JPH05400B2 - - Google Patents

Info

Publication number: JPH05400B2
Authority: JP; Japan
Prior art keywords: alkyl; rebecamycin; alkoxycarbonyl; alkoxy; mono
Prior art date: 1986-11-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

JP62293854A

Other languages

English (en)

Japanese (ja)

Other versions

JPS63198695A (ja

Inventor

Kaneko Takushi

Esu Uon Henri

Jei Utsutsuigu Jeikobu

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bristol Myers Squibb Co

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-11-21

Filing date

1987-11-20

Publication date

1993-01-05

1987-11-20 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1988-08-17 Publication of JPS63198695A publication Critical patent/JPS63198695A/ja

1993-01-05 Publication of JPH05400B2 publication Critical patent/JPH05400B2/ja

Status Granted legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 claims abstract description 44
125000000217 alkyl group Chemical group 0.000 claims abstract description 17
150000003839 salts Chemical class 0.000 claims abstract description 12
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 11
239000002253 acid Substances 0.000 claims abstract description 8
125000003545 alkoxy group Chemical group 0.000 claims abstract description 8
125000004453 alkoxycarbonyl group Chemical group 0.000 claims abstract description 8
239000001257 hydrogen Substances 0.000 claims abstract description 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
229910052799 carbon Inorganic materials 0.000 claims description 3
125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims description 2
-1 nitro, carboxyl Chemical group 0.000 abstract description 20
239000012048 reactive intermediate Substances 0.000 abstract description 7
238000010171 animal model Methods 0.000 abstract description 6
125000003118 aryl group Chemical group 0.000 abstract description 6
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract description 6
206010028980 Neoplasm Diseases 0.000 abstract description 5
239000002246 antineoplastic agent Substances 0.000 abstract description 4
125000003710 aryl alkyl group Chemical group 0.000 abstract description 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract description 4
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract description 3
125000004093 cyano group Chemical group *C#N 0.000 abstract description 3
125000004433 nitrogen atom Chemical group N* 0.000 abstract description 3
INSACQSBHKIWNS-QZQSLCQPSA-N rebeccamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](OC)[C@@H](CO)O[C@H]1N1C2=C3N=C4[C](Cl)C=CC=C4C3=C3C(=O)NC(=O)C3=C2C2=CC=CC(Cl)=C21 INSACQSBHKIWNS-QZQSLCQPSA-N 0.000 abstract 3
ZGCSNRKSJLVANE-UHFFFAOYSA-N Aglycone-Rebeccamycin Natural products N1C2=C3NC4=C(Cl)C=CC=C4C3=C(C(=O)NC3=O)C3=C2C2=C1C(Cl)=CC=C2 ZGCSNRKSJLVANE-UHFFFAOYSA-N 0.000 abstract 2
QEHOIJJIZXRMAN-UHFFFAOYSA-N Rebeccamycin Natural products OC1C(O)C(OC)C(CO)OC1N1C2=C3NC4=C(Cl)C=CC=C4C3=C3C(=O)NC(=O)C3=C2C2=CC=CC(Cl)=C21 QEHOIJJIZXRMAN-UHFFFAOYSA-N 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
125000004663 dialkyl amino group Chemical group 0.000 abstract 2
125000001475 halogen functional group Chemical group 0.000 abstract 2
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
229960005567 rebeccamycin Drugs 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
230000000118 anti-neoplastic effect Effects 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
239000002585 base Substances 0.000 description 24
239000000203 mixture Substances 0.000 description 16
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 15
239000000243 solution Substances 0.000 description 14
238000006243 chemical reaction Methods 0.000 description 13
239000007858 starting material Substances 0.000 description 13
241001465754 Metazoa Species 0.000 description 8
XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 7
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 7
125000004122 cyclic group Chemical group 0.000 description 7
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 6
239000000543 intermediate Substances 0.000 description 6
239000007788 liquid Substances 0.000 description 6
241000970318 Lechevalieria aerocolonigenes Species 0.000 description 5
125000004103 aminoalkyl group Chemical group 0.000 description 5
239000000969 carrier Substances 0.000 description 5
239000007787 solid Substances 0.000 description 5
239000002904 solvent Substances 0.000 description 5
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
229910052786 argon Inorganic materials 0.000 description 4
201000011510 cancer Diseases 0.000 description 4
ZCSHNCUQKCANBX-UHFFFAOYSA-N lithium diisopropylamide Chemical compound [Li+].CC(C)[N-]C(C)C ZCSHNCUQKCANBX-UHFFFAOYSA-N 0.000 description 4
238000000034 method Methods 0.000 description 4
239000008194 pharmaceutical composition Substances 0.000 description 4
239000000047 product Substances 0.000 description 4
229910052708 sodium Inorganic materials 0.000 description 4
238000003756 stirring Methods 0.000 description 4
125000001424 substituent group Chemical group 0.000 description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 3
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
150000001450 anions Chemical class 0.000 description 3
230000000259 anti-tumor effect Effects 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
235000019439 ethyl acetate Nutrition 0.000 description 3
125000005843 halogen group Chemical group 0.000 description 3
150000002475 indoles Chemical class 0.000 description 3
230000002401 inhibitory effect Effects 0.000 description 3
