SU1598873A3 - Способ получени производных хинолина или их фармацевтически приемлемых сложных эфиров или фармацевтически приемлемых аддитивных солей кислоты - Google Patents

Способ получени производных хинолина или их фармацевтически приемлемых сложных эфиров или фармацевтически приемлемых аддитивных солей кислоты Download PDF

Info

Publication number: SU1598873A3
Authority: SU; USSR - Soviet Union
Prior art keywords: group; methyl; hydrogen atom; formula; pharmaceutically acceptable
Prior art date: 1985-10-29

Application number

SU874203548A

Other languages

English (en)

Russian (ru)

Inventor

Мацумото Юн-Ичи

Миямото Теруюки

Эгава Хироси

Накамура Синичи

Original Assignee

Дайниппон Фармасьютикал Ко,Лтд (Фирма)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-10-29

Filing date

1987-10-27

Publication date

1990-10-07

1987-10-27 Application filed by Дайниппон Фармасьютикал Ко,Лтд (Фирма) filed Critical Дайниппон Фармасьютикал Ко,Лтд (Фирма)

1990-10-07 Application granted granted Critical

1990-10-07 Publication of SU1598873A3 publication Critical patent/SU1598873A3/ru

1993-04-23 Priority to LV930262A priority Critical patent/LV5479A3/xx

Links

238000000034 method Methods 0.000 title claims abstract description 9
150000002148 esters Chemical class 0.000 title claims abstract 4
150000003839 salts Chemical class 0.000 title claims abstract 4
125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title claims abstract 3
239000000654 additive Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract description 12
125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 11
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 11
125000005843 halogen group Chemical group 0.000 claims abstract 4
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract 3
125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 claims abstract 2
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 7
239000002253 acid Substances 0.000 claims description 5
229910021529 ammonia Inorganic materials 0.000 claims description 3
125000000217 alkyl group Chemical group 0.000 claims 1
229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 claims 1
150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
150000004677 hydrates Chemical class 0.000 claims 1
ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical compound O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 claims 1
238000002360 preparation method Methods 0.000 abstract description 6
230000000844 anti-bacterial effect Effects 0.000 abstract description 4
125000003277 amino group Chemical group 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
-1 1-piperazinyl Chemical group 0.000 description 8
229920001817 Agar Polymers 0.000 description 8
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
239000008272 agar Substances 0.000 description 8
239000003814 drug Substances 0.000 description 7
229940079593 drug Drugs 0.000 description 7
208000015181 infectious disease Diseases 0.000 description 7
244000005700 microbiome Species 0.000 description 7
239000000203 mixture Substances 0.000 description 7
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
230000005764 inhibitory process Effects 0.000 description 6
230000001580 bacterial effect Effects 0.000 description 5
241000699670 Mus sp. Species 0.000 description 4
WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 description 4
239000012458 free base Substances 0.000 description 4
239000007788 liquid Substances 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
241000204031 Mycoplasma Species 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
QZGZNEIHSDIMDE-UHFFFAOYSA-N 1-cyclopropyl-5,6,8-trifluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid Chemical compound C1CN(C)CCN1C1=C(F)C(F)=C2C(=O)C(C(O)=O)=CN(C3CC3)C2=C1F QZGZNEIHSDIMDE-UHFFFAOYSA-N 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
241000699666 Mus <mouse, genus> Species 0.000 description 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 2
241000193998 Streptococcus pneumoniae Species 0.000 description 2
230000000694 effects Effects 0.000 description 2
238000007912 intraperitoneal administration Methods 0.000 description 2
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
239000011541 reaction mixture Substances 0.000 description 2
239000000243 solution Substances 0.000 description 2
