SK9012003A3 - Complex of modafinil and cyclodextrin - Google Patents

Complex of modafinil and cyclodextrin Download PDF

Info

Publication number: SK9012003A3
Authority: SK; Slovakia
Prior art keywords: cyclodextrin; composition; modafinil; complex; modafinil compound
Prior art date: 2000-12-19

Application number

SK901-2003A

Other languages

English (en)

Slovak (sk)

Inventor

Martin J Jacobs

Piyush R Patel

Original Assignee

Cephalon Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-19

Filing date

2001-12-19

Publication date

2003-12-02

2001-12-19 Application filed by Cephalon Inc filed Critical Cephalon Inc

2003-12-02 Publication of SK9012003A3 publication Critical patent/SK9012003A3/sk

Links

229960001165 modafinil Drugs 0.000 title claims abstract description 191
229920000858 Cyclodextrin Polymers 0.000 title claims abstract description 171
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 title claims abstract description 111
YFGHCGITMMYXAQ-UHFFFAOYSA-N 2-[(diphenylmethyl)sulfinyl]acetamide Chemical compound C=1C=CC=CC=1C(S(=O)CC(=O)N)C1=CC=CC=C1 YFGHCGITMMYXAQ-UHFFFAOYSA-N 0.000 title claims description 72
-1 modafinil compound Chemical class 0.000 claims abstract description 131
239000000203 mixture Substances 0.000 claims abstract description 109
238000000034 method Methods 0.000 claims abstract description 31
239000007787 solid Substances 0.000 claims description 33
239000001116 FEMA 4028 Substances 0.000 claims description 30
229960004853 betadex Drugs 0.000 claims description 30
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
235000011175 beta-cyclodextrine Nutrition 0.000 claims description 27
210000002966 serum Anatomy 0.000 claims description 26
WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 21
239000000546 pharmaceutical excipient Substances 0.000 claims description 12
ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims description 12
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PVPBHKCSQBLDEW-ZQOBQRRWSA-N (1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31S,33R,35R,36R,37R,38R,39R,40R,41R,42R,43R,44R,45R,46R,47R,48R,49R)-5,10,15,20,25,30,35-heptakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecol 4-hydroxybutane-1-sulfonic acid Chemical compound OCCCCS(O)(=O)=O.OC[C@H]1O[C@@H]2O[C@@H]3[C@@H](CO)O[C@H](O[C@@H]4[C@@H](CO)O[C@H](O[C@@H]5[C@@H](CO)O[C@H](O[C@@H]6[C@@H](CO)O[C@H](O[C@@H]7[C@@H](CO)O[C@H](O[C@@H]8[C@@H](CO)O[C@H](O[C@H]1[C@H](O)[C@H]2O)[C@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O PVPBHKCSQBLDEW-ZQOBQRRWSA-N 0.000 claims description 5
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BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 4
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GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 claims description 3
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HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 claims description 2
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DSDAICPXUXPBCC-MWDJDSKUSA-N trimethyl-β-cyclodextrin Chemical compound COC[C@H]([C@H]([C@@H]([C@H]1OC)OC)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COC)[C@H]([C@@H]([C@H]3OC)OC)O[C@H]3O[C@H](COC)[C@H]([C@@H]([C@H]3OC)OC)O[C@H]3O[C@H](COC)[C@H]([C@@H]([C@H]3OC)OC)O[C@H]3O[C@H](COC)[C@H]([C@@H]([C@H]3OC)OC)O3)[C@H](OC)[C@H]2OC)COC)O[C@@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@@H]3O[C@@H]1COC DSDAICPXUXPBCC-MWDJDSKUSA-N 0.000 claims description 2
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LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 4
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Classifications

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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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Pharmacology & Pharmacy (AREA)
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Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
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SK901-2003A 2000-12-19 2001-12-19 Complex of modafinil and cyclodextrin SK9012003A3 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US25668100P	2000-12-19	2000-12-19
US10/023,441 US7141555B2 (en)	2000-12-19	2001-12-18	Modafinil compound and cyclodextrin mixtures
PCT/US2001/049189 WO2002056915A2 (en)	2000-12-19	2001-12-19	Complex of modafinil and cyclodextrin

