PT98394B - Processo para a preparacao de formas multimericas da proteina receptora de rinovirus humano - Google Patents
Processo para a preparacao de formas multimericas da proteina receptora de rinovirus humano Download PDFInfo
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- PT98394B PT98394B PT98394A PT9839491A PT98394B PT 98394 B PT98394 B PT 98394B PT 98394 A PT98394 A PT 98394A PT 9839491 A PT9839491 A PT 9839491A PT 98394 B PT98394 B PT 98394B
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- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55623890A | 1990-07-20 | 1990-07-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT98394A PT98394A (pt) | 1992-06-30 |
| PT98394B true PT98394B (pt) | 1999-01-29 |
Family
ID=24220489
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT98394A PT98394B (pt) | 1990-07-20 | 1991-07-19 | Processo para a preparacao de formas multimericas da proteina receptora de rinovirus humano |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6096862A (fr) |
| EP (2) | EP0468257B1 (fr) |
| JP (1) | JP3091527B2 (fr) |
| KR (1) | KR100208847B1 (fr) |
| AT (1) | ATE184049T1 (fr) |
| DE (1) | DE69131564T2 (fr) |
| DK (1) | DK0468257T3 (fr) |
| ES (1) | ES2134762T3 (fr) |
| FI (1) | FI105687B (fr) |
| GR (1) | GR3031768T3 (fr) |
| IE (1) | IE912552A1 (fr) |
| IL (1) | IL98866A0 (fr) |
| PT (1) | PT98394B (fr) |
| ZA (1) | ZA915678B (fr) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6143298A (en) * | 1988-09-01 | 2000-11-07 | Bayer Corporation | Soluble truncated forms of ICAM-1 |
| US6514936B1 (en) | 1988-09-01 | 2003-02-04 | Bayer Corporation | Antiviral methods using human rhinovirus receptor (ICAM-1) |
| ES2141076T3 (es) | 1988-09-01 | 2000-03-16 | Bayer Ag | Proteina del receptor de rinovirus humano que inhibe la infectividad del virus. |
| US6051231A (en) * | 1988-09-01 | 2000-04-18 | Bayer Corporation | Antiviral methods and prepations |
| ES2134762T3 (es) * | 1990-07-20 | 1999-10-16 | Bayer Ag | Formas multimericas de proteinas receptoras de rinovirus humanos. |
| US6130202A (en) * | 1990-07-20 | 2000-10-10 | Bayer Corporation | Antiviral methods |
| US6107461A (en) * | 1990-07-20 | 2000-08-22 | Bayer Corporation | Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use |
| US5891841A (en) * | 1991-06-11 | 1999-04-06 | The Center For Blood Research, Inc. | Methods of using intercellular adhesion molecule-3 (ICAM-3), antibodies thereto, and soluble fragments thereof |
| US5525487A (en) * | 1992-01-27 | 1996-06-11 | Icos Corporation | DNA encoding I-CAM related protein |
| US5700658A (en) * | 1992-01-27 | 1997-12-23 | Icos Corporation | ICAM-4 materials and methods |
| US5773293A (en) * | 1992-01-27 | 1998-06-30 | Icos Corporation | Anti-ICAM-4 antibodies and hybridomas |
| US6153395A (en) * | 1992-01-27 | 2000-11-28 | Icos Corporation | ICAM-related protein |
| EP0578819A4 (fr) * | 1992-01-27 | 1994-10-12 | Icos Corp | Proteine apparentee a icam. |
| US5837822A (en) * | 1992-01-27 | 1998-11-17 | Icos Corporation | Humanized antibodies specific for ICAM related protein |
| US6818743B1 (en) | 1992-01-27 | 2004-11-16 | Icos Corporation | I-CAM related protein |
