ATE175441T1 - Bmp-9 zusammensetzungen - Google Patents

Bmp-9 zusammensetzungen

Info

Publication number
ATE175441T1
ATE175441T1 AT92914973T AT92914973T ATE175441T1 AT E175441 T1 ATE175441 T1 AT E175441T1 AT 92914973 T AT92914973 T AT 92914973T AT 92914973 T AT92914973 T AT 92914973T AT E175441 T1 ATE175441 T1 AT E175441T1
Authority
AT
Austria
Prior art keywords
pct
bmp
proteins
sec
date
Prior art date
Application number
AT92914973T
Other languages
English (en)
Inventor
John M Wozney
Anthony J Celeste
Original Assignee
Genetics Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Inst filed Critical Genetics Inst
Application granted granted Critical
Publication of ATE175441T1 publication Critical patent/ATE175441T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/51Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Dental Preparations (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT92914973T 1991-06-25 1992-06-25 Bmp-9 zusammensetzungen ATE175441T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72059091A 1991-06-25 1991-06-25

Publications (1)

Publication Number Publication Date
ATE175441T1 true ATE175441T1 (de) 1999-01-15

Family

ID=24894572

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92914973T ATE175441T1 (de) 1991-06-25 1992-06-25 Bmp-9 zusammensetzungen

Country Status (11)

Country Link
US (1) US5661007A (de)
EP (1) EP0592562B1 (de)
JP (2) JP3485917B2 (de)
KR (1) KR100255415B1 (de)
AT (1) ATE175441T1 (de)
AU (1) AU652472B2 (de)
CA (1) CA2108770C (de)
DE (1) DE69228118T2 (de)
DK (1) DK0592562T3 (de)
ES (1) ES2127757T3 (de)
WO (1) WO1993000432A1 (de)