229940031000 streptococcus pneumoniae Drugs 0.000 description 2
AOJJQIZFBKKQBI-UHFFFAOYSA-N 1-cyclopropyl-2-ethyl-5,6,7,8-tetrafluoro-4-oxoquinoline-3-carboxylic acid Chemical compound CCC1=C(C(O)=O)C(=O)C2=C(F)C(F)=C(F)C(F)=C2N1C1CC1 AOJJQIZFBKKQBI-UHFFFAOYSA-N 0.000 description 1
UVPAOMFBMNZWTA-UHFFFAOYSA-N 1-cyclopropyl-5,6,8-trifluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid Chemical compound C1CNC(C)CN1C1=C(F)C(F)=C2C(=O)C(C(O)=O)=CN(C3CC3)C2=C1F UVPAOMFBMNZWTA-UHFFFAOYSA-N 0.000 description 1
CRNDXEVHWDPJSJ-UHFFFAOYSA-N 5-amino-1-ethyl-6,8-difluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid Chemical compound FC1=C2N(CC)C=C(C(O)=O)C(=O)C2=C(N)C(F)=C1N1CCNCC1 CRNDXEVHWDPJSJ-UHFFFAOYSA-N 0.000 description 1
241000203022 Acholeplasma laidlawii Species 0.000 description 1
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
229940126062 Compound A Drugs 0.000 description 1
NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 1
241000202938 Mycoplasma hyorhinis Species 0.000 description 1
241000202934 Mycoplasma pneumoniae Species 0.000 description 1
206010058667 Oral toxicity Diseases 0.000 description 1
241000191967 Staphylococcus aureus Species 0.000 description 1
241000194017 Streptococcus Species 0.000 description 1
230000007059 acute toxicity Effects 0.000 description 1
231100000403 acute toxicity Toxicity 0.000 description 1
238000002814 agar dilution Methods 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
230000002725 anti-mycoplasma Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
210000004556 brain Anatomy 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
230000000973 chemotherapeutic effect Effects 0.000 description 1
230000001332 colony forming effect Effects 0.000 description 1
229940125904 compound 1 Drugs 0.000 description 1
229940125782 compound 2 Drugs 0.000 description 1
229940126214 compound 3 Drugs 0.000 description 1
229940125898 compound 5 Drugs 0.000 description 1
239000013078 crystal Substances 0.000 description 1
239000012895 dilution Substances 0.000 description 1
238000010790 dilution Methods 0.000 description 1
125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
125000004494 ethyl ester group Chemical group 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
238000001802 infusion Methods 0.000 description 1
239000002054 inoculum Substances 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
231100000636 lethal dose Toxicity 0.000 description 1
231100000418 oral toxicity Toxicity 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
229910000027 potassium carbonate Inorganic materials 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
150000003248 quinolines Chemical class 0.000 description 1
239000000523 sample Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
238000010267 two-fold dilution method Methods 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Quinoline Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SU874203548A 1985-10-29 1987-10-27 Способ получени производных хинолина или их фармацевтически приемлемых сложных эфиров или фармацевтически приемлемых аддитивных солей кислоты SU1598873A3 (ru)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
LV930262A LV5479A3 (lv)	1985-10-29	1993-04-23	Hinolina atvasinajumu vai to farmaceitiski pienemamu esteru vai farmaceitiski pienemamu skabes aditivo salu iegusanas metode

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP24225785		1985-10-29
JP28532385		1985-12-17
JP3262786		1986-02-17

Publications (1)

Publication Number	Publication Date
SU1598873A3 true SU1598873A3 (ru)	1990-10-07

Family

ID=27287785

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SU874203548A SU1598873A3 (ru)	1985-10-29	1987-10-27	Способ получени производных хинолина или их фармацевтически приемлемых сложных эфиров или фармацевтически приемлемых аддитивных солей кислоты
SU874203544A SU1635898A3 (ru)	1985-10-29	1987-10-27	Способ получени производных хинолина или их фармацевтически приемлемых сложных эфиров, или фармацевтически приемлемых солей указанных производных или сложных эфиров

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SU874203544A SU1635898A3 (ru)	1985-10-29	1987-10-27	Способ получени производных хинолина или их фармацевтически приемлемых сложных эфиров, или фармацевтически приемлемых солей указанных производных или сложных эфиров

Country Status (26)

