UA77070C2 - Спосіб одержання кислих солей геміфлоксацину - Google Patents

Спосіб одержання кислих солей геміфлоксацину Download PDF

Info

Publication number: UA77070C2
Authority: UA; Ukraine
Prior art keywords: acid; formula; differs; compound; stage
Prior art date: 2002-04-08

Application number

UA20041008144A

Other languages

English (en)

Russian (ru)

Ukrainian (uk)

Inventor

Хун ЧОЙ

Санг-Чул ЧОЙ

До-Хьюн Нам

Бо-Сеунг Чой

Original Assignee

Елджі Лайф Саєнсез Лтд.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-08

Filing date

2003-04-04

Publication date

2006-10-16

2003-04-04 Application filed by Елджі Лайф Саєнсез Лтд. filed Critical Елджі Лайф Саєнсез Лтд.

2006-10-16 Publication of UA77070C2 publication Critical patent/UA77070C2/uk

Links

239000002253 acid Substances 0.000 title claims abstract description 21
150000003839 salts Chemical class 0.000 title claims abstract description 18
238000004519 manufacturing process Methods 0.000 title claims abstract description 14
ZRCVYEYHRGVLOC-HYARGMPZSA-N gemifloxacin Chemical class C1C(CN)C(=N/OC)/CN1C(C(=C1)F)=NC2=C1C(=O)C(C(O)=O)=CN2C1CC1 ZRCVYEYHRGVLOC-HYARGMPZSA-N 0.000 title claims abstract description 5
229960003170 gemifloxacin Drugs 0.000 title abstract description 4
238000000034 method Methods 0.000 claims abstract description 39
150000001875 compounds Chemical class 0.000 claims description 48
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 33
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 27
238000006243 chemical reaction Methods 0.000 claims description 20
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 18
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 14
HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 claims description 12
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 8
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 8
238000005859 coupling reaction Methods 0.000 claims description 8
229940098779 methanesulfonic acid Drugs 0.000 claims description 8
239000003960 organic solvent Substances 0.000 claims description 8
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 6
DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims description 6
239000012046 mixed solvent Substances 0.000 claims description 6
150000007530 organic bases Chemical class 0.000 claims description 6
QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 claims description 6
-1 2-oxybenzaldehyde Chemical compound 0.000 claims description 4
JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 claims description 4
238000010511 deprotection reaction Methods 0.000 claims description 4
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
150000007522 mineralic acids Chemical class 0.000 claims description 4
150000007524 organic acids Chemical class 0.000 claims description 4
ZRSNZINYAWTAHE-UHFFFAOYSA-N p-methoxybenzaldehyde Chemical compound COC1=CC=C(C=O)C=C1 ZRSNZINYAWTAHE-UHFFFAOYSA-N 0.000 claims description 4
229920006395 saturated elastomer Polymers 0.000 claims description 4
239000011877 solvent mixture Substances 0.000 claims description 4
GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 claims description 4
FPYUJUBAXZAQNL-UHFFFAOYSA-N 2-chlorobenzaldehyde Chemical compound ClC1=CC=CC=C1C=O FPYUJUBAXZAQNL-UHFFFAOYSA-N 0.000 claims description 3
BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 claims description 3
125000000217 alkyl group Chemical group 0.000 claims description 3
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 3
XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims description 3
229940071870 hydroiodic acid Drugs 0.000 claims description 3
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 3
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims description 3
125000003545 alkoxy group Chemical group 0.000 claims description 2
125000003118 aryl group Chemical group 0.000 claims description 2
125000004093 cyano group Chemical group *C#N 0.000 claims description 2
125000000753 cycloalkyl group Chemical group 0.000 claims description 2
229910052739 hydrogen Inorganic materials 0.000 claims description 2
239000001257 hydrogen Substances 0.000 claims description 2
125000004356 hydroxy functional group Chemical group O* 0.000 claims description 2
BTFQKIATRPGRBS-UHFFFAOYSA-N o-tolualdehyde Chemical compound CC1=CC=CC=C1C=O BTFQKIATRPGRBS-UHFFFAOYSA-N 0.000 claims 2
YZBFISOEIGOFAF-UHFFFAOYSA-N (4-methoxyiminopyrrolidin-3-yl)methanamine Chemical class CON=C1CNCC1CN YZBFISOEIGOFAF-UHFFFAOYSA-N 0.000 claims 1
SNLMOXFUCILIPL-UHFFFAOYSA-N 1,8-naphthyridine-2-carboxylic acid Chemical compound C1=CC=NC2=NC(C(=O)O)=CC=C21 SNLMOXFUCILIPL-UHFFFAOYSA-N 0.000 claims 1
239000001431 2-methylbenzaldehyde Substances 0.000 claims 1
125000005843 halogen group Chemical group 0.000 claims 1
125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
239000013067 intermediate product Substances 0.000 claims 1
238000012876 topography Methods 0.000 claims 1
230000008569 process Effects 0.000 abstract description 28
230000008901 benefit Effects 0.000 abstract description 4