Families Citing this family (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE20004692U1 (de) 2000-03-14 2001-07-26 Sofamor Danek GmbH, 94469 Deggendorf Wirbelimplantat zum Einschrauben in einen Wirbelzwischenraum
US6150328A (en) * 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
CA2363965C (en) 1991-03-11 2010-05-18 Curis, Inc. Protein-induced morphogenesis
US6495513B1 (en) 1991-03-11 2002-12-17 Curis, Inc. Morphogen-enhanced survival and repair of neural cells
US5656593A (en) * 1991-03-11 1997-08-12 Creative Biomolecules, Inc. Morphogen induced periodontal tissue regeneration
US6287816B1 (en) * 1991-06-25 2001-09-11 Genetics Institute, Inc. BMP-9 compositions
WO1993009229A1 (en) 1991-11-04 1993-05-13 Genetics Institute, Inc. Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
JPH09501305A (ja) * 1993-05-12 1997-02-10 ジェネティックス・インスティテュート・インコーポレイテッド Bmp−10組成物
WO1994026892A1 (en) * 1993-05-12 1994-11-24 Genetics Institute, Inc. Bmp-11 compositions
US6333168B1 (en) * 1993-05-20 2001-12-25 The Trustees Of Columbia University In The City Of New York Cloning, expression and uses of dorsalin-1
EP1716864A1 (de) * 1993-08-26 2006-11-02 Genetics Institute, LLC Neuronale Regeneration mit menschlichen morphogenischen Knochenproteinen
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
US5399677A (en) * 1993-12-07 1995-03-21 Genetics Institute, Inc. Mutants of bone morphogenetic proteins
US6027919A (en) * 1993-12-07 2000-02-22 Genetics Institute, Inc. BMP-12 and BMP-13 proteins and DNA encoding them
AU689184B2 (en) 1993-12-07 1998-03-26 Genetics Institute, Llc BMP-12, BMP-13 and tendon-inducing compositions thereof
US5942496A (en) 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US6551618B2 (en) 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
US5906827A (en) * 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
US5846770A (en) * 1994-11-22 1998-12-08 Genetics Institute, Inc. DNA molecules encoding human chordin
US5645084A (en) * 1995-06-07 1997-07-08 Danek Medical, Inc. Method for spinal fusion without decortication
US5635372A (en) * 1995-05-18 1997-06-03 Genetics Institute, Inc. BMP-15 compositions
EP1364656B1 (de) 1995-06-05 2013-11-20 Genetics Institute, LLC Verwendung von Knochenmorphogeneseproteinen zur Heilung und Reparatur von Bindegewebebefestigung
US5902785A (en) * 1995-06-06 1999-05-11 Genetics Institute, Inc. Cartilage induction by bone morphogenetic proteins
EP0894004B2 (de) 1996-03-22 2007-02-21 Curis, Inc. Verfahren zur verbesserten funktionelle erholung der motorische koordiination, der sprache oder der sinneswahrnehmung nach trauma oder isch?mie des zns
US5700774A (en) * 1996-03-26 1997-12-23 Genetics Institute, Inc. Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
US6492508B1 (en) 1996-06-03 2002-12-10 United States Surgical Corp. A Division Of Tyco Healthcare Group Nucleic acids encoding extracellular matrix proteins
US5965403A (en) 1996-09-18 1999-10-12 Genetics Institute, Inc. Nucleic acids encoding bone morphogenic protein-16 (BMP-16)
US6037519A (en) * 1997-10-20 2000-03-14 Sdgi Holdings, Inc. Ceramic fusion implants and compositions
JP4388602B2 (ja) 1997-02-07 2009-12-24 ストライカー コーポレイション マトリクスを含まない骨形成デバイス、移植片、およびその使用方法
US6034062A (en) * 1997-03-13 2000-03-07 Genetics Institute, Inc. Bone morphogenetic protein (BMP)-9 compositions and their uses
US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
WO1998054572A1 (en) 1997-05-30 1998-12-03 Creative Biomolecules, Inc. Methods for evaluating tissue morphogenesis and activity
US5972368A (en) 1997-06-11 1999-10-26 Sdgi Holdings, Inc. Bone graft composites and spacers
US7923250B2 (en) 1997-07-30 2011-04-12 Warsaw Orthopedic, Inc. Methods of expressing LIM mineralization protein in non-osseous cells