Publications (1)

Publication Number	Publication Date
SK9012003A3 true SK9012003A3 (en)	2003-12-02

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ID=26697157

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Application Number	Title	Priority Date	Filing Date
SK901-2003A SK9012003A3 (en)	2000-12-19	2001-12-19	Complex of modafinil and cyclodextrin

Country Status (22)

Country	Link
US (1)	US7141555B2 (cs)
EP (1)	EP1368063B1 (cs)
JP (1)	JP4094428B2 (cs)
KR (1)	KR20040012696A (cs)
CN (1)	CN100384477C (cs)
AT (1)	ATE396745T1 (cs)
AU (1)	AU2002246711B2 (cs)
BG (1)	BG108009A (cs)
BR (1)	BR0116698A (cs)
CA (1)	CA2432126C (cs)
CZ (1)	CZ20031878A3 (cs)
DE (1)	DE60134274D1 (cs)
EA (1)	EA200300705A1 (cs)
ES (1)	ES2305128T3 (cs)
HU (1)	HUP0401592A2 (cs)
IL (1)	IL156470A0 (cs)
MX (1)	MXPA03005505A (cs)
NO (1)	NO20032788L (cs)
NZ (1)	NZ526780A (cs)
PL (1)	PL362474A1 (cs)
SK (1)	SK9012003A3 (cs)
WO (1)	WO2002056915A2 (cs)

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JP2009091309A (ja) *	2007-10-10	2009-04-30	Japan Organo Co Ltd	バコパモニエラエキスを含有する組成物およびその製造方法ならびに飲食品
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KR101026864B1 (ko) *	2009-10-08	2011-04-12	(주)송호바이오메드	고 수용성 ２―하이드록시프로필―베타사이클로덱스트린을 유효성분으로 함유하는 비만 질환 예방 및 치료용 조성물
US8975241B2 (en)	2009-10-08	2015-03-10	Song Ho Biomed Co., Ltd.	Composition for treating and preventing obesity including high water-soluble 2-hydroxypropyl-betacyclodextrin as effective component
PH12013500477A1 (en)	2010-09-13	2018-01-17	Bev Rx Inc	Aqueous drug delivery system comprising off-flavor masking agent
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US9474715B2 (en)	2011-11-30	2016-10-25	Andreas Voigt	Polymeric drug-delivery material, method for manufacturing thereof and method for delivery of a drug-delivery composition
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KR101719987B1 (ko)	2015-08-03	2017-03-27	(주)상전정공	화물차량의 잠금장치
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US6346548B1 (en) *	1999-08-16	2002-02-12	Cephalon, Inc.	Compositions including modafinil for treatment of attention deficit hyperactivity disorder and multiple sclerosis fatigue
US6455588B1 (en) *	1999-08-20	2002-09-24	Cephalon, Inc.	Compositions including modafinil for treatment of eating disorders and for appetite stimulation

2001
- 2001-12-18 US US10/023,441 patent/US7141555B2/en not_active Expired - Fee Related
- 2001-12-19 DE DE60134274T patent/DE60134274D1/de not_active Expired - Lifetime
- 2001-12-19 HU HU0401592A patent/HUP0401592A2/hu unknown
- 2001-12-19 KR KR10-2003-7008220A patent/KR20040012696A/ko not_active Withdrawn
- 2001-12-19 PL PL01362474A patent/PL362474A1/xx unknown
- 2001-12-19 WO PCT/US2001/049189 patent/WO2002056915A2/en not_active Ceased
- 2001-12-19 CN CNB018207669A patent/CN100384477C/zh not_active Expired - Fee Related
- 2001-12-19 CZ CZ20031878A patent/CZ20031878A3/cs unknown
- 2001-12-19 AU AU2002246711A patent/AU2002246711B2/en not_active Ceased
- 2001-12-19 BR BR0116698-0A patent/BR0116698A/pt not_active IP Right Cessation
- 2001-12-19 MX MXPA03005505A patent/MXPA03005505A/es active IP Right Grant
- 2001-12-19 JP JP2002557422A patent/JP4094428B2/ja not_active Expired - Fee Related
- 2001-12-19 CA CA2432126A patent/CA2432126C/en not_active Expired - Fee Related
- 2001-12-19 AT AT01994302T patent/ATE396745T1/de not_active IP Right Cessation
- 2001-12-19 EP EP01994302A patent/EP1368063B1/en not_active Expired - Lifetime
- 2001-12-19 EA EA200300705A patent/EA200300705A1/ru unknown
- 2001-12-19 ES ES01994302T patent/ES2305128T3/es not_active Expired - Lifetime
- 2001-12-19 SK SK901-2003A patent/SK9012003A3/sk unknown
- 2001-12-19 NZ NZ526780A patent/NZ526780A/en not_active IP Right Cessation
- 2001-12-19 IL IL15647001A patent/IL156470A0/xx unknown
2003
- 2003-06-18 NO NO20032788A patent/NO20032788L/no not_active Application Discontinuation
- 2003-07-18 BG BG108009A patent/BG108009A/xx unknown

