SK9792003A3 - Conjugates of immune cell specific macrolide compounds with anti-inflammatory compounds for improved cellular targeting of anti-inflammatory therapy - Google Patents

Conjugates of immune cell specific macrolide compounds with anti-inflammatory compounds for improved cellular targeting of anti-inflammatory therapy Download PDF

Info

Publication number: SK9792003A3
Authority: SK; Slovakia
Prior art keywords: hydrogen; group; represented; compound; oxygen
Prior art date: 2001-01-09

Application number

SK979-2003A

Other languages

English (en)

Slovak (sk)

Inventor

Mladen Mercep

Milan Mesic

Linda Tomaskovic

Marijana Komac

Boska Hrvacic

Stribor Markovic

Original Assignee

Pliva D D

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-01-09

Filing date

2002-01-03

Publication date

2004-01-08

2002-01-03 Application filed by Pliva D D filed Critical Pliva D D

2004-01-08 Publication of SK9792003A3 publication Critical patent/SK9792003A3/sk

Links

150000001875 compounds Chemical class 0.000 title claims abstract description 121
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230000003110 anti-inflammatory effect Effects 0.000 title claims description 18
238000011861 anti-inflammatory therapy Methods 0.000 title 1
230000001413 cellular effect Effects 0.000 title 1
210000002865 immune cell Anatomy 0.000 title 1
230000008685 targeting Effects 0.000 title 1
241001465754 Metazoa Species 0.000 claims abstract description 8
208000027866 inflammatory disease Diseases 0.000 claims abstract description 6
239000001257 hydrogen Substances 0.000 claims description 189
229910052739 hydrogen Inorganic materials 0.000 claims description 189
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 129
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 57
150000002431 hydrogen Chemical class 0.000 claims description 50
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QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 42
239000001301 oxygen Substances 0.000 claims description 42
229910052760 oxygen Inorganic materials 0.000 claims description 42
150000003431 steroids Chemical class 0.000 claims description 41
229910052731 fluorine Inorganic materials 0.000 claims description 39
239000011737 fluorine Substances 0.000 claims description 39
229910052736 halogen Chemical group 0.000 claims description 39
150000002367 halogens Chemical group 0.000 claims description 39
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 34
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Steroid Compounds (AREA)
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Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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SK979-2003A 2001-01-09 2002-01-03 Conjugates of immune cell specific macrolide compounds with anti-inflammatory compounds for improved cellular targeting of anti-inflammatory therapy SK9792003A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HR20010018A HRP20010018A2 (en)	2001-01-09	2001-01-09	Novel anti-inflammatory compounds
PCT/HR2002/000001 WO2002055531A1 (en)	2001-01-09	2002-01-03	Conjugates of immune cell specific macrolide compounds with anti-inflammatory compounds for improved cellular targeting of anti-inflammatory therapy

Publications (1)

Publication Number	Publication Date
SK9792003A3 true SK9792003A3 (en)	2004-01-08

Family

ID=10947235

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK979-2003A SK9792003A3 (en)	2001-01-09	2002-01-03	Conjugates of immune cell specific macrolide compounds with anti-inflammatory compounds for improved cellular targeting of anti-inflammatory therapy

Country Status (23)

Country	Link
US (2)	US7446097B2 (pl)
EP (1)	EP1351973B1 (pl)
JP (1)	JP4474101B2 (pl)
CN (1)	CN1269836C (pl)
AR (1)	AR035727A1 (pl)
AT (1)	ATE462713T1 (pl)
BG (1)	BG108073A (pl)
BR (1)	BR0206347A (pl)
CA (1)	CA2434009C (pl)
CZ (1)	CZ20031825A3 (pl)
DE (1)	DE60235794D1 (pl)
EA (1)	EA007061B1 (pl)
EE (1)	EE05333B1 (pl)
ES (1)	ES2342364T3 (pl)
GE (1)	GEP20053607B (pl)
HR (1)	HRP20010018A2 (pl)
HU (1)	HUP0500180A3 (pl)
IL (1)	IL156673A0 (pl)
PL (1)	PL207636B1 (pl)
RS (1)	RS51308B (pl)
SK (1)	SK9792003A3 (pl)
UA (1)	UA77166C2 (pl)
WO (1)	WO2002055531A1 (pl)

