ZA971510B - Peptide derivatives. - Google Patents

Peptide derivatives.

Info

Publication number: ZA971510B
Authority: ZA; South Africa
Prior art keywords: amino group; peptide derivatives; insulin; derivatives; long
Prior art date: 1996-02-21

Application number

ZA9701510A

Other languages

English (en)

Inventor

Lauge Schaffer

Per Balschmidt

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-21

Filing date

1997-02-21

Publication date

1997-09-22

1997-02-21 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1997-09-22 Publication of ZA971510B publication Critical patent/ZA971510B/xx

Links

108090000765 processed proteins & peptides Proteins 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
125000003277 amino group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
230000008034 disappearance Effects 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
238000002347 injection Methods 0.000 abstract 1
239000007924 injection Substances 0.000 abstract 1
238000010254 subcutaneous injection Methods 0.000 abstract 1
239000007929 subcutaneous injection Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
150000003751 zinc Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
General Chemical & Material Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Toxicology (AREA)
Zoology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

ZA9701510A 1996-02-21 1997-02-21 Peptide derivatives. ZA971510B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK18896		1996-02-21

Publications (1)

Publication Number	Publication Date
ZA971510B true ZA971510B (en)	1997-09-22

Family

ID=8090772

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9701510A ZA971510B (en)	1996-02-21	1997-02-21	Peptide derivatives.

Country Status (8)

