ATE100453T1 - Sulfhydryl enthaltende tricylische lactame und ihre pharmakologische verwendung. - Google Patents

Sulfhydryl enthaltende tricylische lactame und ihre pharmakologische verwendung.

Info

Publication number: ATE100453T1
Authority: AT; Austria
Prior art keywords: tricylic; lactame; pharmacological use; sulfhydryl containing; hydrogen
Prior art date: 1987-12-30

Application number

AT88121850T

Other languages

English (en)

Inventor

Gary A Flynn

Douglas W Beight

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-30

Filing date

1988-12-29

Publication date

1994-02-15

1988-12-29 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1994-02-15 Application granted granted Critical

1994-02-15 Publication of ATE100453T1 publication Critical patent/ATE100453T1/de

Links

230000000144 pharmacologic effect Effects 0.000 title abstract 2
PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical compound [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 1
108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 1
206010063837 Reperfusion injury Diseases 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
150000003951 lactams Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
General Chemical & Material Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Cephalosporin Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT88121850T 1987-12-30 1988-12-29 Sulfhydryl enthaltende tricylische lactame und ihre pharmakologische verwendung. ATE100453T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/139,485 US4824832A (en)	1987-12-30	1987-12-30	Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
EP88121850A EP0322914B1 (de)	1987-12-30	1988-12-29	Sulfhydryl enthaltende tricylische Lactame und ihre pharmakologische Verwendung

Publications (1)

Publication Number	Publication Date
ATE100453T1 true ATE100453T1 (de)	1994-02-15

Family

ID=22486887

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88121850T ATE100453T1 (de)	1987-12-30	1988-12-29	Sulfhydryl enthaltende tricylische lactame und ihre pharmakologische verwendung.

Country Status (18)