Country	Link
US (1)	US4795751A (2)
EP (2)	EP0375658B1 (2)
JP (2)	JPS62277362A (2)
KR (1)	KR910006806B1 (2)
CN (1)	CN1009930B (2)
AR (3)	AR242031A1 (2)
AT (2)	ATE66210T1 (2)
AU (1)	AU594983B2 (2)
CA (1)	CA1340402C (2)
DE (3)	DE3650018T2 (2)
DK (2)	DK170593B1 (2)
ES (2)	ES2029786T3 (2)
FI (1)	FI87457C (2)
GE (1)	GEP19960467B (2)
GR (1)	GR3002475T3 (2)
HU (1)	HU200452B (2)
IL (1)	IL80404A (2)
LU (2)	LU88596I2 (2)
MY (1)	MY100574A (2)
NL (2)	NL970020I2 (2)
NO (1)	NO170726C (2)
NZ (1)	NZ218089A (2)
PH (1)	PH22862A (2)
PT (1)	PT83643B (2)
SU (2)	SU1598873A3 (2)
YU (3)	YU46414B (2)

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IL88003A (en) *	1987-10-16	1992-11-15	Dainippon Pharmaceutical Co	Quinoline derivatives,their preparation and pharmaceutical compositions containing them
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AU609974B2 (en) *	1988-05-18	1991-05-09	Warner-Lambert Company	Improved process for the preparation of 5-amino-7- (substituted amino)-quinoline-3-carboxylic acids
JPH0674261B2 (ja) *	1988-06-21	1994-09-21	塩野義製薬株式会社	キノロンカルボン酸誘導体
JP2709604B2 (ja) *	1988-06-29	1998-02-04	大日本製薬株式会社	マイコプラズマ汚染の防止または除去
US5262417A (en) *	1988-12-06	1993-11-16	The Upjohn Company	Antibacterial quinolone compounds
FR2655545B1 (fr)	1989-12-11	1994-06-10	Rhone Poulenc Sante	Nouvelle application therapeutique des derives des fluoroquinolones.
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JP2613139B2 (ja) *	1990-07-19	1997-05-21	エスエス製薬株式会社	キノロンカルボン酸誘導体
US5342846A (en) *	1990-12-05	1994-08-30	Synphar Laboratories, Inc.	7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid compounds and 7-(substituted triazolyl pyrrolidin-1-yl) 4-oxoquinoline-3-carboxylic acid derivatives useful as antibacterial agents
FR2681863B1 (fr) *	1991-09-27	1995-02-03	Rhone Dpc Europ	Solution de sparfloxacine sa preparation et sel la constituant.
WO1993024460A1 (en) *	1992-05-26	1993-12-09	Ss Pharmaceutical Co., Ltd.	5-aminoquinolonecarboxylic acid derivative and antibacterial containing the same as active ingredient
WO1993025545A1 (en) *	1992-06-09	1993-12-23	Korea Research Institute Of Chemical Technology	Novel quinoline derivatives and processes for preparing the same
US5290794A (en) *	1992-10-27	1994-03-01	Warner Lambert Co.	Soluble calcium lactate antibacterial complexes as non-irritating parenteral forms
US5646163A (en) *	1992-10-30	1997-07-08	The Procter & Gamble Company	Quinolone 5-(N-heterosubstituted amino) antimicrobials
CN1038326C (zh) *	1993-07-20	1998-05-13	爱斯制药株式会社	5－氨基喹诺酮羧酸衍生物及其含有该衍生物作为活性成分的抗菌剂
US5532239A (en) *	1993-08-02	1996-07-02	Assistance Publique - Hopitaux De Paris	Therapeutic application of fluoroquinolone derivatives
CA2353557A1 (en)	1998-12-04	2000-06-08	Influx, Inc.	Inhibitors of multidrug transporters
AU3192700A (en)	1999-03-17	2000-10-04	Daiichi Pharmaceutical Co., Ltd.	Medicinal compositions
CN1091103C (zh) *	1999-04-02	2002-09-18	中国科学院上海药物研究所	一类喹诺酮类化合物及它的制备和其用途
US6957105B2 (en) *	2002-03-26	2005-10-18	Cardiac Pacemakers, Inc.	Method and apparatus for detecting oscillations in cardiac rhythm with electrogram signals
KR100519158B1 (ko) *	2002-12-21	2005-10-06	주식회사유한양행	퀴놀론 카르복실레이트 유도체의 제조방법
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US20070196398A1 (en) *	2006-02-17	2007-08-23	Murthy Yerramilli V S	Fluoroquinolone fatty acid salt compositions
US7973022B2 (en)	2006-02-17	2011-07-05	Idexx Laboratories, Inc.	Fluoroquinolone carboxylic acid salt compositions
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US20200215074A1 (en)	2017-06-22	2020-07-09	Cipla Limited	Method of Treatment of Cancer
CN112939860B (zh) *	2019-11-11	2022-11-11	山东畜牧兽医职业学院	一种治疗耐药性革兰阴阳性菌的化合物及其制备方法

