutants
preparation
Prior art date
Application number
PT97409A
Other languages
English (en)
Other versions
PT97409B (pt
Inventor
Wilhelmus Johannes Quax
Jan Metske Van Der Laan
Onno Misset Herman B M Lenting
Original Assignee
Gist Brocades Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Nv filed Critical Gist Brocades Nv
Publication of PT97409A publication Critical patent/PT97409A/pt
Publication of PT97409B publication Critical patent/PT97409B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/84—Penicillin amidase (3.5.1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01011—Penicillin amidase (3.5.1.11), i.e. penicillin-amidohydrolase

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)
  • Saccharide Compounds (AREA)
PT97409A 1990-04-18 1991-04-18 Processo para a preparacao de mutantes beta-lactama-acilases por expressao genetica PT97409B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90200962 1990-04-18

Publications (2)

Publication Number Publication Date
PT97409A true PT97409A (pt) 1992-01-31
PT97409B PT97409B (pt) 1998-08-31

Family

ID=8204994

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97409A PT97409B (pt) 1990-04-18 1991-04-18 Processo para a preparacao de mutantes beta-lactama-acilases por expressao genetica

Country Status (10)

Country Link
US (2) US5457032A (pt)
EP (1) EP0453048B1 (pt)
JP (1) JPH05501806A (pt)
KR (1) KR100193802B1 (pt)
AT (1) ATE167520T1 (pt)
DE (1) DE69129604T2 (pt)
ES (1) ES2119756T3 (pt)
IE (1) IE911295A1 (pt)
PT (1) PT97409B (pt)
WO (1) WO1991016435A1 (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE167520T1 (de) * 1990-04-18 1998-07-15 Gist Brocades Nv Mutierte beta-lactamacylasegene
DE69421653D1 (de) * 1993-08-05 1999-12-23 Dsm Nv Neue Anwendung von Alcaligenes faecalis Penicillin G Acylase
AU3346295A (en) * 1994-08-12 1996-03-07 Gist-Brocades B.V. Mutated penicillin g acylase genes
CA2270400C (en) * 1996-11-05 2010-09-28 Bristol-Myers Squibb Company Mutant penicillin g acylases
US8288322B2 (en) 2000-04-17 2012-10-16 Dyax Corp. Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
EP2199393B1 (en) * 2000-04-17 2012-10-31 Dyax Corp. Methods of constructing display libraries of genetic packages for members of a diverse family of peptides
ES2430857T3 (es) 2000-12-18 2013-11-22 Dyax Corp. Bibliotecas focalizadas de paquetes genéticos
US20040067532A1 (en) 2002-08-12 2004-04-08 Genetastix Corporation High throughput generation and affinity maturation of humanized antibody
WO2004111241A1 (en) * 2003-06-12 2004-12-23 Stichting Voor De Technische Wetenschappen Penicillin acylase
KR100530299B1 (ko) * 2003-08-11 2005-11-22 산도즈 게엠베하 변이 세팔로스포린 ｃ 아실라제 및 이를 이용한 7-ａｃａ 제조방법
EP1694835A2 (en) * 2003-12-05 2006-08-30 Stichting Voor De Technische Wetenschappen Glutaryl amidases and their uses
EP1538205A1 (en) * 2003-12-05 2005-06-08 Stichting Voor De Technische Wetenschappen Glutaryl amidases and their uses
ITMI20040016A1 (it) * 2004-01-12 2004-04-12 Antibiotics S P A Cefalosporina c acilasi
CN101351549B (zh) 2005-12-28 2013-03-20 中化帝斯曼制药有限公司荷兰公司 突变体Ⅱ型β-内酰胺酰化酶
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
