AP55A - Therapeutic Acyclic Nucleosides - Google Patents

Therapeutic Acyclic Nucleosides Download PDF

Info

Publication number: AP55A
Authority: AP; ARIPO
Prior art keywords: compound; formula; group; salt; pharmaceutically acceptable
Prior art date: 1987-08-15

Application number

APAP/P/1988/000099A

Other languages

English (en)

Other versions

AP8800099A0 (en

Inventor

Thomas Anthony Krenitsky

Lilia Marie Beauchamp

Original Assignee

The Wellcome Foundation Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-15

Filing date

1988-08-10

Publication date

1989-09-26

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26292613&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP55(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1987-08-15 Priority claimed from GB878719367A external-priority patent/GB8719367D0/en

1987-11-05 Priority claimed from GB878725939A external-priority patent/GB8725939D0/en

1988-08-01 Publication of AP8800099A0 publication Critical patent/AP8800099A0/xx

1988-08-10 Application filed by The Wellcome Foundation Ltd filed Critical The Wellcome Foundation Ltd

1989-09-26 Application granted granted Critical

1989-09-26 Publication of AP55A publication Critical patent/AP55A/en

Links

230000001225 therapeutic effect Effects 0.000 title description 4
239000002777 nucleoside Substances 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims abstract description 82
150000003839 salts Chemical class 0.000 claims abstract description 29
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238000011282 treatment Methods 0.000 claims abstract description 13
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239000004480 active ingredient Substances 0.000 claims description 51
238000006243 chemical reaction Methods 0.000 claims description 15
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 15
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239000002253 acid Substances 0.000 claims description 9
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QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
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QQGRWNMNWONMOO-LEUCUCNGSA-N ethyl (2s,3s)-2-amino-3-methylpentanoate;hydron;chloride Chemical compound Cl.CCOC(=O)[C@@H](N)[C@@H](C)CC QQGRWNMNWONMOO-LEUCUCNGSA-N 0.000 description 1
PQGVTLQEKCJXKF-UHFFFAOYSA-N ethyl 2-amino-3-methylbutanoate;hydrochloride Chemical compound Cl.CCOC(=O)C(N)C(C)C PQGVTLQEKCJXKF-UHFFFAOYSA-N 0.000 description 1
235000019325 ethyl cellulose Nutrition 0.000 description 1
229920001249 ethyl cellulose Polymers 0.000 description 1
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239000003889 eye drop Substances 0.000 description 1
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239000006052 feed supplement Substances 0.000 description 1
239000006260 foam Substances 0.000 description 1
238000005187 foaming Methods 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
238000004108 freeze drying Methods 0.000 description 1
238000003304 gavage Methods 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
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235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
150000002333 glycines Chemical class 0.000 description 1
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GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 description 1
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DWKPPFQULDPWHX-VKHMYHEASA-N l-alanyl ester Chemical compound COC(=O)[C@H](C)N DWKPPFQULDPWHX-VKHMYHEASA-N 0.000 description 1
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 1
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238000011670 long-evans rat Methods 0.000 description 1
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VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
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239000003755 preservative agent Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
235000013772 propylene glycol Nutrition 0.000 description 1
125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
150000003230 pyrimidines Chemical class 0.000 description 1
239000002510 pyrogen Substances 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
229960001860 salicylate Drugs 0.000 description 1
UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
238000007493 shaping process Methods 0.000 description 1
238000007086 side reaction Methods 0.000 description 1
239000002356 single layer Substances 0.000 description 1
201000010153 skin papilloma Diseases 0.000 description 1
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URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
SNYDMZJXWYXCKT-UHFFFAOYSA-M sodium propane-1,2,3-triol benzoate Chemical compound [Na+].OCC(O)CO.[O-]C(=O)c1ccccc1 SNYDMZJXWYXCKT-UHFFFAOYSA-M 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000002798 spectrophotometry method Methods 0.000 description 1
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238000007920 subcutaneous administration Methods 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
239000001117 sulphuric acid Substances 0.000 description 1
235000011149 sulphuric acid Nutrition 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000007916 tablet composition Substances 0.000 description 1
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239000002562 thickening agent Substances 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
229960004906 thiomersal Drugs 0.000 description 1
101150095744 tin-9.1 gene Proteins 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
229940100611 topical cream Drugs 0.000 description 1
229940100615 topical ointment Drugs 0.000 description 1
239000012049 topical pharmaceutical composition Substances 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
125000004665 trialkylsilyl group Chemical group 0.000 description 1
125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
241001529453 unidentified herpesvirus Species 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
210000003501 vero cell Anatomy 0.000 description 1
HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 description 1
229960002555 zidovudine Drugs 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Communicable Diseases (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Saccharide Compounds (AREA)

