PT89346A - Processo para a preparacao de novas lactamas triciclicas contendo grupos sulfridilo e de composicoes farmaceuticas que as contem - Google Patents

Processo para a preparacao de novas lactamas triciclicas contendo grupos sulfridilo e de composicoes farmaceuticas que as contem

Info

Publication number: PT89346A
Authority: PT; Portugal
Prior art keywords: sulfridyl; pharmaceutical compositions; preparing new; tricyclic lactams; lactams containing
Prior art date: 1987-12-30

Application number

PT89346A

Other languages

English (en)

Other versions

PT89346B (pt

Inventor

Gary Alan Flynn

Douglas Wade Beight

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-30

Filing date

1988-12-27

Publication date

1989-12-29

1988-12-27 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1989-12-29 Publication of PT89346A publication Critical patent/PT89346A/pt

1993-08-31 Publication of PT89346B publication Critical patent/PT89346B/pt

Links

150000003951 lactams Chemical class 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 1
108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 1
206010063837 Reperfusion injury Diseases 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
General Chemical & Material Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Cephalosporin Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

PT89346A 1987-12-30 1988-12-27 Processo para a preparacao de novas lactamas triciclicas contendo grupos sulfridilo e de composicoes farmaceuticas que as contem PT89346B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/139,485 US4824832A (en)	1987-12-30	1987-12-30	Sulfhydryl containing tricyclic lactams and their pharmacological methods of use

Publications (2)

Publication Number	Publication Date
PT89346A true PT89346A (pt)	1989-12-29
PT89346B PT89346B (pt)	1993-08-31

Family

ID=22486887

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT89346A PT89346B (pt)	1987-12-30	1988-12-27	Processo para a preparacao de novas lactamas triciclicas contendo grupos sulfridilo e de composicoes farmaceuticas que as contem

Country Status (18)

