TW200730513A - Carbamoylbenzotriazole derivatives as inhibitors of lipases and phospholipases - Google Patents

Carbamoylbenzotriazole derivatives as inhibitors of lipases and phospholipases

Info

Publication number: TW200730513A
Authority: TW; Taiwan
Prior art keywords: phospholipases; lipases; inhibitors; derivatives; carbamoylbenzotriazole
Prior art date: 2005-10-19

Application number

TW095138145A

Other languages

English (en)

Chinese (zh)

Inventor

Stefan Petry

Gerhard Zoller

Norbert Tennagels

Guenter Mueller

Original Assignee

Sanofi Aventis Deutschland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-10-19

Filing date

2006-10-17

Publication date

2007-08-16

2006-10-17 Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland

2007-08-16 Publication of TW200730513A publication Critical patent/TW200730513A/zh

Links

VKMHAJDSSBSCEM-UHFFFAOYSA-N 2h-benzotriazole-4-carboxamide Chemical class NC(=O)C1=CC=CC2=C1N=NN2 VKMHAJDSSBSCEM-UHFFFAOYSA-N 0.000 title 1
102000004882 Lipase Human genes 0.000 title 1
108090001060 Lipase Proteins 0.000 title 1
239000004367 Lipase Substances 0.000 title 1
102000015439 Phospholipases Human genes 0.000 title 1
108010064785 Phospholipases Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
235000019421 lipase Nutrition 0.000 title 1
125000003354 benzotriazolyl group Chemical class N1N=NC2=C1C=CC=C2* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Diabetes (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)

TW095138145A 2005-10-19 2006-10-17 Carbamoylbenzotriazole derivatives as inhibitors of lipases and phospholipases TW200730513A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE102005049953A DE102005049953A1 (de)	2005-10-19	2005-10-19	Carbamoylbenzotriazol-derivate als Inhibitoren von Lipasen und Phospholipasen

Publications (1)

Publication Number	Publication Date
TW200730513A true TW200730513A (en)	2007-08-16

Family

ID=37667178

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW095138145A TW200730513A (en)	2005-10-19	2006-10-17	Carbamoylbenzotriazole derivatives as inhibitors of lipases and phospholipases

Country Status (26)

