ATE223234T1 - Konjugate von methyltrithio-antitumormitteln und zwischenprodukte für deren herstellung - Google Patents

Konjugate von methyltrithio-antitumormitteln und zwischenprodukte für deren herstellung

Info

Publication number: ATE223234T1
Authority: AT; Austria
Prior art keywords: conjugates; carrier; methyltrithio; production; well
Prior art date: 1994-06-03

Application number

AT95303746T

Other languages

English (en)

Inventor

Philip Ross Hamann

Lois Hinman

Irwin Hollander

Ryan Holcomb

Hwei-Ru Tsou

William Hallett

Martin J Weiss

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-06-03

Filing date

1995-06-01

Publication date

2002-09-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22962074&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE223234(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-06-01 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

2002-09-15 Application granted granted Critical

2002-09-15 Publication of ATE223234T1 publication Critical patent/ATE223234T1/de

Links

239000002246 antineoplastic agent Substances 0.000 title 1
239000013067 intermediate product Substances 0.000 title 1
239000003242 anti bacterial agent Substances 0.000 abstract 2
230000000259 anti-tumor effect Effects 0.000 abstract 2
229940088710 antibiotic agent Drugs 0.000 abstract 2
229940079593 drug Drugs 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 2
229930189413 Esperamicin Natural products 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 abstract 1
229930195731 calicheamicin Natural products 0.000 abstract 1
239000000969 carrier Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002019 disulfides Chemical class 0.000 abstract 1
239000012634 fragment Substances 0.000 abstract 1
239000003102 growth factor Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
150000003431 steroids Chemical class 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
230000008685 targeting Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
- A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
Mycology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Saccharide Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Treatments Of Macromolecular Shaped Articles (AREA)

AT95303746T 1994-06-03 1995-06-01 Konjugate von methyltrithio-antitumormitteln und zwischenprodukte für deren herstellung ATE223234T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/253,877 US5773001A (en)	1994-06-03	1994-06-03	Conjugates of methyltrithio antitumor agents and intermediates for their synthesis

Publications (1)

Publication Number	Publication Date
ATE223234T1 true ATE223234T1 (de)	2002-09-15

Family

ID=22962074

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95303746T ATE223234T1 (de)	1994-06-03	1995-06-01	Konjugate von methyltrithio-antitumormitteln und zwischenprodukte für deren herstellung

Country Status (20)

Country	Link
US (4)	US5773001A (de)
EP (1)	EP0689845B1 (de)
JP (2)	JP3650165B2 (de)
KR (1)	KR100408376B1 (de)
AT (1)	ATE223234T1 (de)
AU (1)	AU697280B2 (de)
BR (2)	BR1100990A (de)
CA (1)	CA2150785C (de)
CY (1)	CY2334B1 (de)
DE (1)	DE69528016T2 (de)
DK (1)	DK0689845T3 (de)
ES (1)	ES2181752T3 (de)
FI (1)	FI117690B (de)
IL (1)	IL113984A (de)
NO (1)	NO313617B1 (de)
NZ (3)	NZ272274A (de)
PT (1)	PT689845E (de)
SI (1)	SI0689845T1 (de)
TW (1)	TW394778B (de)
ZA (1)	ZA954570B (de)