ES2320603T3 (es) 1997-07-30 2009-05-25 Emory University Sistemas de expresion, vectores, adn, proteinas de mineralizacion osea novedosos.
US20020052026A1 (en) 1997-10-08 2002-05-02 Steven M. Vicik Methods of refolding proteins
US6391311B1 (en) 1998-03-17 2002-05-21 Genentech, Inc. Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1
US6511509B1 (en) 1997-10-20 2003-01-28 Lifenet Textured bone allograft, method of making and using same
US6027917A (en) 1997-12-10 2000-02-22 Genetics Institute, Inc. Bone morphogenetic protein (BMP)-17 and BMP-18 compositions
NZ525914A (en) 1998-03-10 2004-03-26 Genentech Inc Novel polypeptides and nucleic acids encoding the same
ATE405651T1 (de) * 1998-03-17 2008-09-15 Genentech Inc Zu vegf und bmp1 homologe polypeptide
US6211157B1 (en) 1998-05-01 2001-04-03 Sulzer Biologics, Inc. Protein mixtures to induce therapeutic angiogenesis
US7147839B2 (en) 1998-05-29 2006-12-12 Curis, Inc. Methods for evaluating tissue morphogenesis and activity
AU5341999A (en) 1998-08-06 2000-02-28 Sdgi Holdings, Inc. Composited intervertebral bone spacers
US6849255B2 (en) 1998-08-18 2005-02-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods and compositions for enhancing cartilage repair
US6992066B2 (en) 1998-10-16 2006-01-31 Zimmer Orthobiologics, Inc. Povidone-containing carriers for polypeptide growth factors
US7087577B2 (en) * 1998-10-16 2006-08-08 Zimmer Orthobiologies, Inc. Method of promoting natural bypass
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
DK1223990T3 (da) 1999-10-15 2004-11-29 Inst Genetics Llc Formuleringer af hyaluronsyre til tilförsel af osteogene proteiner
ES2278648T3 (es) 1999-12-06 2007-08-16 Warsaw Orthopedic, Inc. Dispositivo para tratar un disco intervertebral.
US20060078847A1 (en) * 2000-09-29 2006-04-13 Kwan Norman H Dental implant system and additional methods of attachment
US6752831B2 (en) 2000-12-08 2004-06-22 Osteotech, Inc. Biocompatible osteogenic band for repair of spinal disorders
US8758438B2 (en) 2000-12-08 2014-06-24 Warsaw Orthopedic, Inc. Implant for orthopedic applications
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
TW200526779A (en) 2001-02-08 2005-08-16 Wyeth Corp Modified and stabilized GDF propeptides and uses thereof
US7226587B2 (en) 2001-06-01 2007-06-05 Wyeth Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
US7232802B2 (en) * 2001-12-21 2007-06-19 Zimmer Orthobiologics, Inc. Compositions and methods for promoting myocardial and peripheral angiogenesis
CH695985A5 (de) * 2002-01-21 2006-11-15 Straumann Holding Ag Oberflächenmodifizierte Implantate.
US7241740B2 (en) 2002-08-13 2007-07-10 Wyeth Peptides as solubilizing excipients for transforming growth factor beta proteins
AU2003300076C1 (en) 2002-12-30 2010-03-04 Angiotech International Ag Drug delivery from rapid gelling polymer composition
JP5392981B2 (ja) 2003-09-12 2014-01-22 ワイス・エルエルシー 骨形成蛋白の送達のための注入可能なリン酸カルシウム固体ロッドおよびペースト
ATE478008T1 (de) 2004-03-10 2010-09-15 Scil Technology Gmbh Überzogene implantate, ihre herstellung und verwendung davon
EP1740609A2 (de) 2004-04-27 2007-01-10 Research Development Foundation Antagonismus des tgf-beta superfamily signal rezeptors
CA2567405A1 (en) 2004-05-25 2005-12-08 Stryker Corporation Use of morphogenic proteins for treating cartilage defects
US7749268B2 (en) 2004-05-26 2010-07-06 Warsaw Orthopedic, Inc. Methods for treating the spine
JP2008507288A (ja) 2004-07-23 2008-03-13 アクセルロン ファーマ インコーポレーテッド ActRII受容体ポリペプチド、方法、および組成物
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
WO2006081379A1 (en) * 2005-01-26 2006-08-03 Wyeth Use of sfrps as markers of bmp activity
EP1863518A2 (de) * 2005-03-30 2007-12-12 Wyeth VERFAHREN ZUR STIMULATION DES WAARWACHSTUMS MITTELS VERABREICHUNG VON BMPs