Country	Link
US (1)	US4824832A (de)
EP (1)	EP0322914B1 (de)
JP (1)	JP2681291B2 (de)
KR (1)	KR0128158B1 (de)
CN (1)	CN1034721A (de)
AT (1)	ATE100453T1 (de)
AU (1)	AU611984B2 (de)
CA (1)	CA1336191C (de)
DE (1)	DE3887307T2 (de)
DK (1)	DK725988A (de)
ES (1)	ES2061621T3 (de)
FI (1)	FI886005A7 (de)
HU (2)	HU204050B (de)
IL (1)	IL88810A (de)
NO (1)	NO885812L (de)
NZ (1)	NZ227432A (de)
PT (1)	PT89346B (de)
ZA (1)	ZA889542B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2053340C (en) *	1990-10-18	2002-04-02	Timothy P. Burkholder	Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
DK0492369T3 (da) *	1990-12-21	1997-10-13	Merrell Pharma Inc	Hidtil ukendte tricycliske amino- og nitro-forbindelser med ACE-hæmmende virkning
US5208230A (en) *	1990-12-21	1993-05-04	Merrell Dow Pharmaceuticals	Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
US5308841A (en) *	1990-12-21	1994-05-03	Merrell Dow Pharmaceuticals Inc.	Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
US5455242A (en) *	1991-09-27	1995-10-03	Merrell Dow Pharmaceuticals Inc.	Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
ATE155143T1 (de) *	1991-09-27	1997-07-15	Merrell Pharma Inc	2-substituierte indan-2-mercaptoacetylamid- verbindungen mit enkephalinase und ace- hemmwirkung
US5457196A (en) *	1991-09-27	1995-10-10	Merrell Dow Pharmaceuticals Inc.	2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
CA2078759C (en) *	1991-09-27	2003-09-16	Alan M. Warshawsky	Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
DE69317764T2 (de) *	1992-02-14	1998-07-30	Merrell Pharmaceuticals Inc., Cincinnati, Ohio	Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung
US5552397A (en) *	1992-05-18	1996-09-03	E. R. Squibb & Sons, Inc.	Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
ATE182892T1 (de) *	1992-05-15	1999-08-15	Merrell Pharma Inc	Mercaptoacetylamide von pyridazo(1,2-a>(1,2>- diazepin -derivaten als eukephalinase und ace- inhibitoren
US5238932A (en) *	1992-05-20	1993-08-24	Merrell Dow Pharmaceuticals Inc.	Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
US5420271A (en) *	1992-08-24	1995-05-30	Merrell Dow Pharmaceuticals, Inc.	2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
PT669936E (pt) *	1992-10-30	2001-04-30	Merrell Pharma Inc	Derivados de lactama biciclica de mercaptoacetilamida uteis como inibidores de encefalinase e de ace
US5654294A (en) *	1993-05-13	1997-08-05	Bristol-Myers Squibb	Spiro lactam dual action inhibitors
US5362727A (en) *	1993-07-26	1994-11-08	Bristol-Myers Squibb	Substituted azepino[2,1-a]isoquinoline compounds
US5525723A (en) *	1993-11-18	1996-06-11	Bristol-Myers Squibb Co.	Compounds containing a fused multiple ring lactam
NZ275939A (en) *	1993-11-19	1997-04-24	Merrell Pharma Inc	Preparation of (s)-1-[2(s)-(1,3-dihydro-1,3-dioxoisoindol-2-yl)-1-oxo-3-phenylpropyl ]-1,2,3,4-tetrahydropyridine-2-carboxylic acid methyl ester
US5530013A (en) *	1994-02-14	1996-06-25	American Home Products Corporation	Venlafaxine in the inducement of cognition enhancement
JP3561753B2 (ja) *	1994-02-14	2004-09-02	メレルファーマスーティカルズインコーポレーテッド	エンケファリナーゼ及びａｃｅの阻害剤として有用な、新規な２−置換インダン−２−メルカプトアセチルアミドジスルフィド誘導体類
PT750631E (pt) *	1994-02-14	2000-07-31	Merrell Pharma Inc	Novos derivados de dissulfureto de mercapto-aacetilamido-1,3,4,5-tetra-hidro-benzo¬c)azepin-3-ona uteis como inibidores de encefalinase e ace
JP3596778B2 (ja) *	1994-02-14	2004-12-02	メレルファーマスーティカルズインコーポレーテッド	エンケファリナーゼ及びａｃｅの阻害剤として有用な、新規なメルカプトアセチルアミドジスルフィド誘導体類
CA2183313C (en) *	1994-02-14	2001-01-02	Gary A. Flynn	Novel indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase
US5484783A (en) *	1994-03-24	1996-01-16	Merrell Dow Pharmaceuticals Inc.	Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
ATE246927T1 (de) *	1994-03-24	2003-08-15	Merrell Pharma Inc	Cholesterin senkende mercaptoacetylamiddisulfidderivate
PT751783E (pt) *	1994-03-24	2000-05-31	Merrell Pharma Inc	Derivados aminoacetilmercapto hipocolesterolemicos antiateroscleroticos e hipotrigliceridemicos
US5641880A (en) *	1994-12-21	1997-06-24	Hoechst Marion Roussel, Inc.	Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
CN1241924C (zh) *	1994-12-21	2006-02-15	阿温蒂斯药物公司	制备脑啡肽酶与血管紧张素转化酶抑制剂中间体的新方法及其中间体
US5587375A (en) *	1995-02-17	1996-12-24	Bristol-Myers Squibb Company	Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en) *	1995-05-17	1999-03-02	Bristol-Myers Squibb	Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5650408A (en) *	1995-06-07	1997-07-22	Karanewsky; Donald S.	Thiazolo benzazepine containing dual action inhibitors
US5635504A (en) *	1995-06-07	1997-06-03	Bristol-Myers Squibb Co.	Diazepine containing dual action inhibitors
GB0119305D0 (en)	2001-04-12	2001-10-03	Aventis Pharma Gmbh	Mercaptoacetylamide derivatives,a process for their preparation and their use
US20030229007A1 (en) *	2002-05-30	2003-12-11	Roberto Levi	Form of human renin and its use as a target in treatments for cardiac ischemia and arrhythmia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3185680A (en) *	1962-10-16	1965-05-25	American Home Prod	Reduced benzodiazepinium compounds
US4584294A (en) *	1984-11-07	1986-04-22	Merck & Co., Inc.	Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
CA1337654C (en) *	1986-06-13	1995-11-28	Gary A. Flynn	Fused tricyclic lactams as antihypertensive agents

1987
- 1987-12-30 US US07/139,485 patent/US4824832A/en not_active Expired - Lifetime
1988
- 1988-12-21 AU AU27368/88A patent/AU611984B2/en not_active Ceased
- 1988-12-21 NZ NZ227432A patent/NZ227432A/en unknown
- 1988-12-21 ZA ZA889542A patent/ZA889542B/xx unknown
- 1988-12-21 CA CA000586691A patent/CA1336191C/en not_active Expired - Lifetime
- 1988-12-22 HU HU895880A patent/HU204050B/hu not_active IP Right Cessation
- 1988-12-22 HU HU886576A patent/HU200181B/hu not_active IP Right Cessation
- 1988-12-23 JP JP63323844A patent/JP2681291B2/ja not_active Expired - Lifetime
- 1988-12-27 IL IL88810A patent/IL88810A/xx unknown
- 1988-12-27 PT PT89346A patent/PT89346B/pt not_active IP Right Cessation
- 1988-12-28 DK DK725988A patent/DK725988A/da not_active Application Discontinuation
- 1988-12-28 FI FI886005A patent/FI886005A7/fi not_active Application Discontinuation
- 1988-12-28 KR KR1019880017625A patent/KR0128158B1/ko not_active Expired - Fee Related
- 1988-12-29 ES ES88121850T patent/ES2061621T3/es not_active Expired - Lifetime
- 1988-12-29 CN CN88105629A patent/CN1034721A/zh active Pending
- 1988-12-29 DE DE88121850T patent/DE3887307T2/de not_active Expired - Lifetime
- 1988-12-29 EP EP88121850A patent/EP0322914B1/de not_active Expired - Lifetime
- 1988-12-29 AT AT88121850T patent/ATE100453T1/de not_active IP Right Cessation
- 1988-12-29 NO NO88885812A patent/NO885812L/no unknown

