ATE199727T1 - Antithrombotisch wirkende azacycloalkyl-alkanoyl- peptide und-pseudopeptide - Google Patents

Antithrombotisch wirkende azacycloalkyl-alkanoyl- peptide und-pseudopeptide

Info

Publication number
ATE199727T1
ATE199727T1 AT95900403T AT95900403T ATE199727T1 AT E199727 T1 ATE199727 T1 AT E199727T1 AT 95900403 T AT95900403 T AT 95900403T AT 95900403 T AT95900403 T AT 95900403T AT E199727 T1 ATE199727 T1 AT E199727T1
Authority
AT
Austria
Prior art keywords
pct
pseudopeptides
date
peptides
azacycloalkyl
Prior art date
Application number
AT95900403T
Other languages
English (en)
Inventor
Scott I Klein
Bruce F Molino
Original Assignee
Rhone Poulenc Rorer Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Pharma filed Critical Rhone Poulenc Rorer Pharma
Application granted granted Critical
Publication of ATE199727T1 publication Critical patent/ATE199727T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT95900403T 1993-10-15 1994-10-17 Antithrombotisch wirkende azacycloalkyl-alkanoyl- peptide und-pseudopeptide ATE199727T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13882093A 1993-10-15 1993-10-15
PCT/US1994/012135 WO1995010295A1 (en) 1993-10-15 1994-10-17 Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides

Publications (1)

Publication Number Publication Date
ATE199727T1 true ATE199727T1 (de) 2001-03-15

Family

ID=22483811

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95900403T ATE199727T1 (de) 1993-10-15 1994-10-17 Antithrombotisch wirkende azacycloalkyl-alkanoyl- peptide und-pseudopeptide

Country Status (27)

Country Link
US (1) US5866685A (de)
EP (1) EP0812205B1 (de)
JP (1) JP3032297B2 (de)
KR (1) KR100304332B1 (de)
CN (1) CN1135717A (de)
AT (1) ATE199727T1 (de)
AU (1) AU703854B2 (de)
BG (1) BG63166B1 (de)
BR (1) BR9407839A (de)
CA (1) CA2174097C (de)
CZ (1) CZ291378B6 (de)
DE (1) DE69426897T2 (de)
DK (1) DK0812205T3 (de)
ES (1) ES2155122T3 (de)
FI (1) FI961634L (de)
GR (1) GR3035581T3 (de)
HU (1) HU222248B1 (de)
NO (1) NO961460L (de)
NZ (1) NZ275948A (de)
PL (1) PL181749B1 (de)
PT (1) PT812205E (de)
RO (1) RO115520B1 (de)
RU (1) RU2134695C1 (de)
SG (1) SG64919A1 (de)
SK (1) SK47796A3 (de)
UA (1) UA44258C2 (de)
WO (1) WO1995010295A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5780590A (en) * 1993-10-15 1998-07-14 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
US6274705B1 (en) * 1996-05-02 2001-08-14 Aventis Pharmaceuticals Products Inc. Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
US5866685A (en) * 1993-10-15 1999-02-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
AP9901462A0 (en) * 1996-08-21 1999-03-31 Aventis Pharmaceuticals Products Inc Stable non-hygroscopic crystalline form of N-[N-N-(4-(Piperidin-4-YL)Butanoyl)-N-Ethylglycyl] amide.
SI0946185T2 (sl) * 1996-11-27 2010-08-31 Aventis Pharma Inc Farmacevtski sestavek, ki obsega spojino z anti-Xa-aktivnostjo in antagonistično spojino za agregacijo ploščic
WO1999019294A1 (en) * 1997-05-14 1999-04-22 Aventis Pharmaceuticals Products Inc. Legal/Patents Process for the preparation of azacycloalkylalkanoyl pseudotetrapeptides
CN1278791A (zh) * 1997-10-10 2001-01-03 阿温蒂斯药物制品公司 制造氮杂环烷基烷酰基假四肽的方法
AU2844800A (en) * 1998-12-30 2000-07-24 Aventis Pharmaceuticals Products Inc. Process for preparing a stable non-hygroscopic crystalline n-(n-(n- piperdin- 4-yl)butanoyl)- n.ethylglycyl)- (l)-aspartyl) -ss-cyclohexylalanine amide
HUP0301986A2 (hu) * 2000-01-28 2003-09-29 Aventis Pharma Deutschland Gmbh. Eljárás acetil-amidinofenilalanil-ciklohexilglicil-piridinioalanin-amidok elżállítására, valamint kiindulási anyagok és köztitermékek
CN1229339C (zh) * 2000-03-27 2005-11-30 斯克里普斯研究学院 抑制血管生成和肿瘤生长的化合物，含有该化合物的药用制剂，以及该化合物的制药用途
CN101735307B (zh) * 2008-11-18 2012-05-30 北京航空航天大学 一种血小板膜糖蛋白寡肽或其修饰物/衍生物以及它们的应用
MX2014015197A (es) * 2012-06-11 2015-11-16 Cleveland Clinic Foundation Tratamiento y prevencion de la enfermedad cardiovascular y trombosis.