230000000845 anti-microbial effect Effects 0.000 abstract description 3
239000003242 anti bacterial agent Substances 0.000 abstract description 2
229940088710 antibiotic agent Drugs 0.000 abstract description 2
230000003389 potentiating effect Effects 0.000 abstract description 2
LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 abstract description 2
230000015572 biosynthetic process Effects 0.000 description 18
239000011541 reaction mixture Substances 0.000 description 16
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 14
239000000047 product Substances 0.000 description 12
239000000203 mixture Substances 0.000 description 11
238000002360 preparation method Methods 0.000 description 8
238000001819 mass spectrum Methods 0.000 description 7
238000001953 recrystallisation Methods 0.000 description 7
238000003756 stirring Methods 0.000 description 7
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
238000003786 synthesis reaction Methods 0.000 description 6
239000012535 impurity Substances 0.000 description 4
PQXMKYVZAQIFBU-UHFFFAOYSA-N methanesulfonic acid;(4-methoxyiminopyrrolidin-3-yl)methanamine Chemical compound CS(O)(=O)=O.CS(O)(=O)=O.CON=C1CNCC1CN PQXMKYVZAQIFBU-UHFFFAOYSA-N 0.000 description 4
239000007787 solid Substances 0.000 description 4
239000002904 solvent Substances 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
239000006227 byproduct Substances 0.000 description 2
239000007810 chemical reaction solvent Substances 0.000 description 2
125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 description 2
VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 2
SMQUZDBALVYZAC-UHFFFAOYSA-N salicylaldehyde Chemical compound OC1=CC=CC=C1C=O SMQUZDBALVYZAC-UHFFFAOYSA-N 0.000 description 2
239000000126 substance Substances 0.000 description 2
SQAINHDHICKHLX-UHFFFAOYSA-N 1-naphthaldehyde Chemical compound C1=CC=C2C(C=O)=CC=CC2=C1 SQAINHDHICKHLX-UHFFFAOYSA-N 0.000 description 1
MEKOFIRRDATTAG-UHFFFAOYSA-N 2,2,5,8-tetramethyl-3,4-dihydrochromen-6-ol Chemical compound C1CC(C)(C)OC2=C1C(C)=C(O)C=C2C MEKOFIRRDATTAG-UHFFFAOYSA-N 0.000 description 1
XOQQVKDBGLYPGH-UHFFFAOYSA-N 2-oxo-1h-quinoline-3-carboxylic acid Chemical class C1=CC=C2NC(=O)C(C(=O)O)=CC2=C1 XOQQVKDBGLYPGH-UHFFFAOYSA-N 0.000 description 1
WZWIQYMTQZCSKI-UHFFFAOYSA-N 4-cyanobenzaldehyde Chemical compound O=CC1=CC=C(C#N)C=C1 WZWIQYMTQZCSKI-UHFFFAOYSA-N 0.000 description 1
244000298715 Actinidia chinensis Species 0.000 description 1
235000009434 Actinidia chinensis Nutrition 0.000 description 1
235000009436 Actinidia deliciosa Nutrition 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
244000068988 Glycine max Species 0.000 description 1
235000010469 Glycine max Nutrition 0.000 description 1
241000581652 Hagenia abyssinica Species 0.000 description 1
241000102542 Kara Species 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
241000282320 Panthera leo Species 0.000 description 1
YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 description 1
244000172730 Rubus fruticosus Species 0.000 description 1
241001424341 Tara spinosa Species 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
239000007985 Tris NaCl EDTA buffer Substances 0.000 description 1
238000010306 acid treatment Methods 0.000 description 1
150000008043 acidic salts Chemical class 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
230000009471 action Effects 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
125000003277 amino group Chemical group 0.000 description 1
150000003935 benzaldehydes Chemical class 0.000 description 1
235000021029 blackberry Nutrition 0.000 description 1
MIOPJNTWMNEORI-UHFFFAOYSA-N camphorsulfonic acid Chemical compound C1CC2(CS(O)(=O)=O)C(=O)CC1C2(C)C MIOPJNTWMNEORI-UHFFFAOYSA-N 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000001816 cooling Methods 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
239000012467 final product Substances 0.000 description 1
229910052736 halogen Inorganic materials 0.000 description 1
150000002367 halogens Chemical class 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
150000002431 hydrogen Chemical class 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
235000015141 kefir Nutrition 0.000 description 1
150000002576 ketones Chemical class 0.000 description 1
WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
YKWNDAOEJQMLGH-UHFFFAOYSA-N phenyl 2,2-diphenylacetate Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)C(=O)OC1=CC=CC=C1 YKWNDAOEJQMLGH-UHFFFAOYSA-N 0.000 description 1
OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
230000036632 reaction speed Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000035939 shock Effects 0.000 description 1
238000007086 side reaction Methods 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
QQXLDOJGLXJCSE-KNVOCYPGSA-N tropinone Chemical compound C1C(=O)C[C@H]2CC[C@@H]1N2C QQXLDOJGLXJCSE-KNVOCYPGSA-N 0.000 description 1
JABYJIQOLGWMQW-UHFFFAOYSA-N undec-4-ene Chemical compound CCCCCCC=CCCC JABYJIQOLGWMQW-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)