APAP/P/1988/000099A 1987-08-15 1988-08-10 Therapeutic Acyclic Nucleosides AP55A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB878719367A GB8719367D0 (en)	1987-08-15	1987-08-15	Therapeutic compounds
GB878725939A GB8725939D0 (en)	1987-11-05	1987-11-05	Therapeutic compounds

Publications (2)

Publication Number	Publication Date
AP8800099A0 AP8800099A0 (en)	1988-08-01
AP55A true AP55A (en)	1989-09-26

Family

ID=26292613

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
APAP/P/1988/000099A AP55A (en)	1987-08-15	1988-08-10	Therapeutic Acyclic Nucleosides
APAP/P/1991/000238A AP160A (en)	1987-08-15	1988-08-10	Therapeutic acyclic nucleosides.

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
APAP/P/1991/000238A AP160A (en)	1987-08-15	1988-08-10	Therapeutic acyclic nucleosides.

Country Status (30)

Country	Link
EP (2)	EP0308065B1 (fr)
JP (2)	JPH0662623B2 (fr)
KR (2)	KR960002849B1 (fr)
CN (1)	CN1033701C (fr)
AP (2)	AP55A (fr)
AT (1)	ATE138660T1 (fr)
AU (1)	AU612393C (fr)
CS (1)	CS276903B6 (fr)
CY (1)	CY1833A (fr)
DE (1)	DE3855333T2 (fr)
DK (2)	DK170045B1 (fr)
ES (1)	ES2087639T3 (fr)
FI (1)	FI89713C (fr)
GR (1)	GR3020372T3 (fr)
HU (1)	HU201071B (fr)
IE (1)	IE65551B1 (fr)
IL (1)	IL87434A (fr)
LU (1)	LU88746I2 (fr)
LV (1)	LV5264A3 (fr)
MC (1)	MC1968A1 (fr)
MX (1)	MX9203418A (fr)
MY (1)	MY103760A (fr)
NL (1)	NL960001I2 (fr)
NO (2)	NO167805C (fr)
NZ (1)	NZ225809A (fr)
PL (1)	PL158285B1 (fr)
PT (1)	PT88261B (fr)
SA (1)	SA95160244B1 (fr)
SG (1)	SG26346G (fr)
SU (1)	SU1634138A3 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AP160A (en) *	1987-08-15	1991-11-18	The Wellcome Foundation Ltd	Therapeutic acyclic nucleosides.