US8506646B2 (en) 2005-04-29 2013-08-13 Warsaw Orthopedic, Inc. Multi-purpose medical implant devices
ES2649983T3 (es) 2005-11-23 2018-01-16 Acceleron Pharma, Inc. Antagonistas de activina-ActRIIa en su uso para promover el crecimiento óseo
US8128933B2 (en) 2005-11-23 2012-03-06 Acceleron Pharma, Inc. Method of promoting bone growth by an anti-activin B antibody
US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
ES2443581T3 (es) 2006-02-09 2014-02-19 Biomimetic Therapeutics, Llc Composiciones y métodos para el tratamiento de hueso
CA2652549A1 (en) 2006-05-17 2007-12-13 Stryker Corporation Use of a soluble morphogenic protein complex for treating cartilage defects
AU2007269712B2 (en) 2006-06-30 2013-02-07 Biomimetic Therapeutics, Llc PDGF-biomatrix compositions and methods for treating rotator cuff injuries
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
US8524265B2 (en) 2006-08-17 2013-09-03 Warsaw Orthopedic, Inc. Medical implant sheets useful for tissue regeneration
US8895016B2 (en) 2006-12-18 2014-11-25 Acceleron Pharma, Inc. Antagonists of activin-actriia and uses for increasing red blood cell levels
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
MX2009008222A (es) 2007-02-01 2009-10-12 Acceleron Pharma Inc Antagonistas de activina-actriia y usos para tratar o prevenir cancer de mama.
TW201803890A (zh) 2007-02-02 2018-02-01 艾瑟勒朗法瑪公司 衍生自ActRIIB的變體與其用途
EA018221B1 (ru) 2007-02-09 2013-06-28 Акселерон Фарма Инк. АНТАГОНИСТЫ АКТИВИНА-ActRIIa И ПРИМЕНЕНИЕ ДЛЯ СТИМУЛЯЦИИ РОСТА КОСТИ У БОЛЬНЫХ РАКОМ
CN101861161B (zh) 2007-09-18 2017-04-19 阿塞勒隆制药公司 活化素‑actriia拮抗剂和减少或抑制fsh分泌的用途
US8216997B2 (en) 2008-08-14 2012-07-10 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
TW201803586A (zh) 2008-08-14 2018-02-01 艾瑟勒朗法瑪公司 使用gdf阱以增加紅血球水平
BR122020000059B8 (pt) 2008-09-09 2021-06-22 Biomimetic Therapeutics Inc composição que compreende uma matriz biocompatível e um fator de crescimento derivado de plaqueta e kit
AU2010204985A1 (en) 2009-01-13 2011-08-04 Acceleron Pharma Inc. Methods for increasing adiponectin
US8609127B2 (en) 2009-04-03 2013-12-17 Warsaw Orthopedic, Inc. Medical implant with bioactive material and method of making the medical implant
KR20120049214A (ko) 2009-06-08 2012-05-16 악셀레론 파마 인코포레이티드 발열성 지방세포를 증가시키는 방법
WO2010144696A1 (en) 2009-06-11 2010-12-16 Burnham Institute For Medical Research Directed differentiation of stem cells
KR20180026795A (ko) 2009-06-12 2018-03-13 악셀레론 파마 인코포레이티드 절두된 ActRIIB-FC 융합 단백질
US9399086B2 (en) 2009-07-24 2016-07-26 Warsaw Orthopedic, Inc Implantable medical devices
EP3332796A1 (de) 2009-11-17 2018-06-13 Acceleron Pharma Inc. Actriib-proteine und varianten davon sowie verwendungen davon zur utrophin-induktion für therapien gegen muskuläre dystrophie
BR112012020566B1 (pt) 2010-02-22 2021-09-21 Biomimetic Therapeutics, Llc Composição de fator de crescimento derivado de plaqueta
WO2011139594A2 (en) 2010-04-27 2011-11-10 Medtronic, Inc. Artificial bursa for intra-articular drug delivery
TW201138808A (en) 2010-05-03 2011-11-16 Bristol Myers Squibb Co Serum albumin binding molecules
WO2011156596A2 (en) 2010-06-09 2011-12-15 Semprus Biosciences Corp. Articles having non-fouling surfaces and processes for preparing the same including pretreatment of substrates
CA2799786A1 (en) 2010-06-09 2011-12-15 Semprus Biosciences Corp. Non-fouling, anti-microbial, anti-thrombogenic graft compositions
AU2011264834B2 (en) 2010-06-09 2015-03-12 Semprus Biosciences Corp. Non-fouling, anti-microbial, anti-thrombogenic graft-from compositions
WO2012024489A2 (en) 2010-08-18 2012-02-23 Emory University Compounds and compositions for ossification and methods related thereto
AU2011326586A1 (en) 2010-11-08 2013-05-30 Acceleron Pharma, Inc. ActRIIA binding agents and uses thereof