Country	Link
US (1)	US4824832A (pt)
EP (1)	EP0322914B1 (pt)
JP (1)	JP2681291B2 (pt)
KR (1)	KR0128158B1 (pt)
CN (1)	CN1034721A (pt)
AT (1)	ATE100453T1 (pt)
AU (1)	AU611984B2 (pt)
CA (1)	CA1336191C (pt)
DE (1)	DE3887307T2 (pt)
DK (1)	DK725988A (pt)
ES (1)	ES2061621T3 (pt)
FI (1)	FI886005A7 (pt)
HU (2)	HU204050B (pt)
IL (1)	IL88810A (pt)
NO (1)	NO885812L (pt)
NZ (1)	NZ227432A (pt)
PT (1)	PT89346B (pt)
ZA (1)	ZA889542B (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2053340C (en) *	1990-10-18	2002-04-02	Timothy P. Burkholder	Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
DK0492369T3 (da) *	1990-12-21	1997-10-13	Merrell Pharma Inc	Hidtil ukendte tricycliske amino- og nitro-forbindelser med ACE-hæmmende virkning
US5208230A (en) *	1990-12-21	1993-05-04	Merrell Dow Pharmaceuticals	Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
US5308841A (en) *	1990-12-21	1994-05-03	Merrell Dow Pharmaceuticals Inc.	Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
US5455242A (en) *	1991-09-27	1995-10-03	Merrell Dow Pharmaceuticals Inc.	Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
ATE155143T1 (de) *	1991-09-27	1997-07-15	Merrell Pharma Inc	2-substituierte indan-2-mercaptoacetylamid- verbindungen mit enkephalinase und ace- hemmwirkung
US5457196A (en) *	1991-09-27	1995-10-10	Merrell Dow Pharmaceuticals Inc.	2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
CA2078759C (en) *	1991-09-27	2003-09-16	Alan M. Warshawsky	Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
DE69317764T2 (de) *	1992-02-14	1998-07-30	Merrell Pharmaceuticals Inc., Cincinnati, Ohio	Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung
US5552397A (en) *	1992-05-18	1996-09-03	E. R. Squibb & Sons, Inc.	Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
ATE182892T1 (de) *	1992-05-15	1999-08-15	Merrell Pharma Inc	Mercaptoacetylamide von pyridazo(1,2-a>(1,2>- diazepin -derivaten als eukephalinase und ace- inhibitoren
US5238932A (en) *	1992-05-20	1993-08-24	Merrell Dow Pharmaceuticals Inc.	Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
US5420271A (en) *	1992-08-24	1995-05-30	Merrell Dow Pharmaceuticals, Inc.	2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
PT669936E (pt) *	1992-10-30	2001-04-30	Merrell Pharma Inc	Derivados de lactama biciclica de mercaptoacetilamida uteis como inibidores de encefalinase e de ace
US5654294A (en) *	1993-05-13	1997-08-05	Bristol-Myers Squibb	Spiro lactam dual action inhibitors
US5362727A (en) *	1993-07-26	1994-11-08	Bristol-Myers Squibb	Substituted azepino[2,1-a]isoquinoline compounds
US5525723A (en) *	1993-11-18	1996-06-11	Bristol-Myers Squibb Co.	Compounds containing a fused multiple ring lactam
NZ275939A (en) *	1993-11-19	1997-04-24	Merrell Pharma Inc	Preparation of (s)-1-[2(s)-(1,3-dihydro-1,3-dioxoisoindol-2-yl)-1-oxo-3-phenylpropyl ]-1,2,3,4-tetrahydropyridine-2-carboxylic acid methyl ester
US5530013A (en) *	1994-02-14	1996-06-25	American Home Products Corporation	Venlafaxine in the inducement of cognition enhancement
JP3561753B2 (ja) *	1994-02-14	2004-09-02	メレルファーマスーティカルズインコーポレーテッド	エンケファリナーゼ及びａｃｅの阻害剤として有用な、新規な２−置換インダン−２−メルカプトアセチルアミドジスルフィド誘導体類
PT750631E (pt) *	1994-02-14	2000-07-31	Merrell Pharma Inc	Novos derivados de dissulfureto de mercapto-aacetilamido-1,3,4,5-tetra-hidro-benzo¬c)azepin-3-ona uteis como inibidores de encefalinase e ace
JP3596778B2 (ja) *	1994-02-14	2004-12-02	メレルファーマスーティカルズインコーポレーテッド	エンケファリナーゼ及びａｃｅの阻害剤として有用な、新規なメルカプトアセチルアミドジスルフィド誘導体類
CA2183313C (en) *	1994-02-14	2001-01-02	Gary A. Flynn	Novel indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase
US5484783A (en) *	1994-03-24	1996-01-16	Merrell Dow Pharmaceuticals Inc.	Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
ATE246927T1 (de) *	1994-03-24	2003-08-15	Merrell Pharma Inc	Cholesterin senkende mercaptoacetylamiddisulfidderivate
PT751783E (pt) *	1994-03-24	2000-05-31	Merrell Pharma Inc	Derivados aminoacetilmercapto hipocolesterolemicos antiateroscleroticos e hipotrigliceridemicos
US5641880A (en) *	1994-12-21	1997-06-24	Hoechst Marion Roussel, Inc.	Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
CN1241924C (zh) *	1994-12-21	2006-02-15	阿温蒂斯药物公司	制备脑啡肽酶与血管紧张素转化酶抑制剂中间体的新方法及其中间体
US5587375A (en) *	1995-02-17	1996-12-24	Bristol-Myers Squibb Company	Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en) *	1995-05-17	1999-03-02	Bristol-Myers Squibb	Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5650408A (en) *	1995-06-07	1997-07-22	Karanewsky; Donald S.	Thiazolo benzazepine containing dual action inhibitors
US5635504A (en) *	1995-06-07	1997-06-03	Bristol-Myers Squibb Co.	Diazepine containing dual action inhibitors
GB0119305D0 (en)	2001-04-12	2001-10-03	Aventis Pharma Gmbh	Mercaptoacetylamide derivatives,a process for their preparation and their use
US20030229007A1 (en) *	2002-05-30	2003-12-11	Roberto Levi	Form of human renin and its use as a target in treatments for cardiac ischemia and arrhythmia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3185680A (en) *	1962-10-16	1965-05-25	American Home Prod	Reduced benzodiazepinium compounds
US4584294A (en) *	1984-11-07	1986-04-22	Merck & Co., Inc.	Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
CA1337654C (en) *	1986-06-13	1995-11-28	Gary A. Flynn	Fused tricyclic lactams as antihypertensive agents