239000011734 sodium Substances 0.000 description 3
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 3
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 3
230000004614 tumor growth Effects 0.000 description 3
YMDNODNLFSHHCV-UHFFFAOYSA-N 2-chloro-n,n-diethylethanamine Chemical compound CCN(CC)CCCl YMDNODNLFSHHCV-UHFFFAOYSA-N 0.000 description 2
BIKSKRPHKQWJCW-UHFFFAOYSA-N 3,4-dibromopyrrole-2,5-dione Chemical compound BrC1=C(Br)C(=O)NC1=O BIKSKRPHKQWJCW-UHFFFAOYSA-N 0.000 description 2
WVUULNDRFBHTFG-UHFFFAOYSA-N 3-chloro-n,n-diethylpropan-1-amine Chemical compound CCN(CC)CCCCl WVUULNDRFBHTFG-UHFFFAOYSA-N 0.000 description 2
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 2
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
239000004480 active ingredient Substances 0.000 description 2
239000002168 alkylating agent Substances 0.000 description 2
229940100198 alkylating agent Drugs 0.000 description 2
150000001412 amines Chemical class 0.000 description 2
229940041181 antineoplastic drug Drugs 0.000 description 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
230000037396 body weight Effects 0.000 description 2
239000012267 brine Substances 0.000 description 2
239000006172 buffering agent Substances 0.000 description 2
239000011575 calcium Substances 0.000 description 2
229910052791 calcium Inorganic materials 0.000 description 2
125000004432 carbon atom Chemical group C* 0.000 description 2
239000007795 chemical reaction product Substances 0.000 description 2
238000002512 chemotherapy Methods 0.000 description 2
238000004587 chromatography analysis Methods 0.000 description 2
238000007796 conventional method Methods 0.000 description 2
238000012258 culturing Methods 0.000 description 2
125000006165 cyclic alkyl group Chemical group 0.000 description 2
201000010099 disease Diseases 0.000 description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
238000001704 evaporation Methods 0.000 description 2
230000008020 evaporation Effects 0.000 description 2
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
239000012442 inert solvent Substances 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
229910052751 metal Inorganic materials 0.000 description 2
239000002184 metal Substances 0.000 description 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
235000015097 nutrients Nutrition 0.000 description 2
239000012044 organic layer Substances 0.000 description 2
238000007911 parenteral administration Methods 0.000 description 2
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
229910000108 silver(I,III) oxide Inorganic materials 0.000 description 2
HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 2
239000000126 substance Substances 0.000 description 2
125000004493 2-methylbut-1-yl group Chemical group CC(C*)CC 0.000 description 1
239000005711 Benzoic acid Substances 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
229920001353 Dextrin Polymers 0.000 description 1
239000004375 Dextrin Substances 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
BWLUMTFWVZZZND-UHFFFAOYSA-N Dibenzylamine Chemical compound C=1C=CC=CC=1CNCC1=CC=CC=C1 BWLUMTFWVZZZND-UHFFFAOYSA-N 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
229910021055 KNH2 Inorganic materials 0.000 description 1
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
208000008342 Leukemia P388 Diseases 0.000 description 1
WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
241001529936 Murinae Species 0.000 description 1
241000699670 Mus sp. Species 0.000 description 1
229930182474 N-glycoside Natural products 0.000 description 1
MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 description 1
239000007832 Na2SO4 Substances 0.000 description 1
229910018954 NaNH2 Inorganic materials 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical class [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 1
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical class [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 1
UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
SLQLGFHNXVULPV-UHFFFAOYSA-N [Mg]C.C1CCOC1 Chemical compound [Mg]C.C1CCOC1 SLQLGFHNXVULPV-UHFFFAOYSA-N 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
239000003513 alkali Substances 0.000 description 1
229910052783 alkali metal Inorganic materials 0.000 description 1
150000001340 alkali metals Chemical class 0.000 description 1
150000001350 alkyl halides Chemical class 0.000 description 1
PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
150000003863 ammonium salts Chemical class 0.000 description 1
229940034982 antineoplastic agent Drugs 0.000 description 1
239000000010 aprotic solvent Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
239000012300 argon atmosphere Substances 0.000 description 1
239000011668 ascorbic acid Substances 0.000 description 1
229960005070 ascorbic acid Drugs 0.000 description 1
235000010323 ascorbic acid Nutrition 0.000 description 1
239000012298 atmosphere Substances 0.000 description 1
229910052788 barium Inorganic materials 0.000 description 1
JUHORIMYRDESRB-UHFFFAOYSA-N benzathine Chemical compound C=1C=CC=CC=1CNCCNCC1=CC=CC=C1 JUHORIMYRDESRB-UHFFFAOYSA-N 0.000 description 1
235000010233 benzoic acid Nutrition 0.000 description 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000007894 caplet Substances 0.000 description 1
239000002775 capsule Substances 0.000 description 1
150000004649 carbonic acid derivatives Chemical class 0.000 description 1
150000001735 carboxylic acids Chemical class 0.000 description 1
239000012876 carrier material Substances 0.000 description 1