US8613938B2 (en) 2010-11-15 2013-12-24 Zimmer Orthobiologics, Inc. Bone void fillers
EP2678050B1 (de) 2011-02-24 2020-10-14 Emory University Noggin-blockierungszusammensetzungen für verknöcherungen und entsprechende verfahren
US11179500B2 (en) 2011-02-24 2021-11-23 Emory University JAB1 inhibitory compositions for ossification and methods related thereto
US8998925B2 (en) 2011-06-20 2015-04-07 Rdc Holdings, Llc Fixation system for orthopedic devices
WO2012177759A1 (en) 2011-06-20 2012-12-27 Rdc Holdings, Llc System and method for repairing joints
CA2859195C (en) 2011-12-14 2016-09-27 Semprus Biosciences Corp. Imbibing process for contact lens surface modification
US9120119B2 (en) 2011-12-14 2015-09-01 Semprus Biosciences Corporation Redox processes for contact lens modification
WO2013090790A1 (en) 2011-12-14 2013-06-20 Semprus Biosciences Corp. Silicone hydrogel contact lens modified using lanthanide or transition metal oxidants
US9000063B2 (en) 2011-12-14 2015-04-07 Semprus Biosciences Corporation Multistep UV process to create surface modified contact lenses
CA2858730C (en) 2011-12-14 2017-07-18 Semprus Biosciences Corp. Surface modified contact lenses
US9809636B2 (en) * 2012-04-06 2017-11-07 Acceleron Pharma Inc. Methods for increasing red blood cell levels comprising administering BMP9
WO2014012101A1 (en) 2012-07-13 2014-01-16 Trustees Of Tufts College Silk powder compaction for production of constructs with high mechanical strength and stiffness
US9833481B2 (en) * 2012-09-01 2017-12-05 Ken Muneoka Method for articular cartilage and joint formation
US10195249B2 (en) 2012-11-02 2019-02-05 Celgene Corporation Activin-ActRII antagonists and uses for treating bone and other disorders
US9572912B2 (en) 2013-04-19 2017-02-21 Theracell, Inc. Demineralized bone fibers having controlled geometry and shapes and methods thereof
CN114699529A (zh) 2014-06-13 2022-07-05 阿塞勒隆制药公司 用于治疗溃疡的方法和组合物
GB201412290D0 (en) * 2014-07-10 2014-08-27 Cambridge Entpr Ltd Novel use
MA41052A (fr) 2014-10-09 2017-08-15 Celgene Corp Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii
JP2016091701A (ja) 2014-10-31 2016-05-23 北川工業株式会社 コンタクト部材
JP2018501307A (ja) 2014-12-03 2018-01-18 セルジーン コーポレイション アクチビン−ActRIIアンタゴニスト及び貧血を治療するための使用
US10610366B2 (en) 2015-01-29 2020-04-07 Theracell, Inc. Demineralized bone fiber composition for use in minimally invasive surgery
EP3303387A2 (de) 2015-06-05 2018-04-11 Novartis AG Antikörper gegen knochenmorphogenetisches protein 9 (bmp9) und verfahren dafür
EP3834816A1 (de) 2015-06-17 2021-06-16 Warsaw Orthopedic, Inc. Implantate mit einem oxysterol und verfahren zur verwendung
EP3821880A1 (de) 2015-10-26 2021-05-19 President and Fellows of Harvard College Oxidierte polysaccharide und verfahren zur verwendung davon
US10688222B2 (en) 2016-11-21 2020-06-23 Warsaw Orthopedic, Inc. Lyophilized moldable implants containing an oxysterol
US10639157B2 (en) 2017-03-14 2020-05-05 Theracell, Inc. Demineralized bone fiber composition for use in minimally invasive surgery
US11464888B2 (en) 2017-06-12 2022-10-11 Warsaw Orthopedic, Inc. Moldable formulations containing an oxysterol in an acellular tissue matrix
AU2018313306B2 (en) 2017-08-11 2024-06-13 Arteriocyte Medical Systems, Inc. Demineralized bone fiber composition for augmentation of fixation
US11103618B2 (en) 2018-02-22 2021-08-31 Warsaw Orthopedic, Inc. Demineralized bone matrix having improved handling characteristics
US11660373B2 (en) 2019-02-09 2023-05-30 Tetrous, Inc. Demineralized bone fiber implant compositions and methods for rotator cuff and ACL repair
US11498880B2 (en) 2019-07-26 2022-11-15 Warsaw Orthopedic, Inc. Calcium phosphate granules and methods of making them