| US5753502A (en) * | 1993-08-05 | 1998-05-19 | Icos Corporation | Neuron-specific ICAM-4 promoter |
| US5532127A (en) * | 1992-01-27 | 1996-07-02 | Icos Corporation | Assay for 1-CAM related protein expression |
| US5702917A (en) * | 1992-01-27 | 1997-12-30 | Icos Corporation | Polynucleotides encoding human ICAM-4 |
| US5852170A (en) * | 1992-01-27 | 1998-12-22 | Icos Corporation | ICAM-4 materials and methods |
| US5773218A (en) * | 1992-01-27 | 1998-06-30 | Icos Corporation | Method to identify compounds which modulate ICAM-related protein interactions |
| US5989843A (en) * | 1992-01-27 | 1999-11-23 | Icos Corporation | Methods for identifying modulators of protein kinase C phosphorylation of ICAM-related protein |
| US6100383A (en) * | 1992-01-27 | 2000-08-08 | Icos Corporation | Fusion proteins comprising ICAM-R polypeptides and immunoglobulin constant regions |
| FI946006A0 (fi) * | 1992-06-22 | 1994-12-21 | Miles Inc | Humaani-rinoviruksen reseptoriproteiinin multimeerisiä muotoja |
| US5879712A (en) | 1995-06-07 | 1999-03-09 | Sri International | Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced |
| US6867203B2 (en) | 1998-12-29 | 2005-03-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds |
| ATE442386T1 (de) * | 2000-04-28 | 2009-09-15 | Planet Biotechnology Inc | Immunoadhesin zur impfung gegen rhinovirus |
| US20020168367A1 (en) | 2000-04-28 | 2002-11-14 | Planet Biotechnology Incorporated | Novel immunoadhesins for treating and preventing viral and bacterial diseases |
| ATE475424T1 (de) * | 2006-04-04 | 2010-08-15 | Marinomed Biotechnologie Gmbh | Cellulosesulfat zur behandlung von rhinovirus- infektionen |
| US20080131454A1 (en) * | 2006-12-05 | 2008-06-05 | Marinomed Biotechnologie Gmbh | Methods and Compositions for the Treatment of Rhinovirus Infections with Carrageenan |
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| US4261928A (en) * | 1977-08-05 | 1981-04-14 | Sterling Drug Inc. | 2-Benzoyl-8-(2-chloro-4-methoxyphenoxy)-1-phenyl-1-octanone |
| US4171365A (en) * | 1977-08-05 | 1979-10-16 | Sterling Drug Inc. | Antiviral aryloxyalkylpyrazoles |
| US4209526A (en) * | 1977-08-05 | 1980-06-24 | Sterling Drug Inc. | Antiviral arylenedioxyalkyl substituted pyrazoles |
| JPS551594A (en) * | 1978-06-12 | 1980-01-08 | Corning Glass Works | Measuring antigen receptor on cell membrane |
| US4234725A (en) * | 1979-10-24 | 1980-11-18 | Sterling Drug Inc. | 4-[6-(2-Chloro-4-methoxyphenoxy)hexyl]-3,5-diethyl-1-[4-(4-morpholinyl)-1-oxobutyl]-1H-pyrazole |
| US4232161A (en) * | 1979-10-24 | 1980-11-04 | Sterling Drug Inc. | 4-[6-(2-Chloro-4-methoxyphenoxy)hexyl]-3,5-diethyl-1-(2-pyridinyl)-1H-pyrazole |
| US5179017A (en) * | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4427653A (en) * | 1981-01-26 | 1984-01-24 | President And Fellows Of Harvard College | Method of making monoclonal antibodies |
| US4372976A (en) * | 1981-08-07 | 1983-02-08 | Sterling Drug Inc. | Novel aryl-aliphatic ketone and its use as an antiviral agent |
| US4451476A (en) * | 1982-12-13 | 1984-05-29 | Sterling Drug Inc. | Isoxazoles as antiviral agents |
