YU46087B - Postupak za dobijanje analoga rebekamicina - Google Patents

Postupak za dobijanje analoga rebekamicina

Info

Publication number: YU46087B
Authority: YU; Yugoslavia
Prior art keywords: group; alkyl; rebecamycin; alkoxycarbonyl; mono
Prior art date: 1986-11-21

Application number

YU208687A

Other languages

English (en)

Serbo-Croatian (sh)

Other versions

YU208687A (en

Inventor

T. Kaneko

H.S. Wong

J.J. Utzig

Original Assignee

Bristol-Myers Company New York

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-11-21

Filing date

1987-11-18

Publication date

1992-12-21

1987-11-18 Application filed by Bristol-Myers Company New York filed Critical Bristol-Myers Company New York

1988-10-31 Publication of YU208687A publication Critical patent/YU208687A/xx

1992-12-21 Publication of YU46087B publication Critical patent/YU46087B/sh

Links

125000000217 alkyl group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
-1 nitro, carboxyl Chemical group 0.000 abstract 3
150000001450 anions Chemical class 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
125000004663 dialkyl amino group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
239000012048 reactive intermediate Substances 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000012442 inert solvent Substances 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/044—Pyrrole radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Compounds Of Unknown Constitution (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines Containing Plant Substances (AREA)

YU208687A 1986-11-21 1987-11-18 Postupak za dobijanje analoga rebekamicina YU46087B (sh)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/933,428 US4785085A (en)	1986-11-21	1986-11-21	Rebeccamycin analogs

Publications (2)

Publication Number	Publication Date
YU208687A YU208687A (en)	1988-10-31
YU46087B true YU46087B (sh)	1992-12-21

Family

ID=25463937

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
YU208687A YU46087B (sh)	1986-11-21	1987-11-18	Postupak za dobijanje analoga rebekamicina

Country Status (28)

Country	Link
US (1)	US4785085A (2)
EP (1)	EP0269025B1 (2)
JP (1)	JPS63198695A (2)
KR (1)	KR910000897B1 (2)
CN (1)	CN1019806B (2)
AT (1)	ATE84539T1 (2)
AU (1)	AU614068B2 (2)
CA (1)	CA1287349C (2)
CS (1)	CS265248B2 (2)
CY (1)	CY1701A (2)
DE (1)	DE3783577T2 (2)
DK (1)	DK165986C (2)
EG (1)	EG18409A (2)
ES (1)	ES2053510T3 (2)
FI (1)	FI86189C (2)
GR (1)	GR3006776T3 (2)
HK (1)	HK49093A (2)
HU (1)	HU201773B (2)
IE (1)	IE60595B1 (2)
IL (1)	IL84515A (2)
MX (1)	MX9202849A (2)
MY (1)	MY102722A (2)
NO (1)	NO167741C (2)
NZ (1)	NZ222544A (2)
PT (1)	PT86188B (2)
SG (1)	SG25193G (2)
YU (1)	YU46087B (2)
ZA (1)	ZA878714B (2)

