UA80046C2 - Thiadiazine compounds, method for obtaning thereof and pharmaceutical composition containing them - Google Patents

Thiadiazine compounds, method for obtaning thereof and pharmaceutical composition containing them Download PDF

Info

Publication number: UA80046C2
Authority: UA; Ukraine
Prior art keywords: formula; compound; group; compounds; branched
Prior art date: 2003-05-05

Application number

UAA200511454A

Other languages

English (en)

Ukrainian (uk)

Inventor

Emmanuel Grandorge

Pierre Francotte

Stephane Bovery

Tuillot Pascal De

Bernard Pirotte

Pierre Lieustage

Laurence Danober

Pierre Renard

Daniel-Henry Keniard

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-05-05

Filing date

2004-04-05

Publication date

2007-08-10

2004-04-05 Application filed by Servier Lab filed Critical Servier Lab

2007-08-10 Publication of UA80046C2 publication Critical patent/UA80046C2/uk

Links

238000000034 method Methods 0.000 title claims description 17
239000008194 pharmaceutical composition Substances 0.000 title claims description 8
150000008334 thiadiazines Chemical class 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims abstract description 108
125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 20
239000002253 acid Substances 0.000 claims abstract description 13
150000003839 salts Chemical class 0.000 claims abstract description 11
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims abstract description 10
125000005843 halogen group Chemical group 0.000 claims abstract description 10
239000000654 additive Substances 0.000 claims abstract description 7
230000000996 additive effect Effects 0.000 claims abstract description 7
125000001544 thienyl group Chemical group 0.000 claims abstract description 7
FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims abstract description 3
125000002541 furyl group Chemical group 0.000 claims abstract description 3
125000002883 imidazolyl group Chemical group 0.000 claims abstract description 3
ZLTPDFXIESTBQG-UHFFFAOYSA-N isothiazole Chemical compound C=1C=NSC=1 ZLTPDFXIESTBQG-UHFFFAOYSA-N 0.000 claims abstract description 3
125000000217 alkyl group Chemical group 0.000 claims description 20
238000002360 preparation method Methods 0.000 claims description 15
125000001153 fluoro group Chemical group F* 0.000 claims description 8
238000006243 chemical reaction Methods 0.000 claims description 7
229910052717 sulfur Inorganic materials 0.000 claims description 6
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 4
125000004448 alkyl carbonyl group Chemical group 0.000 claims description 4
239000003638 chemical reducing agent Substances 0.000 claims description 4
229910052731 fluorine Inorganic materials 0.000 claims description 4
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230000008569 process Effects 0.000 claims description 4
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201000010099 disease Diseases 0.000 claims description 3
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RELAJOWOFXGXHI-UHFFFAOYSA-N 3h-oxathiole Chemical group C1SOC=C1 RELAJOWOFXGXHI-UHFFFAOYSA-N 0.000 claims description 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 2
239000004480 active ingredient Substances 0.000 claims description 2
125000003277 amino group Chemical group 0.000 claims description 2
125000004432 carbon atom Chemical group C* 0.000 claims description 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
229910052801 chlorine Inorganic materials 0.000 claims description 2
125000001309 chloro group Chemical group Cl* 0.000 claims description 2
230000019771 cognition Effects 0.000 claims description 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
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125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
239000003814 drug Substances 0.000 claims 2
MGRVRXRGTBOSHW-UHFFFAOYSA-N (aminomethyl)phosphonic acid Chemical compound NCP(O)(O)=O MGRVRXRGTBOSHW-UHFFFAOYSA-N 0.000 claims 1
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238000001990 intravenous administration Methods 0.000 description 1
208000028867 ischemia Diseases 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
239000008101 lactose Substances 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
238000004949 mass spectrometry Methods 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
230000010534 mechanism of action Effects 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
230000000626 neurodegenerative effect Effects 0.000 description 1
210000002569 neuron Anatomy 0.000 description 1
230000008587 neuronal excitability Effects 0.000 description 1
230000007996 neuronal plasticity Effects 0.000 description 1
MCSAJNNLRCFZED-UHFFFAOYSA-N nitroethane Chemical compound CC[N+]([O-])=O MCSAJNNLRCFZED-UHFFFAOYSA-N 0.000 description 1
125000004433 nitrogen atom Chemical group N* 0.000 description 1
239000002664 nootropic agent Substances 0.000 description 1
239000002674 ointment Substances 0.000 description 1
230000007170 pathology Effects 0.000 description 1
230000001991 pathophysiological effect Effects 0.000 description 1
210000001871 perforant pathway Anatomy 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
239000002831 pharmacologic agent Substances 0.000 description 1
239000008196 pharmacological composition Substances 0.000 description 1
239000012071 phase Substances 0.000 description 1
230000035790 physiological processes and functions Effects 0.000 description 1
230000001242 postsynaptic effect Effects 0.000 description 1
239000012256 powdered iron Substances 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
230000002265 prevention Effects 0.000 description 1
230000000750 progressive effect Effects 0.000 description 1
229940107700 pyruvic acid Drugs 0.000 description 1
230000005855 radiation Effects 0.000 description 1
239000002994 raw material Substances 0.000 description 1
238000010992 reflux Methods 0.000 description 1
239000012265 solid product Substances 0.000 description 1
239000006190 sub-lingual tablet Substances 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
239000000829 suppository Substances 0.000 description 1
230000024587 synaptic transmission, glutamatergic Effects 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 description 1
WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
229910052721 tungsten Inorganic materials 0.000 description 1
239000010937 tungsten Substances 0.000 description 1
229940100445 wheat starch Drugs 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