| US4843087A (en) * | 1983-08-29 | 1989-06-27 | Sterling Drug Inc. | Di-heterocyclic compounds and their use as antiviral agents |
| EP0169146A3 (fr) * | 1984-07-20 | 1988-07-20 | Merck & Co. Inc. | Anticoprs monoclonaux dirigés contre le récepteur cellulaire du rhinovirus humain |
| EP0169729A3 (fr) * | 1984-07-23 | 1988-08-03 | Becton Dickinson and Company | Récupération de récepteurs cellulaires |
| DE3505148A1 (de) * | 1985-02-15 | 1986-10-30 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Polypeptide des rhinovirusstammes hrv2 sowie die hierfuer codierenden dna-molekuele |
| CA1280753C (fr) * | 1985-07-02 | 1991-02-26 | Philip Michael Carabateas | Methode de preparation de derives de substitution heterocycliques de phenoxyalkylisoxasoles et de phenoxyalkylfuranes |
| EP0227604A3 (fr) * | 1985-12-23 | 1989-01-18 | Sandoz Ag | Emploi d'oligopeptides dans le traitement d'infections virales |
| EP0261403A3 (fr) * | 1986-08-23 | 1988-04-13 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Polypeptide de rhinovirus souche HRV89, et molécule d'ADN qui l'encode |
| EP0280578B1 (fr) * | 1987-02-26 | 1993-12-15 | Dana-Farber Cancer Institute, Inc. | Purification de LFA-3 |
| EP0303692A4 (en) * | 1987-02-26 | 1990-12-05 | Dana Farber Cancer Institute | Cloning of lfa-1 |
| DE3712678A1 (de) * | 1987-04-14 | 1988-10-27 | Boehringer Ingelheim Int | Rezeptor der kleinen rhinovirus rezeptor gruppe |
| US5603932A (en) * | 1987-04-14 | 1997-02-18 | Boehringer Ingelheim International Gmbh | Receptor of the minor human rhinovirus receptor group |
| US5304636A (en) * | 1987-04-14 | 1994-04-19 | Boehringer Ingelheim International Gmbh | Receptor for the human rhinovirus minor group |
| ATE128727T1 (de) * | 1987-05-04 | 1995-10-15 | Dana Farber Cancer Inst Inc | Interzellulare adhäsions-moleküle und deren bindungsliganden. |
| US5831036A (en) * | 1987-05-04 | 1998-11-03 | Dana Farber Cancer Institute | Soluble fragments of human intercellular adhesion molecule-1 |
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| AU629189B2 (en) * | 1987-05-04 | 1992-10-01 | Dana-Farber Cancer Institute | Intercellular adhesion molecules and their binding ligands |
| US4956281A (en) * | 1987-06-03 | 1990-09-11 | Biogen, Inc. | DNA sequences, recombinant DNA molecules and processes for producing lymphocyte function associated antigen-3 |
| US5109123A (en) * | 1988-06-14 | 1992-04-28 | Dana Farber Cancer Institute | Alteration of ability of soluble CD4 fragments to bind HIV |
| EP0314863B1 (fr) * | 1987-11-02 | 1994-12-07 | Baylor College Of Medicine | Utilisation du ICAM-1 ou de ses derivés fonctionels pour le traitement des inflammations non spécifiques |
| US5081228A (en) * | 1988-02-25 | 1992-01-14 | Immunex Corporation | Interleukin-1 receptors |
| CA1341055C (fr) * | 1987-12-08 | 2000-07-18 | Alan Mcclelland | Lignees cellulaires transfectantes exprimant le recepteur majeur du rhinovirus chez l'homme |
| US5395929A (en) * | 1987-12-15 | 1995-03-07 | Dana Farber Cancer Institute | Isolated nucleic acid encoding the alpha subunit of the human leukocyte adhesion receptor |
| WO1989010938A1 (fr) * | 1988-05-04 | 1989-11-16 | Dana-Farber Cancer Institute | Micelles de proteine |