UA20041008144A 2002-04-08 2003-04-04 Спосіб одержання кислих солей геміфлоксацину UA77070C2 (uk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
KR10-2002-0018847A KR100517638B1 (ko)	2002-04-08	2002-04-08	게미플록사신 산염의 새로운 제조방법
PCT/KR2003/000683 WO2003087100A1 (en)	2002-04-08	2003-04-04	Process for preparing acid salts of gemifloxacin

Publications (1)

Publication Number	Publication Date
UA77070C2 true UA77070C2 (uk)	2006-10-16

Family

ID=36241771

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA20041008144A UA77070C2 (uk)	2002-04-08	2003-04-04	Спосіб одержання кислих солей геміфлоксацину

Country Status (31)

Country	Link
US (1)	US7361762B2 (is)
EP (1)	EP1497290B1 (is)
JP (1)	JP4315815B2 (is)
KR (1)	KR100517638B1 (is)
CN (1)	CN1291987C (is)
AP (1)	AP1786A (is)
AT (1)	ATE404559T1 (is)
AU (1)	AU2003219581B2 (is)
BR (1)	BRPI0309037B8 (is)
CA (1)	CA2481217C (is)
CO (1)	CO5611198A2 (is)
CY (1)	CY1108469T1 (is)
DE (1)	DE60322872D1 (is)
DK (1)	DK1497290T3 (is)
EA (1)	EA007222B1 (is)
ES (1)	ES2311694T3 (is)
GE (1)	GEP20074025B (is)
HR (1)	HRP20040929B1 (is)
IL (1)	IL164328A (is)
IS (1)	IS2731B (is)
MA (1)	MA26408A1 (is)
MX (1)	MXPA04009777A (is)
NO (1)	NO330042B1 (is)
NZ (1)	NZ536174A (is)
OA (1)	OA12801A (is)
PL (1)	PL372815A1 (is)
PT (1)	PT1497290E (is)
SI (1)	SI1497290T1 (is)
UA (1)	UA77070C2 (is)
WO (1)	WO2003087100A1 (is)
ZA (1)	ZA200408088B (is)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1412078B1 (en) *	2001-08-02	2008-10-08	LG Life Sciences Limited	Processes for the production of amino-protected derivatives of 4-aminomethylene-pyrrolidin-3-one, gemifloxacin or a salt thereof
WO2006134431A1 (en) *	2005-05-03	2006-12-21	Ranbaxy Laboratories Limited	Formate salt of gemifloxacin
EP2161269A1 (en) *	2005-06-15	2010-03-10	Hetero Drugs Limited	Process for the preparation of amorphous gemifloxacin
CN101500564B (zh) *	2006-03-07	2012-07-25	沃克哈特有限公司	苯并喹嗪-2-羧酸的前药
US20100076193A1 (en) *	2006-10-31	2010-03-25	Chandrasekaran Ramasubbu	process for the preparation of gemifloxacin

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS57134482A (en)	1981-02-13	1982-08-19	Dainippon Pharmaceut Co Ltd	1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8- naphthyridine-3-carboxylic acid-3/2 hydrate and its preparation
IN162769B (is)	1984-11-13	1988-07-09	Kyorin Seiyaku Kk
NZ222047A (en)	1986-10-08	1991-01-29	Bristol Myers Co	Quinoline - or naphthyridine - carboxylic acid anti-bacterial agents
JPH01100165A (ja)	1987-10-13	1989-04-18	Shionogi & Co Ltd	オキシムまたはヒドロキシアミン誘導体系抗菌剤
US4920120A (en)	1988-01-25	1990-04-24	Warner-Lambert Company	Antibacterial agents
JPH0356479A (ja)	1989-07-24	1991-03-12	Takeshi Yokota	水溶性キノロン誘導体のｐ‐トルエンスルホン酸塩
IE66202B1 (en)	1989-08-16	1995-12-13	Pfizer	Azabicyclo quinolone carboxylic acids
US5137892A (en)	1990-12-12	1992-08-11	Abbott Laboratories	Quinoline, naphthyridine and pyridobenzoxazine derivatives
EP0541086A1 (en)	1991-11-08	1993-05-12	Kaken Pharmaceutical Co., Ltd.	Antibacterial 6-fluoro-quinolones having an oxime group on the substituent in position 7
JPH0673056A (ja)	1992-08-26	1994-03-15	Kaken Pharmaceut Co Ltd	キノリンカルボン酸誘導体およびその塩
US5776944A (en)	1994-06-16	1998-07-07	Lg Chemical Ltd.	7-(4-aminomethyl-3-methyloxyiminopyrroplidin-1-yl)-1-cyclopropyl-6-flu oro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid and the process for the preparation thereof
DK0688772T3 (da) *	1994-06-16	1999-11-01	Lg Chemical Ltd	Quinolincarboxylsyrederivater med 7-(4-aminomethyl-3-oxim)-pyrrolidinsubstituenter og fremgangsmåde til deres fremstilling
JP3449658B2 (ja)	1994-12-21	2003-09-22	杏林製薬株式会社	安定性に優れた８−アルコキシキノロンカルボン酸水和物並びにその製造方法
US5763454A (en)	1995-06-06	1998-06-09	Pfizer, Inc.	Crystal form of anhydrous 7-( 1α,5α,6α!-6-amino-3-azabicyclo 3.1.0!hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8 naphthyridine-3-carboxylic acid, methanessulfonic acid salt
NZ309134A (en)	1995-08-11	1999-09-29	Pfizer	(1s,2s)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1- propranolmethanesulfonate trihydrate
AU726694B2 (en)	1996-03-29	2000-11-16	Smithkline Beecham Corporation	Eprosartan dihydrate and a process for its production and formulation
MA24500A1 (fr) *	1997-03-21	1998-10-01	Lg Life Sciences Ltd	Derive du sel d'acide carboxylique de naphthyridine .
KR100286874B1 (ko)	1998-03-04	2001-04-16	성재갑	보호된 4-아미노메틸-피롤리딘-3-온의 제조방법
ATE249432T1 (de)	1998-05-29	2003-09-15	Upjohn Co	3-((1'-n-methylamino)ethyl-n-benzyl)pyrrolidin- monomethanesulfonat
GB9820405D0 (en)	1998-09-18	1998-11-11	Smithkline Beecham Plc	Process
DK1223935T3 (da)	1999-06-29	2008-02-04	Lg Life Sciences Ltd	Anvendelse af gemifloxacinforbindelser mod bakterier
WO2001015695A1 (en)	1999-09-01	2001-03-08	Smithkline Beecham Corporation	Methods of use of fluoroquinolone compounds against bacteria
GB9920917D0 (en) *	1999-09-03	1999-11-10	Sb Pharmco Inc	Novel process
GB9920919D0 (en)	1999-09-03	1999-11-10	Sb Pharmco Inc	Novel compound
WO2001021176A1 (en)	1999-09-22	2001-03-29	Smithkline Beecham Corporation	Methods of use of fluoroquinolone compounds against bacteria
KR20010091379A (ko)	2000-03-15	2001-10-23	성재갑	7-(4-아미노메틸-3-옥심)피롤리딘 치환체를 갖는 퀴놀린카르복실산 유도체의 신규 제조방법
KR20020018560A (ko)	2000-09-01	2002-03-08	성재갑	3-아미노메틸-4-ｚ-메톡시이미노피롤리딘의 신규 제조방법