238000009903 catalytic hydrogenation reaction Methods 0.000 description 1
150000001768 cations Chemical class 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
239000012059 conventional drug carrier Substances 0.000 description 1
125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
235000019425 dextrin Nutrition 0.000 description 1
235000005911 diet Nutrition 0.000 description 1
230000037213 diet Effects 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
239000007884 disintegrant Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
239000008393 encapsulating agent Substances 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
230000029142 excretion Effects 0.000 description 1
238000001914 filtration Methods 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
238000009472 formulation Methods 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
238000005858 glycosidation reaction Methods 0.000 description 1
239000008187 granular material Substances 0.000 description 1
150000004795 grignard reagents Chemical class 0.000 description 1
230000012010 growth Effects 0.000 description 1
229940093915 gynecological organic acid Drugs 0.000 description 1
150000004820 halides Chemical class 0.000 description 1
238000007327 hydrogenolysis reaction Methods 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
150000004679 hydroxides Chemical class 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 1
IENZCGNHSIMFJE-UHFFFAOYSA-N indole-5-carboxylic acid Chemical compound OC(=O)C1=CC=C2NC=CC2=C1 IENZCGNHSIMFJE-UHFFFAOYSA-N 0.000 description 1
RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
239000000644 isotonic solution Substances 0.000 description 1
239000008101 lactose Substances 0.000 description 1
229910052744 lithium Inorganic materials 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
KDXKERNSBIXSRK-UHFFFAOYSA-N lysine Chemical compound NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
239000001095 magnesium carbonate Substances 0.000 description 1
229910000021 magnesium carbonate Inorganic materials 0.000 description 1
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Substances [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
229910052943 magnesium sulfate Inorganic materials 0.000 description 1
235000019341 magnesium sulphate Nutrition 0.000 description 1
NXPHGHWWQRMDIA-UHFFFAOYSA-M magnesium;carbanide;bromide Chemical compound [CH3-].[Mg+2].[Br-] NXPHGHWWQRMDIA-UHFFFAOYSA-M 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
229910052748 manganese Inorganic materials 0.000 description 1
239000000463 material Substances 0.000 description 1
231100000682 maximum tolerated dose Toxicity 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
229940098779 methanesulfonic acid Drugs 0.000 description 1
NIQQIJXGUZVEBB-UHFFFAOYSA-N methanol;propan-2-one Chemical compound OC.CC(C)=O NIQQIJXGUZVEBB-UHFFFAOYSA-N 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
239000011707 mineral Substances 0.000 description 1
229960004857 mitomycin Drugs 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
239000012299 nitrogen atmosphere Substances 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
239000001814 pectin Substances 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
125000003538 pentan-3-yl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 description 1
125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
239000008177 pharmaceutical agent Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
125000004344 phenylpropyl group Chemical group 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920001451 polypropylene glycol Polymers 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
235000015497 potassium bicarbonate Nutrition 0.000 description 1
235000011181 potassium carbonates Nutrition 0.000 description 1
TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical class [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
235000011118 potassium hydroxide Nutrition 0.000 description 1
LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
239000000843 powder Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
229960004919 procaine Drugs 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000006239 protecting group Chemical group 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
238000010992 reflux Methods 0.000 description 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
ODZPKZBBUMBTMG-UHFFFAOYSA-N sodium amide Chemical compound [NH2-].[Na+] ODZPKZBBUMBTMG-UHFFFAOYSA-N 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
235000011182 sodium carbonates Nutrition 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
229910000104 sodium hydride Inorganic materials 0.000 description 1
235000011121 sodium hydroxide Nutrition 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
239000012258 stirred mixture Substances 0.000 description 1
150000003871 sulfonates Chemical class 0.000 description 1
150000003460 sulfonic acids Chemical class 0.000 description 1
230000004083 survival effect Effects 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000003826 tablet Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
230000001875 tumorinhibitory effect Effects 0.000 description 1
239000008215 water for injection Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1
150000003751 zinc Chemical class 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/044—Pyrrole radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Compounds Of Unknown Constitution (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines Containing Plant Substances (AREA)