Families Citing this family (770)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5773001A (en) *	1994-06-03	1998-06-30	American Cyanamid Company	Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
US5714586A (en) *	1995-06-07	1998-02-03	American Cyanamid Company	Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
US5712374A (en) *	1995-06-07	1998-01-27	American Cyanamid Company	Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
WO1999039207A1 (en) *	1998-01-29	1999-08-05	Pharmacopeia, Inc.	Acid cleavable phenoxyalkyl linker for combinatorial synthesis
US6008321A (en) *	1998-03-16	1999-12-28	Pharmacopeia, Inc.	Universal linker for combinatorial synthesis
US6914130B2 (en) *	1998-06-17	2005-07-05	Genentech, Inc.	Compositions and methods for the diagnosis and treatment of tumor
US6733998B1 (en)	1998-12-07	2004-05-11	Sloan-Kettering Institute For Cancer Research	Micromonospora echinospora genes coding for biosynthesis of calicheamicin and self-resistance thereto
US20050159588A1 (en) *	1999-06-02	2005-07-21	Genentech, Inc.	Compositions and methods for the diagnosis and treatment of tumor
CN100340575C (zh)	1999-06-25	2007-10-03	杰南技术公司	人源化抗ErbB2抗体及其在制备药物中的应用
US20060228364A1 (en) *	1999-12-24	2006-10-12	Genentech, Inc.	Serum albumin binding peptides for tumor targeting
US20050287153A1 (en) *	2002-06-28	2005-12-29	Genentech, Inc.	Serum albumin binding peptides for tumor targeting
US20040001827A1 (en) *	2002-06-28	2004-01-01	Dennis Mark S.	Serum albumin binding peptides for tumor targeting
EP1240337B1 (de) *	1999-12-24	2006-08-23	Genentech, Inc.	Verfahren und verbindungen zur verlängerung der halbwertzeiten bei der ausscheidung von biowirksamen verbindungen
JP2003520828A (ja) *	2000-01-27	2003-07-08	ジェネティクスインスティテュート，エルエルシー	Ｃｔｌａ４（ｃｄ１５２）に対する抗体、これを含む結合体、およびその使用
JP2003531588A (ja)	2000-04-11	2003-10-28	ジェネンテック・インコーポレーテッド	多価抗体とその用途
WO2002053761A2 (en)	2000-12-28	2002-07-11	Wyeth	Recombinant protective protein from $i(streptococcus pneumoniae)
US6652853B2 (en) *	2001-03-08	2003-11-25	Ludwig Institute For Cancer Research	Method for treating cancer using A33 specific antibodies and chemotherapeutic agents
NZ511705A (en) *	2001-05-14	2004-03-26	Horticulture & Food Res Inst	Methods and rapid immunoassay device for detecting progesterone and other steroids
US6989452B2 (en) *	2001-05-31	2006-01-24	Medarex, Inc.	Disulfide prodrugs and linkers and stabilizers useful therefor
US20070160576A1 (en)	2001-06-05	2007-07-12	Genentech, Inc.	IL-17A/F heterologous polypeptides and therapeutic uses thereof
US20050107595A1 (en) *	2001-06-20	2005-05-19	Genentech, Inc.	Compositions and methods for the diagnosis and treatment of tumor
US7803915B2 (en)	2001-06-20	2010-09-28	Genentech, Inc.	Antibody compositions for the diagnosis and treatment of tumor
PT2000545E (pt)	2001-06-20	2011-12-21	Genentech Inc	Composições e métodos para o diagnóstico e tratamento do tumor pulmonar
US20040086504A1 (en) *	2001-06-21	2004-05-06	Deepak Sampath	Cyr61 as a target for treatment and diagnosis of breast cancer
US20040235068A1 (en) *	2001-09-05	2004-11-25	Levinson Arthur D.	Methods for the identification of polypeptide antigens associated with disorders involving aberrant cell proliferation and compositions useful for the treatment of such disorders
DE60238143D1 (de) *	2001-09-18	2010-12-09	Genentech Inc	Zusammensetzungen und verfahren für die diagnose von tumoren
US20040023910A1 (en) *	2001-09-28	2004-02-05	Zhiming Zhang	Use of cyr61 in the treatment and diagnosis of human uterine leiomyomas
US20110045005A1 (en)	2001-10-19	2011-02-24	Craig Crowley	Compositions and methods for the treatment of tumor of hematopoietic origin
AU2002367318B2 (en)	2002-01-02	2007-07-12	Genentech, Inc.	Compositions and methods for the diagnosis and treatment of tumor
US20090042291A1 (en) *	2002-03-01	2009-02-12	Xencor, Inc.	Optimized Fc variants
US7662925B2 (en) *	2002-03-01	2010-02-16	Xencor, Inc.	Optimized Fc variants and methods for their generation
US20100311954A1 (en) *	2002-03-01	2010-12-09	Xencor, Inc.	Optimized Proteins that Target Ep-CAM
US20040132101A1 (en)	2002-09-27	2004-07-08	Xencor	Optimized Fc variants and methods for their generation
JP2005536190A (ja)	2002-04-16	2005-12-02	ジェネンテック・インコーポレーテッド	腫瘍の診断と治療のための組成物と方法
SG187991A1 (en)	2002-05-02	2013-03-28	Wyeth Corp	Calicheamicin derivative-carrier conjugates
WO2004008099A2 (en)	2002-07-15	2004-01-22	Genentech, Inc.	METHODS FOR IDENTIFYING TUMORS THAT ARE RESPONSIVE TO TREATMENT WITH ANTI-ErbB2 ANTIBODIES
EP1553975B8 (de)	2002-09-27	2023-04-12	Xencor, Inc.	Optimierte fc-varianten und herstellungsverfahren dafür
WO2004035537A2 (en)	2002-10-16	2004-04-29	Euro-Celtique S.A.	Antibodies that bind cell-associated ca 125/o772p and methods of use thereof
US20040152632A1 (en) *	2002-11-06	2004-08-05	Wyeth	Combination therapy for the treatment of acute leukemia and myelodysplastic syndrome
US8388955B2 (en) *	2003-03-03	2013-03-05	Xencor, Inc.	Fc variants
US20090010920A1 (en) *	2003-03-03	2009-01-08	Xencor, Inc.	Fc Variants Having Decreased Affinity for FcyRIIb
EP2784084B2 (de)	2003-07-08	2023-10-04	Novartis Pharma AG	Heterologe IL-17A/F-Polypeptide und deren therapeutische Verwendungen
CA2532965C (en)	2003-07-22	2013-05-14	Astex Therapeutics Limited	3, 4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators
EP1660519B1 (de) *	2003-07-29	2014-05-14	Immunomedics, Inc.	Konjugate von 2-[18F]Fluor-2-desoxy-D-glucose und einem Peptid-Molekül
AU2004261980A1 (en) *	2003-08-01	2005-02-10	Genentech, Inc.	Antibody CDR polypeptide sequences with restricted diversity
US8101720B2 (en) *	2004-10-21	2012-01-24	Xencor, Inc.	Immunoglobulin insertions, deletions and substitutions
US9714282B2 (en)	2003-09-26	2017-07-25	Xencor, Inc.	Optimized Fc variants and methods for their generation
US20050282168A1 (en) *	2003-09-29	2005-12-22	Wyeth	Cell surface molecules as markers and therapeutic agents against kidney cancers
EP2478912B1 (de)	2003-11-06	2016-08-31	Seattle Genetics, Inc.	Konjugate von Auristatin mit gegen HER2- oder CD22-gerichtete Antikörper und deren therapeutische Verwendung
DK2295073T3 (da)	2003-11-17	2014-07-28	Genentech Inc	Antistof mod cd22 til behandling af tumor af hæmatopoietisk oprindelse
PT1718677E (pt)	2003-12-19	2012-07-18	Genentech Inc	Fragmentos de anticorpo monovalentes úteis como agentes terapêuticos
AR048098A1 (es) *	2004-03-15	2006-03-29	Wyeth Corp	Conjugados de caliqueamicina
EP1740615B1 (de)	2004-03-31	2014-11-05	Genentech, Inc.	Humanisierte anti-tgf-beta-antikörper
WO2005101017A1 (en) *	2004-04-07	2005-10-27	Genentech, Inc.	Mass spectrometry of antibody conjugates
JP4806680B2 (ja) *	2004-05-19	2011-11-02	メダレックスインコーポレイテッド	自己犠牲リンカー及び薬剤複合体
US7691962B2 (en) *	2004-05-19	2010-04-06	Medarex, Inc.	Chemical linkers and conjugates thereof
NZ579482A (en)	2004-06-01	2011-02-25	Genentech Inc	Antibody drug conjugates and methods
EP2471813B1 (de)	2004-07-15	2014-12-31	Xencor, Inc.	Optimierte Fc-Varianten
SI1771474T1 (sl)	2004-07-20	2010-06-30	Genentech Inc	Inhibitorji angiopoetinu podobnega proteina kombinacije in njihova uporaba
MX2007001064A (es)	2004-07-26	2007-04-12	Genentech Inc	Metodos y composiciones para modular la activacion del factor de crecimiento de hepatocitos.
CA2486285C (en) *	2004-08-30	2017-03-07	Viktor S. Goldmakher	Immunoconjugates targeting syndecan-1 expressing cells and use thereof
WO2006026759A2 (en) *	2004-09-03	2006-03-09	Genentech, Inc.	Humanized anti-beta7 antagonists and uses therefor
SV2007002227A (es) *	2004-09-10	2007-03-20	Wyeth Corp	Anticuerpos anti-5t4 humanizados y conjugados anticuerpo anti-5t4/calicheamicina ref. 040000-0317637
DK1791565T3 (en)	2004-09-23	2016-08-01	Genentech Inc	Cysteingensplejsede antibodies and conjugates
MX2007003907A (es) *	2004-10-05	2007-05-21	Genentech Inc	Agentes terapeuticos con toxicidad reducida.
JO3000B1 (ar)	2004-10-20	2016-09-05	Genentech Inc	مركبات أجسام مضادة .
US8802820B2 (en) *	2004-11-12	2014-08-12	Xencor, Inc.	Fc variants with altered binding to FcRn
US20070135620A1 (en) *	2004-11-12	2007-06-14	Xencor, Inc.	Fc variants with altered binding to FcRn
AU2005304624B2 (en)	2004-11-12	2010-10-07	Xencor, Inc.	Fc variants with altered binding to FcRn
US8546543B2 (en)	2004-11-12	2013-10-01	Xencor, Inc.	Fc variants that extend antibody half-life
US8367805B2 (en)	2004-11-12	2013-02-05	Xencor, Inc.	Fc variants with altered binding to FcRn
JP4993645B2 (ja)	2004-12-01	2012-08-08	ジェネンテック，インコーポレイテッド	抗体薬剤結合体および方法
EP2230517A1 (de)	2005-01-07	2010-09-22	Diadexus, Inc.	OVR110-Antikörperzusammensetzungen und Verwendungsverfahren dafür
MX2007008781A (es)	2005-01-21	2007-09-11	Astex Therapeutics Ltd	Compuestos farmaceuticos.
CN102580084B (zh)	2005-01-21	2016-11-23	健泰科生物技术公司	Her抗体的固定剂量给药
RU2436575C2 (ru) *	2005-01-21	2011-12-20	Астекс Терапьютикс Лимитед	Соединения для использования в фармацевтике
US8404718B2 (en)	2005-01-21	2013-03-26	Astex Therapeutics Limited	Combinations of pyrazole kinase inhibitors
AR054425A1 (es)	2005-01-21	2007-06-27	Astex Therapeutics Ltd	Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico.
JP2008529556A (ja) *	2005-02-18	2008-08-07	メダレックス，インク．	前立腺特異的膜抗原（ｐｓｍａ）に対するヒトモノクローナル抗体
EP1850874B1 (de)	2005-02-23	2013-10-16	Genentech, Inc.	Verzögerung des krankheitsverlauf bei eierstockkrebspatienten durch pertuzumab
US20060204505A1 (en) *	2005-03-08	2006-09-14	Sliwkowski Mark X	Methods for identifying tumors responsive to treatment with HER dimerization inhibitors (HDIs)
EP1865981A2 (de)	2005-04-07	2007-12-19	Chiron Corporation	Cacna1e in der diagnose und nachweis von sowie als therapeutisches mittel gegen krebs
CA2604844A1 (en)	2005-04-07	2006-10-19	Novartis Vaccines And Diagnostics, Inc.	Cancer-related genes
US7714016B2 (en) *	2005-04-08	2010-05-11	Medarex, Inc.	Cytotoxic compounds and conjugates with cleavable substrates
WO2006132788A2 (en)	2005-06-06	2006-12-14	Genentech, Inc.	Transgenic models for different genes and their use for gene characterization