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* Cited by examiner, † Cited by third party
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GB8816760D0 (en) *	1988-07-14	1988-08-17	Wellcome Found	Therapeutic compounds
CA2005815C (fr) *	1988-12-19	1999-08-03	Wellcome Foundation Limited (The)	Derives antiviraux de nucleoside acyclique
GB8829571D0 (en) *	1988-12-19	1989-02-08	Wellcome Found	Antiviral compounds
DE4008858A1 (de) *	1990-03-20	1991-09-26	Hoechst Ag	Substituierte purine, verfahren zu ihrer hertellung sowie ihre verwendung als antivirale mittel
ATE250060T1 (de) *	1993-06-08	2003-10-15	Cancer Rec Tech Ltd	O6-substituierte guaninederivate, verfahren zu ihre herstellung und ihre anwendung für behandlung von tumorzellen
ES2157259T3 (es) *	1993-06-10	2001-08-16	Rolabo Sl	Procedimiento para preparar esteres de aminoacidos y analogos de nucleosidos.
GB9317146D0 (en) *	1993-08-18	1993-10-06	Wellcome Found	Therapeutic combinations
GB9320316D0 (en) *	1993-10-01	1993-11-17	Smithkline Beecham Plc	Pharmaceuticals
TW282470B (fr) *	1993-11-18	1996-08-01	Ajinomoto Kk
EP0665229B1 (fr) *	1994-02-01	1999-11-17	Ajinomoto Co., Inc.	Procédé pour la production de dérivés d'une base d'acide nucléique
US5840891A (en) *	1994-07-28	1998-11-24	Syntex (U.S.A.) Inc.	2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
PE32296A1 (es) *	1994-07-28	1996-08-07	Hoffmann La Roche	Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables
US5543414A (en) *	1994-07-28	1996-08-06	Syntex (Usa) Inc.	Achiral amino acid acyl esters of ganciclovir and its derivatives
GB9501178D0 (en) *	1995-01-20	1995-03-08	Wellcome Found	Guanine derivative
GB9501127D0 (en) *	1995-01-20	1995-03-08	Wellcome Found	Tablet
GB9501142D0 (en) *	1995-01-20	1995-03-08	Wellcome Found	Compounds for use in medicine
DE19536164A1 (de) *	1995-09-28	1997-04-03	Boehringer Ingelheim Kg	Verbessertes Verfahren zur Herstellung von 9-[(2-Hyroxyethoxy)methyl]guanin (Acyclovir)
ATE254463T1 (de) *	1996-01-19	2003-12-15	Glaxo Group Ltd	Verwendung von valaciclovir zur herstellung eines arzneimittels zur behandlung von genitalherpes durch einmal tägliche verabreichung
KR100491941B1 (ko) *	1996-01-26	2005-08-05	에프. 호프만-라 로슈 아게	푸린유도체의제조방법
US5700936A (en) *	1996-01-26	1997-12-23	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US5840890A (en) *	1996-01-26	1998-11-24	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US6040446A (en)	1996-01-26	2000-03-21	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5756736A (en) *	1996-01-26	1998-05-26	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5869493A (en)	1996-02-16	1999-02-09	Medivir Ab	Acyclic nucleoside derivatives
US6703394B2 (en)	1996-02-16	2004-03-09	Medivir Ab	Acyclic nucleoside derivatives
IT1283447B1 (it) *	1996-07-18	1998-04-21	Ind Chimica Srl	Processo di preparazione del valaciclovir e relativi intermedi
EP0976750A4 (fr) *	1997-01-17	2001-05-30	Ajinomoto Kk	Nouveaux cristaux de z-valacyclovir
WO1999059574A1 (fr) *	1998-05-21	1999-11-25	Magainin Pharmaceuticals, Inc.	Procede de stimulation de la production de defensine par exposition a de l'isoleucine
EP1436295A4 (fr) *	2001-09-07	2007-07-11	Teva Pharma	Formes cristallines de chlorhydrate de valacyclovir
US20060147519A1 (en)	2002-06-24	2006-07-06	Ashish Gogia	Process for the preparation of robust formulations of valacyclovir hydrochloride tablets
US20050043329A1 (en) *	2002-09-06	2005-02-24	Shlomit Wizel	Crystalline forms of valacyclovir hydrochloride
CN1309732C (zh) *	2002-10-28	2007-04-11	南京长澳医药科技有限公司	6－烷氧基－2’，3’－双脱氧鸟嘌呤核苷的制备方法
EP1638972A2 (fr) *	2003-06-02	2006-03-29	Teva Pharmaceutical Industries Limited	Nouvelles formes cristallines de chlorhydrate de valacyclovir
CN1331471C (zh) *	2003-09-22	2007-08-15	陈云芳	盐酸万乃洛韦软胶囊组合物
MXPA06008197A (es) *	2004-01-21	2007-04-02	Teva Pharma	Proceso para la preparacion de clorhidrato de valaciclovir.
GB2413017A (en) *	2004-04-06	2005-10-12	Ford Global Tech Llc	An electrical connector for a vehicle
WO2006035452A1 (fr) *	2004-09-27	2006-04-06	Matrix Laboratories Ltd	Nouveau pseudomorphe d'hydrochlorure de valaciclovir
ES2379804T3 (es)	2005-05-25	2012-05-03	Eli Lilly And Company	Ésteres de ciclopropanocarboxilato de aciclovir
EP1746098A1 (fr)	2005-07-21	2007-01-24	SOLMAG S.p.A.	Des polymorphes de valacyclovir et procédé pour leur fabrication
CN101456859B (zh) *	2009-01-06	2011-07-20	华南理工大学	抗病毒药物缬昔洛韦的制备方法
WO2011158252A1 (fr)	2010-06-15	2011-12-22	Matrix Laboratories Ltd	Méthode de préparation de la forme polymorphe ii du chlorhydrate de valacyclovir
CN102850354B (zh) *	2012-10-10	2014-07-23	山东金城医药化工股份有限公司	高纯度cbz-万乃洛韦的制备方法
CN106632335A (zh) *	2016-12-27	2017-05-10	河南康达制药有限公司	一种盐酸伐昔洛韦的制备方法
RU2750867C1 (ru) *	2020-05-18	2021-07-05	Александр Сергеевич Самойлов	Производные гуанина

Citations (1)

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DE3534774A1 (de) *	1985-09-30	1987-04-02	Robugen Gmbh	Nucleosid-analoge verbindungen mit antiviraler aktivitaet, verfahren zu deren herstellung sowie arzneimittel mit antiviraler wirkung

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NL8202626A (nl) *	1982-06-29	1984-01-16	Stichting Rega V Z W	Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
DE3627024A1 (de) *	1985-09-24	1987-04-02	Hoechst Ag	In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
AP55A (en) *	1987-08-15	1989-09-26	The Wellcome Foundation Ltd	Therapeutic Acyclic Nucleosides

1988
- 1988-08-10 AP APAP/P/1988/000099A patent/AP55A/en active
- 1988-08-10 AP APAP/P/1991/000238A patent/AP160A/en active
- 1988-08-11 MC MC881999A patent/MC1968A1/fr unknown
- 1988-08-12 MY MYPI88000934A patent/MY103760A/en unknown
- 1988-08-12 KR KR1019880010298A patent/KR960002849B1/ko not_active Expired - Lifetime
- 1988-08-12 HU HU884332A patent/HU201071B/hu unknown
- 1988-08-12 CS CS885594A patent/CS276903B6/cs not_active IP Right Cessation
- 1988-08-12 EP EP88307512A patent/EP0308065B1/fr not_active Expired - Lifetime
- 1988-08-12 AT AT93120604T patent/ATE138660T1/de not_active IP Right Cessation
- 1988-08-12 EP EP93120604A patent/EP0596542B1/fr not_active Expired - Lifetime
- 1988-08-12 PL PL1988274215A patent/PL158285B1/pl unknown
- 1988-08-12 LU LU88746C patent/LU88746I2/fr unknown
- 1988-08-12 IE IE246388A patent/IE65551B1/en not_active IP Right Cessation
- 1988-08-12 ES ES93120604T patent/ES2087639T3/es not_active Expired - Lifetime
- 1988-08-12 DE DE3855333T patent/DE3855333T2/de not_active Expired - Lifetime
- 1988-08-12 FI FI883757A patent/FI89713C/fi not_active IP Right Cessation
- 1988-08-12 PT PT88261A patent/PT88261B/pt not_active IP Right Cessation
- 1988-08-12 NZ NZ225809A patent/NZ225809A/en unknown
- 1988-08-12 CN CN88106535A patent/CN1033701C/zh not_active Expired - Lifetime
- 1988-08-12 JP JP63200320A patent/JPH0662623B2/ja not_active Expired - Lifetime
- 1988-08-12 SU SU884356404A patent/SU1634138A3/ru active
- 1988-08-12 AU AU20978/88A patent/AU612393C/en not_active Expired
- 1988-08-12 IL IL87434A patent/IL87434A/xx not_active IP Right Cessation
- 1988-08-12 DK DK451388A patent/DK170045B1/da not_active IP Right Cessation
- 1988-08-12 NO NO883612A patent/NO167805C/no not_active IP Right Cessation
1990
- 1990-08-28 JP JP2226434A patent/JPH07113025B2/ja not_active Expired - Lifetime
1992
- 1992-06-25 MX MX9203418A patent/MX9203418A/es unknown
- 1992-12-18 LV LV920335A patent/LV5264A3/xx unknown
1994
- 1994-07-08 DK DK082694A patent/DK170803B1/da not_active IP Right Cessation
1995
- 1995-02-24 SG SG1995903373A patent/SG26346G/en unknown
- 1995-09-20 SA SA95160244A patent/SA95160244B1/ar unknown
- 1995-12-01 CY CY183395A patent/CY1833A/xx unknown
1996
- 1996-01-17 KR KR1019960000775A patent/KR960004940B1/ko not_active Expired - Lifetime
- 1996-01-18 NL NL960001C patent/NL960001I2/nl unknown
- 1996-06-27 GR GR960401743T patent/GR3020372T3/el unknown
- 1996-12-17 NO NO1996015C patent/NO1996015I1/no unknown

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3534774A1 (de) *	1985-09-30	1987-04-02	Robugen Gmbh	Nucleosid-analoge verbindungen mit antiviraler aktivitaet, verfahren zu deren herstellung sowie arzneimittel mit antiviraler wirkung

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AP160A (en) *	1987-08-15	1991-11-18	The Wellcome Foundation Ltd	Therapeutic acyclic nucleosides.