1987
- 1987-12-30 US US07/139,485 patent/US4824832A/en not_active Expired - Lifetime
1988
- 1988-12-21 AU AU27368/88A patent/AU611984B2/en not_active Ceased
- 1988-12-21 NZ NZ227432A patent/NZ227432A/en unknown
- 1988-12-21 ZA ZA889542A patent/ZA889542B/xx unknown
- 1988-12-21 CA CA000586691A patent/CA1336191C/en not_active Expired - Lifetime
- 1988-12-22 HU HU895880A patent/HU204050B/hu not_active IP Right Cessation
- 1988-12-22 HU HU886576A patent/HU200181B/hu not_active IP Right Cessation
- 1988-12-23 JP JP63323844A patent/JP2681291B2/ja not_active Expired - Lifetime
- 1988-12-27 IL IL88810A patent/IL88810A/xx unknown
- 1988-12-27 PT PT89346A patent/PT89346B/pt not_active IP Right Cessation
- 1988-12-28 DK DK725988A patent/DK725988A/da not_active Application Discontinuation
- 1988-12-28 FI FI886005A patent/FI886005A7/fi not_active Application Discontinuation
- 1988-12-28 KR KR1019880017625A patent/KR0128158B1/ko not_active Expired - Fee Related
- 1988-12-29 ES ES88121850T patent/ES2061621T3/es not_active Expired - Lifetime
- 1988-12-29 CN CN88105629A patent/CN1034721A/zh active Pending
- 1988-12-29 DE DE88121850T patent/DE3887307T2/de not_active Expired - Lifetime
- 1988-12-29 EP EP88121850A patent/EP0322914B1/en not_active Expired - Lifetime
- 1988-12-29 AT AT88121850T patent/ATE100453T1/de not_active IP Right Cessation
- 1988-12-29 NO NO88885812A patent/NO885812L/no unknown

Also Published As

Publication number	Publication date
JP2681291B2 (ja)	1997-11-26
NO885812D0 (no)	1988-12-29
HU895880D0 (en)	1990-02-28
US4824832A (en)	1989-04-25
JPH01203382A (ja)	1989-08-16
AU2736888A (en)	1989-07-06
DE3887307D1 (de)	1994-03-03
KR890009927A (ko)	1989-08-04
DK725988D0 (da)	1988-12-28
NZ227432A (en)	1990-11-27
ATE100453T1 (de)	1994-02-15
IL88810A (en)	1993-08-18
IL88810A0 (en)	1989-07-31
KR0128158B1 (ko)	1998-04-04
PT89346B (pt)	1993-08-31
ES2061621T3 (es)	1994-12-16
CA1336191C (en)	1995-07-04
HUT49137A (en)	1989-08-28
AU611984B2 (en)	1991-06-27
HU200181B (en)	1990-04-28
EP0322914A2 (en)	1989-07-05
DK725988A (da)	1989-07-01
EP0322914A3 (en)	1990-12-27
FI886005A7 (fi)	1989-07-01
ZA889542B (en)	1989-09-27
CN1034721A (zh)	1989-08-16
HU204050B (en)	1991-11-28
EP0322914B1 (en)	1994-01-19
DE3887307T2 (de)	1994-05-05
NO885812L (no)	1989-07-03