UAA200511454A 2003-05-05 2004-04-05 Thiadiazine compounds, method for obtaning thereof and pharmaceutical composition containing them UA80046C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0305448A FR2854634B1 (fr)	2003-05-05	2003-05-05	Nouveaux derives de thiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR2004/001070 WO2004099217A1 (fr)	2003-05-05	2004-05-04	Derives de thiadiazine et leur utilisation comme modulateurs positifs des recepteurs ampa

Publications (1)

Publication Number	Publication Date
UA80046C2 true UA80046C2 (en)	2007-08-10

Family

ID=33306157

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UAA200511454A UA80046C2 (en)	2003-05-05	2004-04-05	Thiadiazine compounds, method for obtaning thereof and pharmaceutical composition containing them

Country Status (20)

Country	Link
US (1)	US7476668B2 (fr)
EP (1)	EP1620441A1 (fr)
JP (1)	JP4461139B2 (fr)
KR (1)	KR100741235B1 (fr)
CN (1)	CN100363368C (fr)
AR (1)	AR044245A1 (fr)
AU (1)	AU2004236005B2 (fr)
BR (1)	BRPI0410002A (fr)
CA (1)	CA2524377C (fr)
EA (1)	EA009240B1 (fr)
FR (1)	FR2854634B1 (fr)
GE (1)	GEP20084318B (fr)
MA (1)	MA27732A1 (fr)
MX (1)	MXPA05011823A (fr)
MY (1)	MY136694A (fr)
NO (1)	NO20055695L (fr)
NZ (1)	NZ543214A (fr)
UA (1)	UA80046C2 (fr)
WO (1)	WO2004099217A1 (fr)
ZA (1)	ZA200508660B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2008510835A (ja)	2004-08-25	2008-04-10	エッセンシャリス，インク．	カリウムａｔｐチャンネル開放因子の製剤処方、及びその使用
WO2007081521A2 (fr)	2006-01-05	2007-07-19	Essentialis, Inc.	Sels d'ouvreurs des canaux potassiques atp-dépendants et leurs utilisations
US20110218190A1 (en) *	2008-11-10	2011-09-08	The Regents Of The University Of California	Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction
WO2012020848A1 (fr) *	2010-08-10	2012-02-16	Takeda Pharmaceutical Company Limited	Composé hétérocyclique et son utilisation
JP5901365B2 (ja) *	2012-03-12	2016-04-06	株式会社トクヤマ	イミダート化合物の製造方法
EP3311842A1 (fr)	2013-06-13	2018-04-25	VeroScience LLC	Compositions et procédés de traitement des troubles métaboliques
PL3321252T3 (pl)	2015-07-06	2021-04-06	Public University Corporation Yokohama City University	Nowy związek, który specyficznie wiąże się z receptorem AMPA
EP3436021B1 (fr)	2016-03-29	2026-07-29	RespireRx Pharmaceuticals, Inc.	Compositions comprenant des ampakines a faible impact pour traiter des troubles de déficit de l'attention
JP6241974B1 (ja)	2017-01-11	2017-12-06	公立大学法人横浜市立大学	霊長類生体の脳内ａｍｐａ受容体のイメージング方法、プログラム、及びスクリーニング方法
US10680583B1 (en) *	2019-02-26	2020-06-09	Xilinx, Inc.	Control circuit for and method of controlling an operation of an integrated circuit device
TWI873185B (zh)	2019-09-16	2025-02-21	日商武田藥品工業股份有限公司	唑稠合之嗒-3(2h)-酮衍生物

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3733409A (en) *	1969-05-20	1973-05-15	Schering Corp	Method of treating hypertension using thieno (1,2,4) thiadiazines
AU4345297A (en) *	1996-09-17	1998-04-14	Regents Of The University Of California, The	Benzothiadiazide derivatives and their use as allosteric up-modulators of the ampa receptor
AU757693B2 (en) *	1997-07-16	2003-03-06	Novo Nordisk A/S	Fused 1,2,4-thiadiazine derivatives, their preparation and use
RU2214405C2 (ru) *	1998-02-18	2003-10-20	НьюроСёрч А/С	Новые соединения и их применение в качестве положительных модуляторов амра-рецепторов
FR2801587B1 (fr) *	1999-11-30	2002-01-11	Adir	Nouveaux derives de benzothiadiazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