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JPH07113027B2 (ja) *	1987-12-24	1995-12-06	協和醗酵工業株式会社	Ｋ−２５２誘導体
DE3835842A1 (de) *	1988-10-21	1990-04-26	Goedecke Ag	Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
US5438050A (en) *	1988-02-06	1995-08-01	Godecke Aktiengesellschaft	Indolocarbazole derivatives, processes for their preparation and compositions containing them
US5015578A (en) *	1989-03-23	1991-05-14	Bristol-Myers Squibb Company	BMY-41950 antitumor antibiotic
CA2015996C (en) *	1989-05-05	2001-08-28	Hartmut Osswald	Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals
US5496809A (en) *	1989-05-10	1996-03-05	Bristol-Myers Squibb Co	Stable solutions of rebeccamycin analog
US5344823A (en) *	1990-03-06	1994-09-06	Bristol-Myers Squibb Company	Antitumor antibiotic BMY-41219
CA2037596C (en) *	1990-03-06	1995-07-18	Kin Sing Lam	Rebeccamycin analog by bromide precursor feeding
IL97233A (en) *	1990-03-06	1995-03-30	Bristol Myers Squibb Co	Rebeccamycin analogs, their production and pharmaceutical compositions containing them
US5158938A (en) *	1990-03-06	1992-10-27	Bristol-Myers Squibb Company	Rebeccamycin
US5478813A (en) *	1990-05-11	1995-12-26	Banyu Pharmaceutical Co., Ltd.	Antitumor substance BE-13793C derivatives
JP3064416B2 (ja) *	1990-05-11	2000-07-12	萬有製薬株式会社	抗腫瘍性物質ｂｅ―１３７９３ｃ誘導体
US5589365A (en) *	1991-11-29	1996-12-31	Banyu Pharmaceutical Co., Ltd.	Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms
US5437996A (en) *	1992-11-24	1995-08-01	Banyu Pharmaceutical Co., Ltd.	Microtetraspora strain for preparation of indolopyrrolocarbazole derivatives
NZ245203A (en) *	1991-11-29	1997-07-27	Banyu Pharma Co Ltd	5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
US5591842A (en) *	1991-11-29	1997-01-07	Banyu Pharmaceutical Co., Ltd.	Indolopyrrolocarbazole derivatives
US5547976A (en) *	1992-03-20	1996-08-20	Burroughs Wellcome Co.	Further indole derivatives with antiviral activity
JP3603322B2 (ja) *	1992-12-14	2004-12-22	萬有製薬株式会社	インドロピロロカルバゾール誘導体の製造法
US5843935A (en) *	1993-12-07	1998-12-01	Eli Lilly And Company	Protein kinase C inhibitors
US5541347A (en) *	1993-12-07	1996-07-30	Eli Lilly And Company	Synthesis of bisindolylmaleimides
DK0657411T3 (da) *	1993-12-07	1999-11-15	Lilly Co Eli	Forbedret syntese af bisindolylmaleimider
NO308798B1 (no) *	1993-12-07	2000-10-30	Lilly Co Eli	Proteinkinase-C-hemmere, anvendelse av samme for fremstilling av farmasøytika samt farmasøytisk formulering omfattende samme
US5723456A (en) *	1993-12-07	1998-03-03	Eli Lilly & Company	Therapeutic treatment for cardiovascular diseases
US5624949A (en) *	1993-12-07	1997-04-29	Eli Lilly And Company	Protein kinase C inhibitors
ES2236702T3 (es) *	1993-12-23	2005-07-16	Eli Lilly And Company	Inhibidores de la proteina quinasa c.
US5545636A (en) *	1993-12-23	1996-08-13	Eli Lilly And Company	Protein kinase C inhibitors
US5804564A (en) *	1994-05-09	1998-09-08	Banyu Pharmaceutical Co., Ltd.	Antitumor indolopyrrolocarbazole derivatives
WO1995030682A1 (en) *	1994-05-09	1995-11-16	Banyu Pharmaceutical Co., Ltd.	Antitumor indolopyprolocarbazole derivative
US5922860A (en) *	1994-05-09	1999-07-13	Banyu Pharmaceutical Co., Ltd.	Antitumor indolopyrrolocarbazole derivatives
EP0769555B1 (en) *	1994-06-13	2003-09-03	Banyu Pharmaceutical Co., Ltd.	Gene coding for glycosyltransferase and use thereof
US5491242A (en) *	1994-06-22	1996-02-13	Eli Lilly And Company	Protein kinase C inhibitors
US5481003A (en) *	1994-06-22	1996-01-02	Eli Lilly And Company	Protein kinase C inhibitors
DK0695755T3 (da) *	1994-08-04	1999-06-28	Hoffmann La Roche	Pyrrolocarbazoler
WO1997009339A1 (fr) *	1995-09-05	1997-03-13	Banyu Pharmaceutical Co., Ltd.	Derives antitumoraux d'indolopyrrolocarbazole
EP0888339A4 (en) *	1996-03-20	2001-02-28	Lilly Co Eli	SYNTHESIS OF INDOLYLMALEINIMIDES
US5859261A (en) *	1997-03-20	1999-01-12	Eli Lilly And Company	Synthesis of indolylmaleimides
US6610727B2 (en)	2000-10-06	2003-08-26	Bristol-Myers Squibb Company	Anhydro sugar derivatives of indolocarbazoles
US6677450B2 (en)	2000-10-06	2004-01-13	Bristol-Myers Squibb Company	Topoisomerase inhibitors
US6653290B2 (en) *	2000-10-06	2003-11-25	Bristol-Myers Squibb Company	Tumor proliferation inhibitors
KR20030085035A (ko)	2001-03-22	2003-11-01	브리스톨-마이어스스퀴브컴파니	토포아이소머라아제 ｉ 선택성 세포독성인돌로피롤로카바졸 당 유도체
JP4202250B2 (ja)	2001-07-25	2008-12-24	バイオマリンファーマシューティカルインコーポレイテッド	血液脳関門輸送を調節するための組成物および方法
CA2393720C (en) *	2002-07-12	2010-09-14	Eli Lilly And Company	Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
EP1666485A1 (en) *	2003-09-16	2006-06-07	Banyu Pharmaceutical Co., Ltd.	Novel indolopyrrolocarbazole derivative with antitumor activity
EP2671507A3 (en)	2005-04-28	2014-02-19	Proteus Digital Health, Inc.	Pharma-informatics system
MX2009002893A (es)	2006-09-18	2009-07-10	Raptor Pharmaceutical Inc	Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap).
ES2326459B1 (es)	2008-04-08	2010-05-28	Universidad De Oviedo	Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.
CA2752373C (en)	2009-02-20	2017-10-10	To-Bbb Holding B.V.	Glutathione-based drug delivery system
IL255113B (en)	2009-05-06	2022-09-01	Laboratory Skin Care Inc	Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates
CN102125578B (zh) *	2010-11-24	2013-03-27	河南师范大学	具有抗癌活性的蝴蝶霉素类似物及合成方法
CN102898489B (zh) *	2010-11-24	2014-04-02	河南师范大学	具有抗癌活性的蝴蝶霉素类似物及合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4487925A (en) *	1983-01-28	1984-12-11	Bristol-Myers Company	Rebeccamycin and process for its preparation
US4552842A (en) *	1983-01-28	1985-11-12	Bristol-Myers Company	Process for producing rebeccamycin
US4524145A (en) *	1984-09-04	1985-06-18	Bristol-Myers Company	4'-Deschlororebeccamycin pharmaceutical composition and method of use
JPS62220196A (ja) *	1986-03-20	1987-09-28	Kyowa Hakko Kogyo Co Ltd	新規物質ｕｃｎ―０１