JP62293854A 1986-11-21 1987-11-20 レベカマイシン類似体 Granted JPS63198695A (ja)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US933428		1986-11-21
US06/933,428 US4785085A (en)	1986-11-21	1986-11-21	Rebeccamycin analogs

Publications (2)

Publication Number	Publication Date
JPS63198695A JPS63198695A (ja)	1988-08-17
JPH05400B2 true JPH05400B2 (2)	1993-01-05

Family

ID=25463937

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP62293854A Granted JPS63198695A (ja)	1986-11-21	1987-11-20	レベカマイシン類似体

Country Status (28)

Country	Link
US (1)	US4785085A (2)
EP (1)	EP0269025B1 (2)
JP (1)	JPS63198695A (2)
KR (1)	KR910000897B1 (2)
CN (1)	CN1019806B (2)
AT (1)	ATE84539T1 (2)
AU (1)	AU614068B2 (2)
CA (1)	CA1287349C (2)
CS (1)	CS265248B2 (2)
CY (1)	CY1701A (2)
DE (1)	DE3783577T2 (2)
DK (1)	DK165986C (2)
EG (1)	EG18409A (2)
ES (1)	ES2053510T3 (2)
FI (1)	FI86189C (2)
GR (1)	GR3006776T3 (2)
HK (1)	HK49093A (2)
HU (1)	HU201773B (2)
IE (1)	IE60595B1 (2)
IL (1)	IL84515A (2)
MX (1)	MX9202849A (2)
MY (1)	MY102722A (2)
NO (1)	NO167741C (2)
NZ (1)	NZ222544A (2)
PT (1)	PT86188B (2)
SG (1)	SG25193G (2)
YU (1)	YU46087B (2)
ZA (1)	ZA878714B (2)