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4761471A (en) * 1980-08-04 1988-08-02 The Regents Of The University Of California Bone morphogenetic protein composition
US4294753A (en) * 1980-08-04 1981-10-13 The Regents Of The University Of California Bone morphogenetic protein process
US4789732A (en) * 1980-08-04 1988-12-06 Regents Of The University Of California Bone morphogenetic protein composition
US4619989A (en) * 1981-05-05 1986-10-28 The Regents Of The University Of Cal. Bone morphogenetic protein composition
US4455256A (en) * 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
US4434094A (en) * 1983-04-12 1984-02-28 Collagen Corporation Partially purified osteogenic factor and process for preparing same from demineralized bone
US4795804A (en) * 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
US4804744A (en) * 1984-01-04 1989-02-14 International Genetic Engineering, Inc. Osteogenic factors
US4608199A (en) * 1984-03-20 1986-08-26 Arnold Caplan Bone protein purification process
US4843063A (en) * 1984-07-16 1989-06-27 Collagen Corporation Polypeptide cartilage-inducing factors found in bone
US4627982A (en) * 1984-07-16 1986-12-09 Collagen Corporation Partially purified bone-inducing factor
EP0169016B2 (de) * 1984-07-16 2004-04-28 Celtrix Pharmaceuticals, Inc. Knorpel-induzierende Polypeptid-Faktoren aus Knochen
US4563350A (en) * 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
US4886747A (en) * 1985-03-22 1989-12-12 Genentech, Inc. Nucleic acid encoding TGF-β and its uses
US4681763A (en) * 1985-06-11 1987-07-21 University Of Medicine And Dentistry Of New Jersey Composition for stimulating bone growth
US4798885A (en) * 1986-02-07 1989-01-17 Genentech, Inc. Compositions of hormonally active human and porcine inhibin containing an α chain and 62 chain
US4737578A (en) * 1986-02-10 1988-04-12 The Salk Institute For Biological Studies Human inhibin
IL89869A0 (en) * 1988-04-06 1989-12-15 Collagen Corp Bone-inducing protein
US5108753A (en) * 1988-04-08 1992-04-28 Creative Biomolecules Osteogenic devices
US4968590A (en) * 1988-04-08 1990-11-06 Stryker Corporation Osteogenic proteins and polypeptides
US5011691A (en) * 1988-08-15 1991-04-30 Stryker Corporation Osteogenic devices
US5106626A (en) * 1988-10-11 1992-04-21 International Genetic Engineering, Inc. Osteogenic factors
DK0429570T3 (da) * 1989-03-28 1998-04-27 Genetics Inst Osteoinducerende præparater
CA2017466A1 (en) * 1989-06-02 1990-12-02 Michael C. Kiefer Bone calcification factor
CA2020729A1 (en) * 1989-07-19 1991-01-20 Michael C. Kiefer Bone morphogenetic protein
WO1991002744A1 (en) * 1989-08-21 1991-03-07 Celtrix Laboratories, Inc. Bone-specific protein
EP0416578B1 (de) * 1989-09-06 1996-07-31 Takeda Chemical Industries, Ltd. Protein, DNA und ihre Verwendung
WO1991005802A1 (en) * 1989-10-17 1991-05-02 Creative Biomolecules, Inc. Osteogenic devices
WO1991018098A1 (en) * 1990-05-16 1991-11-28 Genetics Institute, Inc. Bone and cartilage inductive proteins
US5168050A (en) * 1990-05-24 1992-12-01 Genentech, Inc. Mammalian expression of the bone morphogenetic protein-2b using bmp2a/bmp2b fusion
AU8941791A (en) * 1990-10-18 1992-05-20 Creative Biomolecules, Inc. Osteogenic protein
JPH07500487A (ja) * 1990-10-18 1995-01-19 ストライカー コーポレイション 骨形成ペプチド
JP3693338B2 (ja) * 1991-08-30 2005-09-07 キュリス インコーポレイテッド 組織形成因子誘導による炎症反応の調節
DE69233559T2 (de) * 1991-08-30 2006-08-31 Curis, Inc., Cambridge Osteogenische proteine in der behandlung von metabolischen knochenkrankheiten