Country	Link
US (2)	US7897625B2 (fr)
EP (1)	EP1940807B1 (fr)
JP (1)	JP2009512650A (fr)
KR (1)	KR20080063474A (fr)
CN (1)	CN101291918A (fr)
AR (1)	AR057554A1 (fr)
AU (1)	AU2006303552A1 (fr)
BR (1)	BRPI0617613A2 (fr)
CA (1)	CA2625722A1 (fr)
CR (1)	CR9850A (fr)
DE (1)	DE102005049953A1 (fr)
DO (1)	DOP2006000226A (fr)
EC (1)	ECSP088377A (fr)
GT (1)	GT200600463A (fr)
HN (1)	HN2006035238A (fr)
IL (1)	IL190714A0 (fr)
MA (1)	MA29858B1 (fr)
NO (1)	NO20081942L (fr)
NZ (1)	NZ567573A (fr)
PE (1)	PE20070724A1 (fr)
RU (1)	RU2430096C2 (fr)
TN (1)	TNSN08177A1 (fr)
TW (1)	TW200730513A (fr)
UY (1)	UY29872A1 (fr)
WO (1)	WO2007045393A1 (fr)
ZA (1)	ZA200802370B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN101541782A (zh) *	2006-10-04	2009-09-23	先灵公司	作为凝血酶受体拮抗剂的二环和三环衍生物
EP2025674A1 (fr)	2007-08-15	2009-02-18	sanofi-aventis	Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament
UY31968A (es)	2008-07-09	2010-01-29	Sanofi Aventis	Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos
US8957219B2 (en)	2008-10-17	2015-02-17	Shionogi & Co., Ltd.	Acetic acid amide derivative having inhibitory activity on endothelial lipase
MX342128B (es) *	2008-12-24	2016-09-14	Bial - Portela & C A S A	Compuestos farmaceuticos.
US8975286B2 (en) *	2009-08-20	2015-03-10	Merck Sharp & Dohme Corp.	Ether benzotriazole derivatives
KR20120123325A (ko)	2009-12-15	2012-11-08	시오노기세야쿠 가부시키가이샤	혈관 내피 리파아제 저해 활성을 갖는 옥사디아졸 유도체
US8450350B2 (en) *	2010-05-05	2013-05-28	Infinity Pharmaceuticals, Inc.	Triazoles as inhibitors of fatty acid synthase
EP2582709B1 (fr)	2010-06-18	2018-01-24	Sanofi	Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases
CA2812593A1 (fr) *	2010-09-27	2012-04-12	Janssen Pharmaceutica Nv	Derives alpha-cetoamide utiles comme inhibiteurs de lipase endotheliale
RS57962B1 (sr) *	2013-02-25	2019-01-31	Aurigene Discovery Tech Ltd	Derivati trisupstituisanog benzotriazola kao inhibitori dihidroorotat oksigenaze
RU2563254C2 (ru) *	2013-07-08	2015-09-20	Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ)	Способ получения производных 7-(гетеро)арил-4,5,6,7-тетрагидро[1,2,3]триазоло[1,5-a]пиридина
RU2553987C1 (ru) *	2013-12-26	2015-06-20	Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный университет" (СПбГУ)	N-адамантилбензотриазолы, проявляющие активность против вируса гриппа а, и способ их получения
CN104292172B (zh) *	2014-09-12	2016-08-17	浙江理工大学	一种苯并三氮唑类衍生物及其制备方法
US20180369206A1 (en)	2017-04-24	2018-12-27	Aurigene Discovery Technologies Limited	Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors
HRP20211462T1 (hr)	2017-04-24	2021-12-24	Aurigene Discovery Technologies Limited	Postupci uporabe za trisupstituirane derivate benzotriazola kao inhibitora dihidroorotatne oksigenaze
TWI818954B (zh)	2018-02-20	2023-10-21	法商施維雅藥廠	三取代之苯并三唑衍生物的使用方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1035188A (fr) *	1974-08-15	1978-07-25	Eastman Kodak Company	Substances retardatrices de developpement partiel
US4273860A (en) *	1977-12-28	1981-06-16	Eastman Kodak Company	Inhibition of image formation utilizing cobalt(III) complexes
CA1124716A (fr)	1978-10-20	1982-06-01	Michael J. Simons	Derives de benzotriazole bloques, utilises comme precurseurs dans la moderation du developpement
JPS6239573A (ja) *	1985-08-13	1987-02-20	Sumitomo Chem Co Ltd	シクロアルケニルアミド誘導体、その製造法およびそれを有効成分とする土壌病害防除剤
US6440648B1 (en) *	2000-06-13	2002-08-27	Eastman Kodak Company	Color photographic element having improved contrast and compatibility with both dry and conventional processing
US6372421B1 (en) *	2000-06-13	2002-04-16	Eastman Kodak Company	Photothermographic imaging element having improved contrast and methods of image formation
WO2002090355A1 (fr)	2001-05-05	2002-11-14	Smithkline Beecham P.L.C.	Amines cycliques n-aroyle
EP1458374A2 (fr)	2001-12-14	2004-09-22	Novo Nordisk A/S	Composes ralentissant l'activite de la lipase hormono-sensible
DE10247680B4 (de) *	2002-10-12	2005-09-01	Aventis Pharma Deutschland Gmbh	Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase
DE602004023062D1 (en) *	2003-03-31	2009-10-22	Lilly Co Eli	3-oxo-1,3-dihydro-indazol-2-carbonsäureamid derivate als phospholipase inhibitoren

