ES2061621T3 - Nuevas lactamas triciclicas que contienen sulfhidrilo y sus metodos farmacologicos de uso. - Google Patents

Nuevas lactamas triciclicas que contienen sulfhidrilo y sus metodos farmacologicos de uso.

Info

Publication number
ES2061621T3
ES2061621T3 ES88121850T ES88121850T ES2061621T3 ES 2061621 T3 ES2061621 T3 ES 2061621T3 ES 88121850 T ES88121850 T ES 88121850T ES 88121850 T ES88121850 T ES 88121850T ES 2061621 T3 ES2061621 T3 ES 2061621T3
Authority
ES
Spain
Prior art keywords
sulfhidrile
pharmacological methods
lactams containing
new tricyclic
tricyclic lactams
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88121850T
Other languages
English (en)
Inventor
Gary A Flynn
Douglas W Beight
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2061621T3 publication Critical patent/ES2061621T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

ESTA INVENCION SE REFIERE A LACTAMA TRICICLICA CONTENIENDO S DE DONFORMACION RIGIDA, A LOS INTERMEDIARIOS Y PROCESOS UTILES PARA SU PREPARACIOM Y A SUS EFECTOS FARMACOLOGICOS EN LA INHIBICION DE ENZIMA CONVERTIDORA DE ANGIOTENSINA, AL TRATAR EL DAÑO POR REPERFUSION Y AL TRATAR ALTERACIONES CARDIACAS
ES88121850T 1987-12-30 1988-12-29 Nuevas lactamas triciclicas que contienen sulfhidrilo y sus metodos farmacologicos de uso. Expired - Lifetime ES2061621T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/139,485 US4824832A (en) 1987-12-30 1987-12-30 Sulfhydryl containing tricyclic lactams and their pharmacological methods of use

Publications (1)

Publication Number Publication Date
ES2061621T3 true ES2061621T3 (es) 1994-12-16

Family

ID=22486887

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88121850T Expired - Lifetime ES2061621T3 (es) 1987-12-30 1988-12-29 Nuevas lactamas triciclicas que contienen sulfhidrilo y sus metodos farmacologicos de uso.

Country Status (18)