US20070003559A1 (en) *	2005-07-01	2007-01-04	Wyeth	Methods of determining pharmacokinetics of targeted therapies
WO2007008943A2 (en)	2005-07-08	2007-01-18	Xencor, Inc.	Optimized anti-ep-cam antibodies
EP1922410A2 (de)	2005-08-15	2008-05-21	Genentech, Inc.	Genunterbrechungen, zusammensetzungen und verfahren in verbindung damit
AU2006297126A1 (en)	2005-09-30	2007-04-12	Government Of The United States Of America, As Represented By The Secretary	Methods and compositions for modulating immune tolerance
WO2007041635A2 (en)	2005-10-03	2007-04-12	Xencor, Inc.	Fc variants with optimized fc receptor binding properties
RS52100B (sr)	2005-10-26	2012-06-30	Medarex, Inc.	Postupci i jedinjenja za pripremu analoga cc-1065
ES2577292T3 (es)	2005-11-07	2016-07-14	Genentech, Inc.	Polipéptidos de unión con secuencias hipervariables de VH/VL diversificadas y consenso
WO2007059404A2 (en)	2005-11-10	2007-05-24	Medarex, Inc.	Duocarmycin derivatives as novel cytotoxic compounds and conjugates
EP1962584A2 (de)	2005-11-21	2008-09-03	Genentech, Inc.	Neuartige genunterbrechung, dazugehörige zusammensetzungen und verfahren
CA2631327C (en) *	2005-12-02	2015-10-13	Genentech, Inc.	Her2 binding polypeptides and uses thereof
BRPI0619118A2 (pt)	2005-12-02	2011-09-13	Genentech Inc	composições e métodos para o tratamento de doenças e desordens associadas com a sinalização de citocina
EP1973951A2 (de) *	2005-12-02	2008-10-01	Genentech, Inc.	Bindende polypeptide mit eingeschränkten diversitätssequenzen
EP1957097A1 (de) *	2005-12-06	2008-08-20	Wyeth a Corporation of the State of Delaware	Interleukin-11-zusammensetzungen und anwendungsverfahren
CA2633887C (en)	2005-12-15	2015-12-22	Genentech, Inc.	Methods and compositions for targeting polyubiquitin
BRPI0706840A2 (pt)	2006-01-05	2011-04-05	Genentech Inc	anticorpos anti- ephb4 isolado polinucleotìdeo, vetor, célula hospedeira, método para produção de um anticorpo anti ephb4, método para produção de um imunoconjugado anti ephb4, método para a detecção de ephb4, método para diagnosticar um distúrbio composição, método para inibir a angiogênese, método para tratar um cáncer, tumor e/ou distúrbio da proliferação celular e uso de um anticorpo
EP2050335A1 (de)	2006-02-17	2009-04-22	Genentech, Inc.	Genunterbrechungen, dazugehörige Zusammensetzungen und Verfahren in Zusammenhang damit
AU2014202414B2 (en) *	2006-02-21	2016-06-02	Wyeth Llc	Processes for the convergent synthesis of calicheamicin derivatives
AU2012261705B2 (en) *	2006-02-21	2014-02-06	Wyeth Llc	Processes for the convergent synthesis of calicheamicin derivatives
TW200806685A (en) *	2006-02-21	2008-02-01	Wyeth Corp	Processes for the convergent synthesis of calicheamicin derivatives
EP1999269B1 (de)	2006-03-08	2014-12-10	Wake Forest University Health Sciences	Lösliches monomeres ephrin-a1
DK2368914T3 (en)	2006-03-10	2019-03-04	Wyeth Llc	Anti-5T4 antibodies and uses thereof
AR059851A1 (es)	2006-03-16	2008-04-30	Genentech Inc	Anticuerpos de la egfl7 y metodos de uso
RU2008141912A (ru)	2006-03-23	2010-04-27	Новартис АГ (CH)	Противоопухолевые лекарства на основе антител к клеточным антигенам
AU2007243946B2 (en)	2006-04-05	2012-11-29	Curis, Inc.	Method for using BOC/CDO to modulate hedgehog signaling
TW200813231A (en)	2006-04-13	2008-03-16	Novartis Vaccines & Diagnostic	Methods of treating, diagnosing or detecting cancer
CA2649387A1 (en)	2006-04-19	2008-03-27	Genentech, Inc.	Novel gene disruptions, compositions and methods relating thereto
WO2007134132A2 (en) *	2006-05-12	2007-11-22	Genentech, Inc.	Compositions and methods for the diagnosis and treatment of bladder and urinary tract tumors
EP2032606B1 (de)	2006-05-30	2013-11-27	Genentech, Inc.	Antikörper und immunkonjugate sowie ihre verwendungen
PL2383297T3 (pl)	2006-08-14	2013-06-28	Xencor Inc	Zoptymalizowane przeciwciała ukierunkowane na CD19
ES2372217T3 (es)	2006-09-12	2012-01-17	Genentech, Inc.	Procedimientos y composiciones para el diagnóstico y tratamiento del cáncer de pulmón utilizando el gen de pdgfra, kit o kdr como marcador genético.
EP2073807A1 (de)	2006-10-12	2009-07-01	Astex Therapeutics Limited	Pharmazeutische kombinationen
WO2008044041A1 (en)	2006-10-12	2008-04-17	Astex Therapeutics Limited	Pharmaceutical combinations
BRPI0717638A2 (pt)	2006-10-27	2013-11-12	Genentech Inc	Anticorpors e imunoconjugados e usos para os mesmos
JP5391073B2 (ja)	2006-11-27	2014-01-15	ディアデクサスインコーポレーテッド	Ｏｖｒ１１０抗体組成物および使用方法
TWI412367B (zh)	2006-12-28	2013-10-21	梅達雷克斯有限責任公司	化學鏈接劑與可裂解基質以及其之綴合物
MX2009008430A (es)	2007-02-09	2009-10-28	Genentech Inc	Anticuerpos anti-robo4 y sus usos.
AR065404A1 (es)	2007-02-21	2009-06-03	Medarex Inc	Conjugados farmaco-ligando, los que se unen a citotoxinas potentes, composicion farmaceutica que los contienen y su uso para retardar o detener el crecimiento de un tumor en un mamifero
SI2132573T1 (sl)	2007-03-02	2014-07-31	Genentech, Inc.	Napovedovanje odziva na inhibitor dimerizacije HER na osnovi nizke ekspresije HER3
EP2474556A3 (de)	2007-03-14	2012-10-17	Novartis AG	APCDD1-Inhibitoren zur Behandlung, Diagnose und Erkennung von Krebs
US7960139B2 (en)	2007-03-23	2011-06-14	Academia Sinica	Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
DK2155248T3 (en)	2007-04-12	2015-09-14	Brigham & Womens Hospital	Targeting abcb5 for cancer therapy
EP2176298B1 (de)	2007-05-30	2017-11-15	Xencor, Inc.	Verfahren und zusammensetzungen zur hemmung von cd32b-expressionszellen
PE20090321A1 (es)	2007-06-04	2009-04-20	Genentech Inc	Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
EP2176295B1 (de)	2007-07-16	2014-11-19	Genentech, Inc.	Humanisierte anti-cd79b-antikörper und immunkonjugate und anwendungsverfahren
PE20090943A1 (es)	2007-07-16	2009-08-05	Genentech Inc	Anticuerpos anti-cd79b e inmunoconjugados
KR101680906B1 (ko)	2007-09-26	2016-11-30	추가이 세이야쿠 가부시키가이샤	항체 정상영역 개변체
JP5695905B2 (ja)	2007-10-02	2015-04-08	ジェネンテック，インコーポレイテッド	Ｎｌｒｒ−１アンタゴニスト及びその使用
US20110033476A1 (en) *	2007-11-12	2011-02-10	Theraclone Sciences Inc.	Compositions and methods for the therapy and diagnosis of influenza
JP4932940B2 (ja)	2007-11-12	2012-05-16	セラクローンサイエンシーズ，インコーポレイテッド	インフルエンザの治療および診断のための組成物および方法
TWI468417B (zh)	2007-11-30	2015-01-11	Genentech Inc	抗－ｖｅｇｆ抗體
WO2009080832A1 (en) *	2007-12-26	2009-07-02	Biotest Ag	Methods and agents for improving targeting of cd138 expressing tumor cells
HRP20150279T1 (hr)	2007-12-26	2015-05-08	Xencor, Inc.	Fc inaäśice s promijenjenim vezanjem na fcrn
CN101965366B (zh) *	2007-12-26	2016-04-27	生物测试股份公司	靶向cd138的免疫缀合物及其应用
WO2009080831A1 (en) *	2007-12-26	2009-07-02	Biotest Ag	Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates
US9221914B2 (en)	2007-12-26	2015-12-29	Biotest Ag	Agents targeting CD138 and uses thereof
BRPI0907046A2 (pt)	2008-01-18	2015-07-28	Medimmune Llc	Anticorpo de cisteína engenheirada, ácido nucleico isolado, vetor, célula hospedeira, conjugado de anticorpo, composição farmacêutica, métodos de detecção de câncer, doenças ou distúrbios autoimunes, inflamatórios ou infecciosos em um indivíduo e de inibição de proliferação de uma célula alvo
TWI472339B (zh)	2008-01-30	2015-02-11	Genentech Inc	包含結合至ｈｅｒ２結構域ii之抗體及其酸性變異體的組合物
KR101607346B1 (ko)	2008-01-31	2016-03-29	제넨테크, 인크.	항-ｃｄ７９ｂ 항체 및 면역접합체 및 사용 방법
US12492253B1 (en)	2008-02-25	2025-12-09	Xencor, Inc.	Anti-human C5 antibodies
AU2009223688B2 (en) *	2008-03-10	2014-12-11	Theraclone Sciences, Inc.	Compositions and methods for the therapy and diagnosis of cytomegalovirus infections
BRPI0906261A2 (pt) *	2008-03-31	2015-07-07	Genentech Inc	"métodos de diagnóstico de um subtipo de asma em uma amostra de paciente, usos de um agente terapêutico e kits de diagnóstico de um subtipo de asma em uma amostra de paciente"
SG10202112838YA (en)	2008-04-09	2021-12-30	Genentech Inc	Novel compositions and methods for the treatment of immune related diseases
KR101361905B1 (ko) *	2008-05-16	2014-02-21	제넨테크, 인크.	베타7 인테그린 길항제를 이용한 위장관 염증 장애의 치료를 평가하기 위한 바이오마커의 용도
ES2442024T3 (es)	2008-07-15	2014-02-07	Academia Sinica	Matrices de glucano sobre portaobjetos de vidrio revestidos con aluminio de tipo PTFE y métodos relacionados
EP2323679A4 (de)	2008-07-25	2012-08-22	Univ Colorado	Clip-hemmer und verfahren zur modulierung der immunfunktion
AR073717A1 (es)	2008-10-01	2010-11-24	Genentech Inc	Anticuerpos anti-notch2 de murino y humano, y metodos de uso
KR20110101212A (ko)	2008-12-17	2011-09-15	제넨테크, 인크.	Ｃ형 간염 바이러스 조합 요법
KR101722961B1 (ko)	2009-02-11	2017-04-04	알부메딕스 에이/에스	알부민 변이체 및 접합체
SI3260136T1 (sl)	2009-03-17	2021-05-31	Theraclone Sciences, Inc.	Humani imunodeficientni virus (HIV)-nevtralizirajoča protitelesa
MY152068A (en)	2009-03-20	2014-08-15	Genentech Inc	Bispecific anti-her antibodies
MA33208B1 (fr)	2009-03-25	2012-04-02	Genentech Inc	Anticorps anti-fgfr3 et procédés d'utilisation de ceux-ci
NZ594343A (en)	2009-03-25	2013-10-25	Genentech Inc	Novel anti-alpha5beta1 antibodies and uses thereof
RU2587621C2 (ru)	2009-04-01	2016-06-20	Дженентек, Инк.	АНТИТЕЛА К FcRH5, ИХ ИММУНОКОНЪЮГАТЫ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
CA2756244A1 (en)	2009-04-02	2010-10-07	Roche Glycart Ag	Multispecific antibodies comprising full length antibodies and single chain fab fragments
PE20120835A1 (es)	2009-04-16	2012-07-23	Abbvie Biotherapeutics Inc	Anticuerpos anti-tnf-alfa y sus usos
WO2010121125A1 (en)	2009-04-17	2010-10-21	Wake Forest University Health Sciences	Il-13 receptor binding peptides
US8609101B2 (en) *	2009-04-23	2013-12-17	Theraclone Sciences, Inc.	Granulocyte-macrophage colony-stimulating factor (GM-CSF) neutralizing antibodies
EP2432803A2 (de)	2009-05-20	2012-03-28	Theraclone Sciences, Inc.	Zusammensetzungen und verfahren zur therapie und diagnose von grippe
MX2011012665A (es)	2009-06-04	2012-03-07	Novartis Ag	Metodos para identificacion de sitios para conjugacion de igg.
EP2443150B1 (de)	2009-06-17	2015-01-21	AbbVie Biotherapeutics Inc.	Anti-vegf-antikörper und anwendungen davon