US8691730B2 (en) * 2007-09-14 2014-04-08 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
US12529164B2 (en) 2007-09-14 2026-01-20 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
US9873957B2 (en) * 2008-03-13 2018-01-23 Dyax Corp. Libraries of genetic packages comprising novel HC CDR3 designs
ES2528963T3 (es) * 2008-04-24 2015-02-13 Dyax Corp. Bibliotecas de paquetes genéticos que comprenden nuevos diseños de CDR1, CDR2, y CDR3 de HC y nuevos diseños de CDR1, CDR2, y CDR3 de LC
WO2010054319A2 (en) * 2008-11-10 2010-05-14 Codexis, Inc. Penicillin-g acylases
US20110082054A1 (en) * 2009-09-14 2011-04-07 Dyax Corp. Libraries of genetic packages comprising novel hc cdr3 designs
DK2593594T3 (en) 2010-07-16 2017-12-11 Adimab Llc ANTIBODY LIBRARIES
US9789216B2 (en) 2012-12-14 2017-10-17 Saban Ventures Pty Limited Synergistic disinfection enhancement
CA2894597C (en) 2012-12-14 2020-09-22 Saban Ventures Pty Limited Disinfectant solution comprising peroxyacetic acid, hydrogen peroxide and a carbonate buffer
CN111172142B (zh) * 2020-02-14 2021-09-28 上海陶宇晟生物技术有限责任公司 一种热稳定性高的头孢菌素c酰化酶突变体
CN116144517B (zh) * 2021-11-22 2024-08-30 中国科学院天津工业生物技术研究所 一种7-氨基头孢烷酸生产菌及其制备方法与应用
CN120843489B (zh) * 2025-09-23 2026-01-30 百葵锐(天津)生物科技有限公司 酰化酶的突变体及其在椰油酰甘氨酸钠合成中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6121097A (ja) * 1984-07-10 1986-01-29 Asahi Chem Ind Co Ltd ７−アミノセフアロスポラン酸及びその誘導体の製造法
US4981789A (en) * 1987-03-18 1991-01-01 Merck & Co., Inc. One-step enzymatic conversion of cephalosporin C and derivatives to 7-aminocephalosporanic acid and derivatives
EP0322032A3 (en) * 1987-12-21 1991-01-30 Merck & Co. Inc. One-step enzymatic conversion of cephalosporin c and derivatives to 7-aminocephalosporanic acid and derivatives
ATE167520T1 (de) * 1990-04-18 1998-07-15 Gist Brocades Nv Mutierte beta-lactamacylasegene
ATE124724T1 (de) * 1990-04-18 1995-07-15 Gist Brocades Nv Penicillin-g-acylase, dafür kodierendes gen und verfahren zur herstellung von diesem enzym.
GB9019724D0 (en) * 1990-09-10 1990-10-24 Fujisawa Pharmaceutical Co Cephalosporin c acylase
GB9204439D0 (en) * 1992-02-27 1992-04-15 Fujisawa Pharmaceutical Co A new cephalosporin c acylase
TW400384B (en) * 1993-11-01 2000-08-01 Fujisawa Pharmaceutical Co A new cephalosporin C acylase

Also Published As

Publication number Publication date
JPH05501806A (ja) 1993-04-08
US5457032A (en) 1995-10-10
ATE167520T1 (de) 1998-07-15
EP0453048A1 (en) 1991-10-23
DE69129604D1 (de) 1998-07-23
WO1991016435A1 (en) 1991-10-31
DE69129604T2 (de) 1998-10-15
ES2119756T3 (es) 1998-10-16
EP0453048B1 (en) 1998-06-17
IE911295A1 (en) 1991-10-23
US5935831A (en) 1999-08-10
KR100193802B1 (ko) 1999-06-15
PT97409B (pt) 1998-08-31

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Legal Events

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BB1A Laying open of patent application

Effective date: 19910912

FG3A Patent granted, date of granting

Effective date: 19980506

PC3A Transfer or assignment

Free format text: 19991026 DSM N.V. NL

PC3A Transfer or assignment

Owner name: DSM IP ASSETS B. V., NL

Effective date: 20050823

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20071106