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AU2003219770B2 (en)	2002-02-15	2008-10-09	Merckle Gmbh	Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
US7271154B2 (en)	2002-02-15	2007-09-18	Merckle Gmbh	Antibiotic conjugates
EP1483579A4 (en)	2002-02-15	2006-07-12	Merckle Gmbh	CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, PROCESS FOR THEIR MANUFACTURE AND USE, FORMULATION AND PHARMACEUTICAL APPLICATIONS THEREOF
EP1521763A2 (en) *	2002-07-08	2005-04-13	Pliva - Istrazivacki Institut d.o.o.	Novel nonsteroidal anti-inflammatory substances, compositions and methods for their use
AU2003264917A1 (en)	2002-07-08	2004-01-23	Pliva - Istrazivacki Institut D.O.O.	Hybrid molecules of macrolides with steroid/non-steroid anti-inflammatory, antineoplastic and antiviral active molecules
RS20050008A (sr) *	2002-07-08	2007-06-04	Pliva-Istraživački Institut D.O.O.,	Nova jedinjenja,kompozicije i metode za lečenje inflamatornih oboljenja i stanja
HRP20030324A2 (en)	2003-04-24	2005-02-28	Pliva-Istra�iva�ki institut d.o.o.	Compounds of antiinflammatory effect
WO2005030227A1 (en)	2003-09-23	2005-04-07	Enanta Pharmaceuticals, Inc.	9a, 11-3C-BICYCLIC 9a-AZALIDE DERIVATIVES
JP4737495B2 (ja) *	2004-01-14	2011-08-03	塩野義製薬株式会社	エリスロマイシン誘導体
KR20070046917A (ko) *	2004-08-12	2007-05-03	글락소스미쓰클라인 이스트라지바치키 센타 자그레브 디.오.오.	위장관의 염증성 질환의 치료를 위한 세포-특이적컨쥬게이트의 용도
US20060183696A1 (en) *	2004-08-12	2006-08-17	Pliva-Istrazivacki Institut D.O.O.	Use of immune cell specific conjugates for treatment of inflammatory diseases of gastrointestinal tract
US7402568B2 (en)	2004-09-29	2008-07-22	Enanta Pharmaceuticals, Inc.	Bicyclic 9a-azalide derivatives
ES2337915T3 (es) *	2004-10-27	2010-04-30	Glaxosmithkline Istrazivacki Centar Zagreb D.O.O.	Conjugados con adtividad antiinflamatoria.
US7271155B2 (en)	2005-01-07	2007-09-18	Enanta Pharmaceuticals, Inc.	9A, 11-2C-bicyclic 9a-azalide derivatives
US20080249034A1 (en) *	2005-03-21	2008-10-09	Zambon S.P.A.	Use of Macrolides for Treating Intestinal Inflammation
WO2011116312A1 (en) *	2010-03-19	2011-09-22	Catabasis Pharmaceuticals, Inc.	Fatty acid macrolide derivatives and their uses
EP2948152A4 (en) *	2013-01-23	2016-12-14	Sphaera Pharma Private Ltd	NOVEL COMPOUNDS OF 11-BETA HYDROXY-STEROIDS FOR USE IN MITOCHONDRIA BIOGENESIS AND DISEASES RELATED TO MITOCHONDRIA DYSFUNCTION OR ADDITIONAL
WO2016013030A2 (en)	2014-07-23	2016-01-28	Sphaera Pharma Pvt. Ltd.	Hydroxysteroid compounds, their intermediates, process of preparation, composition and uses thereof
GB201520419D0 (en)	2015-11-19	2016-01-06	Epi Endo Pharmaceuticals Ehf	Compounds
WO2023248010A2 (en) *	2022-06-23	2023-12-28	Synovo Gmbh	Targeted modulators of jak3 for treatment of inflammatory and autoimmune diseases