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US5496809A (en) *	1989-05-10	1996-03-05	Bristol-Myers Squibb Co	Stable solutions of rebeccamycin analog
US5344823A (en) *	1990-03-06	1994-09-06	Bristol-Myers Squibb Company	Antitumor antibiotic BMY-41219
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US5158938A (en) *	1990-03-06	1992-10-27	Bristol-Myers Squibb Company	Rebeccamycin
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JP3064416B2 (ja) *	1990-05-11	2000-07-12	萬有製薬株式会社	抗腫瘍性物質ｂｅ―１３７９３ｃ誘導体
US5589365A (en) *	1991-11-29	1996-12-31	Banyu Pharmaceutical Co., Ltd.	Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms
US5437996A (en) *	1992-11-24	1995-08-01	Banyu Pharmaceutical Co., Ltd.	Microtetraspora strain for preparation of indolopyrrolocarbazole derivatives
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US5591842A (en) *	1991-11-29	1997-01-07	Banyu Pharmaceutical Co., Ltd.	Indolopyrrolocarbazole derivatives
US5547976A (en) *	1992-03-20	1996-08-20	Burroughs Wellcome Co.	Further indole derivatives with antiviral activity
JP3603322B2 (ja) *	1992-12-14	2004-12-22	萬有製薬株式会社	インドロピロロカルバゾール誘導体の製造法
US5843935A (en) *	1993-12-07	1998-12-01	Eli Lilly And Company	Protein kinase C inhibitors
US5541347A (en) *	1993-12-07	1996-07-30	Eli Lilly And Company	Synthesis of bisindolylmaleimides
DK0657411T3 (da) *	1993-12-07	1999-11-15	Lilly Co Eli	Forbedret syntese af bisindolylmaleimider
NO308798B1 (no) *	1993-12-07	2000-10-30	Lilly Co Eli	Proteinkinase-C-hemmere, anvendelse av samme for fremstilling av farmasøytika samt farmasøytisk formulering omfattende samme
US5723456A (en) *	1993-12-07	1998-03-03	Eli Lilly & Company	Therapeutic treatment for cardiovascular diseases
US5624949A (en) *	1993-12-07	1997-04-29	Eli Lilly And Company	Protein kinase C inhibitors
ES2236702T3 (es) *	1993-12-23	2005-07-16	Eli Lilly And Company	Inhibidores de la proteina quinasa c.
US5545636A (en) *	1993-12-23	1996-08-13	Eli Lilly And Company	Protein kinase C inhibitors
US5804564A (en) *	1994-05-09	1998-09-08	Banyu Pharmaceutical Co., Ltd.	Antitumor indolopyrrolocarbazole derivatives
WO1995030682A1 (en) *	1994-05-09	1995-11-16	Banyu Pharmaceutical Co., Ltd.	Antitumor indolopyprolocarbazole derivative
US5922860A (en) *	1994-05-09	1999-07-13	Banyu Pharmaceutical Co., Ltd.	Antitumor indolopyrrolocarbazole derivatives
EP0769555B1 (en) *	1994-06-13	2003-09-03	Banyu Pharmaceutical Co., Ltd.	Gene coding for glycosyltransferase and use thereof
US5491242A (en) *	1994-06-22	1996-02-13	Eli Lilly And Company	Protein kinase C inhibitors
US5481003A (en) *	1994-06-22	1996-01-02	Eli Lilly And Company	Protein kinase C inhibitors
DK0695755T3 (da) *	1994-08-04	1999-06-28	Hoffmann La Roche	Pyrrolocarbazoler
WO1997009339A1 (fr) *	1995-09-05	1997-03-13	Banyu Pharmaceutical Co., Ltd.	Derives antitumoraux d'indolopyrrolocarbazole
EP0888339A4 (en) *	1996-03-20	2001-02-28	Lilly Co Eli	SYNTHESIS OF INDOLYLMALEINIMIDES
US5859261A (en) *	1997-03-20	1999-01-12	Eli Lilly And Company	Synthesis of indolylmaleimides
US6610727B2 (en)	2000-10-06	2003-08-26	Bristol-Myers Squibb Company	Anhydro sugar derivatives of indolocarbazoles
US6677450B2 (en)	2000-10-06	2004-01-13	Bristol-Myers Squibb Company	Topoisomerase inhibitors
US6653290B2 (en) *	2000-10-06	2003-11-25	Bristol-Myers Squibb Company	Tumor proliferation inhibitors
KR20030085035A (ko)	2001-03-22	2003-11-01	브리스톨-마이어스스퀴브컴파니	토포아이소머라아제 ｉ 선택성 세포독성인돌로피롤로카바졸 당 유도체
JP4202250B2 (ja)	2001-07-25	2008-12-24	バイオマリンファーマシューティカルインコーポレイテッド	血液脳関門輸送を調節するための組成物および方法
CA2393720C (en) *	2002-07-12	2010-09-14	Eli Lilly And Company	Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
EP1666485A1 (en) *	2003-09-16	2006-06-07	Banyu Pharmaceutical Co., Ltd.	Novel indolopyrrolocarbazole derivative with antitumor activity
EP2671507A3 (en)	2005-04-28	2014-02-19	Proteus Digital Health, Inc.	Pharma-informatics system
MX2009002893A (es)	2006-09-18	2009-07-10	Raptor Pharmaceutical Inc	Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap).
ES2326459B1 (es)	2008-04-08	2010-05-28	Universidad De Oviedo	Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.
CA2752373C (en)	2009-02-20	2017-10-10	To-Bbb Holding B.V.	Glutathione-based drug delivery system
IL255113B (en)	2009-05-06	2022-09-01	Laboratory Skin Care Inc	Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates
CN102125578B (zh) *	2010-11-24	2013-03-27	河南师范大学	具有抗癌活性的蝴蝶霉素类似物及合成方法
CN102898489B (zh) *	2010-11-24	2014-04-02	河南师范大学	具有抗癌活性的蝴蝶霉素类似物及合成方法