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JPS6110574A (ja) *	1984-06-25	1986-01-18	Hokuriku Seiyaku Co Ltd	６−フルオロ−１，４−ジヒドロ−４−オキソ−７−置換ピペラジニルキノリン−３−カルボン酸誘導体
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JPS6191183A (ja) *	1984-10-11	1986-05-09	Kyorin Pharmaceut Co Ltd	キノロンカルボン酸誘導体
EP0181521A1 (en) *	1984-10-19	1986-05-21	Otsuka Pharmaceutical Co., Ltd.	Antimicrobial 1-substituted Phenyl-4-oxoquinoline-3-carboxylic acid compounds
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JPS6259263A (ja) *	1985-09-10	1987-03-14	Kyorin Pharmaceut Co Ltd	キノロンカルボン酸誘導体
US4977154A (en) *	1985-12-12	1990-12-11	Warner-Lambert Company	5-amino and 5-hydroxy-6-fluoroquinolones as antibacterial agents
US4668680A (en) *	1985-12-12	1987-05-26	Warner-Lambert Company	5-amino-6,8-difluoroquinolones as antibacterial agents
EP0230053A3 (en) *	1986-01-17	1988-03-30	American Cyanamid Company	7-(substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
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GB8612137D0 (en) *	1986-05-19	1986-06-25	Fujisawa Pharmaceutical Co	Quinolone compounds

1986
- 1986-10-22 AU AU64277/86A patent/AU594983B2/en not_active Expired
- 1986-10-23 ES ES198686114748T patent/ES2029786T3/es not_active Expired - Lifetime
- 1986-10-23 EP EP90101210A patent/EP0375658B1/en not_active Expired - Lifetime
- 1986-10-23 AT AT86114748T patent/ATE66210T1/de not_active IP Right Cessation
- 1986-10-23 DE DE3650018T patent/DE3650018T2/de not_active Expired - Lifetime
- 1986-10-23 IL IL80404A patent/IL80404A/xx not_active IP Right Cessation
- 1986-10-23 DE DE8686114748T patent/DE3680859D1/de not_active Expired - Lifetime
- 1986-10-23 FI FI864299A patent/FI87457C/fi not_active IP Right Cessation
- 1986-10-23 NO NO864247A patent/NO170726C/no not_active IP Right Cessation
- 1986-10-23 DE DE2000175028 patent/DE10075028I2/de active Active
- 1986-10-23 EP EP86114748A patent/EP0221463B1/en not_active Expired - Lifetime
- 1986-10-23 AT AT90101210T patent/ATE109472T1/de active
- 1986-10-23 ES ES90101210T patent/ES2057197T3/es not_active Expired - Lifetime
- 1986-10-23 LU LU88596C patent/LU88596I2/fr unknown
- 1986-10-24 HU HU864479A patent/HU200452B/hu unknown
- 1986-10-28 US US06/928,297 patent/US4795751A/en not_active Expired - Lifetime
- 1986-10-28 DK DK514586A patent/DK170593B1/da not_active IP Right Cessation
- 1986-10-28 NZ NZ218089A patent/NZ218089A/xx unknown
- 1986-10-28 JP JP61257175A patent/JPS62277362A/ja active Granted
- 1986-10-28 MY MYPI86000045A patent/MY100574A/en unknown
- 1986-10-28 CA CA000521561A patent/CA1340402C/en not_active Expired - Lifetime
- 1986-10-29 PT PT83643A patent/PT83643B/pt unknown
- 1986-10-29 CN CN86107491A patent/CN1009930B/zh not_active Expired
- 1986-10-29 KR KR1019860009083A patent/KR910006806B1/ko not_active Expired
- 1986-10-29 AR AR86305742A patent/AR242031A1/es active
- 1986-10-29 YU YU183586A patent/YU46414B/sh unknown
- 1986-10-29 PH PH34426A patent/PH22862A/en unknown
1987
- 1987-10-27 SU SU874203548A patent/SU1598873A3/ru active
- 1987-10-27 SU SU874203544A patent/SU1635898A3/ru active
1990
- 1990-11-19 AR AR90318410A patent/AR243520A1/es active
- 1990-11-19 AR AR90318409A patent/AR243178A1/es active
1991
- 1991-08-08 YU YU137191A patent/YU137191A/sh unknown
- 1991-08-08 YU YU137291A patent/YU137291A/sh unknown
- 1991-08-16 GR GR91401047T patent/GR3002475T3/el unknown
- 1991-12-26 JP JP35979491A patent/JPH0714918B2/ja not_active Expired - Lifetime
1992
- 1992-02-28 DK DK025992A patent/DK170774B1/da not_active IP Right Cessation
1993
- 1993-07-29 GE GEAP19931276A patent/GEP19960467B/en unknown
1997
- 1997-05-30 NL NL970020C patent/NL970020I2/nl unknown
2000
- 2000-08-08 NL NL300014C patent/NL300014I2/nl unknown
- 2000-08-09 LU LU90621C patent/LU90621I2/fr unknown