EP2711018A1 (de)	2009-06-22	2014-03-26	MedImmune, LLC	Manipulierte Fc-Regionen für standortspezifische Konjugation
NZ597531A (en)	2009-07-31	2014-05-30	Genentech Inc	Inhibition of tumor metastasis using bv8- or g-csf-antagonists
CA2772715C (en)	2009-09-02	2019-03-26	Genentech, Inc.	Mutant smoothened and methods of using the same
WO2011028952A1 (en)	2009-09-02	2011-03-10	Xencor, Inc.	Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
EP2478013B1 (de)	2009-09-16	2018-10-24	F.Hoffmann-La Roche Ag	Coiled-coil- und/oder tether-haltige proteinkomplexe und verwendungen davon
CN102596922A (zh)	2009-10-06	2012-07-18	免疫基因公司	有效的缀合物和亲水性连接体
DK2488873T3 (en)	2009-10-16	2015-11-09	Novartis Ag	Biomarkers for pharmacodynamic tumor responses
MX2012002013A (es)	2009-10-19	2012-03-16	Genentech Inc	Moduladores de activador del factor de crecimiento de hepatocitos.
RU2559533C2 (ru)	2009-10-22	2015-08-10	Дженентек, Инк.	Антитела против гепсина и способы их применения
JP5819308B2 (ja)	2009-10-22	2015-11-24	ジェネンテック，インコーポレイテッド	マクロファージ刺激タンパク質のヘプシン活性化を調節するための方法及び組成物
WO2011056502A1 (en)	2009-10-26	2011-05-12	Genentech, Inc.	Bone morphogenetic protein receptor type ii compositions and methods of use
WO2011056497A1 (en)	2009-10-26	2011-05-12	Genentech, Inc.	Activin receptor type iib compositions and methods of use
WO2011056494A1 (en)	2009-10-26	2011-05-12	Genentech, Inc.	Activin receptor-like kinase-1 antagonist and vegfr3 antagonist combinations
CA2777825A1 (en)	2009-10-28	2011-05-19	Abbott Biotherapeutics Corp.	Anti-egfr antibodies and their uses
EP2493921B1 (de)	2009-10-30	2018-09-26	Albumedix Ltd	Albuminvarianten
EP2496601B1 (de)	2009-11-05	2017-06-07	F. Hoffmann-La Roche AG	Methoden und zusammensetzung zur sekretion heterologer polypeptide
PH12012500982A1 (en)	2009-11-30	2019-07-10	Genentech Inc	Antibodies for treating and diagnosing tumors expressing slc34a2 (tat211=seqid2)
US11377485B2 (en)	2009-12-02	2022-07-05	Academia Sinica	Methods for modifying human antibodies by glycan engineering
US10087236B2 (en)	2009-12-02	2018-10-02	Academia Sinica	Methods for modifying human antibodies by glycan engineering
CN102770456B (zh)	2009-12-04	2018-04-06	弗·哈夫曼-拉罗切有限公司	多特异性抗体、抗体类似物、组合物和方法
ES2722300T3 (es) *	2009-12-10	2019-08-09	Hoffmann La Roche	Anticuerpos que se unen preferentemente al dominio extracelular 4 de CSF1R y su uso
WO2011071577A1 (en)	2009-12-11	2011-06-16	Genentech, Inc.	Anti-vegf-c antibodies and methods using same
EP2513148B1 (de)	2009-12-16	2016-08-31	AbbVie Biotherapeutics Inc.	Anti-her2-antikörper und ihre verwendung
EP2516465B1 (de)	2009-12-23	2016-05-18	F.Hoffmann-La Roche Ag	Anti-bv8 antikörper und deren verwendungen
DK2516468T3 (en)	2009-12-23	2016-05-23	Synimmune Gmbh	ANTI-FLT3 ANTIBODIES AND METHODS FOR USING THESE
WO2011089211A1 (en)	2010-01-22	2011-07-28	Synimmune Gmbh	Anti-cd133 antibodies and methods of using the same
CN102844044B (zh)	2010-02-04	2016-10-26	摩尔弗泰克有限公司	氯毒素多肽和结合物及其应用
CN102844045A (zh)	2010-02-08	2012-12-26	艾更斯司股份有限公司	结合于161p2f10b蛋白的抗体药物偶联物(adc)
US9556249B2 (en)	2010-02-18	2017-01-31	Genentech, Inc.	Neuregulin antagonists and use thereof in treating cancer
MA34057B1 (fr)	2010-02-23	2013-03-05	Genentech Inc	Compositions et methodes pour le diagnostic et le traitement d'une tumeur
JP5989547B2 (ja)	2010-03-05	2016-09-07	エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト	ヒトｃｓｆ−１ｒに対する抗体及びその使用
US9169323B2 (en)	2010-03-05	2015-10-27	Hoffmann-La Roche Inc.	Antibodies against human CSF-1R
CN106432474A (zh)	2010-03-12	2017-02-22	艾伯维生物医疗股份有限公司	Ctla4蛋白和其用途
AR080795A1 (es)	2010-03-24	2012-05-09	Genentech Inc	Anticuerpos anti-lrp6 (proteina relacionada con el receptor ldl tipo 6)
TW201138821A (en)	2010-03-26	2011-11-16	Roche Glycart Ag	Bispecific antibodies
EP2556087A1 (de)	2010-04-09	2013-02-13	Novozymes Biopharma DK A/S	Albuminderivate und varianten
US10338069B2 (en)	2010-04-12	2019-07-02	Academia Sinica	Glycan arrays for high throughput screening of viruses
KR101860963B1 (ko)	2010-04-23	2018-05-24	제넨테크, 인크.	이종다량체 단백질의 생산
SG185027A1 (en)	2010-05-03	2012-11-29	Genentech Inc	Compositions and methods for the diagnosis and treatment of tumor
WO2011146568A1 (en)	2010-05-19	2011-11-24	Genentech, Inc.	Predicting response to a her inhibitor
NZ701208A (en)	2010-06-03	2016-05-27	Genentech Inc	Immuno-pet imaging of antibodies and immunoconjugates and uses thereof
CA2799540A1 (en)	2010-06-08	2011-12-15	Genentech, Inc.	Cysteine engineered antibodies and conjugates
RU2577986C2 (ru)	2010-06-18	2016-03-20	Дженентек, Инк.	Антитела против axl и способы их применения
WO2011161119A1 (en)	2010-06-22	2011-12-29	F. Hoffmann-La Roche Ag	Antibodies against insulin-like growth factor i receptor and uses thereof
WO2011161189A1 (en)	2010-06-24	2011-12-29	F. Hoffmann-La Roche Ag	Anti-hepsin antibodies and methods of use
AU2011283694B2 (en)	2010-07-29	2017-04-13	Xencor, Inc.	Antibodies with modified isoelectric points
KR20130045914A (ko)	2010-08-03	2013-05-06	에프. 호프만-라 로슈 아게	만성 림프구성 백혈병(cll) 생체지표
CA2807664A1 (en)	2010-08-12	2012-02-16	Theraclone Sciences, Inc.	Anti-hemagglutinin antibody compositions and methods of use thereof
CA2806021C (en)	2010-08-13	2019-05-21	Roche Glycart Ag	Anti-fap antibodies and methods of use
CA2808185A1 (en)	2010-08-13	2012-02-16	Genentech, Inc.	Antibodies to il-1.beta. and il-18, for treatment of disease
EP2603529A1 (de)	2010-08-13	2013-06-19	Roche Glycart AG	Anti-tenascin-c-a2-antikörper und verwendungsverfahren dafür
CN103068846B9 (zh)	2010-08-24	2016-09-28	弗·哈夫曼-拉罗切有限公司	包含二硫键稳定性Fv片段的双特异性抗体
MX2013002084A (es)	2010-08-31	2013-05-09	Genentech Inc	Biomarcadores y metodos de tratamiento.
PT3556396T (pt)	2010-08-31	2022-07-04	Scripps Research Inst	Anticorpos neutralizantes do vírus da imunodeficiência humana (vih)
CN103328511B (zh)	2010-09-10	2016-01-20	埃派斯进有限公司	抗-IL-1β抗体及其使用方法
MX347954B (es)	2010-09-29	2017-05-19	Agensys Inc	Conjugados de anticuerpo farmaco (adc) que enlazan a proteinas 191p4d12.
EP3828205A1 (de)	2010-10-01	2021-06-02	Oxford BioTherapeutics Ltd	Anti-ror1-antikörper
UA112062C2 (uk)	2010-10-04	2016-07-25	Бьорінгер Інгельхайм Інтернаціональ Гмбх	Cd33-зв'язувальний агент
DK2625197T3 (en)	2010-10-05	2016-10-03	Genentech Inc	Smoothened MUTANT AND METHODS OF USING THE SAME
WO2012064836A1 (en)	2010-11-10	2012-05-18	Genentech, Inc.	Methods and compositions for neural disease immunotherapy
EP2637692A4 (de)	2010-11-12	2014-09-10	Scott & White Healthcare	Antikörper gegen den endothelialen tumormarker 8
RU2578468C2 (ru)	2010-12-16	2016-03-27	Дженентек, Инк.	Способы диагностики и лечения, связанные с ингибированием th2
BR112013014527A2 (pt)	2010-12-20	2017-03-07	Genentech Inc	anticorpo isolado, ácido nucleico isolado, célula hospedeira, método para produzir um anticorpo, imunoconjugado, formulação farmacêutica, uso do imunoconjugado, método para tratamento de um indivíduo que tem um câncer positivo para mesotelina, para inibição de proliferação de uma célula positiva para mesotelina, para detecção de mesotelina humana em uma amostra biológica e para detectar um câncer positivo para mesotelina
CN103261230A (zh)	2010-12-22	2013-08-21	霍夫曼-拉罗奇有限公司	抗pcsk9抗体及使用方法
SG191153A1 (en)	2010-12-23	2013-07-31	Hoffmann La Roche	Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
JOP20210044A1 (ar)	2010-12-30	2017-06-16	Takeda Pharmaceuticals Co	الأجسام المضادة لـ cd38
WO2012092539A2 (en)	2010-12-31	2012-07-05	Takeda Pharmaceutical Company Limited	Antibodies to dll4 and uses thereof
US10689447B2 (en)	2011-02-04	2020-06-23	Genentech, Inc.	Fc variants and methods for their production
RU2018108836A (ru)	2011-02-04	2019-03-14	Дженентек, Инк.	ВАРИАНТЫ Fc И СПОСОБЫ ИХ ПОЛУЧЕНИЯ
EP2673297A2 (de)	2011-02-11	2013-12-18	Zyngenia, Inc.	Monovalente und multivalente multispezifische komplexe und verwendungen davon
WO2012112489A2 (en)	2011-02-14	2012-08-23	Theraclone Sciences, Inc.	Compositions and methods for the therapy and diagnosis of influenza
MX342810B (es)	2011-03-03	2016-10-13	Apexigen Inc	Anticuerpos del receptor anti-interleucina-6 (anti-il-6) y sus metodos de uso.
AU2012225246B2 (en)	2011-03-10	2016-01-21	Omeros Corporation	Generation of anti-FN14 monoclonal antibodies by ex-vivo accelerated antibody evolution
BR112013023576A2 (pt)	2011-03-15	2016-12-06	Theraclone Sciences Inc	composições e métodos para a terapia e diagnóstico de influenza
CN103561771B (zh)	2011-03-17	2019-01-04	伯明翰大学	重新定向的免疫治疗
ES2692268T5 (en)	2011-03-29	2025-02-26	Roche Glycart Ag	Antibody fc variants
CA2828890A1 (en)	2011-04-07	2012-10-11	Genentech, Inc.	Anti-fgfr4 antibodies and methods of use
RU2013150331A (ru)	2011-04-20	2015-05-27	Рош Гликарт Аг	СПОСОБ И УСТРОЙСТВА ДЛЯ рН-ЗАВИСИМОГО ПРОХОЖДЕНИЯ ГЕМАТОЭНЦЕФАЛИЧЕСКОГО БАРЬЕРА
ES2709654T3 (es)	2011-04-29	2019-04-17	Apexigen Inc	Anticuerpos anti-CD40 y métodos de uso
EA030462B1 (ru)	2011-05-16	2018-08-31	Дженентек, Инк.	Агонисты fgfr1 и способы их применения
EP2714738B1 (de)	2011-05-24	2018-10-10	Zyngenia, Inc.	Multivalente und monovalente multispezifische komplexe und ihre verwendungen
KR101972446B1 (ko)	2011-05-27	2019-04-25	글락소 그룹 리미티드	Ｂｃｍａ（ｃｄ２６９／ｔｎｆｒｓｆ１７）결합 단백질
WO2012171020A1 (en)	2011-06-10	2012-12-13	Mersana Therapeutics, Inc.	Protein-polymer-drug conjugates
WO2013003507A1 (en)	2011-06-27	2013-01-03	Morphotek, Inc.	Multifunctional agents
AR086823A1 (es)	2011-06-30	2014-01-22	Genentech Inc	Formulaciones de anticuerpo anti-c-met, metodos
WO2013022855A1 (en)	2011-08-05	2013-02-14	Xencor, Inc.	Antibodies with modified isoelectric points and immunofiltering
WO2013025446A2 (en)	2011-08-12	2013-02-21	Omeros Corporation	Anti-fzd10 monoclonal antibodies and methods for their use
MX2014001766A (es)	2011-08-17	2014-05-01	Genentech Inc	Anticuerpos de neuregulina y sus usos.
KR20140068877A (ko)	2011-08-17	2014-06-09	제넨테크, 인크.	불응성 종양에서의 혈관신생의 억제
JP6060162B2 (ja)	2011-08-23	2017-01-11	ロシュグリクアートアーゲー	２つのＦａｂフラグメントを含むＦｃ不含抗体および使用方法
WO2013026839A1 (en)	2011-08-23	2013-02-28	Roche Glycart Ag	Bispecific antibodies specific for t-cell activating antigens and a tumor antigen and methods of use
US8822651B2 (en)	2011-08-30	2014-09-02	Theraclone Sciences, Inc.	Human rhinovirus (HRV) antibodies
WO2013040433A1 (en)	2011-09-15	2013-03-21	Genentech, Inc.	Methods of promoting differentiation
SG11201400724SA (en)	2011-09-19	2014-04-28	Genentech Inc	Combination treatments comprising c-met antagonists and b-raf antagonists
JP6041882B2 (ja)	2011-09-23	2016-12-14	ロシュグリクアートアーゲー	二重特異性抗ｅｇｆｒ／抗ｉｇｆ−１ｒ抗体
US9663573B2 (en)	2011-10-05	2017-05-30	Genentech, Inc.	Methods of treating liver conditions using Notch2 antagonists
US12466897B2 (en)	2011-10-10	2025-11-11	Xencor, Inc.	Heterodimeric human IgG1 polypeptides with isoelectric point modifications
US10851178B2 (en)	2011-10-10	2020-12-01	Xencor, Inc.	Heterodimeric human IgG1 polypeptides with isoelectric point modifications
AU2012323287B2 (en)	2011-10-10	2018-02-01	Xencor, Inc.	A method for purifying antibodies
JP6134725B2 (ja)	2011-10-14	2017-05-24	ジェネンテック，インコーポレイテッド	Ｂａｃｅ１のペプチド阻害剤
BR112014008862A2 (pt)	2011-10-14	2018-08-07	Genentech Inc	anticorpo isolado que se liga à htra1, ácido nucleico isolado, célula hospedeira, imunoconjugado, formulação farmacêutica, métodos e usos
US9358250B2 (en)	2011-10-15	2016-06-07	Genentech, Inc.	Methods of using SCD1 antagonists
WO2013063312A1 (en)	2011-10-25	2013-05-02	Memorial Sloan-Kettering Cancer Center	Free psa antibodies as diagnostics, prognostics and therapeutics for prostate cancer
MX2014004991A (es)	2011-10-28	2014-05-22	Genentech Inc	Combinaciones terapeuticas y metodos para tratar el melanoma.
EP2785742B1 (de)	2011-11-02	2020-01-08	Apexigen, Inc.	Anti-kdr-antikörper und verwendungsverfahren dafür
EP2589609A1 (de)	2011-11-03	2013-05-08	Pierre Fabre Medicament	Antigenbindendes Protein und dessen Verwendung als Adressierungsprodukt bei der Behandlung von Krebs
EP2780364A2 (de)	2011-11-18	2014-09-24	Eleven Biotherapeutics, Inc.	Proteine mit verbesserter halbwertzeit und anderen eigenschaften
SG11201402485UA (en)	2011-11-21	2014-06-27	Genentech Inc	Purification of anti-c-met antibodies
KR20140100571A (ko)	2011-12-08	2014-08-14	바이오테스트 아게	Ｃｄ１３８을 타겟팅하는 면역접합체의 용도
RU2658603C2 (ru)	2011-12-15	2018-06-21	Ф.Хоффманн-Ля Рош Аг	Антитела против человеческого csf-1r и их применения
US20130195851A1 (en)	2011-12-23	2013-08-01	Genentech, Inc.	Articles of manufacture and methods for co-administration of antibodies
JP2015509091A (ja)	2012-01-09	2015-03-26	ザスクリプスリサーチインスティテュート	ヒト化抗体
CA2863224A1 (en)	2012-01-09	2013-07-18	The Scripps Research Institute	Ultralong complementarity determining regions and uses thereof
JP2015506944A (ja)	2012-01-18	2015-03-05	ジェネンテック，インコーポレイテッド	Ｆｇｆ１９修飾薬を使用する方法
US9200072B2 (en)	2012-01-18	2015-12-01	Genentech Inc.	Anti-LRP5 antibodies and methods of use
US9567642B2 (en)	2012-02-02	2017-02-14	Massachusetts Institute Of Technology	Methods and products related to targeted cancer therapy
CA2861124A1 (en)	2012-02-10	2013-08-15	Genentech, Inc.	Single-chain antibodies and other heteromultimers
KR102148303B1 (ko)	2012-02-11	2020-08-26	제넨테크, 인크.	R-스폰딘 전위 및 그의 사용 방법
MX360352B (es)	2012-02-15	2018-10-30	Hoffmann La Roche	Cromatografia de afinidad basada en receptores fc.
GB201203442D0 (en)	2012-02-28	2012-04-11	Univ Birmingham	Immunotherapeutic molecules and uses
DK2825556T3 (en)	2012-03-16	2018-04-16	Albumedix As	albumin Variants
US10024860B2 (en)	2012-03-28	2018-07-17	Massachusetts Institute Of Technology	Cancer-related extracellular matrix signatures and related methods and products
US9526800B2 (en)	2012-03-28	2016-12-27	Massachusetts Institute Of Technology	Cancer-related extracellular matrix signatures and related methods and products
AR090549A1 (es)	2012-03-30	2014-11-19	Genentech Inc	Anticuerpos anti-lgr5 e inmunoconjugados
US10130714B2 (en)	2012-04-14	2018-11-20	Academia Sinica	Enhanced anti-influenza agents conjugated with anti-inflammatory activity
US9056910B2 (en)	2012-05-01	2015-06-16	Genentech, Inc.	Anti-PMEL17 antibodies and immunoconjugates
WO2013170191A1 (en)	2012-05-11	2013-11-14	Genentech, Inc.	Methods of using antagonists of nad biosynthesis from nicotinamide
EP2861624A1 (de)	2012-06-15	2015-04-22	F. Hoffmann-La Roche AG	Anti-pcsk9-antikörper, formulierungen, dosierung und verfahren zur verwendung
WO2014001326A1 (en)	2012-06-27	2014-01-03	F. Hoffmann-La Roche Ag	Method for the selection and production of tailor-made, selective and multi-specific therapeutic molecules comprising at least two different targeting entities and uses thereof
KR20150030744A (ko)	2012-06-27	2015-03-20	에프. 호프만-라 로슈 아게	표적에 특이적으로 결합하는 하나 이상의 결합 단위를 포함하는 항체 Ｆｃ－영역 접합체의 제조 방법 및 그의 용도
RU2639287C2 (ru)	2012-06-27	2017-12-20	Ф. Хоффманн-Ля Рош Аг	Способ отбора и получения высокоселективных и мультиспецифичных нацеливающих групп с заданными свойствами, включающих по меньшей мере две различные связывающие группировки, и их применения
EP2870180B1 (de)	2012-07-04	2024-08-28	F. Hoffmann-La Roche AG	Anti-biotin-antikörper und verwendungsverfahren
DK2869837T3 (en)	2012-07-04	2016-09-26	Hoffmann La Roche	Anti-theophylline antibodies and methods of use
RU2684595C2 (ru)	2012-07-04	2019-04-09	Ф.Хоффманн-Ля Рош Аг	Ковалентно связанные конъюгаты антиген-антитело
SG11201408538PA (en)	2012-07-13	2015-02-27	Roche Glycart Ag	Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases
WO2014031498A1 (en)	2012-08-18	2014-02-27	Academia Sinica	Cell-permeable probes for identification and imaging of sialidases
TWI606063B (zh)	2012-08-23	2017-11-21	艾澤西公司	結合至１５８ｐ１ｄ７蛋白之抗體藥物結合物（ａｄｃ）
KR20150056788A (ko)	2012-09-19	2015-05-27	애브비 바이오테라퓨틱스 인크.	면역원성이 감소된 항체의 동정 방법
RU2015117393A (ru)	2012-10-08	2016-12-10	Роше Гликарт Аг	Лишенные fc антитела, содержащие два Fab-фрагмента, и способы их применения
ES2773710T3 (es)	2012-10-11	2020-07-14	Daiichi Sankyo Co Ltd	Enlazadores para conjugados de anticuerpo - fármaco
WO2014061277A1 (ja)	2012-10-19	2014-04-24	第一三共株式会社	親水性構造を含むリンカーで結合させた抗体－薬物コンジュゲート
US9365542B2 (en)	2012-10-26	2016-06-14	Memorial Sloan-Kettering Cancer Center	Modulators of resistant androgen receptor
KR102270618B1 (ko)	2012-10-30	2021-06-30	아펙시젠, 인코포레이티드	항-cd40 항체 및 사용 방법
WO2014068079A1 (en)	2012-11-01	2014-05-08	Max-Delbrück-Centrum für Molekulare Medizin	An antibody that binds cd269 (bcma) suitable for use in the treatment of plasma cell diseases such as multiple myeloma and autoimmune diseases
PL2914630T3 (pl)	2012-11-05	2021-09-06	Pierre Fabre Médicament	Nowe białka wiążące antygen i ich zastosowanie jako produktu ukierunkowanego do leczenia raka
MX2015005363A (es)	2012-11-08	2015-11-06	Novozymes Biopharma Dk As	Variantes de albumina.
MA38165A1 (fr)	2012-11-08	2018-07-31	Hoffmann La Roche	Protéines de liaison à l'antigène her3 se liant à l'épingle à cheveux beta de her3
CN104968367B (zh)	2012-11-13	2018-04-13	弗·哈夫曼-拉罗切有限公司	抗血凝素抗体和使用方法
CA2891280C (en)	2012-11-24	2018-03-20	Hangzhou Dac Biotech Co., Ltd.	Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
US20140154255A1 (en)	2012-11-30	2014-06-05	Abbvie Biotherapeutics Inc.	Anti-vegf antibodies and their uses
CA2892863C (en)	2012-12-10	2022-03-15	Mersana Therapeutics, Inc.	Polymeric scaffold based on phf for targeted drug delivery
WO2014093640A1 (en)	2012-12-12	2014-06-19	Mersana Therapeutics,Inc.	Hydroxy-polmer-drug-protein conjugates
WO2014107739A1 (en)	2013-01-07	2014-07-10	Eleven Biotherapeutics, Inc.	Antibodies against pcsk9
KR102211837B1 (ko)	2013-01-14	2021-02-03	젠코어 인코포레이티드	신규한 이형이량체 단백질
US10487155B2 (en)	2013-01-14	2019-11-26	Xencor, Inc.	Heterodimeric proteins
US9701759B2 (en)	2013-01-14	2017-07-11	Xencor, Inc.	Heterodimeric proteins
US9605084B2 (en)	2013-03-15	2017-03-28	Xencor, Inc.	Heterodimeric proteins
US11053316B2 (en)	2013-01-14	2021-07-06	Xencor, Inc.	Optimized antibody variable regions
US10131710B2 (en)	2013-01-14	2018-11-20	Xencor, Inc.	Optimized antibody variable regions
US10968276B2 (en)	2013-03-12	2021-04-06	Xencor, Inc.	Optimized anti-CD3 variable regions
WO2014113510A1 (en)	2013-01-15	2014-07-24	Xencor, Inc.	Rapid clearance of antigen complexes using novel antibodies
JP2016509045A (ja)	2013-02-22	2016-03-24	エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト	がんを治療し、薬剤耐性を防止する方法
US20140242083A1 (en)	2013-02-26	2014-08-28	Roche Glycart Ag	Anti-mcsp antibodies
MX2015011428A (es)	2013-03-06	2016-02-03	Genentech Inc	Metodos para tratar y prevenir la resistencia a los farmacos para el cancer.
JP6436965B2 (ja)	2013-03-14	2018-12-12	ジェネンテック，インコーポレイテッド	抗ｂ７−ｈ４抗体及びイムノコンジュゲート
JP2016516046A (ja)	2013-03-14	2016-06-02	ジェネンテック，インコーポレイテッド	がんの治療方法及びがん薬物耐性を阻止する方法
US9562099B2 (en)	2013-03-14	2017-02-07	Genentech, Inc.	Anti-B7-H4 antibodies and immunoconjugates
US10519242B2 (en)	2013-03-15	2019-12-31	Xencor, Inc.	Targeting regulatory T cells with heterodimeric proteins
EP2970486B1 (de)	2013-03-15	2018-05-16	Xencor, Inc.	Modulation von t-zellen mit bispezifischen antikörpern und fc-fusionen
US20140377253A1 (en)	2013-03-15	2014-12-25	Abbvie Biotherapeutics Inc.	Fc variants
SG11201507427QA (en)	2013-03-15	2015-10-29	Genentech Inc	Compositions and methods for diagnosis and treatment of hepatic cancers
US10106624B2 (en)	2013-03-15	2018-10-23	Xencor, Inc.	Heterodimeric proteins
US10150800B2 (en)	2013-03-15	2018-12-11	Zyngenia, Inc.	EGFR-binding modular recognition domains
BR112015023120A2 (pt)	2013-03-15	2017-11-21	Genentech Inc	método para identificar um indivíduo com uma doença ou disfunção, método para prever a responsividade de um indivíduo com uma doença ou disfunção, método para determinar a probabilidade de que um indivíduo com uma doença ou disfunção exibirá benefício do tratamento, método para selecionar uma terapia, usos de um antagonista de ligação do eixo pd-l1, ensaio para identificar um indivíduo com uma doença, kit de diagnóstico, método para avaliar uma resposta ao tratamento e método para monitorar a resposta de um indivíduo tratado
CA2905123A1 (en)	2013-03-15	2014-09-18	Genentech, Inc.	Methods of treating cancer and preventing cancer drug resistance
US10858417B2 (en)	2013-03-15	2020-12-08	Xencor, Inc.	Heterodimeric proteins
HK1220470A1 (zh)	2013-03-15	2017-05-05	Abbvie Biotechnology Ltd.	抗cd25抗体及其用途
JP6594855B2 (ja)	2013-03-15	2019-10-23	ゼンコアインコーポレイテッド	ヘテロ二量体タンパク質
MX2015012563A (es)	2013-03-15	2016-10-26	Abbvie Biotechnology Ltd	Anticuerpos anti-cd25 y sus usos.
WO2014150877A2 (en)	2013-03-15	2014-09-25	Ac Immune S.A.	Anti-tau antibodies and methods of use
KR20150131177A (ko)	2013-03-15	2015-11-24	제넨테크, 인크.	항-CRTh2 항체 및 그의 용도
AR095882A1 (es)	2013-04-22	2015-11-18	Hoffmann La Roche	Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9
WO2014177459A2 (en)	2013-04-29	2014-11-06	F. Hoffmann-La Roche Ag	Fc-receptor binding modified asymmetric antibodies and methods of use
WO2014179657A1 (en)	2013-05-03	2014-11-06	Eleven Biotherapeutics, Inc.	Albumin variants binding to fcrn
EP3594240B1 (de)	2013-05-20	2023-12-06	F. Hoffmann-La Roche AG	Anti-transferrin-rezeptor-antikörper und verfahren zur verwendung
EP3013365B1 (de)	2013-06-26	2019-06-05	Academia Sinica	Rm2-antigene und verwendung davon
EP3013347B1 (de)	2013-06-27	2019-12-11	Academia Sinica	Glykankonjugate und verwendung davon
WO2015017146A2 (en)	2013-07-18	2015-02-05	Fabrus, Inc.	Antibodies with ultralong complementarity determining regions
CA2918370A1 (en)	2013-07-18	2015-01-22	Fabrus, Inc.	Humanized antibodies with ultralong complementarity determining regions
WO2015017552A1 (en)	2013-08-01	2015-02-05	Agensys, Inc.	Antibody drug conjugates (adc) that bind to cd37 proteins
WO2015035044A2 (en)	2013-09-04	2015-03-12	Abbvie Biotherapeutics Inc.	Fc VARIANTS WITH IMPROVED ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY
JP6486368B2 (ja)	2013-09-06	2019-03-20	アカデミアシニカＡｃａｄｅｍｉａＳｉｎｉｃａ	改変されたグリコシル基を含む糖脂質を用いたヒトｉＮＫＴ細胞の活性化
AR097584A1 (es)	2013-09-12	2016-03-23	Hoffmann La Roche	Terapia de combinación de anticuerpos contra el csf-1r humano y anticuerpos contra el pd-l1 humano
JP2016537399A (ja)	2013-09-17	2016-12-01	ジェネンテック，インコーポレイテッド	抗ｌｇｒ５抗体を使用する方法
MX384984B (es)	2013-10-10	2025-03-14	Beth Israel Deaconess Medical Ct Inc	Proteinas de union del miembro 1 de la familia de transmembrana 4 l-seis (tm4sf1) y metodos de uso de las mismas.
KR102087850B1 (ko)	2013-10-11	2020-03-12	메르사나 테라퓨틱스, 인코포레이티드	단백질-고분자-약물 접합체
CN105745224B (zh)	2013-10-11	2019-11-05	牛津生物疗法有限公司	用于治疗癌症的针对ly75的偶联抗体
ES2754397T3 (es)	2013-10-11	2020-04-17	Asana Biosciences Llc	Conjugados de proteína-polímero-fármaco
BR112016008477A2 (pt)	2013-10-18	2017-10-03	Genentech Inc	Corpos, ácido nucleico, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica e usos do anticorpo
CN108047287B (zh) *	2013-11-04	2021-04-27	辉瑞大药厂	用于合成加利车霉素衍生物的中间体和方法
JP2016540826A (ja)	2013-11-04	2016-12-28	ファイザー・インク	抗ｅｆｎａ４抗体−薬物コンジュゲート
SG11201604784XA (en)	2013-12-13	2016-07-28	Genentech Inc	Anti-cd33 antibodies and immunoconjugates
WO2015095227A2 (en)	2013-12-16	2015-06-25	Genentech, Inc.	Peptidomimetic compounds and antibody-drug conjugates thereof
TWI670283B (zh)	2013-12-23	2019-09-01	美商建南德克公司	抗體及使用方法
US10113169B2 (en)	2013-12-23	2018-10-30	Memorial Sloan-Kettering Cancer Center	Methods and compositions for treating cancer using peptide nucleic acid-based agents
CN105899540B (zh)	2014-01-03	2020-02-07	豪夫迈·罗氏有限公司	双特异性抗-半抗原/抗-血脑屏障受体的抗体、其复合物及它们作为血脑屏障穿梭物的应用
EP3089758B1 (de)	2014-01-03	2021-01-27	F.Hoffmann-La Roche Ag	Kovalent verknüpfte helikar-/anti-helikar-antikörperkonjugate und verwendungen davon
BR112016014945A2 (pt)	2014-01-03	2018-01-23	F. Hoffmann-La Roche Ag	conjugado, formulação farmacêutica e uso
AU2015206370A1 (en)	2014-01-16	2016-07-07	Academia Sinica	Compositions and methods for treatment and detection of cancers
US10150818B2 (en)	2014-01-16	2018-12-11	Academia Sinica	Compositions and methods for treatment and detection of cancers
EP3096797A1 (de)	2014-01-24	2016-11-30	F. Hoffmann-La Roche AG	Verfahren zur verwendung von anti-steap1-antikörpern und immunkonjugaten
US10562977B2 (en)	2014-01-29	2020-02-18	Shanghai Hengrui Pharmaceutical Co., Ltd.	Ligand-cytotoxic drug conjugate, preparation method thereof, and uses thereof
ES2694857T3 (es)	2014-02-04	2018-12-27	Genentech, Inc.	Smoothened mutante y métodos de uso de la misma
EA201691610A8 (ru)	2014-02-12	2018-05-31	Дженентек, Инк.	Анти-jagged1 антитела и способы применения
UA117608C2 (uk)	2014-02-21	2018-08-27	Дженентек, Інк.	Спосіб лікування еозинофільного захворювання у пацієнта шляхом застосування біспецифічного анти-il-13/il-17 антитіла
US10464955B2 (en)	2014-02-28	2019-11-05	Hangzhou Dac Biotech Co., Ltd.	Charged linkers and their uses for conjugation
AU2015229035B2 (en)	2014-03-14	2021-08-05	Genentech, Inc.	Methods and compositions for secretion of heterologous polypeptides
CN106103478B (zh)	2014-03-21	2020-04-03	豪夫迈·罗氏有限公司	抗体体内半寿期的体外预测
AR099812A1 (es)	2014-03-21	2016-08-17	Abbvie Inc	Anticuerpos y conjugados de anticuerpo y fármaco anti-egfr
RU2016141385A (ru)	2014-03-24	2018-04-28	Дженентек, Инк.	Лечение рака антагонистами с-мет и их корреляция с экспрессией hgf
CN106415244B (zh)	2014-03-27	2020-04-24	中央研究院	反应性标记化合物及其用途
EP3699195A3 (de)	2014-03-28	2020-11-04	Xencor, Inc.	Bispezifische, an cd38 und cd3 bindende antikörper
SG11201607969XA (en)	2014-03-31	2016-10-28	Genentech Inc	Anti-ox40 antibodies and methods of use
KR20160146747A (ko)	2014-03-31	2016-12-21	제넨테크, 인크.	항혈관신생제 및 ox40 결합 효능제를 포함하는 조합 요법
SG11201608192SA (en)	2014-04-11	2016-10-28	Medimmune Llc	Bispecific her2 antibodies
DK3134438T3 (da)	2014-04-25	2020-12-07	Pf Medicament	IGF-1R-antistof og anvendelse heraf som adresseringsvehikel til behandling af cancer
RU2708075C2 (ru)	2014-04-30	2019-12-04	Пфайзер Инк.	Конъюгаты анти-ртк7 антитело-лекарственное средство
BR122021009041B1 (pt)	2014-05-06	2022-11-29	Genentech, Inc	Métodos para a preparação de uma proteína heteromultimérica
WO2015179658A2 (en)	2014-05-22	2015-11-26	Genentech, Inc.	Anti-gpc3 antibodies and immunoconjugates
RU2016144405A (ru)	2014-05-23	2018-06-26	Дженентек, Инк.	MiT БИОМАРКЕРЫ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
US10118969B2 (en)	2014-05-27	2018-11-06	Academia Sinica	Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
JP7093612B2 (ja)	2014-05-27	2022-06-30	アカデミアシニカ	Ｂａｃｔｅｒｏｉｄｅｓ由来のフコシダーゼおよびそれを使用する方法
CN106661099A (zh)	2014-05-27	2017-05-10	中央研究院	抗her2醣抗体及其用途
CA2950415A1 (en)	2014-05-27	2015-12-03	Academia Sinica	Anti-cd20 glycoantibodies and uses thereof
WO2015184001A1 (en)	2014-05-28	2015-12-03	Academia Sinica	Anti-tnf-alpha glycoantibodies and uses thereof
CN107073121A (zh)	2014-06-13	2017-08-18	基因泰克公司	治疗及预防癌症药物抗性的方法
BR112016029935A2 (pt)	2014-06-26	2017-10-31	Hoffmann La Roche	?anticorpos anti-brdu, complexo, formulação farmacêutica e uso de anticorpo?
CN106488775A (zh)	2014-07-11	2017-03-08	基因泰克公司	Notch途径抑制
EP3194449A1 (de)	2014-07-24	2017-07-26	Xencor, Inc.	Schnelle beseitigung von antigenkomplexen unter verwendung neuartiger antikörper
DK4074735T3 (da)	2014-08-28	2025-07-14	Bioatla Inc	Betinget aktive kimæriske antigenreceptorer til modificerede t-celler
TWI751102B (zh)	2014-08-28	2022-01-01	美商奇諾治療有限公司	對ｃｄ１９具專一性之抗體及嵌合抗原受體
TWI745275B (zh)	2014-09-08	2021-11-11	中央研究院	使用醣脂激活人類ｉＮＫＴ細胞
LT3191135T (lt)	2014-09-12	2020-11-25	Genentech, Inc.	Anti-her2 antikūnai ir imunokonjugatai
WO2016040724A1 (en)	2014-09-12	2016-03-17	Genentech, Inc.	Anti-b7-h4 antibodies and immunoconjugates
MA40579A (fr)	2014-09-12	2016-03-17	Genentech Inc	Anticorps anti-cll-1 et immunoconjugués
SG11201701128YA (en)	2014-09-12	2017-03-30	Genentech Inc	Cysteine engineered antibodies and conjugates
HUE049175T2 (hu)	2014-09-23	2020-09-28	Hoffmann La Roche	Eljárás anti-CD79b immunkonjugátumok alkalmazására
RU2715905C2 (ru)	2014-10-01	2020-03-04	МЕДИММЬЮН, ЭлЭлСи	Способ конъюгации полипептида
JP2017536102A (ja)	2014-10-16	2017-12-07	ジェネンテック，インコーポレイテッド	抗アルファ−シヌクレイン抗体及び使用方法
JP6723509B2 (ja)	2014-10-24	2020-07-15	日油株式会社	環状ベンジリデンアセタールリンカーを有する抗体―薬物複合体
WO2016070062A2 (en)	2014-10-31	2016-05-06	Genentech, Inc.	Anti-il-17a and il-17f cross reactive antibody variants and compositions comprising and methods of making and using same
WO2016073380A1 (en)	2014-11-03	2016-05-12	Genentech, Inc.	Method and biomarkers for predicting efficacy and evaluation of an ox40 agonist treatment
CA2966523A1 (en)	2014-11-03	2016-05-12	Genentech, Inc.	Assays for detecting t cell immune subsets and methods of use thereof
CA2961439A1 (en)	2014-11-05	2016-05-12	Genentech, Inc.	Anti-fgfr2/3 antibodies and methods using same
DK3215528T3 (da)	2014-11-06	2019-10-07	Hoffmann La Roche	Fc-regionvarianter med modificeret FcRn-binding og anvendelsesfremgangsmåder
WO2016073157A1 (en)	2014-11-06	2016-05-12	Genentech, Inc.	Anti-ang2 antibodies and methods of use thereof
CR20170240A (es)	2014-11-10	2018-04-03	Genentech Inc	Anticuerpos anti-interleucina-33 y sus usos
US10508151B2 (en)	2014-11-19	2019-12-17	Genentech, Inc.	Anti-transferrin receptor antibodies and methods of use
WO2016081640A1 (en)	2014-11-19	2016-05-26	Genentech, Inc.	Anti-transferrin receptor / anti-bace1 multispecific antibodies and methods of use
JP6859259B2 (ja)	2014-11-19	2021-04-14	ジェネンテック，インコーポレイテッド	ＢＡＣＥｌに対する抗体及び神経疾患免疫療法のためのその使用
EP3223907A2 (de)	2014-11-26	2017-10-04	Xencor, Inc.	Cd3 und cd38 bindende heterodimere antikörper
US10259887B2 (en)	2014-11-26	2019-04-16	Xencor, Inc.	Heterodimeric antibodies that bind CD3 and tumor antigens
PE20171324A1 (es)	2014-11-26	2017-09-11	Xencor Inc	Anticuerpos heterodimericos que se unen a cd3 y a antigenos tumorales
EP3227332B1 (de)	2014-12-03	2019-11-06	F.Hoffmann-La Roche Ag	Multispezifische antikörper
ES2744540T3 (es)	2014-12-05	2020-02-25	Hoffmann La Roche	Anticuerpos anti-CD79b y procedimientos de uso
KR20170085595A (ko)	2014-12-10	2017-07-24	제넨테크, 인크.	혈뇌 장벽 수용체 항체 및 사용 방법
AU2015366284B2 (en)	2014-12-19	2021-07-22	Ablynx N.V.	Cysteine linked nanobody dimers
BR112017011235A2 (pt)	2014-12-19	2018-02-06	Chugai Pharmaceutical Co Ltd	anticorpos anti-c5 e métodos de uso
KR101860280B1 (ko)	2014-12-19	2018-05-21	추가이 세이야쿠 가부시키가이샤	항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법
WO2016105450A2 (en)	2014-12-22	2016-06-30	Xencor, Inc.	Trispecific antibodies
US9975965B2 (en)	2015-01-16	2018-05-22	Academia Sinica	Compositions and methods for treatment and detection of cancers
US10495645B2 (en)	2015-01-16	2019-12-03	Academia Sinica	Cancer markers and methods of use thereof
ES2818103T3 (es)	2015-01-16	2021-04-09	Juno Therapeutics Inc	Anticuerpos y receptores de antígenos quiméricos específicos para ROR1
GB201501004D0 (en)	2015-01-21	2015-03-04	Cancer Rec Tech Ltd	Inhibitors
CN113956354A (zh)	2015-01-22	2022-01-21	中外制药株式会社	两种以上抗-c5抗体的组合与使用方法
JP6779887B2 (ja)	2015-01-24	2020-11-04	アカデミアシニカＡｃａｄｅｍｉａＳｉｎｉｃａ	新規なグリカンコンジュゲートおよびその使用方法
AU2016209056B2 (en)	2015-01-24	2021-01-28	Academia Sinica	Cancer markers and methods of use thereof
US10441649B2 (en)	2015-02-02	2019-10-15	The University Of Birmingham	Targeting moiety peptide epitope complexes having a plurality of T-cell epitopes
EP3253784B1 (de)	2015-02-04	2020-05-06	Genentech, Inc.	Smoothened-mutant und verfahren zur verwendung davon
KR102605798B1 (ko)	2015-02-05	2023-11-23	추가이 세이야쿠 가부시키가이샤	이온 농도 의존적 항원 결합 도메인을 포함하는 항체, Fc 영역 개변체, IL-8에 결합하는 항체, 및 그들의 사용
US10227411B2 (en)	2015-03-05	2019-03-12	Xencor, Inc.	Modulation of T cells with bispecific antibodies and FC fusions
KR20170139110A (ko) *	2015-04-21	2017-12-18	애브비 스템센트알엑스 엘엘씨	칼리케아마이신 구성체 및 사용 방법
WO2016172485A2 (en)	2015-04-24	2016-10-27	Genentech, Inc.	Multispecific antigen-binding proteins
CN107810197B (zh)	2015-04-24	2022-10-25	豪夫迈·罗氏有限公司	鉴定包含结合多肽的细菌的方法
EP3288981A1 (de)	2015-05-01	2018-03-07	Genentech, Inc.	Maskierte anti-cd3-antikörper und verfahren zur verwendung
HK1248577A1 (zh)	2015-05-11	2018-10-19	F. Hoffmann-La Roche Ag	治疗狼疮性肾炎的组合物和方法
ES2835866T5 (es)	2015-05-12	2024-12-02	Hoffmann La Roche	Procedimientos terapéuticos y de diagnóstico para el cáncer
ES2789500T5 (es)	2015-05-29	2023-09-20	Hoffmann La Roche	Procedimientos terapéuticos y de diagnóstico para el cáncer
HK1250723A1 (zh)	2015-05-29	2019-01-11	F. Hoffmann-La Roche Ag	人源化抗埃博拉病毒糖蛋白抗体和使用方法
JP2018521019A (ja)	2015-06-08	2018-08-02	ジェネンテック，インコーポレイテッド	抗ｏｘ４０抗体を使用して癌を治療する方法
MX2017015937A (es)	2015-06-08	2018-12-11	Genentech Inc	Métodos de tratamiento del cáncer con anticuerpos anti-ox40 y antagonistas de unión al eje de pd-1.
EP3916018A1 (de)	2015-06-16	2021-12-01	Genentech, Inc.	Anti-cd3-antikörper und verfahren zur verwendung
DK3310814T5 (da)	2015-06-16	2024-10-07	Hoffmann La Roche	Humaniserede og affinitetsmodnede antistoffer mod FcRH5 og fremgangsmåder til anvendelse
US10501545B2 (en)	2015-06-16	2019-12-10	Genentech, Inc.	Anti-CLL-1 antibodies and methods of use
CN107787331B (zh)	2015-06-17	2022-01-11	豪夫迈·罗氏有限公司	抗her2抗体和使用方法
CN107531788B (zh)	2015-06-24	2022-06-21	豪夫迈·罗氏有限公司	对her2和血脑屏障受体特异性的三特异性抗体及使用方法
HUE057952T2 (hu)	2015-06-24	2022-06-28	Hoffmann La Roche	Anti-transzferrin receptor antitestek testreszabott affinitással
EP3313885A1 (de)	2015-06-29	2018-05-02	H. Hoffnabb-La Roche Ag	Typ-ii-cd20-antikörper zur verwendung in der organtransplantation
NZ739830A (en)	2015-07-12	2021-12-24	Hangzhou Dac Biotech Co Ltd	Bridge linkers for conjugation of cell-binding molecules
US9839687B2 (en)	2015-07-15	2017-12-12	Suzhou M-Conj Biotech Co., Ltd.	Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
UA123398C2 (uk)	2015-08-05	2021-03-31	Янссен Байотек, Інк.	Виділене антагоністичне антитіло, яке специфічно зв'язує cd154, та фармацевтична композиція, яка його містить
CN105384825B (zh)	2015-08-11	2018-06-01	南京传奇生物科技有限公司	一种基于单域抗体的双特异性嵌合抗原受体及其应用
WO2018028647A1 (en)	2016-08-10	2018-02-15	Legend Biotech Usa Inc.	Chimeric antigen receptors targeting bcma and methods of use thereof
JP7007261B2 (ja)	2015-08-20	2022-01-24	アルブミディクスリミティド	アルブミン変異体及びコンジュゲート
CA3289997A1 (en)	2015-09-20	2026-03-02	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Monoclonal Antibodies Specific for Fibroblast Growth Factor Receptor 4 (FGFR4) and Methods of Their Use
PE20181363A1 (es)	2015-09-23	2018-08-27	Genentech Inc	Variantes optimizadas de anticuerpos anti-vegf
JP6955487B2 (ja)	2015-09-24	2021-10-27	アブビトロ，エルエルシー	Ｈｉｖ抗体組成物および使用方法
PE20181046A1 (es)	2015-09-25	2018-07-03	Genentech Inc	Anticuerpos anti-tigit y metodos de uso
BR112018006251A2 (pt)	2015-09-30	2018-10-16	Janssen Biotech Inc	anticorpos antagonistas que se ligam especificamente a cd40 humano e métodos de uso
WO2017055404A1 (en)	2015-10-02	2017-04-06	F. Hoffmann-La Roche Ag	Bispecific antibodies specific for pd1 and tim3
AR106189A1 (es)	2015-10-02	2017-12-20	Hoffmann La Roche	ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO
ES2895034T3 (es)	2015-10-02	2022-02-17	Hoffmann La Roche	Anticuerpos anti-PD1 y procedimientos de uso
TWI873952B (zh)	2015-10-02	2025-02-21	瑞士商赫孚孟拉羅股份公司	雙特異性抗‐人類cd20/人類轉鐵蛋白受體抗體及使用方法
MA43354A (fr)	2015-10-16	2018-08-22	Genentech Inc	Conjugués médicamenteux à pont disulfure encombré
EP3365025B1 (de)	2015-10-20	2020-07-15	Genentech, Inc.	Calicheamicin-antikörper-arzneimittelkonjugate und verfahren zur verwendung
EP3184547A1 (de)	2015-10-29	2017-06-28	F. Hoffmann-La Roche AG	Anti-tpbg-antikörper und verfahren zur verwendung
HRP20220064T1 (hr)	2015-10-30	2022-04-15	F. Hoffmann - La Roche Ag	Zglobno modificirani fragmenti protutijela i postupci za pripravu
PE20181326A1 (es)	2015-11-03	2018-08-20	Janssen Biotech Inc	Anticuerpos que se unen especificamente a pd-1 y sus usos
CN118725134A (zh)	2015-11-08	2024-10-01	豪夫迈·罗氏有限公司	筛选多特异性抗体的方法
FI3377103T4 (fi)	2015-11-19	2025-04-16	Revitope Limited	Funktionaalinen vasta-ainefragmenttikomplementointi kaksikomponenttiselle järjestelmälle epätoivottujen solujen uudelleenohjattua tappamista varten
SI3383920T1 (sl)	2015-11-30	2024-06-28	The Regents Of The University Of California	Dostava tumorsko specifičnega koristnega tovora in imunska aktivacija z uporabo humanega protitelesa, ki cilja visoko specifičen površinski antigen tumorskih celic
CA3007030A1 (en)	2015-12-07	2017-06-15	Xencor, Inc.	Heterodimeric antibodies that bind cd3 and psma
IL313608A (en)	2015-12-09	2024-08-01	Hoffmann La Roche	Antibody against CD20 type II to reduce the formation of antibodies against drugs
EP3178848A1 (de)	2015-12-09	2017-06-14	F. Hoffmann-La Roche AG	Type ii anti-cd20 antikörper zur verringerung der bildung von antikörpern gegen medikamente
HUE065073T2 (hu)	2015-12-18	2024-04-28	Chugai Pharmaceutical Co Ltd	Anti-C5 antitestek és alkalmazási eljárások
AR107078A1 (es)	2015-12-18	2018-03-21	Chugai Pharmaceutical Co Ltd	Anticuerpo antimiostatina, polipéptidos que contienen regiones fc variantes así como métodos de uso
CN108495653A (zh)	2016-01-27	2018-09-04	免疫医疗有限责任公司	用于制备具有定义的糖基化模式抗体的方法
EP3411396A1 (de)	2016-02-04	2018-12-12	Curis, Inc.	Smoothened-mutant und verfahren zur verwendung davon
FI3895736T3 (fi)	2016-02-05	2023-06-26	Rigshospitalet	Uparap:hen kohdistuvia vasta-aine-lääkekonjugaatteja
JP6821693B2 (ja)	2016-02-29	2021-01-27	ジェネンテック，インコーポレイテッド	がんのための治療方法及び診断方法
WO2017153432A1 (en)	2016-03-07	2017-09-14	Pierre Fabre Medicament	A new universal method to capture and analyze adcs for characterization of drug distribution and the drug-to-antibody ratio in biological samples
EP3426693A4 (de)	2016-03-08	2019-11-13	Academia Sinica	Verfahren zur modularen synthese von n-glykanen und anordnungen davon
WO2017172907A1 (en) *	2016-03-29	2017-10-05	Sorrento Therapeutics, Inc.	Calicheamicin antibody drug conjugates linking an amidoacetyl group to a sugar moiety on calicheamicin
BR112018070948A2 (pt)	2016-04-13	2019-01-29	Orimabs Ltd.	anticorpos anti-psma e utilização dos mesmos
EP3865511A1 (de)	2016-04-14	2021-08-18	F. Hoffmann-La Roche AG	Anti-rspo3-antikörper und verfahren zur verwendung
KR20190003958A (ko)	2016-04-15	2019-01-10	제넨테크, 인크.	암의 치료 및 모니터링 방법
SMT202600033T1 (it)	2016-04-15	2026-03-09	Bioatla Inc	Anticorpi anti-axl, frammenti di anticorpo e loro immunoconiugati e loro utilizzi
MX2018012493A (es)	2016-04-15	2019-06-06	Genentech Inc	Métodos para controlar y tratar el cáncer.
GEP20227398B (en)	2016-04-15	2022-07-25	Macrogenics Inc	Novel b7-h3 binding molecules, antibody drug conjugates thereof and usage thereof
WO2017191101A1 (en)	2016-05-02	2017-11-09	F. Hoffmann-La Roche Ag	The contorsbody - a single chain target binder
WO2017196847A1 (en)	2016-05-10	2017-11-16	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Variable new antigen receptor (vnar) antibodies and antibody conjugates targeting tumor and viral antigens
JP7089483B2 (ja)	2016-05-11	2022-06-22	エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト	修飾された抗テネイシン抗体及び使用方法
PL3455261T3 (pl)	2016-05-13	2022-12-12	Bioatla, Inc.	Przeciwciała anty-ror2, fragmenty przeciwciał, ich immunokoniugaty oraz ich zastosowania
EP3465221B1 (de)	2016-05-27	2020-07-22	H. Hoffnabb-La Roche Ag	Bioanalytisches verfahren zur charakterisierung von ortsspezifischen antikörper-wirkstoff-konjugaten
WO2017207540A1 (en)	2016-05-30	2017-12-07	Toxinvent Oü	Antibody-drug-conjugates comprising novel anthracycline-derivatives for cancer treatment
EP3252078A1 (de)	2016-06-02	2017-12-06	F. Hoffmann-La Roche AG	Typ ii anti-cd20 antikörper und anti-cd20/cd3 bispecific antikörper zur behandlung von krebs
WO2018220099A1 (en)	2017-06-02	2018-12-06	F. Hoffmann-La Roche Ag	Type ii anti-cd20 antibody and anti-cd20/cd3 bispecific antibody for treatment of cancer
WO2017214182A1 (en)	2016-06-07	2017-12-14	The United States Of America. As Represented By The Secretary, Department Of Health & Human Services	Fully human antibody targeting pdi for cancer immunotherapy
JP2019524651A (ja)	2016-06-08	2019-09-05	アッヴィ・インコーポレイテッド	抗ｃｄ９８抗体及び抗体薬物コンジュゲート
WO2017214452A1 (en)	2016-06-08	2017-12-14	Xencor, Inc.	Treatment of igg4-related diseases with anti-cd19 antibodies crossbinding to cd32b
MX2018015285A (es)	2016-06-08	2019-09-18	Abbvie Inc	Anticuerpos anti-b7-h3 y conjugados de anticuerpo y farmaco.
AU2017279550A1 (en)	2016-06-08	2019-01-03	Abbvie Inc.	Anti-B7-H3 antibodies and antibody drug conjugates