1986
- 1986-11-21 US US06/933,428 patent/US4785085A/en not_active Expired - Lifetime
1987
- 1987-11-12 AU AU81148/87A patent/AU614068B2/en not_active Expired
- 1987-11-13 NZ NZ222544A patent/NZ222544A/en unknown
- 1987-11-17 CS CS878249A patent/CS265248B2/cs not_active IP Right Cessation
- 1987-11-17 EG EG656/87A patent/EG18409A/xx active
- 1987-11-18 YU YU208687A patent/YU46087B/sh unknown
- 1987-11-18 FI FI875091A patent/FI86189C/fi not_active IP Right Cessation
- 1987-11-18 IL IL84515A patent/IL84515A/xx not_active IP Right Cessation
- 1987-11-20 PT PT86188A patent/PT86188B/pt unknown
- 1987-11-20 ES ES87117167T patent/ES2053510T3/es not_active Expired - Lifetime
- 1987-11-20 CN CN87107928A patent/CN1019806B/zh not_active Expired
- 1987-11-20 NO NO874857A patent/NO167741C/no not_active IP Right Cessation
- 1987-11-20 ZA ZA878714A patent/ZA878714B/xx unknown
- 1987-11-20 EP EP87117167A patent/EP0269025B1/en not_active Expired - Lifetime
- 1987-11-20 AT AT87117167T patent/ATE84539T1/de not_active IP Right Cessation
- 1987-11-20 DE DE8787117167T patent/DE3783577T2/de not_active Expired - Lifetime
- 1987-11-20 JP JP62293854A patent/JPS63198695A/ja active Granted
- 1987-11-20 KR KR1019870013102A patent/KR910000897B1/ko not_active Expired
- 1987-11-20 CA CA000552337A patent/CA1287349C/en not_active Expired - Lifetime
- 1987-11-20 MY MYPI87003080A patent/MY102722A/en unknown
- 1987-11-20 DK DK612987A patent/DK165986C/da not_active IP Right Cessation
- 1987-11-20 IE IE315287A patent/IE60595B1/en not_active IP Right Cessation
- 1987-11-20 HU HU875164A patent/HU201773B/hu unknown
1992
- 1992-06-12 MX MX9202849A patent/MX9202849A/es unknown
1993
- 1993-01-14 GR GR920402547T patent/GR3006776T3/el unknown
- 1993-03-06 SG SG251/93A patent/SG25193G/en unknown
- 1993-05-20 HK HK490/93A patent/HK49093A/en not_active IP Right Cessation
1994
- 1994-01-14 CY CY170194A patent/CY1701A/xx unknown

