ATE151461T1 - Verfahren zur enzymatischen herstellung von 7- aminocephalosporinsäure - Google Patents

Verfahren zur enzymatischen herstellung von 7- aminocephalosporinsäure

Info

Publication number: ATE151461T1
Authority: AT; Austria
Prior art keywords: coli; beta; acylase; carboxybutanamido; sequence
Prior art date: 1990-08-03

Application number

AT91307108T

Other languages

English (en)

Inventor

Christian Croux

Perez Javier Costa

Fuentes Jose Luis Barredo

Maldonado Francisco Salto

Original Assignee

Antibioticos Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-08-03

Filing date

1991-08-02

Publication date

1997-04-15

1991-08-02 Application filed by Antibioticos Spa filed Critical Antibioticos Spa

1997-04-15 Application granted granted Critical

1997-04-15 Publication of ATE151461T1 publication Critical patent/ATE151461T1/de

Links

238000000034 method Methods 0.000 title abstract 3
239000002253 acid Substances 0.000 title 1
230000002255 enzymatic effect Effects 0.000 title 1
241000588724 Escherichia coli Species 0.000 abstract 8
239000013598 vector Substances 0.000 abstract 4
108010073038 Penicillin Amidase Proteins 0.000 abstract 3
108700023418 Amidases Proteins 0.000 abstract 2
108020004414 DNA Proteins 0.000 abstract 2
102000005922 amidase Human genes 0.000 abstract 2
IXUSDMGLUJZNFO-BXUZGUMPSA-N (7R)-7-(4-carboxybutanamido)cephalosporanic acid Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCCC(O)=O)[C@@H]12 IXUSDMGLUJZNFO-BXUZGUMPSA-N 0.000 abstract 1
HSHGZXNAXBPPDL-HZGVNTEJSA-N 7beta-aminocephalosporanic acid Chemical compound S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H]([NH3+])[C@@H]12 HSHGZXNAXBPPDL-HZGVNTEJSA-N 0.000 abstract 1
108090000204 Dipeptidase 1 Proteins 0.000 abstract 1
108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
102000006635 beta-lactamase Human genes 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1
238000010187 selection method Methods 0.000 abstract 1
239000000758 substrate Substances 0.000 abstract 1
230000001131 transforming effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)

AT91307108T 1990-08-03 1991-08-02 Verfahren zur enzymatischen herstellung von 7- aminocephalosporinsäure ATE151461T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ES9002109A ES2020792A6 (es)	1990-08-03	1990-08-03	Un procedimiento enzimatico para la presentacion de acido 7-amino-cefa-losporanico y un procedimiento para expresar la enzima 7b (4-carboxibutanamido) cefalosporinacilasa.

Publications (1)

Publication Number	Publication Date
ATE151461T1 true ATE151461T1 (de)	1997-04-15

Family

ID=8268451

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91307108T ATE151461T1 (de)	1990-08-03	1991-08-02	Verfahren zur enzymatischen herstellung von 7- aminocephalosporinsäure

Country Status (8)

Country	Link
US (1)	US5354667A (de)
EP (1)	EP0469919B1 (de)
JP (1)	JP3404406B2 (de)
AT (1)	ATE151461T1 (de)
DE (1)	DE69125541T2 (de)
DK (1)	DK0469919T3 (de)
ES (1)	ES2020792A6 (de)
GR (1)	GR3023866T3 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR0171897B1 (ko) *	1989-12-27	1999-02-01	후지사와 도모끼찌로	7-아미노세펨 화합물 또는 그 염류의 제조 방법
IT1269180B (it) *	1994-01-14	1997-03-21	Mini Ricerca Scient Tecnolog	Processo per la produzione dell'enzima acido 7beta- (4-carbossibutanamido)-cefalosporanico acilasi
DE4437420A1 (de) *	1994-10-19	1996-04-25	Hoechst Ag	Verbessertes, induktionsfreies Verfahren zur gentechnischen Herstellung von Glutarylamidase
ES2108652B1 (es) *	1996-04-19	1998-07-16	Antibioticos Sa	Un procedimiento para modificar la enzima 7/3-(4-carboxibutanamido) cefalosporinacilasa y purificarla en un solo paso cromatografico.
FR2780416B1 (fr) *	1998-06-10	2002-12-20	Rhone Poulenc Nutrition Animal	Procede industriel de production de proteines heterologues chez e. coli et souches utiles pour le procede
IT1312567B1 (it) *	1999-05-21	2002-04-22	Antibioticos Spa	Processo per la sintesi di derivati beta-lattamici.
ES2252302T3 (es)	2000-09-22	2006-05-16	Bristol-Myers Squibb Company	Amidasa de glutaril cefalosporina a partir de pseudomonas diminuta bs-203.
KR100530299B1 (ko)	2003-08-11	2005-11-22	산도즈 게엠베하	변이 세팔로스포린 ｃ 아실라제 및 이를 이용한 7-ａｃａ 제조방법
CN1912127B (zh) *	2005-08-08	2011-05-25	百瑞全球有限公司	一种大肠杆菌表达载体及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6121097A (ja) *	1984-07-10	1986-01-29	Asahi Chem Ind Co Ltd	７−アミノセフアロスポラン酸及びその誘導体の製造法
EP0322032A3 (de) *	1987-12-21	1991-01-30	Merck & Co. Inc.	Enzymatische Umwandlung von Cephalosporin C und Derivaten in 7-Aminocephalosporinsäure und Derivate in einem Schritt
JPH04504362A (ja) *	1989-04-04	1992-08-06	バイオピユア・コーポレーシヨン	酵素による７―アミノセフアロスポラン酸の製造

1990
- 1990-08-03 ES ES9002109A patent/ES2020792A6/es not_active Expired - Lifetime
1991
- 1991-08-02 DE DE69125541T patent/DE69125541T2/de not_active Expired - Fee Related
- 1991-08-02 DK DK91307108.0T patent/DK0469919T3/da active
- 1991-08-02 EP EP91307108A patent/EP0469919B1/de not_active Expired - Lifetime
- 1991-08-02 AT AT91307108T patent/ATE151461T1/de not_active IP Right Cessation
- 1991-08-02 JP JP28234391A patent/JP3404406B2/ja not_active Expired - Fee Related
- 1991-08-05 US US07/740,381 patent/US5354667A/en not_active Expired - Fee Related
1997
- 1997-06-24 GR GR970401509T patent/GR3023866T3/el unknown

Also Published As

Publication number	Publication date
ES2020792A6 (es)	1991-09-16
DE69125541T2 (de)	1997-11-13
EP0469919A2 (de)	1992-02-05
EP0469919B1 (de)	1997-04-09
US5354667A (en)	1994-10-11
DK0469919T3 (da)	1997-07-21
GR3023866T3 (en)	1997-09-30
EP0469919A3 (de)	1992-03-04
DE69125541D1 (de)	1997-05-15
JPH0690746A (ja)	1994-04-05
JP3404406B2 (ja)	2003-05-06

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Legal Events

Date	Code	Title	Description
1998-06-15	UEP	Publication of translation of european patent specification
2007-05-15	REN	Ceased due to non-payment of the annual fee