Also Published As

Publication number	Publication date
ES2305128T3 (es)	2008-11-01
EP1368063B1 (en)	2008-05-28
WO2002056915A3 (en)	2003-01-03
DE60134274D1 (en)	2008-07-10
AU2002246711B2 (en)	2006-12-14
HK1059055A1 (en)	2004-06-18
CZ20031878A3 (cs)	2004-10-13
NZ526780A (en)	2005-07-29
CN100384477C (zh)	2008-04-30
PL362474A1 (en)	2004-11-02
BG108009A (en)	2004-09-30
NO20032788D0 (no)	2003-06-18
CA2432126C (en)	2011-03-08
EP1368063A2 (en)	2003-12-10
NO20032788L (no)	2003-07-07
CA2432126A1 (en)	2002-07-25
IL156470A0 (en)	2004-01-04
BR0116698A (pt)	2003-10-21
CN1486196A (zh)	2004-03-31
KR20040012696A (ko)	2004-02-11
WO2002056915A2 (en)	2002-07-25
JP2004525104A (ja)	2004-08-19
HUP0401592A2 (hu)	2004-11-29
US20020160982A1 (en)	2002-10-31
MXPA03005505A (es)	2003-10-06
US7141555B2 (en)	2006-11-28
EA200300705A1 (ru)	2003-12-25
ATE396745T1 (de)	2008-06-15
JP4094428B2 (ja)	2008-06-04

Publication	Publication Date	Title
US7141555B2 (en)	2006-11-28	Modafinil compound and cyclodextrin mixtures
AU2002246711A1 (en)	2003-02-13	Complex of modafinil and cyclodextrin
KR100349754B1 (ko)	2002-12-18	제약조성물
JP2007536228A (ja)	2007-12-13	セルトラリンおよびスルホアルキルエーテルシクロデキストリンを含有するテイストマスク製剤
KR20060096490A (ko)	2006-09-11	술포알킬 에테르-알킬 에테르 시클로덱스트린 유도체
JP2011116776A (ja)	2011-06-16	アミオダロンおよびスルホアルキルエーテルシクロデキストリンを含む製剤
CN101010067B (zh)	2011-03-16	莫达非尼口腔冻干剂
US6077871A (en)	2000-06-20	Droloxifene pharmaceutical compositions
US7704975B2 (en)	2010-04-27	Modafinil compound and cyclodextrin mixtures
HK1059055B (en)	2009-01-30	Complex of modafinil and cyclodextrin
ZA200305346B (en)	2004-10-11	Complex of modafinil and cyclodextrin.
RU2179036C2 (ru)	2002-02-10	Составы эстрамустина с улучшенными фармацевтическими свойствами
Erdoğar et al.	2014	Cyclodextrins in drug delivery
Gibara	0	Cyclodextrins–A Review on Pharmaceutical Application for Drug Delivery
MXPA98009888A (en)	2000-01-01	Pharmaceutical compositions of droloxif
JPWO2001041757A1 (ja)	2003-06-03	シクロデキストリン含有医薬組成物
WO2006034849A1 (en)	2006-04-06	Antitumoral pharmaceutical compositions comprising a spisulosine and a cyclodextrin