2005
- 2005-10-19 DE DE102005049953A patent/DE102005049953A1/de not_active Ceased
2006
- 2006-10-12 RU RU2008119460/04A patent/RU2430096C2/ru not_active IP Right Cessation
- 2006-10-12 CA CA002625722A patent/CA2625722A1/fr not_active Abandoned
- 2006-10-12 WO PCT/EP2006/009857 patent/WO2007045393A1/fr not_active Ceased
- 2006-10-12 NZ NZ567573A patent/NZ567573A/en not_active IP Right Cessation
- 2006-10-12 KR KR1020087009298A patent/KR20080063474A/ko not_active Withdrawn
- 2006-10-12 BR BRPI0617613-5A patent/BRPI0617613A2/pt not_active IP Right Cessation
- 2006-10-12 JP JP2008535942A patent/JP2009512650A/ja not_active Abandoned
- 2006-10-12 CN CNA2006800384397A patent/CN101291918A/zh active Pending
- 2006-10-12 EP EP06806216.5A patent/EP1940807B1/fr active Active
- 2006-10-12 AU AU2006303552A patent/AU2006303552A1/en not_active Abandoned
- 2006-10-17 TW TW095138145A patent/TW200730513A/zh unknown
- 2006-10-17 DO DO2006000226A patent/DOP2006000226A/es unknown
- 2006-10-17 AR ARP060104521A patent/AR057554A1/es unknown
- 2006-10-17 PE PE2006001257A patent/PE20070724A1/es not_active Application Discontinuation
- 2006-10-17 GT GT200600463A patent/GT200600463A/es unknown
- 2006-10-18 HN HN2006035238A patent/HN2006035238A/es unknown
- 2006-10-18 UY UY29872A patent/UY29872A1/es not_active Application Discontinuation
2008
- 2008-03-13 ZA ZA200802370A patent/ZA200802370B/xx unknown
- 2008-03-28 CR CR9850A patent/CR9850A/es not_active Application Discontinuation
- 2008-04-08 IL IL190714A patent/IL190714A0/en unknown
- 2008-04-08 MA MA30825A patent/MA29858B1/fr unknown
- 2008-04-09 US US12/099,924 patent/US7897625B2/en not_active Expired - Fee Related
- 2008-04-17 EC EC2008008377A patent/ECSP088377A/es unknown
- 2008-04-18 TN TNP2008000177A patent/TNSN08177A1/en unknown
- 2008-04-23 NO NO20081942A patent/NO20081942L/no not_active Application Discontinuation
2011
- 2011-01-20 US US13/009,951 patent/US20110118321A1/en not_active Abandoned

Also Published As

Publication number	Publication date
BRPI0617613A2 (pt)	2011-08-02
PE20070724A1 (es)	2007-08-07
EP1940807B1 (fr)	2015-06-17
RU2008119460A (ru)	2009-11-27
NO20081942L (no)	2008-04-23
CA2625722A1 (fr)	2007-04-26
US20080287503A1 (en)	2008-11-20
US7897625B2 (en)	2011-03-01
JP2009512650A (ja)	2009-03-26
TNSN08177A1 (en)	2009-10-30
KR20080063474A (ko)	2008-07-04
WO2007045393A1 (fr)	2007-04-26
ZA200802370B (en)	2008-12-31
HN2006035238A (es)	2010-05-24
DE102005049953A1 (de)	2007-04-26
NZ567573A (en)	2010-06-25
GT200600463A (es)	2007-05-21
US20110118321A1 (en)	2011-05-19
CN101291918A (zh)	2008-10-22
MA29858B1 (fr)	2008-10-03
DOP2006000226A (es)	2007-05-15
ECSP088377A (es)	2008-05-30
CR9850A (es)	2008-06-18
AU2006303552A1 (en)	2007-04-26
RU2430096C2 (ru)	2011-09-27
IL190714A0 (en)	2008-11-03
EP1940807A1 (fr)	2008-07-09
UY29872A1 (es)	2007-05-31
AR057554A1 (es)	2007-12-05

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TW200800993A (en)	2008-01-01	Organic compounds
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