2003
- 2003-05-05 FR FR0305448A patent/FR2854634B1/fr not_active Expired - Fee Related
2004
- 2004-04-05 UA UAA200511454A patent/UA80046C2/uk unknown
- 2004-04-30 MY MYPI20041647A patent/MY136694A/en unknown
- 2004-05-04 KR KR1020057020817A patent/KR100741235B1/ko not_active Expired - Fee Related
- 2004-05-04 BR BRPI0410002-6A patent/BRPI0410002A/pt not_active IP Right Cessation
- 2004-05-04 EA EA200501696A patent/EA009240B1/ru not_active IP Right Cessation
- 2004-05-04 AR ARP040101515A patent/AR044245A1/es unknown
- 2004-05-04 US US10/555,743 patent/US7476668B2/en not_active Expired - Fee Related
- 2004-05-04 WO PCT/FR2004/001070 patent/WO2004099217A1/fr not_active Ceased
- 2004-05-04 CN CNB200480014886XA patent/CN100363368C/zh not_active Expired - Fee Related
- 2004-05-04 GE GEAP20049092A patent/GEP20084318B/en unknown
- 2004-05-04 CA CA2524377A patent/CA2524377C/fr not_active Expired - Fee Related
- 2004-05-04 AU AU2004236005A patent/AU2004236005B2/en not_active Ceased
- 2004-05-04 JP JP2006505830A patent/JP4461139B2/ja not_active Expired - Fee Related
- 2004-05-04 EP EP04742632A patent/EP1620441A1/fr not_active Withdrawn
- 2004-05-04 NZ NZ543214A patent/NZ543214A/en not_active IP Right Cessation
- 2004-05-04 MX MXPA05011823A patent/MXPA05011823A/es active IP Right Grant
- 2004-05-04 ZA ZA200508660A patent/ZA200508660B/en unknown
2005
- 2005-10-21 MA MA28567A patent/MA27732A1/fr unknown
- 2005-12-01 NO NO20055695A patent/NO20055695L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
MY136694A (en)	2008-11-28
FR2854634A1 (fr)	2004-11-12
BRPI0410002A (pt)	2006-04-25
CA2524377C (fr)	2010-08-24
JP4461139B2 (ja)	2010-05-12
US7476668B2 (en)	2009-01-13
AU2004236005A1 (en)	2004-11-18
AR044245A1 (es)	2005-09-07
EP1620441A1 (fr)	2006-02-01
GEP20084318B (en)	2008-03-10
MA27732A1 (fr)	2006-01-02
KR100741235B1 (ko)	2007-07-19
EA009240B1 (ru)	2007-12-28
JP2006525292A (ja)	2006-11-09
US20070004709A1 (en)	2007-01-04
ZA200508660B (en)	2007-01-31
CN100363368C (zh)	2008-01-23
AU2004236005B2 (en)	2010-01-21
NZ543214A (en)	2009-02-28
HK1088327A1 (en)	2006-11-03
MXPA05011823A (es)	2006-05-25
NO20055695L (no)	2005-12-01
EA200501696A1 (ru)	2006-06-30
FR2854634B1 (fr)	2005-07-08
KR20060006830A (ko)	2006-01-19
CA2524377A1 (fr)	2004-11-18
WO2004099217A1 (fr)	2004-11-18
CN1798750A (zh)	2006-07-05

Publication	Publication Date	Title
FR2703051A1 (fr)	1994-09-30	Nouvelles pyridothiadiazines, leurs procédés de préparation, et les compositions pharmaceutiques qui les contiennent.
US20070270415A1 (en)	2007-11-22	Benzothiadiazine compounds
US7476668B2 (en)	2009-01-13	Thiadiazine derivatives and use thereof as positive AMPA receptor modulators
JP2003515599A (ja)	2003-05-07	新しいベンゾチアジアジン誘導体、これらの製造方法及びこれらを含む医薬組成物
US7741320B2 (en)	2010-06-22	Cycloalkylated benzothiadiazines, a process for their preparation and pharmaceutical compositions containing them
UA78743C2 (en)	2007-04-25	Benzothia(dia)zine derivatives and their use as ampa modulators
NZ533472A (en)	2005-09-30	Benzothiazine and benzothiadiazine compounds, pharmaceutical compositions and preparation process thereof
US7268129B2 (en)	2007-09-11	Fluorinated benzothiadiazine compounds
CA2350560C (fr)	2006-10-31	Nouveaux types de composes de pyridazinone condenses
UA78742C2 (en)	2007-04-25	Benzothiazine and benzothiadiazine derivatives, method for preparing same and pharmaceutical composition containing thereof
US7262191B2 (en)	2007-08-28	Benzothiadiazine compounds
CA2449189A1 (fr)	2002-12-19	Modulateurs allosteriques positifs des recepteurs ampa naphtothiazine (paarm)
HK1088327B (en)	2008-05-02	Thiadiazine derivatives and use thereof as positive ampa receptor modulators
UA82182C2 (uk)	2008-03-25	Похідні бензотіазину і бензотіадіазину, спосіб їх одержання і фармацевтична композиція, яка їх містить