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Бюлер К., Пирсон Д. Органические синтезы, ч. 1. - М.: Мир, 1973, . . . с. 504. (.54) СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ ХИНОЛИНА ИЛИ ИХ ФАРМАЦЕВТИЧЕСКИ ПРИЕМЛЕМЫХ СЛОЖНЫХ ЭФИРОВ ИЛИ ФАРМАЦЕВ-.. ТИЧЕСКИ ПРИЕМЛЕМЫХ АДДИТИВНЫХ СОЛЕЙ КИСЛОТЫ *

Also Published As

Publication number	Publication date
FI864299L (fi)	1987-04-30
DK170774B1 (da)	1996-01-15
DE3680859D1 (de)	1991-09-19
YU46414B (sh)	1993-10-20
NO170726B (no)	1992-08-17
DE10075028I2 (de)	2004-01-29
FI864299A0 (fi)	1986-10-23
AU594983B2 (en)	1990-03-22
FI87457B (fi)	1992-09-30
NL300014I1 (nl)	2000-10-02
DE10075028I1 (de)	2000-12-14
EP0221463B1 (en)	1991-08-14
AR243520A1 (es)	1993-08-31
GEP19960467B (en)	1996-05-27
LU90621I2 (fr)	2000-10-09
KR870004019A (ko)	1987-05-06
PT83643A (en)	1986-11-01
ATE109472T1 (de)	1994-08-15
JPH0541633B2 (2)	1993-06-24
SU1635898A3 (ru)	1991-03-15
ATE66210T1 (de)	1991-08-15
IL80404A (en)	1990-06-10
IL80404A0 (en)	1987-01-30
EP0375658A1 (en)	1990-06-27
DK25992D0 (da)	1992-02-28
ES2057197T3 (es)	1994-10-16
ES2029786T3 (es)	1992-10-01
JPH0543551A (ja)	1993-02-23
JPS62277362A (ja)	1987-12-02
DK514586A (da)	1987-04-30
NO864247D0 (no)	1986-10-23
NZ218089A (en)	1989-03-29
HUT43839A (en)	1987-12-28
KR910006806B1 (ko)	1991-09-02
PH22862A (en)	1989-01-19
HU200452B (en)	1990-06-28
YU137291A (sh)	1994-01-20
DK25992A (da)	1992-02-28
LU88596I2 (fr)	1995-07-10
DK170593B1 (da)	1995-11-06
NL970020I1 (nl)	1997-08-01
EP0221463A3 (en)	1987-12-02
NO170726C (no)	1992-11-25
DE3650018T2 (de)	1995-01-05
CA1340402C (en)	1999-02-23
AU6427786A (en)	1987-04-30
JPH0714918B2 (ja)	1995-02-22
US4795751A (en)	1989-01-03
NL970020I2 (nl)	1998-01-05
AR243178A1 (es)	1993-07-30
YU137191A (sh)	1994-01-20
NO864247L (no)	1987-04-30
EP0375658B1 (en)	1994-08-03
CN86107491A (zh)	1987-04-29
DE3650018D1 (de)	1994-09-08
CN1009930B (zh)	1990-10-10
MY100574A (en)	1990-12-15
YU183586A (en)	1988-04-30
FI87457C (fi)	1993-01-11
AR242031A1 (es)	1993-02-26
DK514586D0 (da)	1986-10-28
GR3002475T3 (en)	1992-12-30
EP0221463A2 (en)	1987-05-13
PT83643B (pt)	1988-10-14
NL300014I2 (nl)	2001-02-01