Also Published As

Publication number Publication date
WO1993000432A1 (en) 1993-01-07
DK0592562T3 (da) 1999-08-30
KR100255415B1 (ko) 2000-05-01
ES2127757T3 (es) 1999-05-01
EP0592562A1 (de) 1994-04-20
CA2108770C (en) 2007-04-03
EP0592562B1 (de) 1999-01-07
JP2004002464A (ja) 2004-01-08
AU652472B2 (en) 1994-08-25
CA2108770A1 (en) 1992-12-26
DE69228118D1 (de) 1999-02-18
US5661007A (en) 1997-08-26
JP3485917B2 (ja) 2004-01-13
DE69228118T2 (de) 1999-08-19
JPH06508990A (ja) 1994-10-13
AU2269992A (en) 1993-01-25

Similar Documents

Publication Publication Date Title
DE69228118D1 (de) Bmp-9 zusammensetzungen
ATE223486T1 (de) Bmp-9 zusammensetzungen
ATE162223T1 (de) Osteoinduktive zusammensetzungen
DK0536186T3 (da) Knogle- og brusk-dannelsesfremkaldende proteiner
DE69233022D1 (de) Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung
ES2088006T3 (es) Composiciones farmaceuticas osteoinductivas.
DE69528475D1 (de) Verwendung von serotonin-antagonisten (5ht3) zur behandlung von fibromyalgie
ATE253589T1 (de) Bmp-5-derivate
NO962304L (no) BMP-12, BMP-13 og sene-induserende sammensetninger derav
DE69521620D1 (de) Verwendung von 9-deoxyprostaglandinderivaten zur behandlung von glaukom
ATE258984T1 (de) Bmp-11 zusammensetzungen
DE69532804D1 (de) Verwendung von hemmern des maillard-reaktion zur behandlung von krankheiten zufolge amyloidosis
EP0693928A4 (de) Aminozucker- und glykosaminoglykanzusammensetzung zur behandlung und reparatus von bindegewebe
PT1690874E (pt) Bmp-12, bmp-13 e suas composições indutoras de tendões
DE69526937D1 (de) Verwendung von methanbisphosphonsäurederivaten zur behandlung von aufgelockerten prothesen
DE69821793D1 (de) Neuronale verwendungen des bmp-11
DE60000501D1 (de) Verwendung von melanomhemmendem faktor zur reparatur von knorpelgewebe und knochen
ATE159937T1 (de) 1,4-disubstituierte piperazine zur behandlung von asthma und entzündungen der atemwege
DE59503194D1 (de) Verfahren zur herstellung von stärkeabbauprodukten
ATE255920T1 (de) Methoden und zusammensetzungen zur heilung und reparatur von gelenkknorpeln
DE69633392D1 (de) Verwendung von betalycan zur verminderung der narbenbildung
ATE200624T1 (de) Verwendung von 4'-iodo - 4 - deoxydoxorubicin zur behandlung von amyloidosis
DE59006159D1 (de) Verwendung von macrolactonen als antiallergica.
ATE211460T1 (de) Verfahren zur herstellung von substituierten anthrachinonen und deren verwendung zur herstellung von rheinen
SE9403861D0 (sv) Novel medicinal use

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEFA Change of the company name
REN Ceased due to non-payment of the annual fee