TR200201087T2 - Doğrudan sıkıştırmalı polimer tablet - Google Patents

Doğrudan sıkıştırmalı polimer tablet

Info

Publication number
TR200201087T2
TR200201087T2 TR2002/01087T TR200201087T TR200201087T2 TR 200201087 T2 TR200201087 T2 TR 200201087T2 TR 2002/01087 T TR2002/01087 T TR 2002/01087T TR 200201087 T TR200201087 T TR 200201087T TR 200201087 T2 TR200201087 T2 TR 200201087T2
Authority
TR
Turkey
Prior art keywords
aliphatic amine
amine polymer
tablet
weight
direct compression
Prior art date
Application number
TR2002/01087T
Other languages
English (en)
Inventor
Tyler Joseph
S.Petersen John
Original Assignee
Geltex Pharmaceuticals,Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geltex Pharmaceuticals,Inc. filed Critical Geltex Pharmaceuticals,Inc.
Publication of TR200201087T2 publication Critical patent/TR200201087T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Mevcut bulus, agirlik olarak en az yaklasik %95 alifatik amin polimer içeren bir tablet saglar.Bulus ayni zamanda,agirlik olarak en az yaklasik %95 alifatik amin polimer reçine içeren bir tablet üretme yöntemi saglar. Yöntem,alifatik amin polimerin,tablet olusturmak üzere sikistirilmasi adimini içerir.Tablet ayrica bir veya daha fazla eksipiyan madde içerebilir. Bu düzenlemede,tablet üretme yöntemi su adimlari içerir: (1) alifatik amin polimerin hidratlanarak istenilen nemlilik seviyesine getirilmesi; (2) alifatik amin polimerin,polimer elde edilen karisimin agirlik olarak en az yaklasik %95'ini içerecek sekilde eksipiya madde miktarlariyla karistirilmasi; (3) karisimin sikistirilarak tabletlerin olusturulmasi.Mevcut bulus ayrica,kaplama maddesi su bazli olmak üzere,bir alifatik amin polimer çekirdek içeren kaplanmis bir tabletle ilgilidir.
TR2002/01087T 1999-10-19 2000-10-13 Doğrudan sıkıştırmalı polimer tablet TR200201087T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16025899P 1999-10-19 1999-10-19
US17422700P 2000-01-03 2000-01-03

Publications (1)

Publication Number Publication Date
TR200201087T2 true TR200201087T2 (tr) 2002-08-21

Family

ID=26856737

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2002/01087T TR200201087T2 (tr) 1999-10-19 2000-10-13 Doğrudan sıkıştırmalı polimer tablet

Country Status (29)

