WO2020072821A3 - Protéines de fusion fc hétérodimères d'il -12 - Google Patents

Protéines de fusion fc hétérodimères d'il -12 Download PDF

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Publication number
WO2020072821A3
WO2020072821A3 PCT/US2019/054570 US2019054570W WO2020072821A3 WO 2020072821 A3 WO2020072821 A3 WO 2020072821A3 US 2019054570 W US2019054570 W US 2019054570W WO 2020072821 A3 WO2020072821 A3 WO 2020072821A3
Authority
WO
WIPO (PCT)
Prior art keywords
fusion proteins
heterodimeric
cancer
useful
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2019/054570
Other languages
English (en)
Other versions
WO2020072821A9 (fr
WO2020072821A2 (fr
Inventor
Matthew Bernett
John R. Desjarlais
Rajat VARMA
Ke Liu
Nargess HASSANZADEH-KIABI
Rumana RASHID
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xencor Inc
Original Assignee
Xencor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP19797407.4A priority Critical patent/EP3861016A2/fr
Priority to SG11202103192RA priority patent/SG11202103192RA/en
Priority to MX2021003765A priority patent/MX2021003765A/es
Priority to CA3115096A priority patent/CA3115096A1/fr
Priority to KR1020217009578A priority patent/KR102884523B1/ko
Priority to AU2019355971A priority patent/AU2019355971B2/en
Priority to JP2021517799A priority patent/JP7612571B2/ja
Application filed by Xencor Inc filed Critical Xencor Inc
Priority to CN201980075579.9A priority patent/CN113195523B/zh
Publication of WO2020072821A2 publication Critical patent/WO2020072821A2/fr
Publication of WO2020072821A9 publication Critical patent/WO2020072821A9/fr
Publication of WO2020072821A3 publication Critical patent/WO2020072821A3/fr
Priority to IL281962A priority patent/IL281962A/en
Anticipated expiration legal-status Critical
Priority to JP2024229412A priority patent/JP7801418B2/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/208—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention porte sur des dispositifs endovasculaires et sur des méthodes de production et d'utilisation de ceux-ci. Les protéines de fusion Fc d'IL-12 sont utiles pour le traitement du cancer et peuvent être utilisées en combinaison avec un blocage de points de contrôle.
PCT/US2019/054570 2018-10-03 2019-10-03 Protéines de fusion fc hétérodimères d'il -12 Ceased WO2020072821A2 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
AU2019355971A AU2019355971B2 (en) 2018-10-03 2019-10-03 IL-12 heterodimeric Fc-fusion proteins
SG11202103192RA SG11202103192RA (en) 2018-10-03 2019-10-03 Il-12 heterodimeric fc-fusion proteins
MX2021003765A MX2021003765A (es) 2018-10-03 2019-10-03 Proteínas il-12 de fusión a fc heterodimérico.
CA3115096A CA3115096A1 (fr) 2018-10-03 2019-10-03 Proteines de fusion fc heterodimeres d'il-12
KR1020217009578A KR102884523B1 (ko) 2018-10-03 2019-10-03 IL-12 이종이량체 Fc-융합 단백질
JP2021517799A JP7612571B2 (ja) 2018-10-03 2019-10-03 Ｉｌ－１２ヘテロ二量体ｆｃ－融合タンパク質
CN201980075579.9A CN113195523B (zh) 2018-10-03 2019-10-03 IL-12异源二聚体Fc融合蛋白
EP19797407.4A EP3861016A2 (fr) 2018-10-03 2019-10-03 Protéines de fusion fc hétérodimères d'il -12
IL281962A IL281962A (en) 2018-10-03 2021-04-01 Il-12 heterodimeric fc-fusion proteins
JP2024229412A JP7801418B2 (ja) 2018-10-03 2024-12-25 Ｉｌ－１２ヘテロ二量体ｆｃ－融合タンパク質

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862740813P 2018-10-03 2018-10-03
US62/740,813 2018-10-03
US201962810038P 2019-02-25 2019-02-25
US62/810,038 2019-02-25
US201962848512P 2019-05-15 2019-05-15
US62/848,512 2019-05-15

Publications (3)

Publication Number Publication Date
WO2020072821A2 WO2020072821A2 (fr) 2020-04-09
WO2020072821A9 WO2020072821A9 (fr) 2020-05-22
WO2020072821A3 true WO2020072821A3 (fr) 2020-06-18

Family

ID=68425252

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2019/054570 Ceased WO2020072821A2 (fr) 2018-10-03 2019-10-03 Protéines de fusion fc hétérodimères d'il -12

Country Status (12)