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US4487925A (en) *	1983-01-28	1984-12-11	Bristol-Myers Company	Rebeccamycin and process for its preparation
US4552842A (en) *	1983-01-28	1985-11-12	Bristol-Myers Company	Process for producing rebeccamycin
US4524145A (en) *	1984-09-04	1985-06-18	Bristol-Myers Company	4'-Deschlororebeccamycin pharmaceutical composition and method of use
JPS62220196A (ja) *	1986-03-20	1987-09-28	Kyowa Hakko Kogyo Co Ltd	新規物質ｕｃｎ―０１

1986
- 1986-11-21 US US06/933,428 patent/US4785085A/en not_active Expired - Lifetime
1987
- 1987-11-12 AU AU81148/87A patent/AU614068B2/en not_active Expired
- 1987-11-13 NZ NZ222544A patent/NZ222544A/en unknown
- 1987-11-17 CS CS878249A patent/CS265248B2/cs not_active IP Right Cessation
- 1987-11-17 EG EG656/87A patent/EG18409A/xx active
- 1987-11-18 YU YU208687A patent/YU46087B/sh unknown
- 1987-11-18 FI FI875091A patent/FI86189C/fi not_active IP Right Cessation
- 1987-11-18 IL IL84515A patent/IL84515A/xx not_active IP Right Cessation
- 1987-11-20 PT PT86188A patent/PT86188B/pt unknown
- 1987-11-20 ES ES87117167T patent/ES2053510T3/es not_active Expired - Lifetime
- 1987-11-20 CN CN87107928A patent/CN1019806B/zh not_active Expired
- 1987-11-20 NO NO874857A patent/NO167741C/no not_active IP Right Cessation
- 1987-11-20 ZA ZA878714A patent/ZA878714B/xx unknown
- 1987-11-20 EP EP87117167A patent/EP0269025B1/en not_active Expired - Lifetime
- 1987-11-20 AT AT87117167T patent/ATE84539T1/de not_active IP Right Cessation
- 1987-11-20 DE DE8787117167T patent/DE3783577T2/de not_active Expired - Lifetime
- 1987-11-20 JP JP62293854A patent/JPS63198695A/ja active Granted
- 1987-11-20 KR KR1019870013102A patent/KR910000897B1/ko not_active Expired
- 1987-11-20 CA CA000552337A patent/CA1287349C/en not_active Expired - Lifetime
- 1987-11-20 MY MYPI87003080A patent/MY102722A/en unknown
- 1987-11-20 DK DK612987A patent/DK165986C/da not_active IP Right Cessation
- 1987-11-20 IE IE315287A patent/IE60595B1/en not_active IP Right Cessation
- 1987-11-20 HU HU875164A patent/HU201773B/hu unknown
1992
- 1992-06-12 MX MX9202849A patent/MX9202849A/es unknown
1993
- 1993-01-14 GR GR920402547T patent/GR3006776T3/el unknown
- 1993-03-06 SG SG251/93A patent/SG25193G/en unknown
- 1993-05-20 HK HK490/93A patent/HK49093A/en not_active IP Right Cessation
1994
- 1994-01-14 CY CY170194A patent/CY1701A/xx unknown

