TW409148B - Process for preparing nicotinamide - Google Patents

Process for preparing nicotinamide Download PDF

Info

Publication number: TW409148B
Authority: TW; Taiwan
Prior art keywords: preparation; item; patent application; scope; catalyst
Prior art date: 1995-11-01

Application number

TW085113648A

Other languages

English (en)

Chinese (zh)

Inventor

Josef Dr Heveling

Erich Dr Armbruster

Lukas Dr Utiger

Markus Dr Rohner

Hans-Rudolf Dr Dettwiler

Original Assignee

Lonza Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-01

Filing date

1996-11-08

Publication date

2000-10-21

1996-11-08 Application filed by Lonza Ag filed Critical Lonza Ag

2000-10-21 Application granted granted Critical

2000-10-21 Publication of TW409148B publication Critical patent/TW409148B/zh

Links

DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 title claims description 30
229960003966 nicotinamide Drugs 0.000 title claims description 14
235000005152 nicotinamide Nutrition 0.000 title claims description 14
239000011570 nicotinamide Substances 0.000 title claims description 14
238000004519 manufacturing process Methods 0.000 title description 3
ITQTTZVARXURQS-UHFFFAOYSA-N 3-methylpyridine Chemical compound CC1=CC=CN=C1 ITQTTZVARXURQS-UHFFFAOYSA-N 0.000 claims abstract description 36
238000000034 method Methods 0.000 claims abstract description 24
GZPHSAQLYPIAIN-UHFFFAOYSA-N 3-pyridinecarbonitrile Chemical compound N#CC1=CC=CN=C1 GZPHSAQLYPIAIN-UHFFFAOYSA-N 0.000 claims abstract description 8
DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims abstract description 3
239000003054 catalyst Substances 0.000 claims description 90
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 81
229910021529 ammonia Inorganic materials 0.000 claims description 39
238000002360 preparation method Methods 0.000 claims description 38
GNTDGMZSJNCJKK-UHFFFAOYSA-N divanadium pentaoxide Chemical compound O=[V](=O)O[V](=O)=O GNTDGMZSJNCJKK-UHFFFAOYSA-N 0.000 claims description 34
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 32
229910052760 oxygen Inorganic materials 0.000 claims description 32
239000001301 oxygen Substances 0.000 claims description 32
239000007789 gas Substances 0.000 claims description 30
238000006243 chemical reaction Methods 0.000 claims description 28
244000005700 microbiome Species 0.000 claims description 23
JKQOBWVOAYFWKG-UHFFFAOYSA-N molybdenum trioxide Chemical compound O=[Mo](=O)=O JKQOBWVOAYFWKG-UHFFFAOYSA-N 0.000 claims description 22
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 21
238000011049 filling Methods 0.000 claims description 16
230000003647 oxidation Effects 0.000 claims description 15
238000007254 oxidation reaction Methods 0.000 claims description 15
MCMNRKCIXSYSNV-UHFFFAOYSA-N ZrO2 Inorganic materials O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 claims description 12
QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 claims description 11
230000002079 cooperative effect Effects 0.000 claims description 10
239000004408 titanium dioxide Substances 0.000 claims description 10
238000006356 dehydrogenation reaction Methods 0.000 claims description 9
230000000813 microbial effect Effects 0.000 claims description 9
RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 claims description 9
LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical compound [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 claims description 9
229910001928 zirconium oxide Inorganic materials 0.000 claims description 9
229910000476 molybdenum oxide Inorganic materials 0.000 claims description 8
PQQKPALAQIIWST-UHFFFAOYSA-N oxomolybdenum Chemical compound [Mo]=O PQQKPALAQIIWST-UHFFFAOYSA-N 0.000 claims description 8
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 7
241000316848 Rhodococcus <scale insect> Species 0.000 claims description 7
RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 7
239000010936 titanium Substances 0.000 claims description 7
OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 claims description 6
229910001935 vanadium oxide Inorganic materials 0.000 claims description 6
239000012467 final product Substances 0.000 claims description 5
FMCKWHVKSJTVHU-UHFFFAOYSA-N C1(=CC=CC=2C3=CC=CC=C3CC12)C(CN)CCCN Chemical compound C1(=CC=CC=2C3=CC=CC=C3CC12)C(CN)CCCN FMCKWHVKSJTVHU-UHFFFAOYSA-N 0.000 claims description 3
230000002378 acidificating effect Effects 0.000 claims description 3
229910052782 aluminium Inorganic materials 0.000 claims description 3
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 3
150000001412 amines Chemical class 0.000 claims description 2
238000003798 microbiological reaction Methods 0.000 claims 4
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 3
229910052720 vanadium Inorganic materials 0.000 claims 3
229910052726 zirconium Inorganic materials 0.000 claims 3
PCTMTFRHKVHKIS-BMFZQQSSSA-N (1s,3r,4e,6e,8e,10e,12e,14e,16e,18s,19r,20r,21s,25r,27r,30r,31r,33s,35r,37s,38r)-3-[(2r,3s,4s,5s,6r)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-19,25,27,30,31,33,35,37-octahydroxy-18,20,21-trimethyl-23-oxo-22,39-dioxabicyclo[33.3.1]nonatriaconta-4,6,8,10 Chemical compound C1C=C2C[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2.O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 PCTMTFRHKVHKIS-BMFZQQSSSA-N 0.000 claims 2
WZXJVSMLELGKTQ-UHFFFAOYSA-N 3-methyl-2h-oxete Chemical compound CC1=COC1 WZXJVSMLELGKTQ-UHFFFAOYSA-N 0.000 claims 2
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 2
238000009434 installation Methods 0.000 claims 2
150000002978 peroxides Chemical class 0.000 claims 2
239000010970 precious metal Substances 0.000 claims 2
229910052710 silicon Inorganic materials 0.000 claims 2
239000010703 silicon Substances 0.000 claims 2
238000003756 stirring Methods 0.000 claims 2
229910052719 titanium Inorganic materials 0.000 claims 2
239000011701 zinc Substances 0.000 claims 2
XLOMVQKBTHCTTD-UHFFFAOYSA-N zinc oxide Inorganic materials [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims 2
SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 1
KVGZZAHHUNAVKZ-UHFFFAOYSA-N 1,4-Dioxin Chemical group O1C=COC=C1 KVGZZAHHUNAVKZ-UHFFFAOYSA-N 0.000 claims 1
BSKHPKMHTQYZBB-UHFFFAOYSA-N 2-methylpyridine Chemical compound CC1=CC=CC=N1 BSKHPKMHTQYZBB-UHFFFAOYSA-N 0.000 claims 1
HSDSMVWMLHEKNR-UHFFFAOYSA-N ClN.CN1CCCC1C1=CC=CN=C1 Chemical compound ClN.CN1CCCC1C1=CC=CN=C1 HSDSMVWMLHEKNR-UHFFFAOYSA-N 0.000 claims 1
241000270666 Testudines Species 0.000 claims 1
230000015556 catabolic process Effects 0.000 claims 1
229960002715 nicotine Drugs 0.000 claims 1
SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 1
MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 claims 1
JZUHIOJYCPIVLQ-UHFFFAOYSA-N 2-methylpentane-1,5-diamine Chemical compound NCC(C)CCCN JZUHIOJYCPIVLQ-UHFFFAOYSA-N 0.000 abstract description 9
230000008569 process Effects 0.000 abstract description 5
239000007795 chemical reaction product Substances 0.000 abstract 1
239000000047 product Substances 0.000 description 21
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 19
239000000203 mixture Substances 0.000 description 13
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 12
239000000243 solution Substances 0.000 description 11
229910052757 nitrogen Inorganic materials 0.000 description 9
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 8
125000004093 cyano group Chemical group *C#N 0.000 description 7
JJQHTLAUSSTREE-UHFFFAOYSA-N hexane-3,3-diamine Chemical compound CCCC(N)(N)CC JJQHTLAUSSTREE-UHFFFAOYSA-N 0.000 description 7
238000002347 injection Methods 0.000 description 7
239000007924 injection Substances 0.000 description 7
102000004190 Enzymes Human genes 0.000 description 6
108090000790 Enzymes Proteins 0.000 description 6
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 6
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
238000005516 engineering process Methods 0.000 description 6
238000002474 experimental method Methods 0.000 description 6