Country Link
US (3) US11358999B2 (fr)
EP (1) EP3861016A2 (fr)
JP (2) JP7612571B2 (fr)
KR (1) KR102884523B1 (fr)
CN (1) CN113195523B (fr)
AU (1) AU2019355971B2 (fr)
CA (1) CA3115096A1 (fr)
IL (1) IL281962A (fr)
MA (1) MA53822A (fr)
MX (1) MX2021003765A (fr)
SG (1) SG11202103192RA (fr)
WO (1) WO2020072821A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12103954B2 (en) 2021-10-20 2024-10-01 Synthekine, Inc. Heterodimeric Fc cytokines and uses thereof

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KR102050463B1 (ko) 2016-08-10 2019-11-29 아주대학교산학협력단 항체 중쇄불변부위 이종이중체 (heterodimeric Fc)에 융합된 사이토카인 (heterodimeric Fc-fused cytokine) 및 이를 포함하는 약제학적 조성물
TW202235438A (zh) 2016-11-28 2022-09-16 日商中外製藥股份有限公司 能夠調節配體結合活性的配體結合分子
MX2019005756A (es) 2016-11-28 2019-08-14 Chugai Pharmaceutical Co Ltd Dominio de union al antigeno y polipeptido que incluye seccion de transporte.
EP3719035A4 (fr) 2017-11-28 2021-09-01 Chugai Seiyaku Kabushiki Kaisha Polypeptide comprenant un domaine de liaison à l'antigène et une section de transport
TWI880235B (zh) 2017-11-28 2025-04-11 日商中外製藥股份有限公司 可調整配體結合活性的配體結合分子
MX2021003543A (es) 2018-09-27 2021-06-23 Xilio Dev Inc Polipeptidos de citocinas enmascaradas.
SG11202103192RA (en) * 2018-10-03 2021-04-29 Xencor Inc Il-12 heterodimeric fc-fusion proteins
CA3117212A1 (fr) * 2018-10-23 2020-04-30 Dragonfly Therapeutics, Inc. Proteines heterodimeres fusionnees a un fragment fc
WO2021067863A2 (fr) 2019-10-03 2021-04-08 Xencor, Inc. Protéines de fusion fc hétérodimères d'il-12 ciblées
CN115734806A (zh) * 2020-04-01 2023-03-03 西里欧发展公司 掩蔽的il-12细胞因子和其切割产物
IL297186A (en) * 2020-04-17 2022-12-01 Univ Leland Stanford Junior Engineered il-12 and il-23 polypeptides and uses thereof
EP4138778A1 (fr) * 2020-04-22 2023-03-01 Dragonfly Therapeutics, Inc. Formulation, schéma posologique et procédé de fabrication de protéines fusionnées avec fc hétérodimères
WO2022094046A1 (fr) * 2020-10-29 2022-05-05 Proviva Therapeutics (Hong Kong) Limited Compositions d'il-12 et leurs procédés d'utilisation
JP2023553323A (ja) 2020-11-25 2023-12-21 エクシリオ デベロップメント， インコーポレイテッド 腫瘍特異的に切断可能なリンカー
CN116601175A (zh) * 2020-12-18 2023-08-15 豪夫迈·罗氏有限公司 用于靶向疗法的前体蛋白和试剂盒
US20240392004A1 (en) * 2021-03-10 2024-11-28 Immunowake Inc. Immunomodulatory molecules and uses thereof
EP4314073A4 (fr) * 2021-03-24 2025-02-19 Alkermes, Inc. Anticorps anti-upar et protéines de fusion les comprenant
CA3226924A1 (fr) 2021-07-19 2023-01-26 Regeneron Pharmaceuticals, Inc. Agonistes du recepteur de l'il12 et leurs procedes d'utilisation
KR20240068070A (ko) * 2021-09-29 2024-05-17 자임워크스 비씨 인코포레이티드 변형된 인터루킨 p40 서브유닛 단백질 및 이의 사용 방법
CN118317974A (zh) * 2021-10-20 2024-07-09 辛德凯因股份有限公司 人IL-12p40变体及其用途
WO2023133540A1 (fr) * 2022-01-07 2023-07-13 Lyell Immunopharma, Inc. Variants de l'il-12 à affinité modifiée
US20250101107A1 (en) * 2022-01-20 2025-03-27 Repertoire Immune Medicines, Inc. Cd8-targeted il-12 fusion proteins
JP2025520411A (ja) * 2022-06-17 2025-07-03 ファイザー・インク Ｉｌ－１２バリアント、抗ｐｄ１抗体、融合タンパク質、およびその使用
US20250375502A1 (en) * 2022-06-22 2025-12-11 Wuhan Houxian Biopharmaceutical Co. Ltd. Combination of il-12 and ox40l for cancer immunotherapy
WO2024006563A1 (fr) 2022-07-01 2024-01-04 Sutro Biopharma, Inc. Mutants d'il-12 à toxicité réduite, leurs compositions et leurs procédés d'utilisation
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US20220396605A1 (en) 2022-12-15
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