SK281807B6 - Spôsob výroby n-[3-(3-kyanopyrazolo[1,5-a]pyrimidin-7-yl)fenyl]- n-etyl-acetamidu - Google Patents

Spôsob výroby n-[3-(3-kyanopyrazolo[1,5-a]pyrimidin-7-yl)fenyl]- n-etyl-acetamidu Download PDF

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Publication number
SK281807B6
SK281807B6 SK1536-96A SK153696A SK281807B6 SK 281807 B6 SK281807 B6 SK 281807B6 SK 153696 A SK153696 A SK 153696A SK 281807 B6 SK281807 B6 SK 281807B6
Authority
SK
Slovakia
Prior art keywords
reaction
phenyl
pyrimidin
acetic acid
cyanopyrazolo
Prior art date
Application number
SK1536-96A
Other languages
English (en)
Slovak (sk)
Other versions
SK153696A3 (en
Inventor
Padmanathan Thuralrajah
Original Assignee
American Cyanamid Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Company filed Critical American Cyanamid Company
Publication of SK153696A3 publication Critical patent/SK153696A3/sk
Publication of SK281807B6 publication Critical patent/SK281807B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SK1536-96A 1995-12-01 1996-11-29 Spôsob výroby n-[3-(3-kyanopyrazolo[1,5-a]pyrimidin-7-yl)fenyl]- n-etyl-acetamidu SK281807B6 (sk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US785995P 1995-12-01 1995-12-01

Publications (2)

Publication Number Publication Date
SK153696A3 SK153696A3 (en) 1997-11-05
SK281807B6 true SK281807B6 (sk) 2001-08-06

Family

ID=21728482

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1536-96A SK281807B6 (sk) 1995-12-01 1996-11-29 Spôsob výroby n-[3-(3-kyanopyrazolo[1,5-a]pyrimidin-7-yl)fenyl]- n-etyl-acetamidu

Country Status (25)