Also Published As

Publication number	Publication date
SU1634138A3 (ru)	1991-03-07
EP0596542B1 (fr)	1996-05-29
ATE138660T1 (de)	1996-06-15
EP0308065B1 (fr)	1995-01-04
KR960002849B1 (ko)	1996-02-27
NO883612D0 (no)	1988-08-12
DK451388A (da)	1989-02-16
EP0308065A3 (en)	1989-09-27
NO883612L (no)	1989-02-16
DK82694A (da)	1994-07-08
NZ225809A (en)	1991-07-26
FI883757L (fi)	1989-02-16
EP0308065A2 (fr)	1989-03-22
NO167805B (no)	1991-09-02
FI89713C (fi)	1993-11-10
MC1968A1 (fr)	1989-09-29
LV5264A3 (lv)	1993-10-10
NO1996015I1 (no)	1996-12-17
KR960004940B1 (ko)	1996-04-18
CN1033701C (zh)	1997-01-01
CS8805594A2 (en)	1990-06-13
LU88746I2 (fr)	1996-10-04
MX9203418A (es)	1992-07-01
JPH07113025B2 (ja)	1995-12-06
SG26346G (en)	1995-09-01
GR3020372T3 (en)	1996-09-30
KR890003761A (ko)	1989-04-17
CY1833A (en)	1995-12-01
FI883757A0 (fi)	1988-08-12
MY103760A (en)	1993-09-30
NL960001I1 (nl)	1996-03-01
CN1032538A (zh)	1989-04-26
SA95160244B1 (ar)	2006-10-02
ES2087639T3 (es)	1996-07-16
AU612393B2 (en)	1991-07-11
IE882463L (en)	1989-02-15
IL87434A (en)	1993-06-10
HU201071B (en)	1990-09-28
NO167805C (no)	1991-12-11
DK451388D0 (da)	1988-08-12
JPH0662623B2 (ja)	1994-08-17
AU612393C (en)	2006-08-17
IE65551B1 (en)	1995-11-01
DE3855333D1 (de)	1996-07-04
PL158285B1 (en)	1992-08-31
AU2097888A (en)	1989-02-16
JPS6468373A (en)	1989-03-14
FI89713B (fi)	1993-07-30
JPH03115284A (ja)	1991-05-16
AP8800099A0 (en)	1988-08-01
PT88261B (pt)	1995-03-01
DK170803B1 (da)	1996-01-22
IL87434A0 (en)	1989-01-31
NL960001I2 (nl)	1996-11-01
DE3855333T2 (de)	1996-12-05
DK170045B1 (da)	1995-05-08
PT88261A (pt)	1989-06-30
AP160A (en)	1991-11-18
CS276903B6 (en)	1992-09-16
PL274215A1 (en)	1990-02-19
HUT47935A (en)	1989-04-28
EP0596542A1 (fr)	1994-05-11

Publication	Publication Date	Title
AP160A (en)	1991-11-18	Therapeutic acyclic nucleosides.
US4957924A (en)	1990-09-18	Therapeutic valine esters of acyclovir and pharmaceutically acceptable salts thereof
US4548819A (en)	1985-10-22	Derivatives of 9-(2-hydroxyethoxymethyl) guanine
US5043339A (en)	1991-08-27	Antiviral compounds
EP0072027B1 (fr)	1988-05-18	Composés antiviraux
US5840891A (en)	1998-11-24	2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
CA2154721C (fr)	2001-01-02	Derive de 2-(2-amino-1,6-dihydro-6-oxopurin-9-yl)methoxypropane-1,3-diol
JPS6147839B2 (fr)	1986-10-21
US5061708A (en)	1991-10-29	Therapeutic guanine esters
EP0366385B1 (fr)	1993-06-09	Dérivés de guanine ayant une activité anti-virale et leurs sels pharmaceutiquement acceptables
US5079252A (en)	1992-01-07	Therapeutic compounds
US5318974A (en)	1994-06-07	Antiviral compounds
CA1340084C (fr)	1998-10-13	Esters de 9-(hydroxethoxymethyl)guanine possedant des proprietes antivirales
IE80513B1 (en)	1998-08-26	Therapeutic nucleosides
HK1012339B (en)	2000-04-07	2-(2-amino-1, 6-dihydro-6-oxo-purin-9-yl)methoxy-1, 3-propanediol derivatives

AP55A - Therapeutic Acyclic Nucleosides - Google Patents

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