Legal Events

Date

Code

Title

Description

1993-08-31

FG3A

Patent granted, date of granting

Effective date: 19930209

1995-01-31

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19940831

Publication	Publication Date	Title
IL88810A0 (en)	1989-07-31	Sulfhydryl containing tricyclic lactams and pharmaceutical compositions containing same
TNSN87033A1 (fr)	1990-01-01	TOLUNITRILES SUBSTITUES PAR DESα - HETEROCYCLES
FI901530A0 (fi)	1990-03-27	Menetelmä immunomoduloivien atsaspiraanien valmistamiseksi
PT80986A (en)	1985-09-01	Process for the preparation of (used) benz (thio) amides and ofpharmaceutical compositions containing the same
NO905608L (no)	1991-07-01	Fremgangsmaate for fremstilling av a-nor-steroid-3-karboksylsyrederivater.
ATE25525T1 (de)	1987-03-15	N-glycosylierte carbonsaeureamid-derivate, verfahren zu ihrer herstellung sowie ihre verwendung zur beeinflussung der koerpereigenen abwehr.
PT92714A (pt)	1990-06-29	Processo de preparacao de compostos de quinoxalina e de composicoes farmaceuticas que os contem
PT82032B (pt)	1988-07-01	Processo para a preparacao de derivados de aminoacidos com accao anticonvulsiva e de composicoes farmaceuticas que os contem
NZ218170A (en)	1990-07-26	Piperidine derivatives and pharmaceutical compositions
PT91555A (pt)	1990-03-08	Processo de preparacao de derivados de dibenzo{2,3:6,7}-(oxepino ou tiepino){4,5-c}(piridina ou pirrol)e de composicoes farmaceuticas que os contem
ATE36319T1 (de)	1988-08-15	Verfahren zur herstellung von pyrrolidonderivaten.
ATE59295T1 (de)	1991-01-15	Prazosin-pirbuterol-mischung zur bronchendilatation.
BG102255A (en)	1998-12-30	Carbamoylcarboxy acid amides
PT90719A (pt)	1989-12-29	Processo de preparacao de 2-etenil-3,4,5,6-tetra-hidrotieno{4,3,2-ef}{3} benzazepinas substituidas e de composicoes farmaceuticas que as contem
NO165200C (no)	1991-01-16	Fremgangsmaate for fremstilling av arfamenin ved dyrking av mikroorganismestammen chromobacterium violaceum bmg 361-cf4.
PT99331B (pt)	2000-08-31	Processo para a preparacao de 3-difenilmetoxi-8-azabiciclo{3.2.1}octilalquil-tiazolidinomas e de composicoes farmaceuticas que as contem
DE3750117D1 (de)	1994-07-28	Verfahren zur Herstellung von Indolinon-2-Derivaten.
ES2183476T3 (es)	2003-03-16	Procedimiento de preparacion del acido 3-isoxazol-carboxilico.
PT90717A (pt)	1989-12-29	Processo de preparacao de 3,4,5,6-tetra-hidrofuro {4,3,2,ef}{3}benzazepinas substituidas e de composicoes farmaceuticas que as contem
ES8802496A1 (es)	1988-07-01	Procedimiento para preparar dihidropiridinas
DE3660959D1 (de)	1988-11-24	Benz-trisubstituted 2-aminotetralins
PT81771B (pt)	1987-11-11	Processo para a preparacao de novas aminas alilicas, e de composicoes farmaceuticas que as contem
ES2036561T3 (es)	1993-06-01	Un procedimiento para preparar un grupo de compuestos que son acidos 4-hidroxi-4-(alquenil sustituido)ciclohexanocarboxilicos.
LU88449I2 (fr)	1994-09-09	Fleroxacine et ses dérivés pharmaceutiquement acceptables.