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2001
- 2001-01-09 HR HR20010018A patent/HRP20010018A2/hr not_active Application Discontinuation
2002
- 2002-01-03 EP EP02729470A patent/EP1351973B1/en not_active Expired - Lifetime
- 2002-01-03 HU HU0500180A patent/HUP0500180A3/hu unknown
- 2002-01-03 PL PL363478A patent/PL207636B1/pl unknown
- 2002-01-03 DE DE60235794T patent/DE60235794D1/de not_active Expired - Lifetime
- 2002-01-03 JP JP2002556599A patent/JP4474101B2/ja not_active Expired - Fee Related
- 2002-01-03 EE EEP200300293A patent/EE05333B1/xx not_active IP Right Cessation
- 2002-01-03 AT AT02729470T patent/ATE462713T1/de not_active IP Right Cessation
- 2002-01-03 US US10/250,934 patent/US7446097B2/en not_active Expired - Fee Related
- 2002-01-03 IL IL15667302A patent/IL156673A0/xx unknown
- 2002-01-03 SK SK979-2003A patent/SK9792003A3/sk unknown
- 2002-01-03 EA EA200300781A patent/EA007061B1/ru not_active IP Right Cessation
- 2002-01-03 CN CNB02804715XA patent/CN1269836C/zh not_active Expired - Fee Related
- 2002-01-03 BR BR0206347-6A patent/BR0206347A/pt not_active Application Discontinuation
- 2002-01-03 CZ CZ20031825A patent/CZ20031825A3/cs unknown
- 2002-01-03 ES ES02729470T patent/ES2342364T3/es not_active Expired - Lifetime
- 2002-01-03 CA CA002434009A patent/CA2434009C/en not_active Expired - Fee Related
- 2002-01-03 GE GE5260A patent/GEP20053607B/en unknown
- 2002-01-03 RS YUP-552/03A patent/RS51308B/sr unknown
- 2002-01-03 WO PCT/HR2002/000001 patent/WO2002055531A1/en not_active Ceased
- 2002-01-08 AR ARP020100040A patent/AR035727A1/es active IP Right Grant
- 2002-03-01 UA UA2003076135A patent/UA77166C2/uk unknown
2003
- 2003-08-07 BG BG108073A patent/BG108073A/bg unknown
2008
- 2008-09-16 US US12/211,213 patent/US7928078B2/en not_active Expired - Fee Related

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Publication number	Publication date
US20040198677A1 (en)	2004-10-07
CA2434009A1 (en)	2002-07-18
IL156673A0 (en)	2004-01-04
HK1065320A1 (en)	2005-02-18
ATE462713T1 (de)	2010-04-15
EE05333B1 (et)	2010-08-16
WO2002055531A1 (en)	2002-07-18
EE200300293A (et)	2003-10-15
HRP20010018A2 (en)	2002-12-31
EP1351973B1 (en)	2010-03-31
CZ20031825A3 (cs)	2003-11-12
CN1491230A (zh)	2004-04-21
YU55203A (sh)	2006-03-03
AR035727A1 (es)	2004-07-07
HUP0500180A2 (en)	2006-09-28
ES2342364T3 (es)	2010-07-06
PL207636B1 (pl)	2011-01-31
HUP0500180A3 (en)	2009-12-28
CA2434009C (en)	2009-09-29
DE60235794D1 (de)	2010-05-12
JP4474101B2 (ja)	2010-06-02
US7446097B2 (en)	2008-11-04
GEP20053607B (en)	2005-09-12
EA007061B1 (ru)	2006-06-30
UA77166C2 (en)	2006-11-15
US7928078B2 (en)	2011-04-19
EA200300781A1 (ru)	2003-12-25
EP1351973A1 (en)	2003-10-15
PL363478A1 (pl)	2004-11-15
BR0206347A (pt)	2004-02-10
CN1269836C (zh)	2006-08-16
BG108073A (bg)	2005-05-31
RS51308B (sr)	2010-12-31
US20090105163A1 (en)	2009-04-23
JP2004518670A (ja)	2004-06-24

Legal Events

Date	Code	Title	Description
2011-11-04	FB9A	Suspension of patent application procedure

Publication	Publication Date	Title
US7928078B2 (en)	2011-04-19	Conjugates of immune cell specific macrolide compounds with anti-inflammatory compounds for improved cellular targeting of anti-inflammatory therapy
US7091187B2 (en)	2006-08-15	Compounds, compositions and methods for treatment of inflammatory diseases and conditions
EP1551865B1 (en)	2009-04-22	Hybrid molecules of macrolides with steroidal/non-steroidal anti-inflammatory molecules
CZ302513B6 (cs)	2011-06-29	Steroid, farmaceutická kompozice tento steroid obsahující, zpusob prípravy tohoto steroidu a meziprodukty pro tento zpusob
NO20130898L (no)	2006-01-16	Makrolidkonjugater med anti-inflammatorisk aktivitet
AU2008227246B2 (en)	2012-06-14	Fatty acid esters of glucocorticoids as anti-inflammatory and anti-cancer agents
CN101321535A (zh)	2008-12-10	杂芳香磺酰胺前药
JP2008532927A (ja)	2008-08-21	抗炎症マクロライド接合体
JP2014091677A (ja)	2014-05-19	キチナーゼ阻害剤