2002
- 2002-04-08 KR KR10-2002-0018847A patent/KR100517638B1/ko not_active Expired - Lifetime
2003
- 2003-04-04 PT PT03715805T patent/PT1497290E/pt unknown
- 2003-04-04 MX MXPA04009777A patent/MXPA04009777A/es active IP Right Grant
- 2003-04-04 HR HRP20040929AA patent/HRP20040929B1/hr not_active IP Right Cessation
- 2003-04-04 CN CNB038095483A patent/CN1291987C/zh not_active Expired - Lifetime
- 2003-04-04 PL PL03372815A patent/PL372815A1/xx not_active Application Discontinuation
- 2003-04-04 EP EP03715805A patent/EP1497290B1/en not_active Expired - Lifetime
- 2003-04-04 OA OA1200400271A patent/OA12801A/en unknown
- 2003-04-04 SI SI200331341T patent/SI1497290T1/sl unknown
- 2003-04-04 EA EA200401328A patent/EA007222B1/ru not_active IP Right Cessation
- 2003-04-04 UA UA20041008144A patent/UA77070C2/uk unknown
- 2003-04-04 AT AT03715805T patent/ATE404559T1/de active
- 2003-04-04 NZ NZ536174A patent/NZ536174A/en not_active IP Right Cessation
- 2003-04-04 US US10/510,514 patent/US7361762B2/en not_active Expired - Lifetime
- 2003-04-04 DK DK03715805T patent/DK1497290T3/da active
- 2003-04-04 BR BRPI0309037A patent/BRPI0309037B8/pt not_active IP Right Cessation
- 2003-04-04 ES ES03715805T patent/ES2311694T3/es not_active Expired - Lifetime
- 2003-04-04 AP APAP/P/2004/003148A patent/AP1786A/en active
- 2003-04-04 DE DE60322872T patent/DE60322872D1/de not_active Expired - Lifetime
- 2003-04-04 AU AU2003219581A patent/AU2003219581B2/en not_active Ceased
- 2003-04-04 CA CA2481217A patent/CA2481217C/en not_active Expired - Lifetime
- 2003-04-04 WO PCT/KR2003/000683 patent/WO2003087100A1/en not_active Ceased
- 2003-04-04 GE GEAP8436A patent/GEP20074025B/en unknown
- 2003-04-04 JP JP2003584056A patent/JP4315815B2/ja not_active Expired - Fee Related
2004
- 2004-09-30 IS IS7477A patent/IS2731B/is unknown
- 2004-10-05 CO CO04099283A patent/CO5611198A2/es active IP Right Grant
- 2004-10-07 MA MA27894A patent/MA26408A1/fr unknown
- 2004-10-07 ZA ZA200408088A patent/ZA200408088B/xx unknown
- 2004-10-21 IL IL164328A patent/IL164328A/en unknown
- 2004-10-27 NO NO20044629A patent/NO330042B1/no not_active IP Right Cessation
2008
- 2008-10-31 CY CY20081101234T patent/CY1108469T1/el unknown

Also Published As

Publication number	Publication date
CO5611198A2 (es)	2006-02-28
CN1649868A (zh)	2005-08-03
AU2003219581B2 (en)	2006-08-24
OA12801A (en)	2006-07-11
EP1497290A4 (en)	2006-05-10
CA2481217C (en)	2010-06-01
AP1786A (en)	2007-10-04
WO2003087100A1 (en)	2003-10-23
BRPI0309037B1 (pt)	2018-07-31
HRP20040929B1 (hr)	2013-12-06
PT1497290E (pt)	2008-11-14
IS7477A (is)	2004-09-30
SI1497290T1 (sl)	2008-12-31
ATE404559T1 (de)	2008-08-15
EA200401328A1 (ru)	2005-06-30
KR100517638B1 (ko)	2005-09-28
BRPI0309037B8 (pt)	2021-05-25
MA26408A1 (fr)	2004-12-01
EP1497290B1 (en)	2008-08-13
HRP20040929A2 (en)	2005-02-28
BR0309037A (pt)	2005-02-01
JP4315815B2 (ja)	2009-08-19
AP2004003148A0 (en)	2004-12-31
US20050148622A1 (en)	2005-07-07
NO330042B1 (no)	2011-02-07
CA2481217A1 (en)	2003-10-23
EA007222B1 (ru)	2006-08-25
DE60322872D1 (de)	2008-09-25
PL372815A1 (en)	2005-08-08
CN1291987C (zh)	2006-12-27
HK1074440A1 (en)	2005-11-11
NZ536174A (en)	2006-09-29
US7361762B2 (en)	2008-04-22
NO20044629L (no)	2004-10-27
MXPA04009777A (es)	2004-12-13
AU2003219581A1 (en)	2003-10-27
ES2311694T3 (es)	2009-02-16
KR20030080292A (ko)	2003-10-17
IS2731B (is)	2011-04-15
GEP20074025B (en)	2007-01-25
IL164328A (en)	2009-08-03
ZA200408088B (en)	2006-05-31
EP1497290A1 (en)	2005-01-19
IL164328A0 (en)	2005-12-18
DK1497290T3 (da)	2008-12-15
JP2005529112A (ja)	2005-09-29
CY1108469T1 (el)	2014-04-09