239000002245 particle Substances 0.000 description 6
239000008188 pellet Substances 0.000 description 6
-1 Amberlite) Chemical compound 0.000 description 5
239000011942 biocatalyst Substances 0.000 description 5
238000010438 heat treatment Methods 0.000 description 5
239000007858 starting material Substances 0.000 description 5
238000012546 transfer Methods 0.000 description 5
PAMIQIKDUOTOBW-UHFFFAOYSA-N 1-methylpiperidine Chemical compound CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 description 4
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
239000002253 acid Substances 0.000 description 4
239000007864 aqueous solution Substances 0.000 description 4
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 3
GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 3
241000187562 Rhodococcus sp. Species 0.000 description 3
238000004458 analytical method Methods 0.000 description 3
230000036983 biotransformation Effects 0.000 description 3
230000009849 deactivation Effects 0.000 description 3
230000000694 effects Effects 0.000 description 3
238000004817 gas chromatography Methods 0.000 description 3
229910017604 nitric acid Inorganic materials 0.000 description 3
229910052763 palladium Inorganic materials 0.000 description 3
239000011148 porous material Substances 0.000 description 3
238000000746 purification Methods 0.000 description 3
235000015170 shellfish Nutrition 0.000 description 3
229910001220 stainless steel Inorganic materials 0.000 description 3
239000010935 stainless steel Substances 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
NTSLROIKFLNUIJ-UHFFFAOYSA-N 5-Ethyl-2-methylpyridine Chemical compound CCC1=CC=C(C)N=C1 NTSLROIKFLNUIJ-UHFFFAOYSA-N 0.000 description 2
PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 2
241000158504 Rhodococcus hoagii Species 0.000 description 2
241000187693 Rhodococcus rhodochrous Species 0.000 description 2
239000002250 absorbent Substances 0.000 description 2
230000002745 absorbent Effects 0.000 description 2
229920001429 chelating resin Polymers 0.000 description 2
230000000875 corresponding effect Effects 0.000 description 2
239000012043 crude product Substances 0.000 description 2
238000002425 crystallisation Methods 0.000 description 2
230000008025 crystallization Effects 0.000 description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
238000004821 distillation Methods 0.000 description 2
239000003814 drug Substances 0.000 description 2
238000000605 extraction Methods 0.000 description 2
238000001914 filtration Methods 0.000 description 2
239000001257 hydrogen Substances 0.000 description 2
229910052739 hydrogen Inorganic materials 0.000 description 2
238000009776 industrial production Methods 0.000 description 2
239000011261 inert gas Substances 0.000 description 2
238000007069 methylation reaction Methods 0.000 description 2
TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 2
230000008092 positive effect Effects 0.000 description 2
238000012545 processing Methods 0.000 description 2
239000000376 reactant Substances 0.000 description 2
238000007363 ring formation reaction Methods 0.000 description 2
JPJALAQPGMAKDF-UHFFFAOYSA-N selenium dioxide Chemical compound O=[Se]=O JPJALAQPGMAKDF-UHFFFAOYSA-N 0.000 description 2
239000002904 solvent Substances 0.000 description 2
239000007921 spray Substances 0.000 description 2
238000004659 sterilization and disinfection Methods 0.000 description 2
KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical compound O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 2
238000004448 titration Methods 0.000 description 2
238000000108 ultra-filtration Methods 0.000 description 2
NJCWHFAIXRJJBP-XZBKPIIZSA-N (2S,3R,4R)-2,3,4,5-tetrahydroxy-2-[(1R)-1-hydroxy-2-oxoethyl]pentanenitrile Chemical compound OC[C@@H](O)[C@@H](O)[C@@](O)(C#N)[C@@H](O)C=O NJCWHFAIXRJJBP-XZBKPIIZSA-N 0.000 description 1
HGUFODBRKLSHSI-UHFFFAOYSA-N 2,3,7,8-tetrachloro-dibenzo-p-dioxin Chemical compound O1C2=CC(Cl)=C(Cl)C=C2OC2=C1C=C(Cl)C(Cl)=C2 HGUFODBRKLSHSI-UHFFFAOYSA-N 0.000 description 1