Country Link
EP (1) EP1239837B1 (tr)
JP (4) JP4942271B2 (tr)
KR (1) KR100794427B1 (tr)
CN (1) CN1202812C (tr)
AR (1) AR026067A1 (tr)
AT (1) ATE286386T1 (tr)
AU (1) AU778262B2 (tr)
BG (1) BG106626A (tr)
BR (1) BRPI0015061B8 (tr)
CA (1) CA2387915C (tr)
CZ (1) CZ20021344A3 (tr)
DE (1) DE60017285T2 (tr)
EA (1) EA200200387A1 (tr)
EE (1) EE200200209A (tr)
ES (1) ES2235969T3 (tr)
HK (1) HK1049451B (tr)
HU (1) HUP0203334A2 (tr)
IL (1) IL149146A0 (tr)
IS (1) IS6343A (tr)
MX (1) MXPA02003684A (tr)
MY (1) MY125495A (tr)
NO (1) NO20021827L (tr)
NZ (1) NZ518334A (tr)
PL (1) PL364888A1 (tr)
PT (1) PT1239837E (tr)
SK (1) SK5412002A3 (tr)
TR (1) TR200201087T2 (tr)
TW (1) TWI225413B (tr)
WO (1) WO2001028527A2 (tr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100794427B1 (ko) * 1999-10-19 2008-01-16 젠자임 코포레이션 직접 압축형 중합체 정제 코어
US7449605B2 (en) 2003-11-03 2008-11-11 Ilypsa, Inc. Crosslinked amine polymers
US7335795B2 (en) 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
US7608674B2 (en) 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US7767768B2 (en) 2003-11-03 2010-08-03 Ilypsa, Inc. Crosslinked amine polymers
US7385012B2 (en) 2003-11-03 2008-06-10 Ilypsa, Inc. Polyamine polymers
US7459502B2 (en) 2003-11-03 2008-12-02 Ilypsa, Inc. Pharmaceutical compositions comprising crosslinked polyamine polymers
WO2005065291A2 (en) * 2003-12-31 2005-07-21 Genzyme Corporation Enteric coated aliphatic amine polymer bile acid sequestrants
PT2184059E (pt) 2004-03-30 2012-07-06 Relypsa Inc Polímeros de ligação a ião e seus usos
US7985418B2 (en) * 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
AU2012200480B2 (en) * 2004-11-01 2014-10-16 Genzyme Corporation "Aliphatic amine polymer salts for tableting"
US20060276534A1 (en) * 2005-03-17 2006-12-07 Amgen Inc. Methods of decreasing calcification
US8986669B2 (en) 2005-09-02 2015-03-24 Genzyme Corporation Method for removing phosphate and polymer used therefore
EP3000460A1 (en) * 2005-09-15 2016-03-30 Genzyme Corporation Sachet formulation for amine polymers
CA2749074A1 (en) * 2006-09-01 2008-05-29 Usv Limited Process for the preparation of sevelamer hydrochloride and formulation thereof
EP2066293A2 (en) 2006-09-29 2009-06-10 Genzyme Corporation Amide dendrimer compositions
US8163799B2 (en) 2006-12-14 2012-04-24 Genzyme Corporation Amido-amine polymer compositions
WO2009034540A1 (en) * 2007-09-11 2009-03-19 Ranbaxy Laboratories Limited Pharmaceutical composition of sevelamer
DE102008030046A1 (de) 2008-06-25 2009-12-31 Ratiopharm Gmbh Kompaktiertes Polyallylamin-Polymer
WO2010041268A2 (en) 2008-09-02 2010-04-15 Usv Limited Crosslinked polymers
US20100330175A1 (en) * 2009-06-24 2010-12-30 Jobdevairakkam Christopher N Cross-linked polyallylamine tablet core
ES2350999B1 (es) * 2009-06-26 2011-12-07 Combino Pharm, S.L. Nueva composición farmacéutica comprendiendo hidrocloruro de poli (alilamin-co-n,n'-dialil-1,3-diamino-2-hidroxi propano).
WO2010149794A2 (en) * 2009-06-26 2010-12-29 Combino Pharm, S.L. Novel pharmaceutical composition comprising poly (allylamin-co-n,n'-diallyl- 1,3-diamino-2-hydroxypropane)
ES2720869T3 (es) * 2009-10-22 2019-07-25 Synthon Bv Composiciones farmacéuticas de sevelámero
EP2545907A1 (en) 2011-07-15 2013-01-16 Combino Pharm, S.L. Aqueous wet granulation process for cross-linked polyallylamine polymers
US9693962B2 (en) * 2012-06-05 2017-07-04 Takeda Pharmaceutical Limited Dry-coated tablet
CN102908325B (zh) * 2012-11-12 2014-07-30 南京生命能科技开发有限公司 一种碳酸司维拉姆药用片剂组合物及其制备方法
CN107412166B (zh) * 2017-08-08 2020-03-24 同济大学 一种纳米复合吸附磷材料及其制备与应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK281920B6 (sk) * 1991-07-03 2001-09-11 Pharmacia And Upjohn Company Farmaceutická tableta na báze ionexových živíc a spôsob jej výroby
US5496545A (en) * 1993-08-11 1996-03-05 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
TW592727B (en) * 1997-04-04 2004-06-21 Chugai Pharmaceutical Co Ltd Phosphate-binding polymer preparations
JP3389493B2 (ja) * 1997-04-04 2003-03-24 中外製薬株式会社 リン酸結合性ポリマー製剤
US6083497A (en) * 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
TW568788B (en) * 1998-10-12 2004-01-01 Chugai Pharmaceutical Co Ltd Polymer combining with phosphoric acid and preparation containing the same
KR100794427B1 (ko) * 1999-10-19 2008-01-16 젠자임 코포레이션 직접 압축형 중합체 정제 코어

Also Published As

Publication number Publication date
WO2001028527A2 (en) 2001-04-26
IS6343A (is) 2002-04-15
EP1239837B1 (en) 2005-01-05
NO20021827D0 (no) 2002-04-18
EA200200387A1 (ru) 2002-10-31
JP2012067132A (ja) 2012-04-05
HK1049451B (zh) 2005-12-16
WO2001028527A3 (en) 2002-01-03
JP4942271B2 (ja) 2012-05-30
JP2003512317A (ja) 2003-04-02
CA2387915A1 (en) 2001-04-26
BRPI0015061B1 (pt) 2016-03-22
HK1049451A1 (en) 2003-05-16
JP2016000753A (ja) 2016-01-07
DE60017285T2 (de) 2005-12-08
PT1239837E (pt) 2005-05-31
AR026067A1 (es) 2002-12-26
AU1088701A (en) 2001-04-30
CZ20021344A3 (cs) 2002-08-14
NO20021827L (no) 2002-05-29
TWI225413B (en) 2004-12-21
AU778262B2 (en) 2004-11-25
ATE286386T1 (de) 2005-01-15
MY125495A (en) 2006-08-30
JP5583110B2 (ja) 2014-09-03
JP2014065749A (ja) 2014-04-17
CN1202812C (zh) 2005-05-25
EE200200209A (et) 2003-06-16
EP1239837A2 (en) 2002-09-18
KR20020059629A (ko) 2002-07-13
CN1382041A (zh) 2002-11-27
BG106626A (bg) 2003-03-31
PL364888A1 (en) 2004-12-27
DE60017285D1 (de) 2005-02-10
NZ518334A (en) 2003-08-29
BRPI0015061B8 (pt) 2021-05-25
IL149146A0 (en) 2002-11-10
CA2387915C (en) 2007-04-17
ES2235969T3 (es) 2005-07-16
BR0015061A (pt) 2002-07-23
MXPA02003684A (es) 2002-08-30
HUP0203334A2 (hu) 2003-02-28
JP5903111B2 (ja) 2016-04-13
KR100794427B1 (ko) 2008-01-16
SK5412002A3 (en) 2002-09-10

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