Country	Link
US (2)	US6451970B1 (de)
EP (1)	EP0894095B1 (de)
JP (1)	JP4044140B2 (de)
AT (1)	ATE241645T1 (de)
AU (1)	AU1766497A (de)
DE (1)	DE69722397T2 (de)
WO (1)	WO1997031022A1 (de)
ZA (1)	ZA971510B (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
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US6451970B1 (en)	1996-02-21	2002-09-17	Novo Nordisk A/S	Peptide derivatives
US6310038B1 (en) *	1997-03-20	2001-10-30	Novo Nordisk A/S	Pulmonary insulin crystals
US6451762B1 (en) *	1997-10-24	2002-09-17	Novo Nordisk A/S	Aggregates of human insulin derivatives
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US7316999B2 (en)	2000-06-02	2008-01-08	Novo Nordisk A/S	Glucose dependent release of insulin from glucose sensing insulin derivatives
US8003605B2 (en) *	2002-03-13	2011-08-23	Novo Nordisk A/S	Minimising body weight gain in insulin treatment
AU2004261353B2 (en) *	2003-08-05	2009-12-10	Novo Nordisk A/S	Novel insulin derivatives
ES2472421T3 (es) *	2003-08-05	2014-07-01	Novo Nordisk A/S	Nuevos derivados de insulina
EP1687428A1 (de)	2003-11-14	2006-08-09	Novo Nordisk A/S	Verfahren zur herstellung von acyliertem insulin
EP2033662B1 (de)	2004-01-21	2012-10-17	Novo Nordisk Health Care AG	Transglutaminase vermittelte konjugation von peptiden.
CN101027318B (zh)	2004-07-19	2016-05-25	比奥孔有限公司	胰岛素-低聚物共轭物，制剂及其用途
JP2008515856A (ja) *	2004-10-07	2008-05-15	ノボノルディスクアクティーゼルスカブ	遅延性ｇｌｐ−１化合物
JP5107713B2 (ja) *	2004-10-07	2012-12-26	ノヴォノルディスクアー／エス	遅延性のエキセンディン−４化合物
WO2006082204A1 (en) *	2005-02-02	2006-08-10	Novo Nordisk A/S	Insulin derivatives
ES2435522T3 (es)	2005-02-02	2013-12-20	Novo Nordisk A/S	Derivados de insulina
PL373543A1 (pl) *	2005-03-10	2006-09-18	Instytut Biotechnologii i Antybiotyków	Kompozycja farmaceutyczna zawierająca biosyntetyczny analog insuliny ludzkiej, oraz jej zastosowanie w terapii cukrzycy
ATE513921T1 (de)	2005-08-16	2011-07-15	Novo Nordisk As	Verfahren zur herstellung reifer insulinpolypeptide
EP1969004B1 (de)	2005-12-28	2011-08-10	Novo Nordisk A/S	Ein acyliertes insulin und zink enthaltende zusammensetzungen und verfahren zur herstellung dieser zusammensetzungen
JP5202338B2 (ja) *	2006-02-27	2013-06-05	ノボ・ノルデイスク・エー／エス	新規インシュリン誘導体
WO2007104737A1 (en) *	2006-03-13	2007-09-20	Novo Nordisk A/S	Acylated single chain insulin
CN101437849B (zh) *	2006-05-09	2015-09-30	诺沃-诺迪斯克有限公司	胰岛素衍生物
AU2007247109B2 (en) *	2006-05-09	2012-03-15	Novo Nordisk A/S	Insulin derivative
CN101573133B (zh) *	2006-07-31	2014-08-27	诺沃-诺迪斯克有限公司	Peg化延长的胰岛素
CN101541830A (zh) *	2006-09-22	2009-09-23	诺沃-诺迪斯克有限公司	蛋白酶抗性的胰岛素类似物
WO2008037735A1 (en)	2006-09-27	2008-04-03	Novo Nordisk A/S	Method for making maturated insulin polypeptides
WO2008132224A2 (en) *	2007-04-30	2008-11-06	Novo Nordisk A/S	Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
US8465282B2 (en)	2007-05-29	2013-06-18	Immediate Implant Technologies, Llc	Oral implant placement system and method
US8087934B2 (en) *	2007-05-29	2012-01-03	Immediate Implant Technologies, Llc	Oral implant placement system and method
AU2008257505B2 (en) *	2007-06-01	2013-05-16	Novo Nordisk A/S	Stable non-aqueous pharmaceutical compositions
JP5552046B2 (ja) *	2007-06-13	2014-07-16	ノボ・ノルデイスク・エー／エス	インスリン誘導体を含有する薬学的製剤
US9241908B2 (en) *	2007-10-16	2016-01-26	Biocon Limited	Orally administrable solid pharmaceutical composition and a process thereof
EP2058330A1 (de) *	2007-11-08	2009-05-13	Novo Nordisk A/S	Insulinderivat
ES2543393T3 (es) *	2007-11-08	2015-08-18	Novo Nordisk A/S	Derivado de insulina
CN101970477B (zh) *	2008-03-14	2014-12-31	诺沃-诺迪斯克有限公司	蛋白酶稳定的胰岛素类似物
HUE032284T2 (en)	2008-03-18	2017-09-28	Novo Nordisk As	Protease-stabilized, acylated insulin analogues
CN102202683A (zh) *	2008-10-30	2011-09-28	诺沃-诺迪斯克有限公司	用少于每日一次的注射频率注射胰岛素来治疗糖尿病
DK2632478T3 (da)	2010-10-27	2019-10-07	Novo Nordisk As	Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller
EP2836508B1 (de)	2012-04-11	2016-06-29	Novo Nordisk A/S	Insulinformulierungen
EP2991672A1 (de)	2013-04-30	2016-03-09	Novo Nordisk A/S	Neuartiges verabreichungsschema
CA2926701A1 (en)	2013-10-07	2015-04-16	Novo Nordisk A/S	Novel derivative of an insulin analogue
AR099569A1 (es)	2014-02-28	2016-08-03	Novo Nordisk As	Derivados de insulina y los usos médicos de estos
EP3341401A1 (de)	2015-08-25	2018-07-04	Novo Nordisk A/S	Neuartige insulinderivate und medizinische verwendungen davon
CN108368163A (zh)	2015-08-25	2018-08-03	诺和诺德股份有限公司	新型胰岛素衍生物及其医学用途
ES3057136T3 (en)	2016-12-05	2026-02-26	Nuritas Ltd	Compositions comprising peptide wkdeagkplvk
EP3329930A1 (de)	2016-12-05	2018-06-06	Nuritas Limited	Pharmazeutische zusammensetzungen
ES2886837T3 (es)	2016-12-16	2021-12-21	Novo Nordisk As	Composiciones farmacéuticas que contienen insulina
CA3071686A1 (en)	2017-08-17	2019-02-21	Novo Nordisk A/S	Novel acylated insulin analogues and uses thereof
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin
TW202039437A (zh)	2018-12-11	2020-11-01	法商賽諾菲公司	肽黏合劑
CN114096269B (zh)	2019-07-12	2024-06-11	诺和诺德股份有限公司	高浓度胰岛素制剂

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JPH01254699A (ja)	1988-04-05	1989-10-11	Kodama Kk	インスリン誘導体及びその用途
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NZ273285A (en)	1993-09-17	1997-10-24	Novo Nordisk As	Insulin derivatives and compositions thereof
CA2179597A1 (en)	1993-12-23	1995-06-29	Nils Langeland Johansen	Compounds with growth hormone releasing properties
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MY113488A (en)	1995-01-27	2002-03-30	Novo Nordisk As	Compounds with growth hormone releasing properties
CA2215694A1 (en)	1995-03-17	1996-09-26	Novo Nordisk A/S	Insulin derivatives
US5631347A (en) *	1995-06-07	1997-05-20	Eli Lilly And Company	Reducing gelation of a fatty acid-acylated protein
US6451970B1 (en)	1996-02-21	2002-09-17	Novo Nordisk A/S	Peptide derivatives

1997
- 1997-02-20 US US08/801,393 patent/US6451970B1/en not_active Expired - Lifetime
- 1997-02-21 DE DE69722397T patent/DE69722397T2/de not_active Expired - Lifetime
- 1997-02-21 AU AU17664/97A patent/AU1766497A/en not_active Abandoned
- 1997-02-21 WO PCT/DK1997/000080 patent/WO1997031022A1/en not_active Ceased
- 1997-02-21 EP EP97903214A patent/EP0894095B1/de not_active Expired - Lifetime
- 1997-02-21 JP JP52971997A patent/JP4044140B2/ja not_active Expired - Fee Related
- 1997-02-21 AT AT97903214T patent/ATE241645T1/de not_active IP Right Cessation
- 1997-02-21 ZA ZA9701510A patent/ZA971510B/xx unknown
2002
- 2002-07-02 US US10/179,355 patent/US20030171535A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US6451970B1 (en)	2002-09-17
WO1997031022A1 (en)	1997-08-28
DE69722397D1 (de)	2003-07-03
DE69722397T2 (de)	2004-04-01
JP2000504732A (ja)	2000-04-18
US20020045731A1 (en)	2002-04-18
EP0894095A1 (de)	1999-02-03
ATE241645T1 (de)	2003-06-15
AU1766497A (en)	1997-09-10
US20030171535A1 (en)	2003-09-11
JP4044140B2 (ja)	2008-02-06
EP0894095B1 (de)	2003-05-28

Publication	Publication Date	Title
AU1766497A (en)	1997-09-10	Insulin derivatives and their use
WO1997001579A3 (en)	1997-02-27	Somatostatin peptides
EP0375437A3 (de)	1991-09-11	Analoge vom menschlichen Insulin
DE60045524D1 (de)	2011-02-24	Ein Huhn GnRH-II Analog zur Verwendung in der Reduktion des Tumorzellwachstums
CA2032499A1 (en)	1991-01-21	Polypeptide derivatives
MY106120A (en)	1995-03-31	Peptide derivatives.
PL322299A1 (en)	1998-01-19	Derivatives of insulin
SI1105409T1 (sl)	2006-06-30	Zascita endogenih peptidov pred peptidazno ucinkovitostjo s konjugacijo na krvne komponente
NO2017041I2 (no)	2018-11-19	Insulin detemir
CA2064689A1 (en)	1991-02-02	Stabilized protein or peptide conjugates
ATE93142T1 (de)	1993-09-15	Chelatierte aminosaeurezusammensetzungen zur verabreichung an bestimmte gewebestellen.
TW347334B (en)	1998-12-11	Monomeric insulin analog compositions
CA2207078A1 (en)	1998-01-26	Insulin derivatives with increased zinc binding
KR900007870A (ko)	1990-06-02	브라디키닌 길항 작용을 갖는 펩티드
MY109309A (en)	1997-01-31	Improvements in or relating to somatostatins
EP0357067A3 (de)	1991-08-21	Rekombinanter natürlicher Killerzellen-Aktivator
KR910009930A (ko)	1991-06-28	인슐린 유도체, 이의 제조방법, 이의 용도 및 이를 함유하는 약제
MX9709962A (es)	1998-03-31	Peptidos de somatostatina.
Jansen et al.	1981	The effect of somatostatin on bombesin-stimulated serum gastrin and gastric acid secretion in man
AU3693097A (en)	1998-02-02	Derivatives of somatostatin, amino acids or oligopeptides and their combination useful for promoting body growth
HU9303247D0 (en)	1994-03-28	Processfor producing 5-thia-1,4-diazabicyclo(4.2.0)octene-3,8-dioxo analogues of beta-lactame
ES8606397A1 (es)	1986-04-16	Un procedimiento de preparacion de inhibidores de la renina que contienen estatina o sus derivados.