Also Published As

Publication number	Publication date
DK612987A (da)	1988-05-22
JPS63198695A (ja)	1988-08-17
AU614068B2 (en)	1991-08-22
SG25193G (en)	1993-05-21
FI875091A0 (fi)	1987-11-18
ATE84539T1 (de)	1993-01-15
CS265248B2 (en)	1989-10-13
NO874857L (no)	1988-05-24
EP0269025A3 (en)	1990-08-29
HU201773B (en)	1990-12-28
ZA878714B (2)	1988-05-20
FI86189B (fi)	1992-04-15
MY102722A (en)	1992-09-30
NZ222544A (en)	1990-11-27
DK165986B (da)	1993-02-22
KR880006246A (ko)	1988-07-22
FI86189C (fi)	1992-07-27
EG18409A (en)	1993-02-28
HK49093A (en)	1993-05-27
NO167741C (no)	1991-12-04
ES2053510T3 (es)	1994-08-01
CN87107928A (zh)	1988-08-10
CA1287349C (en)	1991-08-06
EP0269025B1 (en)	1993-01-13
DK165986C (da)	1993-07-19
NO874857D0 (no)	1987-11-20
DK612987D0 (da)	1987-11-20
AU8114887A (en)	1988-05-26
DE3783577T2 (de)	1993-05-19
CS824987A2 (en)	1989-01-12
IE873152L (en)	1988-05-21
IE60595B1 (en)	1994-07-27
US4785085A (en)	1988-11-15
KR910000897B1 (ko)	1991-02-12
DE3783577D1 (de)	1993-02-25
FI875091A7 (fi)	1988-05-22
NO167741B (no)	1991-08-26
GR3006776T3 (2)	1993-06-30
IL84515A0 (en)	1988-04-29
IL84515A (en)	1991-11-21
PT86188A (en)	1987-12-01
YU208687A (en)	1988-10-31
EP0269025A2 (en)	1988-06-01
CN1019806B (zh)	1992-12-30
MX9202849A (es)	1992-06-30
CY1701A (en)	1994-01-14
PT86188B (pt)	1990-11-07
HUT45543A (en)	1988-07-28
JPH05400B2 (2)	1993-01-05

Publication	Publication Date	Title
YU46087B (sh)	1992-12-21	Postupak za dobijanje analoga rebekamicina
AU598491B2 (en)	1990-06-28	Pyridyl-methylthio substituted benzimidazoles
RU92004336A (ru)	1995-08-20	Водорастворимые производные камптотецина, способ их получения, фармацевтическая композиция, способ ингибирования энзима топоизомеразы, промежуточные продукты
ATE14423T1 (de)	1985-08-15	Hydroxamsaeurederivate vom typ der mannich-basen mit verbesserter biologischer verfuegbarkeit von nicht-steroiden entzuendungshemmern, verfahren zur herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzung.
DK44682A (da)	1982-08-06	Fremgangsmaade til fremstilling af substituerede imidazolderivater
ES8307760A1 (es)	1983-08-01	Un procedimiento para la preparacion de derivados de 4-anilino-pirimidina.
ES8700856A1 (es)	1986-11-16	Un procedimiento para la preparacion de compuestos de 1, 4-dihidropiridina
DK531282A (da)	1983-06-05	Fremgangsmaade til fremstilling af substituerede imidazolderivater eller ugiftige, farmaceutisk acceptable syreadditionssalte deraf
ATE41423T1 (de)	1989-04-15	1,6-naphthyridinon-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel.
GB1053825A (2)
ATE18196T1 (de)	1986-03-15	1,4-acyloxynaphthalenderivate, diese enthaltende kompositionen, verfahren fuer ihre herstellung und zwischenprodukte dafuer.
ATE5141T1 (de)	1983-11-15	Xanthon- und thioxanthonderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
KR910011760A (ko)	1991-08-07	글리세롤 유도체, 이의 제조 방법 및 이를 함유하는 치료 조성물
ATE108440T1 (de)	1994-07-15	Arylaralkylether, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung.
DE2965377D1 (en)	1983-06-16	6-amino substituted n-pyrrolyl-3-pyridazine amines, their preparation, and pharmaceutically antihypertensive compositions containing them
KR830005164A (ko)	1983-08-03	이종원자고리화합물의 제조방법 및 이의 조성물
ES8105704A1 (es)	1981-06-01	Procedimiento de preparacion de nuevos eteres oximas, de sussales de adicion acidas y de sus derivados amonicos cuater- narios
KR880007539A (ko)	1988-08-27	축합된 디아제피논, 이의 제조방법 및 이들 화합물을 함유하는 약제학적 조성물
HK67287A (en)	1987-09-25	Ergoline derivatives
EP0026989A3 (en)	1981-06-24	Nitrosourea derivatives, process for preparing them, pharmaceutical compositions containing them and intermediates for their preparation
GB1469197A (en)	1977-03-30	Preparation of 1-aminoalkyl triazolobenzodiazepines
DE69113851D1 (de)	1995-11-23	Verfahren zur Herstellung von optisch aktiven Norbornylaminderivaten.
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