Country Link
US (1) US4824832A (es)
EP (1) EP0322914B1 (es)
JP (1) JP2681291B2 (es)
KR (1) KR0128158B1 (es)
CN (1) CN1034721A (es)
AT (1) ATE100453T1 (es)
AU (1) AU611984B2 (es)
CA (1) CA1336191C (es)
DE (1) DE3887307T2 (es)
DK (1) DK725988A (es)
ES (1) ES2061621T3 (es)
FI (1) FI886005A7 (es)
HU (2) HU204050B (es)
IL (1) IL88810A (es)
NO (1) NO885812L (es)
NZ (1) NZ227432A (es)
PT (1) PT89346B (es)
ZA (1) ZA889542B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2053340C (en) * 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5308841A (en) * 1990-12-21 1994-05-03 Merrell Dow Pharmaceuticals Inc. Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
US5208230A (en) * 1990-12-21 1993-05-04 Merrell Dow Pharmaceuticals Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
ATE158303T1 (de) * 1990-12-21 1997-10-15 Merrell Pharma Inc Neue trizyklische amino- und nitro verbindungen mit ace-hemmenden eigenschaften
CA2078758C (en) * 1991-09-27 2003-12-09 Alan M. Warshawsky 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
ZA927211B (en) * 1991-09-27 1993-03-24 Merrell Dow Pharma Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE.
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
DE69317764T2 (de) * 1992-02-14 1998-07-30 Merrell Pharmaceuticals Inc., Cincinnati, Ohio Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
DK0640086T3 (da) * 1992-05-15 1999-12-06 Merrell Pharma Inc Mercaptoacetylamido-pyridazo[1,2-a][1,2]diazepin-derivateranvendelige som enkephalinase- og ACE-inhibitorer
US5238932A (en) * 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
US5420271A (en) * 1992-08-24 1995-05-30 Merrell Dow Pharmaceuticals, Inc. 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
PT669936E (pt) * 1992-10-30 2001-04-30 Merrell Pharma Inc Derivados de lactama biciclica de mercaptoacetilamida uteis como inibidores de encefalinase e de ace
US5654294A (en) * 1993-05-13 1997-08-05 Bristol-Myers Squibb Spiro lactam dual action inhibitors
US5362727A (en) * 1993-07-26 1994-11-08 Bristol-Myers Squibb Substituted azepino[2,1-a]isoquinoline compounds
US5525723A (en) * 1993-11-18 1996-06-11 Bristol-Myers Squibb Co. Compounds containing a fused multiple ring lactam
CN1041627C (zh) * 1993-11-19 1999-01-13 默里尔药物公司 (s)－2,2,2－三氯－n－(2－氯环己－2－烯基)－乙酰胺和(s)－2－氯环己－2－烯胺
CA2183313C (en) * 1994-02-14 2001-01-02 Gary A. Flynn Novel indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase
JPH09508906A (ja) * 1994-02-14 1997-09-09 メレル ファーマスーティカルズ インコーポレーテッド エンケファリナーゼ及びａｃｅの阻害剤として有用な新規なメルカプトアセチルアミド１，３，４，５−テトラヒドロベンゾ［ｃ］アゼピン−３−オンジスルフィド誘導体類
WO1995021839A1 (en) * 1994-02-14 1995-08-17 Merrell Pharmaceuticals Inc. Novel mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
CA2183314C (en) * 1994-02-14 1999-08-31 Gary A. Flynn Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
NZ282568A (en) * 1994-03-24 1997-07-27 Merrell Pharma Inc Use of condensed aminoacetylmercaptobenzazepines in treating elevated cholesterol levels, atherosclerosis, and hypotriglyceridemia
FI963784A0 (fi) * 1994-03-24 1996-09-23 Merrell Pharma Inc Hypokolesteroleemisiä, antiateroskleroottisia ja hypotriglyserideemisiä merkaptoasetyyliamididisulfidijohdannaisia
DK0800527T3 (da) * 1994-12-21 2000-06-05 Aventis Pharma Inc Nye fremgangsmåder til fremstilling af mellemprodukter for inhibitorer af enkephalinase og angiotensinomdannende enzym og m
US5641880A (en) * 1994-12-21 1997-06-24 Hoechst Marion Roussel, Inc. Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en) 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
US20030229007A1 (en) * 2002-05-30 2003-12-11 Roberto Levi Form of human renin and its use as a target in treatments for cardiac ischemia and arrhythmia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3185680A (en) * 1962-10-16 1965-05-25 American Home Prod Reduced benzodiazepinium compounds
US4584294A (en) * 1984-11-07 1986-04-22 Merck & Co., Inc. Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
CA1337654C (en) * 1986-06-13 1995-11-28 Gary A. Flynn Fused tricyclic lactams as antihypertensive agents

Also Published As

Publication number Publication date
ATE100453T1 (de) 1994-02-15
EP0322914A2 (en) 1989-07-05
JPH01203382A (ja) 1989-08-16
NZ227432A (en) 1990-11-27
HUT49137A (en) 1989-08-28
CN1034721A (zh) 1989-08-16
KR0128158B1 (ko) 1998-04-04
HU204050B (en) 1991-11-28
EP0322914B1 (en) 1994-01-19
NO885812L (no) 1989-07-03
IL88810A (en) 1993-08-18
PT89346B (pt) 1993-08-31
DE3887307T2 (de) 1994-05-05
NO885812D0 (no) 1988-12-29
AU2736888A (en) 1989-07-06
ZA889542B (en) 1989-09-27
EP0322914A3 (en) 1990-12-27
FI886005A7 (fi) 1989-07-01
US4824832A (en) 1989-04-25
KR890009927A (ko) 1989-08-04
DK725988A (da) 1989-07-01
DK725988D0 (da) 1988-12-28
PT89346A (pt) 1989-12-29
DE3887307D1 (de) 1994-03-03
CA1336191C (en) 1995-07-04
AU611984B2 (en) 1991-06-27
JP2681291B2 (ja) 1997-11-26
HU200181B (en) 1990-04-28
IL88810A0 (en) 1989-07-31
HU895880D0 (en) 1990-02-28

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