UHSVROPHFKRJIN-UHFFFAOYSA-N 2-methylcyclopentane-1,1-diamine Chemical class CC1CCCC1(N)N UHSVROPHFKRJIN-UHFFFAOYSA-N 0.000 description 1
VOUJRNMURLYCFQ-UHFFFAOYSA-N 2-methylpentane-1,5-diamine Chemical compound CC(CN)CCCN.NCC(CCCN)C VOUJRNMURLYCFQ-UHFFFAOYSA-N 0.000 description 1
OMUQVIKOMHDAEY-UHFFFAOYSA-N 3-methylpiperidine Chemical compound CC1CNCCC1.CC1CNCCC1 OMUQVIKOMHDAEY-UHFFFAOYSA-N 0.000 description 1
QDHHCQZDFGDHMP-UHFFFAOYSA-N Chloramine Chemical compound ClN QDHHCQZDFGDHMP-UHFFFAOYSA-N 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
101100412856 Mus musculus Rhod gene Proteins 0.000 description 1
235000006040 Prunus persica var persica Nutrition 0.000 description 1
240000006413 Prunus persica var. persica Species 0.000 description 1
241000271570 Rhea americana Species 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
101100242191 Tetraodon nigroviridis rho gene Proteins 0.000 description 1
229930003270 Vitamin B Natural products 0.000 description 1
QOCJITIEZIWNLJ-UHFFFAOYSA-M [OH-].[O-2].[Eu+3] Chemical compound [OH-].[O-2].[Eu+3] QOCJITIEZIWNLJ-UHFFFAOYSA-M 0.000 description 1
FRIKWZARTBPWBN-UHFFFAOYSA-N [Si].O=[Si]=O Chemical compound [Si].O=[Si]=O FRIKWZARTBPWBN-UHFFFAOYSA-N 0.000 description 1
125000005210 alkyl ammonium group Chemical group 0.000 description 1
239000000908 ammonium hydroxide Substances 0.000 description 1
150000003863 ammonium salts Chemical class 0.000 description 1
230000008901 benefit Effects 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
239000000872 buffer Substances 0.000 description 1
239000013065 commercial product Substances 0.000 description 1
IBAHLNWTOIHLKE-UHFFFAOYSA-N cyano cyanate Chemical compound N#COC#N IBAHLNWTOIHLKE-UHFFFAOYSA-N 0.000 description 1
125000006159 dianhydride group Chemical class 0.000 description 1
229910001873 dinitrogen Inorganic materials 0.000 description 1
201000010099 disease Diseases 0.000 description 1
229940079593 drug Drugs 0.000 description 1
210000005069 ears Anatomy 0.000 description 1
238000004945 emulsification Methods 0.000 description 1
239000011552 falling film Substances 0.000 description 1
JVQUBHIPPUVHCN-UHFFFAOYSA-N hexane-1,2-diamine Chemical compound CCCCC(N)CN JVQUBHIPPUVHCN-UHFFFAOYSA-N 0.000 description 1
150000002431 hydrogen Chemical class 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
239000012535 impurity Substances 0.000 description 1
TWRXJAOTZQYOKJ-UHFFFAOYSA-L magnesium chloride Substances [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 1
229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
235000019796 monopotassium phosphate Nutrition 0.000 description 1
230000008520 organization Effects 0.000 description 1
238000012856 packing Methods 0.000 description 1
NFVUDQKTAWONMJ-UHFFFAOYSA-I pentafluorovanadium Chemical compound [F-].[F-].[F-].[F-].[F-].[V+5] NFVUDQKTAWONMJ-UHFFFAOYSA-I 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
229920005990 polystyrene resin Polymers 0.000 description 1
PBEXQBWLOXMXCU-UHFFFAOYSA-N pyridine-3-carbonitrile Chemical compound N#CC1=CC=CN=C1.N#CC1=CC=CN=C1 PBEXQBWLOXMXCU-UHFFFAOYSA-N 0.000 description 1
238000000197 pyrolysis Methods 0.000 description 1
230000005855 radiation Effects 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
229910052814 silicon oxide Inorganic materials 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
229960002317 succinimide Drugs 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
FSPPEHRFPWPTQL-UHFFFAOYSA-N triazole-1-carbonitrile Chemical compound N#CN1C=CN=N1 FSPPEHRFPWPTQL-UHFFFAOYSA-N 0.000 description 1
238000005292 vacuum distillation Methods 0.000 description 1
235000019156 vitamin B Nutrition 0.000 description 1
239000011720 vitamin B Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Life Sciences & Earth Sciences (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Pyridine Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