Country Link
US (1) US5714607A (cs)
EP (1) EP0776898B1 (cs)
JP (1) JP4112032B2 (cs)
KR (1) KR100439282B1 (cs)
CN (1) CN1057525C (cs)
AR (1) AR004822A1 (cs)
AT (1) ATE227290T1 (cs)
AU (1) AU718310B2 (cs)
BR (1) BR9605760A (cs)
CA (1) CA2191647C (cs)
CY (1) CY2440B1 (cs)
CZ (1) CZ292253B6 (cs)
DE (1) DE69624657T2 (cs)
DK (1) DK0776898T3 (cs)
ES (1) ES2184844T3 (cs)
HU (1) HU226398B1 (cs)
IL (1) IL119710A (cs)
MX (1) MX9605974A (cs)
NO (1) NO307181B1 (cs)
NZ (1) NZ299848A (cs)
PT (1) PT776898E (cs)
RU (1) RU2178415C2 (cs)
SK (1) SK281807B6 (cs)
TW (1) TW382629B (cs)
ZA (1) ZA9610008B (cs)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6399621B1 (en) 1999-08-10 2002-06-04 American Cyanamid Company N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
US6485746B1 (en) 2000-08-25 2002-11-26 Neurocrine Biosciences, Inc. Controlled-release sedative-hypnotic compositions and methods related thereto
US20030091632A1 (en) * 1999-08-26 2003-05-15 Neurocrine Biosciences, Inc. Controlled-release sedative-hypnotic compositions and methods related thereto
US6384221B1 (en) * 1999-09-02 2002-05-07 Neurocrine Biosciences, Inc. Polymorphs of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
SG125971A1 (en) * 2000-08-03 2006-10-30 Wyeth Corp Variable water hydrates of zaleplon and method forthe preparation thereof
EP1526136A1 (en) * 2000-08-03 2005-04-27 Wyeth Polymorphs of zaleplon and methods for the preparation thereof
AR029780A1 (es) 2000-12-13 2003-07-16 Gador Sa Procedimiento mejorado para la obtencion de n-[3(3-ciano-pirazolo[1,5-a]pirimidin-7-il)fenil]-n-etil-acetamida
US20050032818A1 (en) * 2001-06-12 2005-02-10 Entire Interest N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethylacetamide and crystalline forms of zaleplon
DE02778962T1 (de) * 2001-06-12 2005-02-10 Biogal Gyogyszergyar Rt. VERFAHREN ZUR HERSTELLUNG VON N ç3 (3 CYANOPYRAZOLOç1,5 A!PYRIMIDIN 7 YL)PHENYL!-N-ETHYLACETAMID (ZALEPLON)
PL374176A1 (en) * 2001-08-01 2005-10-03 Biogal Gyogyszergyar Rt Process for purifying n-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-n-ethylacetamide(zaleplon) and crystalline forms of zaleplon accessible with the process
US7034155B2 (en) 2002-02-14 2006-04-25 Cilag Ag Method for producing n-ethyl-n-[3-(3-cyanopyrazolo[1,5a]pyrimidine-7-yl)phenyl]acetamide
HRP20040764A2 (en) * 2002-02-15 2005-02-28 Biogal Gyogyszergyar Rt. Powder composition comprising zaleplon of defined particle size distribution and pharmaceutical products made therefrom
PL207322B1 (pl) * 2002-05-14 2010-11-30 Adamed Społka Z Ograniczoną Odpowiedzialnością Sposób wytwarzania zaleplonu
WO2005023813A1 (en) * 2003-09-04 2005-03-17 Cipla Limited Zaleplon synthesis
PL1691811T3 (pl) 2003-12-11 2014-12-31 Sunovion Pharmaceuticals Inc Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji
US7498434B2 (en) * 2004-01-14 2009-03-03 Mallinckrodt Inc Two-phase method for the synthesis of selected pyrazolopyrimidines
HUP0400325A3 (en) 2004-02-02 2005-11-28 Richter Gedeon Vegyeszet Pure n-[3-(-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-n-ethyl-acetamide, process for its preparation and intermediates
DK1742624T3 (da) 2004-02-18 2010-03-08 Sepracor Inc Dopamin-agonist-kombinationsterapi med sedativer til forbedring af søvnkvalitet
WO2006070244A2 (en) * 2004-11-22 2006-07-06 Bakulesh Mafatlal Khamar A process for the preparation of zaleplon
WO2008021309A1 (en) * 2006-08-15 2008-02-21 Wyeth Imidazolidin-2-one derivatives useful as pr modulators
US7649007B2 (en) * 2006-08-15 2010-01-19 Wyeth Llc Oxazolidine derivatives as PR modulators
TW200815428A (en) * 2006-08-15 2008-04-01 Wyeth Corp Oxazolidone derivatives as PR modulators
US7538107B2 (en) 2006-08-15 2009-05-26 Wyeth Oxazinan-2-one derivatives useful as PR modulators
WO2008068600A2 (en) * 2006-12-06 2008-06-12 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of zaleplo
CZ2008468A3 (cs) 2008-07-31 2009-11-18 Farmak, A. S. Zpusob prípravy N-(1-benzo[b]thien-2-ylethyl)-N-hydroxymocoviny
CN102816163A (zh) * 2012-08-20 2012-12-12 四川禾邦阳光制药股份有限公司 扎来普隆的新晶型及制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3907799A (en) * 1971-08-16 1975-09-23 Icn Pharmaceuticals Xanthine oxidase inhibitors
US4281000A (en) * 1979-07-09 1981-07-28 American Cyanamid Company Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents
NZ208554A (en) * 1983-06-23 1987-06-30 American Cyanamid Co (aryl and heteroaryl)-(7-(aryl and heteroaryl)-pyrazolo (1,5-a) pyrimidin-3-yl)-methanone derivatives and pharmaceutical compositions
US4521422A (en) * 1983-06-23 1985-06-04 American Cyanamid Company Aryl and heteroaryl[7-(aryl and heteroaryl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones
US4626538A (en) * 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
JPS62270584A (ja) * 1986-04-28 1987-11-24 Yoshitomi Pharmaceut Ind Ltd ４，７−ジヒドロピラゾロ〔１，５−ａ〕ピリミジン誘導体
RO108347B1 (ro) * 1989-10-30 1994-04-28 Bellon Labor Sa Roger DERIVATI DE BENZO-(b)-NAFTIRIDIN-1,8 SI PROCEDEU DE PREPARARE A ACESTORA
US5356897A (en) * 1991-09-09 1994-10-18 Fujisawa Pharmaceutical Co., Ltd. 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines
GB9321162D0 (en) * 1993-10-13 1993-12-01 Boots Co Plc Therapeutic agents

Also Published As

Publication number Publication date
CN1163893A (zh) 1997-11-05
KR100439282B1 (ko) 2004-08-31
IL119710A (en) 1999-11-30
CA2191647C (en) 2005-01-25
AR004822A1 (es) 1999-03-10
ES2184844T3 (es) 2003-04-16
MX9605974A (es) 1998-04-30
CN1057525C (zh) 2000-10-18
CZ350596A3 (en) 1997-09-17
CA2191647A1 (en) 1997-06-02
PT776898E (pt) 2003-02-28
DK0776898T3 (da) 2003-02-24
EP0776898B1 (en) 2002-11-06
JP4112032B2 (ja) 2008-07-02
NO307181B1 (no) 2000-02-21
IL119710A0 (en) 1997-02-18
ATE227290T1 (de) 2002-11-15
US5714607A (en) 1998-02-03
EP0776898A1 (en) 1997-06-04
HUP9603275A2 (en) 1997-08-28
HU9603275D0 (en) 1997-01-28
NO965084L (no) 1997-06-02
HU226398B1 (en) 2008-11-28
BR9605760A (pt) 1998-08-25
HUP9603275A3 (en) 1997-10-28
DE69624657D1 (de) 2002-12-12
JPH09216885A (ja) 1997-08-19
TW382629B (en) 2000-02-21
KR970042543A (ko) 1997-07-24
NZ299848A (en) 1998-09-24
NO965084D0 (no) 1996-11-28
ZA9610008B (en) 1998-08-28
RU2178415C2 (ru) 2002-01-20
DE69624657T2 (de) 2003-08-21
AU718310B2 (en) 2000-04-13
AU7409196A (en) 1997-06-05
CZ292253B6 (cs) 2003-08-13
CY2440B1 (en) 2004-11-12
SK153696A3 (en) 1997-11-05

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MK4A Patent expired

Expiry date: 20161129