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683291A (en) * 1985-10-28 1987-07-28 Scripps Clinic And Research Foundation Platelet binding inhibitors
FR2608160B1 (fr) * 1986-12-15 1989-03-31 Inst Nat Sante Rech Med Nouveaux derives peptidiques et leur application notamment en therapeutique
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
US5037808A (en) * 1988-07-20 1991-08-06 Monsanto Co. Indolyl platelet-aggregation inhibitors
US4992463A (en) * 1988-07-20 1991-02-12 Monsanto Company Thienyl peptide mimetic compounds which are useful in inhibiting platelet aggregation
US4879313A (en) * 1988-07-20 1989-11-07 Mosanto Company Novel platelet-aggregation inhibitors
CA2008116C (en) * 1989-02-23 2001-11-20 Thomas Weller Glycine derivatives
US5023233A (en) * 1989-07-28 1991-06-11 Merck & Co., Inc. Fibrinogen receptor antagonists
EP0494248A4 (en) * 1989-09-29 1992-08-26 Rhone-Poulenc Rorer International (Holdings) Inc. Anti-thrombotic peptides and pseudopeptides
US5051405A (en) * 1989-10-10 1991-09-24 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-thrombotic peptides and pseudopeptides
US5064814A (en) * 1990-04-05 1991-11-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-thrombotic peptide and pseudopeptide derivatives
IL99539A0 (en) * 1990-09-27 1992-08-18 Merck & Co Inc Fibrinogen receptor antagonists and pharmaceutical compositions containing them
NZ239876A (en) * 1990-09-27 1993-12-23 Merck & Co Inc Glycyl-b-alanine derivatives and pharmaceutical compositions thereof.
EP0503203A1 (de) * 1991-03-15 1992-09-16 Merrell Dow Pharmaceuticals Inc. Neue Thrombin-Inhibitoren
WO1992018117A1 (en) * 1991-04-11 1992-10-29 Rhone-Poulenc Rorer International (Holdings), Inc. Anti-thrombotic peptide and pseudopeptide derivatives
SE9102462D0 (sv) * 1991-08-28 1991-08-28 Astra Ab New isosteric peptides
US5866685A (en) * 1993-10-15 1999-02-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides

Also Published As

Publication number Publication date
CN1135717A (zh) 1996-11-13
CZ291378B6 (cs) 2003-02-12
WO1995010295A1 (en) 1995-04-20
EP0812205A4 (de) 1999-03-31
JPH09507213A (ja) 1997-07-22
DK0812205T3 (da) 2001-04-17
CZ108496A3 (en) 1996-12-11
SG64919A1 (en) 1999-05-25
HU222248B1 (hu) 2003-05-28
ES2155122T3 (es) 2001-05-01
PL313975A1 (en) 1996-08-05
EP0812205B1 (de) 2001-03-14
JP3032297B2 (ja) 2000-04-10
HUT73856A (en) 1996-09-30
NO961460L (no) 1996-06-17
US5866685A (en) 1999-02-02
SK47796A3 (en) 1997-03-05
CA2174097A1 (en) 1995-04-20
DE69426897T2 (de) 2001-07-05
PT812205E (pt) 2001-08-30
DE69426897D1 (de) 2001-04-19
NO961460D0 (no) 1996-04-12
GR3035581T3 (en) 2001-06-29
RU2134695C1 (ru) 1999-08-20
HU9600983D0 (en) 1996-06-28
AU8123794A (en) 1995-05-04
CA2174097C (en) 2002-06-04
BR9407839A (pt) 1997-05-13
AU703854B2 (en) 1999-04-01
HK1006225A1 (en) 1999-02-19
FI961634A7 (fi) 1996-05-23
RO115520B1 (ro) 2000-03-30
UA44258C2 (uk) 2002-02-15
BG100544A (bg) 1996-11-29
BG63166B1 (bg) 2001-05-31
EP0812205A1 (de) 1997-12-17
FI961634A0 (fi) 1996-04-12
KR100304332B1 (ko) 2001-11-26
NZ275948A (en) 1997-02-24
FI961634L (fi) 1996-05-23
PL181749B1 (pl) 2001-09-28

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee