ZA971510B - Peptide derivatives. - Google Patents

Peptide derivatives.

Info

Publication number: ZA971510B
Authority: ZA; South Africa
Prior art keywords: amino group; peptide derivatives; insulin; derivatives; long
Prior art date: 1996-02-21

Application number

ZA9701510A

Other languages

English (en)

Inventor

Lauge Schaffer

Per Balschmidt

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-21

Filing date

1997-02-21

Publication date

1997-09-22

1997-02-21 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1997-09-22 Publication of ZA971510B publication Critical patent/ZA971510B/xx

Links

108090000765 processed proteins & peptides Proteins 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
125000003277 amino group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
230000008034 disappearance Effects 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
238000002347 injection Methods 0.000 abstract 1
239000007924 injection Substances 0.000 abstract 1
238000010254 subcutaneous injection Methods 0.000 abstract 1
239000007929 subcutaneous injection Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
150000003751 zinc Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Toxicology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Biophysics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

ZA9701510A 1996-02-21 1997-02-21 Peptide derivatives. ZA971510B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK18896		1996-02-21

Publications (1)

Publication Number	Publication Date
ZA971510B true ZA971510B (en)	1997-09-22

Family

ID=8090772

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9701510A ZA971510B (en)	1996-02-21	1997-02-21	Peptide derivatives.

Country Status (8)

Country	Link
US (2)	US6451970B1 (de)
EP (1)	EP0894095B1 (de)
JP (1)	JP4044140B2 (de)
AT (1)	ATE241645T1 (de)
AU (1)	AU1766497A (de)
DE (1)	DE69722397T2 (de)
WO (1)	WO1997031022A1 (de)
ZA (1)	ZA971510B (de)

Families Citing this family (50)

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US6451970B1 (en)	1996-02-21	2002-09-17	Novo Nordisk A/S	Peptide derivatives
US6310038B1 (en) *	1997-03-20	2001-10-30	Novo Nordisk A/S	Pulmonary insulin crystals
US6451762B1 (en) *	1997-10-24	2002-09-17	Novo Nordisk A/S	Aggregates of human insulin derivatives
CN1240718C (zh) *	1997-10-24	2006-02-08	诺沃挪第克公司	人胰岛素衍生物的聚集体
US7316999B2 (en)	2000-06-02	2008-01-08	Novo Nordisk A/S	Glucose dependent release of insulin from glucose sensing insulin derivatives
US8003605B2 (en) *	2002-03-13	2011-08-23	Novo Nordisk A/S	Minimising body weight gain in insulin treatment
SI2107069T1 (sl) *	2003-08-05	2013-04-30	Novo Nordisk A/S	Novi inzulinski derivati
MXPA06001283A (es) *	2003-08-05	2006-04-11	Novo Nordisk As	Derivados de insulina novedosos.
EP1687428A1 (de)	2003-11-14	2006-08-09	Novo Nordisk A/S	Verfahren zur herstellung von acyliertem insulin
EP2033662B1 (de)	2004-01-21	2012-10-17	Novo Nordisk Health Care AG	Transglutaminase vermittelte konjugation von peptiden.
BRPI0513508B1 (pt)	2004-07-19	2021-06-01	Biocon Limited	Conjugados de insulina-oligômero, formulações e usos desses
US8030273B2 (en)	2004-10-07	2011-10-04	Novo Nordisk A/S	Protracted exendin-4 compounds
US7893017B2 (en) *	2004-10-07	2011-02-22	Novo Nordisk A/S	Protracted GLP-1 compounds
EP1846447B1 (de)	2005-02-02	2013-08-21	Novo Nordisk A/S	Insulinderivate
WO2006082204A1 (en) *	2005-02-02	2006-08-10	Novo Nordisk A/S	Insulin derivatives
PL373543A1 (pl) *	2005-03-10	2006-09-18	Instytut Biotechnologii i Antybiotyków	Kompozycja farmaceutyczna zawierająca biosyntetyczny analog insuliny ludzkiej, oraz jej zastosowanie w terapii cukrzycy
CN102660614A (zh)	2005-08-16	2012-09-12	诺沃-诺迪斯克有限公司	制备成熟胰岛素多肽的方法
JP4808785B2 (ja)	2005-12-28	2011-11-02	ノボ・ノルデイスク・エー／エス	インスリン組成物および組成物の製造方法
EP1991576B1 (de) *	2006-02-27	2010-09-29	Novo Nordisk A/S	Insulinderivate
US20090069215A1 (en) *	2006-03-13	2009-03-12	Novo Nordisk A/S	Acylated Single Chain Insulin
MX2008014061A (es)	2006-05-09	2008-11-14	Novo Nordisk As	Derivado de insulina.
CN101437849B (zh) *	2006-05-09	2015-09-30	诺沃-诺迪斯克有限公司	胰岛素衍生物
ES2542146T3 (es)	2006-07-31	2015-07-31	Novo Nordisk A/S	Insulinas extendidas PEGiladas.
DK2074141T3 (en) *	2006-09-22	2016-11-28	Novo Nordisk As	The protease resistant insulin analogues.
EP2069502B1 (de)	2006-09-27	2014-02-26	Novo Nordisk A/S	Verfahren zur herstellung gereifter insulinpolypeptide
US9387176B2 (en) *	2007-04-30	2016-07-12	Novo Nordisk A/S	Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
US8465282B2 (en) *	2007-05-29	2013-06-18	Immediate Implant Technologies, Llc	Oral implant placement system and method
US8087934B2 (en) *	2007-05-29	2012-01-03	Immediate Implant Technologies, Llc	Oral implant placement system and method
AU2008257505B2 (en) *	2007-06-01	2013-05-16	Novo Nordisk A/S	Stable non-aqueous pharmaceutical compositions
US9034818B2 (en) *	2007-06-13	2015-05-19	Novo Nordisk A/S	Pharmaceutical formulations comprising an insulin derivative
JP5868594B2 (ja) *	2007-10-16	2016-02-24	バイオコン・リミテッドＢｉｏｃｏｎＬｉｍｉｔｅｄ	経口投与可能な固形医薬組成物及びそのプロセス
US8710000B2 (en)	2007-11-08	2014-04-29	Novo Nordisk A/S	Insulin derivative
EP2058330A1 (de) *	2007-11-08	2009-05-13	Novo Nordisk A/S	Insulinderivat
WO2009112583A2 (en) *	2008-03-14	2009-09-17	Novo Nordisk A/S	Protease-stabilized insulin analogues
CN102037008B (zh)	2008-03-18	2016-08-31	诺沃-诺迪斯克有限公司	蛋白酶稳定化的、酰化胰岛素类似物
AU2009309623B9 (en) *	2008-10-30	2014-10-02	Novo Nordisk A/S	Treating diabetes melitus using insulin injections with less than daily injection frequency
DK2632478T3 (da)	2010-10-27	2019-10-07	Novo Nordisk As	Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller
US9481721B2 (en)	2012-04-11	2016-11-01	Novo Nordisk A/S	Insulin formulations
JP2016519127A (ja)	2013-04-30	2016-06-30	ノヴォノルディスクアー／エス	新規投与レジメン
AU2014333979B2 (en)	2013-10-07	2018-02-15	Novo Nordisk A/S	Novel derivative of an insulin analogue
AR099569A1 (es)	2014-02-28	2016-08-03	Novo Nordisk As	Derivados de insulina y los usos médicos de estos
JP2018531899A (ja)	2015-08-25	2018-11-01	ノヴォノルディスクアー／エス	新規インスリン誘導体及びその医学的使用
EP3341401A1 (de)	2015-08-25	2018-07-04	Novo Nordisk A/S	Neuartige insulinderivate und medizinische verwendungen davon
ES2932498T3 (es)	2016-12-05	2023-01-20	Nuritas Ltd	Composiciones que comprenden el péptido WKDEAGKPLVK
EP3329930A1 (de)	2016-12-05	2018-06-06	Nuritas Limited	Pharmazeutische zusammensetzungen
TWI700091B (zh)	2016-12-16	2020-08-01	丹麥商諾佛儂迪克股份有限公司	含胰島素醫藥組成物
CN111032685A (zh)	2017-08-17	2020-04-17	诺沃挪第克公司	新型酰化胰岛素类似物及其用途
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin
SG11202106167XA (en)	2018-12-11	2021-07-29	Sanofi Sa	Insulin conjugates
US12343383B2 (en)	2019-07-12	2025-07-01	Novo Nordisk A/S	High concentration insulin formulation