| EP0364690A3 (fr) * | 1988-08-23 | 1990-07-18 | Dana Farber Cancer Institute | Sous-unité du récepteur d'adhésion de leukocyte Mac-1 |
| DE68923048T2 (de) * | 1988-08-23 | 1995-11-16 | Dana Farber Cancer Inst Inc | Alpha-Subeinheit des LFA-1-Leukocyt-Adhäsions-Rezeptors. |
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| US5372933A (en) * | 1988-10-03 | 1994-12-13 | The Scripps Research Institute | Polypeptides that mimic receptor-induced binding sites, and methods of using same |
| CA2008368C (fr) * | 1989-01-24 | 2003-04-08 | Jeffrey Greve | Molecule soluble apparentee a l'icam-i mais distincte |
| PT92900A (pt) * | 1989-01-24 | 1990-07-31 | Sistema de vectores de expressao para a producao de anticorpos monoclonais quimericos | |
| US5235049A (en) * | 1989-01-24 | 1993-08-10 | Molecular Therapeutics, Inc. | Nucleic acid sequences encoding a soluble molecule (SICAM-1) related to but distinct from ICAM-1 |
| NO900155L (no) * | 1989-01-24 | 1990-07-25 | Molecular Therapeutics Inc | Et opploeselig molekyl som er relatert til, men forskjellig fra icam-1. |
| DK0387701T3 (da) * | 1989-03-09 | 1992-12-07 | Boehringer Ingelheim Pharma | Anvendelse af intercellulære adhæsionsmolekyler samt deres bindende ligander ved behandling af astma |
| CA2011633C (fr) * | 1989-03-09 | 2007-05-15 | Timothy A. Springer | Molecules d'adhesion intercellulaire (icam-2) et ses liquides |
| HU217792B (hu) * | 1989-03-16 | 2000-04-28 | Dana Farber Cancer Institute | Eljárás intercelluláris adhéziós molekula (ICAM-1) oldható származékai és ezeket tartalmazó gyógyszerkészítmények előállítására |
| EP0391088B1 (fr) * | 1989-03-16 | 1997-01-02 | Center For Blood Research, Inc. | Utilisation de dérivés fonctionnels de la molécule d'adhésion intercellulaire ICAM-1 dans une thérapie anti-virale |
| US5324510A (en) * | 1989-09-01 | 1994-06-28 | Boehringer Ingelheim Pharmaceuticals, Inc. | Use of antibodies to intercellular adhesion molecule-1 (ICAM-1) in the treatment of asthma |
| EP0459577A3 (en) * | 1990-06-01 | 1992-08-05 | Merck & Co. Inc. | Microbially expressed portions of a monoclonal antibody block rhinovirus attachment to cell receptors |
| US5349053A (en) * | 1990-06-01 | 1994-09-20 | Protein Design Labs, Inc. | Chimeric ligand/immunoglobulin molecules and their uses |
| ES2134762T3 (es) * | 1990-07-20 | 1999-10-16 | Bayer Ag | Formas multimericas de proteinas receptoras de rinovirus humanos. |
| US5871733A (en) * | 1990-07-20 | 1999-02-16 | Bayer Corporation | Multimeric forms of human rhinovirus receptor protein |
| US5686581A (en) * | 1990-07-20 | 1997-11-11 | Bayer Corporation | Multimeric form of human rhinovirus receptor protein |
| JPH06500555A (ja) * | 1990-08-27 | 1994-01-20 | カイロン コーポレイション | 病気の処置のためのペプチドの薬物 |
| US5288854A (en) * | 1990-11-28 | 1994-02-22 | Center For Blood Research, Inc. | Functional derivatives of ICAM-1 which are substantially capable of binding to LFA-1 but are substantially incapable of binding to MAC-1 |
| ATE145428T1 (de) * | 1990-12-14 | 1996-12-15 | Cell Genesys Inc | Chimärische ketten zur transduktion von rezeptorverbundenen signalwegen |