Also Published As

Publication number	Publication date
YU46087B (sh)	1992-12-21
DK612987A (da)	1988-05-22
JPS63198695A (ja)	1988-08-17
AU614068B2 (en)	1991-08-22
SG25193G (en)	1993-05-21
FI875091A0 (fi)	1987-11-18
ATE84539T1 (de)	1993-01-15
CS265248B2 (en)	1989-10-13
NO874857L (no)	1988-05-24
EP0269025A3 (en)	1990-08-29
HU201773B (en)	1990-12-28
ZA878714B (2)	1988-05-20
FI86189B (fi)	1992-04-15
MY102722A (en)	1992-09-30
NZ222544A (en)	1990-11-27
DK165986B (da)	1993-02-22
KR880006246A (ko)	1988-07-22
FI86189C (fi)	1992-07-27
EG18409A (en)	1993-02-28
HK49093A (en)	1993-05-27
NO167741C (no)	1991-12-04
ES2053510T3 (es)	1994-08-01
CN87107928A (zh)	1988-08-10
CA1287349C (en)	1991-08-06
EP0269025B1 (en)	1993-01-13
DK165986C (da)	1993-07-19
NO874857D0 (no)	1987-11-20
DK612987D0 (da)	1987-11-20
AU8114887A (en)	1988-05-26
DE3783577T2 (de)	1993-05-19
CS824987A2 (en)	1989-01-12
IE873152L (en)	1988-05-21
IE60595B1 (en)	1994-07-27
US4785085A (en)	1988-11-15
KR910000897B1 (ko)	1991-02-12
DE3783577D1 (de)	1993-02-25
FI875091A7 (fi)	1988-05-22
NO167741B (no)	1991-08-26
GR3006776T3 (2)	1993-06-30
IL84515A0 (en)	1988-04-29
IL84515A (en)	1991-11-21
PT86188A (en)	1987-12-01
YU208687A (en)	1988-10-31
EP0269025A2 (en)	1988-06-01
CN1019806B (zh)	1992-12-30
MX9202849A (es)	1992-06-30
CY1701A (en)	1994-01-14
PT86188B (pt)	1990-11-07
HUT45543A (en)	1988-07-28

Publication	Publication Date	Title
JPH05400B2 (2)	1993-01-05
US4808613A (en)	1989-02-28	Rebeccamycin derivative containing pharmaceutical composition
KR100312444B1 (ko)	2002-02-28	트리플루오로메틸피롤로인돌카르복실산에스테르유도체및그의제조방법
AU727608B2 (en)	2000-12-14	CBI analogs of CC-1065 and the duocarmycins
EP0354583B1 (en)	1993-11-03	DC-88A derivatives
HU211556A9 (en)	1995-12-28	Pyrroloindole derivatives related to dc-88a compound
KR910006637B1 (ko)	1991-08-29	트립타민 유도체의 제조방법
KR20000029637A (ko)	2000-05-25	세포증식억제용으로서의치환된비스인돌릴말레이미드
CA2205872A1 (en)	1996-06-06	Acrylamide derivatives and process for production thereof
US6037475A (en)	2000-03-14	Synthesis of indolymaleimides
EP0680950B1 (en)	2001-05-23	Propenone derivatives
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