ZA945639B - Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from streptomyces avermitillis - Google Patents

Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from streptomyces avermitillis

Info

Publication number
ZA945639B
ZA945639B ZA945639A ZA945639A ZA945639B ZA 945639 B ZA945639 B ZA 945639B ZA 945639 A ZA945639 A ZA 945639A ZA 945639 A ZA945639 A ZA 945639A ZA 945639 B ZA945639 B ZA 945639B
Authority
ZA
South Africa
Prior art keywords
dehydrogenase complex
chain alpha
genes encoding
ketoacid dehydrogenase
novel
Prior art date
Application number
ZA945639A
Other languages
English (en)
Inventor
Claudio D Denoya
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ZA945639B publication Critical patent/ZA945639B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/04—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with a disulfide as acceptor (1.2.4)
    • C12Y102/04004—3-Methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) (1.2.4.4), i.e. branched-chain-alpha-ketoacid dehydrogenase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ZA945639A 1993-07-30 1994-07-29 Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from streptomyces avermitillis ZA945639B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10051893A 1993-07-30 1993-07-30

Publications (1)

Publication Number Publication Date
ZA945639B true ZA945639B (en) 1996-01-29

Family

ID=22280171

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA945639A ZA945639B (en) 1993-07-30 1994-07-29 Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from streptomyces avermitillis

Country Status (22)

Country Link
US (1) US5728561A (cs)
EP (1) EP0711349B1 (cs)
JP (1) JP2807348B2 (cs)
KR (1) KR100221385B1 (cs)
CN (2) CN1104502C (cs)
AT (1) ATE248916T1 (cs)
AU (2) AU6657294A (cs)
BR (1) BR9407211A (cs)
CA (1) CA2167520C (cs)
CZ (3) CZ26096A3 (cs)
DE (1) DE69433112T2 (cs)
DK (1) DK0711349T3 (cs)
ES (1) ES2204914T3 (cs)
FI (1) FI960401L (cs)
HU (1) HU218964B (cs)
IL (2) IL110430A (cs)
NO (2) NO321077B1 (cs)
NZ (2) NZ266014A (cs)
PL (3) PL181916B1 (cs)
PT (1) PT711349E (cs)
WO (1) WO1995004150A1 (cs)
ZA (1) ZA945639B (cs)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5466102A (en) * 1993-12-16 1995-11-14 Kennametal Inc. System for coupling machine tools
WO1999000505A1 (en) * 1997-06-30 1999-01-07 The Curators Of The University Of Missouri Use of dna encoding plastid pyruvate dehydrogenase and branched chain oxoacid dehydrogenase components to enhance polyhydroxyalkanoate biosynthesis in plants
US6248579B1 (en) 1998-02-13 2001-06-19 Pfizer Inc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
US6197591B1 (en) 1998-09-14 2001-03-06 Pfizer Inc. Streptomyces avermitilis regulatory genes for increased avermectin production
BRPI0013119B8 (pt) * 1999-08-12 2021-05-25 Pah Usa 15 Llc molécula polinucleotídica isolada, vetor recombinante purificado, célula hospedeira procariótica e célula de streptomyces avermitilis mutada, método para obtenção de uma nova cepa de s. avermitilis e processo para produção de avermectinas
EP1210460B1 (en) * 1999-08-19 2007-05-23 Omniscience Pharmaceuticals Gene cloning
CN1321684A (zh) * 2000-04-29 2001-11-14 上海博德基因开发有限公司 一种新的多肽——人krab包含的锌指蛋白kraz2－12和编码这种多肽的多核苷酸
CN1321752A (zh) * 2000-04-29 2001-11-14 上海博德基因开发有限公司 一种新的多肽——人分支alpha－酮酸脱氢酶E1－beta亚单位9和编码这种多肽的多核苷酸
AT410217B (de) * 2000-06-15 2003-03-25 Cistem Biotechnologies Gmbh Vektor und ein verfahren zur expression und selektion randomisierter peptid-sequenzen
EP2141236A1 (en) 2008-07-03 2010-01-06 KRKA, D.D., Novo Mesto Process for production of lipstatin and microorganisms therefore
CN112410389B (zh) * 2019-08-23 2023-07-18 中国科学院微生物研究所 支链α-酮酸脱氢酶复合体在制备丙二酸单酰辅酶A中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN167980B (cs) * 1987-01-23 1991-01-19 Pfizer
IL85119A (en) * 1987-01-23 1993-01-14 Pfizer Streptomyces avermitilis strains, their preparation and use in production of avermectins

Also Published As

Publication number Publication date
PL181778B1 (pl) 2001-09-28
IL110430A (en) 2005-08-31
JPH08507931A (ja) 1996-08-27
HUT71323A (en) 1995-11-28
US5728561A (en) 1998-03-17
CZ289136B6 (cs) 2001-11-14
PL177922B1 (pl) 2000-01-31
DE69433112T2 (de) 2004-04-01
NZ328926A (en) 1998-02-26
HU218964B (hu) 2001-01-29
CN1104502C (zh) 2003-04-02
CZ289866B6 (cs) 2002-04-17
NO20052209D0 (no) 2005-05-04
JP2807348B2 (ja) 1998-10-08
CZ20002929A3 (cs) 2001-11-14
IL154136A0 (en) 2003-07-31
CA2167520A1 (en) 1995-02-09
IL110430A0 (en) 1994-10-21
WO1995004150A1 (en) 1995-02-09
CN1128046A (zh) 1996-07-31
PL312733A1 (en) 1996-05-13
PL181916B1 (en) 2001-10-31
NO960372L (no) 1996-01-29
FI960401A7 (fi) 1996-01-29
CZ26096A3 (en) 1996-05-15
AU712442B2 (en) 1999-11-04
AU9421898A (en) 1999-03-04
FI960401A0 (fi) 1996-01-29
EP0711349B1 (en) 2003-09-03
ATE248916T1 (de) 2003-09-15
HU9402192D0 (en) 1994-10-28
NO321077B1 (no) 2006-03-13
KR100221385B1 (ko) 1999-10-01
BR9407211A (pt) 1996-09-17
AU6657294A (en) 1995-02-28
FI960401L (fi) 1996-01-29
DE69433112D1 (de) 2003-10-09
CA2167520C (en) 1999-07-27
PT711349E (pt) 2003-12-31
CN1208078A (zh) 1999-02-17
NO20052209L (no) 1996-01-29
EP0711349A1 (en) 1996-05-15
NO960372D0 (no) 1996-01-29
ES2204914T3 (es) 2004-05-01
DK0711349T3 (da) 2003-11-24
NZ266014A (en) 1997-11-24

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