| EP0510483A1 (fr) * | 1991-04-22 | 1992-10-28 | Boehringer Ingelheim Pharmaceuticals Inc. | Procédé pour la détection des virus |
| US5223396A (en) * | 1991-05-03 | 1993-06-29 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method for detecting organ transplant rejection |
| US5240694A (en) * | 1991-09-23 | 1993-08-31 | University Of Virginia | Combined antiviral and antimediator treatment of common colds |
| JP3679112B2 (ja) * | 1991-10-04 | 2005-08-03 | アメリカ合衆国 | 細胞接着分子の遮断による眼の炎症の治療 |
| US5532127A (en) * | 1992-01-27 | 1996-07-02 | Icos Corporation | Assay for 1-CAM related protein expression |
| EP0578819A4 (fr) * | 1992-01-27 | 1994-10-12 | Icos Corp | Proteine apparentee a icam. |
| US5525487A (en) * | 1992-01-27 | 1996-06-11 | Icos Corporation | DNA encoding I-CAM related protein |
| DE69328514T2 (de) * | 1992-03-13 | 2001-01-11 | Monsanto Co., St. Louis | Herstellung rekombinanter Proteine unter Verwendung von Herpes-Virus-Promotoren und VP16-Transaktivatoren |
| US5580969A (en) * | 1992-07-24 | 1996-12-03 | The United States Of America As Represented By The Secretary Of The Navy | Antisense oligonucleotides directed against human ICAM-I RNA |
-
1991
- 1991-07-06 ES ES91111272T patent/ES2134762T3/es not_active Expired - Lifetime
- 1991-07-06 DK DK91111272T patent/DK0468257T3/da active
- 1991-07-06 EP EP91111272A patent/EP0468257B1/fr not_active Expired - Lifetime
- 1991-07-06 EP EP98124642A patent/EP0987329A3/fr not_active Withdrawn
- 1991-07-06 DE DE69131564T patent/DE69131564T2/de not_active Expired - Lifetime
- 1991-07-06 AT AT91111272T patent/ATE184049T1/de not_active IP Right Cessation
- 1991-07-17 IL IL98866A patent/IL98866A0/xx unknown
- 1991-07-18 FI FI913470A patent/FI105687B/fi not_active IP Right Cessation
- 1991-07-18 JP JP03202211A patent/JP3091527B2/ja not_active Expired - Lifetime
- 1991-07-19 ZA ZA915678A patent/ZA915678B/xx unknown
- 1991-07-19 IE IE255291A patent/IE912552A1/en not_active IP Right Cessation
- 1991-07-19 PT PT98394A patent/PT98394B/pt not_active IP Right Cessation
- 1991-07-20 KR KR1019910012433A patent/KR100208847B1/ko not_active Expired - Lifetime
-
1994
- 1994-10-04 US US08/318,039 patent/US6096862A/en not_active Expired - Lifetime
-
1999
- 1999-11-05 GR GR990402859T patent/GR3031768T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP3091527B2 (ja) | 2000-09-25 |
| FI105687B (fi) | 2000-09-29 |
| ATE184049T1 (de) | 1999-09-15 |
| GR3031768T3 (en) | 2000-02-29 |
| JPH04297499A (ja) | 1992-10-21 |
| KR100208847B1 (ko) | 1999-07-15 |
| FI913470A0 (fi) | 1991-07-18 |
| AU652567B2 (en) | 1994-09-01 |
| DE69131564T2 (de) | 2000-01-13 |
| KR930002511A (ko) | 1993-02-23 |
| DE69131564D1 (de) | 1999-10-07 |
| EP0987329A2 (fr) | 2000-03-22 |
| EP0468257A1 (fr) | 1992-01-29 |
| US6096862A (en) | 2000-08-01 |
| ZA915678B (en) | 1992-05-27 |
| FI913470L (fi) | 1992-01-21 |
| EP0468257B1 (fr) | 1999-09-01 |
| ES2134762T3 (es) | 1999-10-16 |
| IE912552A1 (en) | 1992-01-29 |
| IL98866A0 (en) | 1992-07-15 |
| PT98394A (pt) | 1992-06-30 |
| AU8117691A (en) | 1992-01-23 |
| DK0468257T3 (da) | 2000-03-27 |
| EP0987329A3 (fr) | 2004-03-03 |
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