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US3869437A (en) *	1970-05-08	1975-03-04	Nat Res Dev	Mono-, di, and N{HD A1{B , N{HU B1{B , N{HU B29{B -tri-acylated insulin
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CZ287945B6 (cs)	1993-09-17	2001-03-14	Novo Nordisk A/S	Inzulinový derivát a farmaceutický prostředek s jeho obsahem pro léčení diabetu
HU224345B1 (hu)	1993-12-23	2005-08-29	Novo Nordisk A/S.	Növekedési hormont felszabadító tulajdonságú peptidek, ezeket hatóanyagként tartalmazó gyógyszerkészítmények és alkalmazásuk
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US5646242A (en) *	1994-11-17	1997-07-08	Eli Lilly And Company	Selective acylation of epsilon-amino groups
WO1996022997A1 (en)	1995-01-27	1996-08-01	Novo Nordisk A/S	Compounds with growth hormone releasing properties
PL183698B1 (pl)	1995-03-17	2002-06-28	Novo Nordisk As	Pochodna insuliny, kompozycja farmaceutyczna i zastosowanie pochodnej insuliny
US5631347A (en) *	1995-06-07	1997-05-20	Eli Lilly And Company	Reducing gelation of a fatty acid-acylated protein
US6451970B1 (en)	1996-02-21	2002-09-17	Novo Nordisk A/S	Peptide derivatives

1997
- 1997-02-20 US US08/801,393 patent/US6451970B1/en not_active Expired - Lifetime
- 1997-02-21 AU AU17664/97A patent/AU1766497A/en not_active Abandoned
- 1997-02-21 DE DE69722397T patent/DE69722397T2/de not_active Expired - Lifetime
- 1997-02-21 ZA ZA9701510A patent/ZA971510B/xx unknown
- 1997-02-21 EP EP97903214A patent/EP0894095B1/de not_active Expired - Lifetime
- 1997-02-21 AT AT97903214T patent/ATE241645T1/de not_active IP Right Cessation
- 1997-02-21 JP JP52971997A patent/JP4044140B2/ja not_active Expired - Fee Related
- 1997-02-21 WO PCT/DK1997/000080 patent/WO1997031022A1/en not_active Ceased
2002
- 2002-07-02 US US10/179,355 patent/US20030171535A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP4044140B2 (ja)	2008-02-06
US20030171535A1 (en)	2003-09-11
US20020045731A1 (en)	2002-04-18
DE69722397D1 (de)	2003-07-03
JP2000504732A (ja)	2000-04-18
DE69722397T2 (de)	2004-04-01
EP0894095B1 (de)	2003-05-28
AU1766497A (en)	1997-09-10
ATE241645T1 (de)	2003-06-15
EP0894095A1 (de)	1999-02-03
US6451970B1 (en)	2002-09-17
WO1997031022A1 (en)	1997-08-28

Publication	Publication Date	Title
ZA971510B (en)	1997-09-22	Peptide derivatives.
WO1997001579A3 (en)	1997-02-27	Somatostatin peptides
EP0375437A3 (de)	1991-09-11	Analoge vom menschlichen Insulin
HK189995A (en)	1995-12-29	Detectable somatostatin analogues containing a chelating group
DE60045524D1 (de)	2011-02-24	Ein Huhn GnRH-II Analog zur Verwendung in der Reduktion des Tumorzellwachstums
CA2171424A1 (en)	1995-03-23	Acylated insulin
PL322299A1 (en)	1998-01-19	Derivatives of insulin
AU7038587A (en)	1987-08-25	Amino acid chelated compositions
CA2064689A1 (en)	1991-02-02	Stabilized protein or peptide conjugates
CA2207078A1 (en)	1998-01-26	Insulin derivatives with increased zinc binding
HU906177D0 (en)	1991-08-28	Process for the production of peptide derivatives and medical and diagnostical preparations containing such derivatives
EP0357067A3 (de)	1991-08-21	Rekombinanter natürlicher Killerzellen-Aktivator
MX9709962A (es)	1998-03-31	Peptidos de somatostatina.
US5049545A (en)	1991-09-17	Insulin derivatives, a process for their preparation, and their use
Jansen et al.	1981	The effect of somatostatin on bombesin-stimulated serum gastrin and gastric acid secretion in man
AU3693097A (en)	1998-02-02	Derivatives of somatostatin, amino acids or oligopeptides and their combination useful for promoting body growth
HU9303247D0 (en)	1994-03-28	Processfor producing 5-thia-1,4-diazabicyclo(4.2.0)octene-3,8-dioxo analogues of beta-lactame
GR1002475B (el)	1996-11-26	Μεθοδος παρασκευης πεπτιδικων παραγωγων.
ES8606397A1 (es)	1986-04-16	Un procedimiento de preparacion de inhibidores de la renina que contienen estatina o sus derivados.