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SU1598873A3 (ru)	1990-10-07	Способ получени производных хинолина или их фармацевтически приемлемых сложных эфиров или фармацевтически приемлемых аддитивных солей кислоты
SU1588282A3 (ru)	1990-08-23	Способ получени производного хинолина, или его фармацевтически приемлемого сложного эфира, или фармацевтически приемлемых солей указанного производного или его эфира
EP0009425B1 (en)	1982-01-27	Novel naphtyridine derivatives and pharmaceutical compositions containing them
HU199821B (en)	1990-03-28	Process for production of derivatives of in 8 position substituated quinoline carbonic acid and medical compositions containing them
EP0109284B1 (en)	1989-01-11	6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1h,5h-benzo(ij)quinolizine-2-carboxylic acid and derivatives
SU1075976A3 (ru)	1984-02-23	Способ получени производных 1,8-нафтиридина или их солей
KR880002355B1 (ko)	1988-10-29	카복실산 유도체의 제조방법
US4382937A (en)	1983-05-10	Naphthyridine derivatives and their use as anti-bacterials
KR900006741B1 (ko)	1990-09-20	아제티디닐 퀴놀론 카복실산 및 에스테르
EP0181521A1 (en)	1986-05-21	Antimicrobial 1-substituted Phenyl-4-oxoquinoline-3-carboxylic acid compounds
JPS60126284A (ja)	1985-07-05	ピリドンカルボン酸誘導体およびその塩
US4496566A (en)	1985-01-29	Naphthyridine derivatives
SU1456015A3 (ru)	1989-01-30	Способ получени производных 1,8-нафтиридина или их кислотно-аддитивных солей (его варианты)
JPH0717609B2 (ja)	1995-03-01	ノルフロキサシンの水溶性付加物
SU1442075A3 (ru)	1988-11-30	Способ получени производных 1,8-нафтиридина или их солей
US6822098B2 (en)	2004-11-23	Ester or amide derivatives
EP0364943A2 (en)	1990-04-25	Benzoheterocyclic compounds
JPS58174367A (ja)	1983-10-13	キノリン誘導体及びその製法
CA2102196A1 (en)	1993-11-27	5-aminoquinolone carboxylic acid derivative and antibacterial agent containing the same as active ingredient
KR0166179B1 (ko)	1999-01-15	새로운 퀴놀론 카르복실산 유도체 및 그 제조방법
SU1029829A3 (ru)	1983-07-15	Способ получени производных 1,8-нафтиридина или их фармацевтически пригодных солей
JPS6270370A (ja)	1987-03-31	キノロンカルボン酸誘導体およびその製造方法
SU1519529A3 (ru)	1989-10-30	Способ получени производного хинолина, его фармацевтически приемлемого сложного эфира или фармацевтически приемлемой соли производного хинолина или сложного эфира
WO1991016311A1 (fr)	1991-10-31	Derive d'acide 7-(hydrazino substitue)-4-oxoquinoline-3-carboxylique, son sel et son ester
IT8322311A1 (it)	1985-01-28	7-(4-piridil)-1,8-naftiridin-derivati