Publication	Publication Date	Title
KR100451672B1 (ko)	2004-10-08	결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법
JP6234471B2 (ja)	2017-11-22	スピロ環状イソキサゾリン誘導体の合成
DD150898A5 (de)	1981-09-23	Verfahren zur herstellung von bisestern von methandiol mit penicillinen
CN105188712A (zh)	2015-12-23	用于制备大环内酯抗菌剂的收敛方法
DE60311869T2 (de)	2007-09-20	Kristalline Cefdinir-Salze
UA77070C2 (uk)	2006-10-16	Спосіб одержання кислих солей геміфлоксацину
DE602004009962T2 (de)	2008-08-28	Verfahren zur herstellung von substituierten 5-aminopyrazoloä4,3-eü-1,2,4-triazoloä1,5-cüpyrimidinen
DE2804508A1 (de)	1978-08-10	4"-deoxy-4"-substituierte-amino-derivate von oleandomycin
US20020095034A1 (en)	2002-07-18	Imipenem production process
DE60012196T2 (de)	2005-08-18	Verfahren zur Herstellung von Naphthyridin-3-carbonsäurederivaten
DE60204024T2 (de)	2006-03-02	9a-n-[n'-(phenylsulfonyl)carbamoyl] derivate von 9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin a und von 5-o-desosaminyl-9-deoxo-9-dihydro-9a-aza-9a-homoerythronolid a
EP1319011B1 (de)	2012-12-05	Triazolo-epothilone
DE4400749A1 (de)	1995-07-20	Neues hochenantioselektives Verfahren zur Herstellung von enantiomerenreinen Cyclopentan- und -penten-beta-Aminosäuren
DE60003671T2 (de)	2004-06-17	Halo-derivate von 9-deoxo-9a-aza-9a-homerythromycin a
DE60102378T2 (de)	2005-02-24	Derivate des carbamates und thiocarbamates von podophyllotoxin, ihre herstellungsweise und pharmazeutische zusammensetzungen, die diese enthalten
ES2320954B1 (es)	2010-03-16	Nuevo procedimiento de preparacion de 3-metil-4-fenilisoxazolo (3,4-d)iridazin-7(6h)-ona.
DE4329600A1 (de)	1995-03-09	Pyrido [1,2,3-d,e] [1,3,4] benzoxadiazinderivate
EP0858447A1 (de)	1998-08-19	Verfahren zur herstellung von aminophenylsulfonylharnstoffen und zwischenprodukte zu den verfahren
DE60306807T2 (de)	2007-01-18	SUBSTITUIERTE 9a-N-(N'[4-(SULFONYL)PHENYLCARBAMOYL])-DERIVATE VON 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A UND 5-0-DESOSAMINYL-9-DEOXO-9-DI-HYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
EP0284380A1 (en)	1988-09-28	Mitomycin Derivatives
DE3913757A1 (de)	1990-10-25	Substituierte imidazolin-2-yl-acrylsaeurederivate, verfahren und zwischenstufen zu ihrer herstellung und ihre verwendung als mittel mit herbizider wirkung
EP0133670A2 (de)	1985-03-06	Verfahren zur Herstellung von 7-Acylamino-3-hydrocy-cephem-4-carbonsäuren und 7-Acylamino-3-hydroxy-1-de-thia-1-oxacephem-4-carbonsäuren
CZ338297A3 (cs)	1998-06-17	Nové polyhydroderiváty tylosinu a způsob jejich přípravy
KR100929414B1 (ko)	2009-12-03	트로스피움 클로라이드의 제조방법
DE3328707A1 (de)	1985-02-28	Verfahren zur herstellung von 7-acylamino-3-hydroxy-cephem-4-carbonsaeuren und 7-acylamino-3-hydroxy-1-dethia-1-oxacephem-4-car bonsaeuren