Also Published As

Publication number	Publication date
JP2681291B2 (ja)	1997-11-26
NO885812D0 (no)	1988-12-29
HU895880D0 (en)	1990-02-28
US4824832A (en)	1989-04-25
JPH01203382A (ja)	1989-08-16
AU2736888A (en)	1989-07-06
DE3887307D1 (de)	1994-03-03
KR890009927A (ko)	1989-08-04
DK725988D0 (da)	1988-12-28
NZ227432A (en)	1990-11-27
IL88810A (en)	1993-08-18
IL88810A0 (en)	1989-07-31
KR0128158B1 (ko)	1998-04-04
PT89346B (pt)	1993-08-31
ES2061621T3 (es)	1994-12-16
CA1336191C (en)	1995-07-04
HUT49137A (en)	1989-08-28
AU611984B2 (en)	1991-06-27
HU200181B (en)	1990-04-28
EP0322914A2 (de)	1989-07-05
DK725988A (da)	1989-07-01
PT89346A (pt)	1989-12-29
EP0322914A3 (en)	1990-12-27
FI886005A7 (fi)	1989-07-01
ZA889542B (en)	1989-09-27
CN1034721A (zh)	1989-08-16
HU204050B (en)	1991-11-28
EP0322914B1 (de)	1994-01-19
DE3887307T2 (de)	1994-05-05
NO885812L (no)	1989-07-03

Legal Events

Date	Code	Title	Description
1994-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE3887307D1 (de)	1994-03-03	Sulfhydryl enthaltende tricylische Lactame und ihre pharmakologische Verwendung.
EP0262399A3 (en)	1989-04-26	Cyclic enol derivatives, production and use thereof
NZ212750A (en)	1989-04-26	3-acylamino-2-azetidinone derivatives useful as intermediates in the preparation of antibacterial agents
IL99525A0 (en)	1992-08-18	Fused ring analogs of nitrogen containing nonaromatic heterocycles
IE882929L (en)	1989-03-28	"immunomodulatory azaspiranes"
EP1035123A4 (de)	2001-12-12	Neue heterozyklische verbindungen
ES2175615T3 (es)	2002-11-16	Derivados de azaindol etilamina como agentes de union al receptor nicotinico de acetilcolina.
ES8604128A1 (es)	1986-01-16	Un procedimiento para la preparacion de nuevos derivados de bencenosulfonamida
ZA93218B (en)	1993-08-17	Heterocyclic compounds and their preparation and use.
ES2031892T3 (es)	1996-07-16	Agentes antialergicos y antiinflamatorios.
ATE79257T1 (de)	1992-08-15	Verwendung von tetrahydrobenz(c,d>indol-6carboxamiden zur herstellung von arzneimitteln zur behandlung von angstzustaenden.
ATE91128T1 (de)	1993-07-15	5,11-dihydro-6h-dipyrido (3,2-b:2',3'-e>diazepin- 6-one und deren verwendung in der vorbeugung und behandlung von aids.
IL95012A0 (en)	1991-06-10	Hemoregulatory peptides
ATE121395T1 (de)	1995-05-15	Cumarinderivate, ihre herstellung und ihre verwendung zur behandlung von zerebrovaskulären störungen.
MX170732B (es)	1993-09-10	Composicion de derivados de succinimida y su uso
ATE71092T1 (de)	1992-01-15	Hydroxybutenolid-derivate, ihre herstellung und ihre verwendung.
GR852040B (de)	1985-12-19
DE3866719D1 (de)	1992-01-23	Verwendung von oxochinazolinderivaten bei der behandlung von hyperurikaemie.
LT2199B (lt)	1993-10-15	2-triazolidinono dariniu gavimo budas
EP0574271A3 (de)	1994-04-06
DE3666430D1 (en)	1989-11-23	Condensed seven-membered heterocyclic compounds, their production and use
DE69214205D1 (de)	1996-11-07	Neue Isatineoxime Derivate, ihre Herstellung und Verwendung
ATE81466T1 (de)	1992-10-15	Verwendung von 2-oxo-imidazolidin-derivaten zur prophylaxe und zur behandlung von herzinsuffizienz.
ATE81465T1 (de)	1992-10-15	Verwendung von 2-oxo-imidazolidin-derivaten zur behandlung von nierenkrankheiten.