TW085113648A 1995-11-01 1996-11-08 Process for preparing nicotinamide TW409148B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH309095		1995-11-01

Publications (1)

Publication Number	Publication Date
TW409148B true TW409148B (en)	2000-10-21

Family

ID=4248403

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW085113648A TW409148B (en)	1995-11-01	1996-11-08	Process for preparing nicotinamide

Country Status (28)

Country	Link
US (1)	US5719045A (fr)
EP (1)	EP0770687B1 (fr)
JP (1)	JP3911734B2 (fr)
CN (1)	CN1149199C (fr)
AR (1)	AR004260A1 (fr)
AT (1)	ATE212380T1 (fr)
AU (1)	AU700409B2 (fr)
BG (1)	BG63314B1 (fr)
BR (1)	BR9605410A (fr)
CA (1)	CA2187979C (fr)
CZ (1)	CZ290836B6 (fr)
DE (1)	DE59608641D1 (fr)
DK (1)	DK0770687T3 (fr)
EE (1)	EE03573B1 (fr)
ES (1)	ES2167503T3 (fr)
HU (1)	HU217689B (fr)
IL (1)	IL119402A (fr)
MX (1)	MX9605272A (fr)
MY (1)	MY119113A (fr)
NO (1)	NO318584B1 (fr)
PL (1)	PL185286B1 (fr)
PT (1)	PT770687E (fr)
RU (1)	RU2177474C2 (fr)
SI (1)	SI0770687T1 (fr)
SK (1)	SK283653B6 (fr)
TR (1)	TR199600857A2 (fr)
TW (1)	TW409148B (fr)
ZA (1)	ZA968485B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5863750A (en) *	1996-12-18	1999-01-26	Cytec Tech Corp	Methods for the detoxification of nitrile and/or amide compounds
JP4476390B2 (ja) *	1998-09-04	2010-06-09	株式会社半導体エネルギー研究所	半導体装置の作製方法
US20050089987A1 (en) *	2003-10-27	2005-04-28	Lonza Ltd.	Polyacryamide beads containing encapsulated cells
US8324388B2 (en) *	2006-02-15	2012-12-04	Basf Aktiengesellschaft	Dehydrogenation process
KR101474573B1 (ko) *	2006-08-08	2014-12-18	다우 아그로사이언시즈 엘엘씨	시아노피리딘을 함유하는 기상 반응 생성물의 켄칭 방법
EP2305377A1 (fr) *	2009-09-29	2011-04-06	Lonza Ltd.	Catalyseurs pour la préparation de cyanopyridines et leur utilisation
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1996
- 1996-10-08 ZA ZA968485A patent/ZA968485B/xx unknown
- 1996-10-10 IL IL11940296A patent/IL119402A/xx not_active IP Right Cessation
- 1996-10-16 CA CA002187979A patent/CA2187979C/fr not_active Expired - Fee Related
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- 1996-10-28 DK DK96117280T patent/DK0770687T3/da active
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- 1996-10-28 AT AT96117280T patent/ATE212380T1/de active
- 1996-10-28 EP EP96117280A patent/EP0770687B1/fr not_active Expired - Lifetime
- 1996-10-29 CZ CZ19963173A patent/CZ290836B6/cs not_active IP Right Cessation
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Also Published As

Publication number	Publication date
DE59608641D1 (de)	2002-03-14
IL119402A (en)	2000-10-31
MX9605272A (es)	1997-05-31
AR004260A1 (es)	1998-11-04
BR9605410A (pt)	1998-08-04
DK0770687T3 (da)	2002-04-22
PT770687E (pt)	2002-07-31
NO318584B1 (no)	2005-04-11
ES2167503T3 (es)	2002-05-16
HU217689B (hu)	2000-03-28
HU9603029D0 (en)	1996-12-30
ATE212380T1 (de)	2002-02-15
CA2187979C (fr)	2007-04-17
EE9600153A (et)	1997-06-16
EP0770687B1 (fr)	2002-01-23
CN1149199C (zh)	2004-05-12
IL119402A0 (en)	1997-01-10
ZA968485B (en)	1997-05-20
NO964611D0 (no)	1996-10-31
EE03573B1 (et)	2001-12-17
TR199600857A2 (tr)	1997-05-21
EP0770687A2 (fr)	1997-05-02
JPH09163995A (ja)	1997-06-24
AU700409B2 (en)	1999-01-07
SK283653B6 (sk)	2003-11-04
CA2187979A1 (fr)	1997-05-02
MY119113A (en)	2005-03-31
US5719045A (en)	1998-02-17
PL316778A1 (en)	1997-05-12
AU7034896A (en)	1997-05-08
HUP9603029A2 (en)	1997-09-29
PL185286B1 (pl)	2003-04-30
BG63314B1 (bg)	2001-09-28
BG100942A (en)	1997-11-28
CZ290836B6 (cs)	2002-10-16
RU2177474C2 (ru)	2001-12-27
JP3911734B2 (ja)	2007-05-09
CZ317396A3 (en)	1997-05-14
SK140596A3 (en)	1997-07-09
HUP9603029A3 (en)	1999-03-01
SI0770687T1 (en)	2002-04-30
CN1154364A (zh)	1997-07-16
NO964611L (no)	1997-05-02
EP0770687A3 (fr)	1998-08-19

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2016-07-21	MM4A	Annulment or lapse of patent due to non-payment of fees

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JPS62248493A (ja)	1987-10-29	桂皮酸の製造方法
JPS6363668A (ja)	1988-03-22	５−メチルピリミジン誘導体の製造法