US20200147235A1 (en)	2016-06-08	2020-05-14	Abbvie Inc.	Anti-cd98 antibodies and antibody drug conjugates
WO2017214322A1 (en)	2016-06-08	2017-12-14	Abbvie Inc.	Anti-b7-h3 antibodies and antibody drug conjugates
JP7010854B2 (ja)	2016-06-14	2022-01-26	ゼンコアインコーポレイテッド	二重特異性チェックポイント阻害剤抗体
KR102376582B1 (ko)	2016-06-17	2022-03-18	추가이 세이야쿠 가부시키가이샤	항-마이오스타틴 항체 및 사용 방법
WO2018004338A1 (en)	2016-06-27	2018-01-04	Tagworks Pharmaceuticals B.V.	Cleavable tetrazine used in bio-orthogonal drug activation
CN109715663B (zh)	2016-06-28	2022-11-25	Xencor股份有限公司	结合生长抑素受体2的异源二聚抗体
JP2019524706A (ja)	2016-07-08	2019-09-05	ジェネンテック，インコーポレイテッド	Ｍｕｃ１６陽性癌治療の応答性を評価するためのヒト精巣上体タンパク質４（ｈｅ４）の使用
JP7062640B2 (ja)	2016-07-29	2022-05-06	ジュノーセラピューティクスインコーポレイテッド	抗ｃｄ１９抗体に対する抗イディオタイプ抗体
EP3494135A1 (de)	2016-08-02	2019-06-12	The United States of America, as represented by The Secretary, Department of Health and Human Services	Gegen glypican-2 (gpc2) gerichtete monoklonale antikörper und verwendung davon
WO2018025168A1 (en)	2016-08-03	2018-02-08	Pfizer Inc.	Heteroaryl sulfone-based conjugation handles, methods for their preparation, and their use in synthesizing antibody drug conjugates
WO2018027204A1 (en)	2016-08-05	2018-02-08	Genentech, Inc.	Multivalent and multiepitopic anitibodies having agonistic activity and methods of use
EP3494991A4 (de)	2016-08-05	2020-07-29	Chugai Seiyaku Kabushiki Kaisha	Zusammensetzung zur vorbeugung oder behandlung von erkrankungen im zusammenhang mit il-8
CA3034057A1 (en)	2016-08-22	2018-03-01	CHO Pharma Inc.	Antibodies, binding fragments, and methods of use
CN109790220A (zh)	2016-08-25	2019-05-21	豪夫迈·罗氏有限公司	与巨噬细胞激活剂组合的抗csf-1r抗体的间歇给药
US10793632B2 (en)	2016-08-30	2020-10-06	Xencor, Inc.	Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
SG10201607778XA (en)	2016-09-16	2018-04-27	Chugai Pharmaceutical Co Ltd	Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
CN109689682B (zh)	2016-09-19	2022-11-29	豪夫迈·罗氏有限公司	基于补体因子的亲和层析
CA3038712A1 (en)	2016-10-06	2018-04-12	Genentech, Inc.	Therapeutic and diagnostic methods for cancer
MY203000A (en)	2016-10-14	2024-06-01	Xencor Inc	Il15/il15r� heterodimeric fc-fusion proteins
CN110177805B (zh)	2016-10-19	2024-04-02	英温拉公司	抗体构建体
WO2018081648A2 (en)	2016-10-29	2018-05-03	Genentech, Inc.	Anti-mic antibidies and methods of use
KR20220150408A (ko)	2016-11-14	2022-11-10	항저우 디에이씨 바이오테크 씨오, 엘티디	결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
JP7784795B2 (ja)	2016-11-15	2025-12-12	ジェネンテック，インコーポレイテッド	抗ｃｄ２０／抗ｃｄ３二重特異性抗体による処置のための投与
TW201829463A (zh)	2016-11-18	2018-08-16	瑞士商赫孚孟拉羅股份公司	抗hla-g抗體及其用途
EP4015532A1 (de)	2016-11-21	2022-06-22	cureab GmbH	Anti-gp73-antikörper und immunkonjugate
US11135307B2 (en)	2016-11-23	2021-10-05	Mersana Therapeutics, Inc.	Peptide-containing linkers for antibody-drug conjugates
AU2017382883B2 (en)	2016-12-21	2024-07-04	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Human monoclonal antibodies specific for FLT3 and uses thereof
AU2017383142A1 (en)	2016-12-22	2019-07-04	Università Degli Studi Magna Graecia Catanzaro	A monoclonal antibody targeting a unique sialoglycosilated cancer-associated epitope of CD43
CN110072553B (zh)	2016-12-22	2023-09-15	豪夫迈·罗氏有限公司	在抗pd-l1/pd1治疗失败之后抗csf-1r抗体与抗pd-l1抗体组合对肿瘤的治疗
WO2018138591A1 (en) *	2017-01-24	2018-08-02	Pfizer Inc.	Calicheamicin derivatives and antibody drug conjugates thereof
JP6995127B2 (ja)	2017-02-10	2022-02-04	ジェネンテック，インコーポレイテッド	抗トリプターゼ抗体、その組成物、及びその使用
TW201837467A (zh)	2017-03-01	2018-10-16	美商建南德克公司	用於癌症之診斷及治療方法
SG11201909395TA (en)	2017-04-27	2019-11-28	Tesaro Inc	Antibody agents directed against lymphocyte activation gene-3 (lag-3) and uses thereof
WO2018213064A1 (en)	2017-05-19	2018-11-22	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Human monoclonal antibody targeting tnfer2 for cancer immunotherapy
AR111963A1 (es)	2017-05-26	2019-09-04	Univ California	Método y moléculas
AU2018290330A1 (en)	2017-06-22	2020-01-02	Mersana Therapeutics, Inc.	Methods of producing drug-carrying polymer scaffolds and protein-polymer-drug conjugates
WO2019006472A1 (en)	2017-06-30	2019-01-03	Xencor, Inc.	TARGETED HETETRODIMERIC FUSION PROTEINS CONTAINING IL-15 / IL-15RA AND ANTIGEN-BINDING DOMAINS
WO2019005208A1 (en)	2017-06-30	2019-01-03	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	ANTIBODIES TO HUMAN MESOTHELIN AND USES IN ANTICANCER THERAPY
WO2019006280A1 (en)	2017-06-30	2019-01-03	Lentigen Technology, Inc.	HUMAN MONOCLONAL ANTIBODIES SPECIFIC TO CD33 AND METHODS OF USE
WO2019018647A1 (en)	2017-07-20	2019-01-24	Pfizer Inc.	ANTI-GD3 ANTIBODIES AND CONJUGATES ANTIBODY-MEDICATION
JP7760242B2 (ja)	2017-07-21	2025-10-27	ジェネンテック，インコーポレイテッド	がんの治療法及び診断法
EP3699590A4 (de)	2017-10-20	2021-09-08	Chugai Seiyaku Kabushiki Kaisha	Verfahren zur messung der internalisierung eines moleküls in eine zelle
WO2019084057A2 (en)	2017-10-24	2019-05-02	Magenta Therapeutics, Inc.	COMPOSITIONS AND METHODS FOR DEPLOYING CD117 + CELLS
JP7438942B2 (ja)	2017-10-30	2024-02-27	エフ．ホフマン－ラロシュアーゲー	単一特異性抗体から多重特異性抗体をインビボ生成させるための方法
WO2019086394A1 (en)	2017-11-01	2019-05-09	F. Hoffmann-La Roche Ag	The compbody - a multivalent target binder
SG11202003501XA (en)	2017-11-01	2020-05-28	Juno Therapeutics Inc	Antibodies and chimeric antigen receptors specific for b-cell maturation antigen
MX2020004196A (es)	2017-11-01	2020-11-09	Hoffmann La Roche	Trifab-contorsbody.
TW201923089A (zh)	2017-11-06	2019-06-16	美商建南德克公司	癌症之診斷及治療方法
US10981992B2 (en)	2017-11-08	2021-04-20	Xencor, Inc.	Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
JP2021502100A (ja)	2017-11-08	2021-01-28	ゼンコアインコーポレイテッド	新規抗ｐｄ−１配列を用いた二重特異性および単一特異性抗体
EP4640703A3 (de)	2017-11-14	2026-04-08	Chugai Seiyaku Kabushiki Kaisha	Anti-c1s-antikörper und verfahren zur verwendung
CN119857155A (zh)	2017-11-29	2025-04-22	海德堡医药研究有限责任公司	用于耗尽cd5+细胞的组合物和方法
IL275426B2 (en)	2017-12-19	2025-03-01	Xencor Inc	Engineered il-2 fc fusion proteins
JP7314146B2 (ja)	2017-12-28	2023-07-25	中外製薬株式会社	細胞傷害誘導治療剤
US12247060B2 (en)	2018-01-09	2025-03-11	Marengo Therapeutics, Inc.	Calreticulin binding constructs and engineered T cells for the treatment of diseases
EP3740505A1 (de)	2018-01-16	2020-11-25	Lakepharma Inc.	Bispezifischer antikörper, der cd3 und ein anderes ziel bindet
US12398209B2 (en)	2018-01-22	2025-08-26	Janssen Biotech, Inc.	Methods of treating cancers with antagonistic anti-PD-1 antibodies
IL325995A (en)	2018-02-08	2026-03-01	Genentech Inc	Bispecific antigen binding molecules and methods of use
CN111836831A (zh)	2018-02-26	2020-10-27	豪夫迈·罗氏有限公司	用于抗tigit拮抗剂抗体和抗pd-l1拮抗剂抗体治疗的给药
US20200040103A1 (en)	2018-03-14	2020-02-06	Genentech, Inc.	Anti-klk5 antibodies and methods of use
EA202092044A1 (ru)	2018-03-14	2021-03-03	Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез	Химерные рецепторы антигена против cd33 и их применения
EP3765517A1 (de)	2018-03-14	2021-01-20	Elstar Therapeutics, Inc.	An calreticulin bindende multifunktionsmoleküle und ihre verwendungen
CN112119090B (zh)	2018-03-15	2023-01-13	中外制药株式会社	对寨卡病毒具有交叉反应性的抗登革热病毒抗体及使用方法
JP7104458B2 (ja)	2018-04-02	2022-07-21	上海博威生物医薬有限公司	リンパ球活性化遺伝子－３（ｌａｇ－３）結合抗体およびその使用
TW202011029A (zh)	2018-04-04	2020-03-16	美商建南德克公司	偵測及定量fgf21之方法
CA3096052A1 (en)	2018-04-04	2019-10-10	Xencor, Inc.	Heterodimeric antibodies that bind fibroblast activation protein
EP3781598A1 (de)	2018-04-18	2021-02-24	Xencor, Inc.	Auf tim-3 abzielende heterodimere fusionsproteine mit il-15-/il-15ra-fc-fusionsproteinen und tim-3-antigen-bindenden domänen
SG11202010163QA (en)	2018-04-18	2020-11-27	Xencor Inc	Pd-1 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and pd-1 antigen binding domains and uses thereof
AR114789A1 (es)	2018-04-18	2020-10-14	Hoffmann La Roche	Anticuerpos anti-hla-g y uso de los mismos
AU2019262520B2 (en)	2018-05-04	2025-07-10	Tagworks Pharmaceuticals B.V.	Tetrazines for high click conjugation yield in vivo and high click release yield
CA3099421C (en)	2018-05-04	2025-05-06	Tagworks Pharmaceuticals B.V.	COMPOUNDS INCLUDING A BINDER TO INCREASE TRANSCYCLOOCTENE STABILITY
AU2019271148B9 (en)	2018-05-14	2025-05-29	Werewolf Therapeutics, Inc.	Activatable interleukin-2 polypeptides and methods of use thereof
WO2019222296A1 (en)	2018-05-14	2019-11-21	Werewolf Therapeutics, Inc.	Activatable interleukin 12 polypeptides and methods of use thereof
PE20211916A1 (es)	2018-05-24	2021-09-28	Janssen Biotech Inc	Agentes aglutinantes del psma y usos de estos
CN120795120A (zh)	2018-06-05	2025-10-17	伦敦大学国王学院	向胃肠系统递送酬载的btnl3/8导引构建体
TW202519260A (zh)	2018-07-02	2025-05-16	美商安進公司	抗steap1抗原結合蛋白
CA3105448A1 (en)	2018-07-03	2020-01-09	Elstar Therapeutics, Inc.	Anti-tcr antibody molecules and uses thereof
US11939377B2 (en)	2018-07-12	2024-03-26	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Affinity matured CD22-specific monoclonal antibody and uses thereof
CA3107383A1 (en)	2018-07-23	2020-01-30	Magenta Therapeutics, Inc.	Use of anti-cd5 antibody drug conjugate (adc) in allogeneic cell therapy
EP3833684A1 (de)	2018-08-08	2021-06-16	The United States of America, as represented by the Secretary, Department of Health and Human Services	Gegen glypican-2 gerichtete, hochaffine monoklonale antikörper und verwendungen davon
KR102259473B1 (ko)	2018-08-10	2021-06-02	추가이 세이야쿠 가부시키가이샤	항cd137 항원 결합 분자 및 그의 사용
EP3850013A4 (de)	2018-09-10	2022-10-05	Nanjing Legend Biotech Co., Ltd.	Einzeldomänenantikörper gegen cll1 und verwendungen davon
WO2020056170A1 (en)	2018-09-12	2020-03-19	Fred Hutchinson Cancer Research Center	Reducing cd33 expression to selectively protect therapeutic cells
AU2019342099A1 (en)	2018-09-19	2021-04-08	Genentech, Inc.	Therapeutic and diagnostic methods for bladder cancer
WO2020063676A1 (zh)	2018-09-26	2020-04-02	江苏恒瑞医药股份有限公司	依喜替康类似物的配体-药物偶联物及其制备方法和应用
US20220002370A1 (en)	2018-09-27	2022-01-06	Xilio Development, Inc.	Masked cytokine polypeptides
AU2019355971B2 (en)	2018-10-03	2025-05-08	Xencor, Inc.	IL-12 heterodimeric Fc-fusion proteins
EP3867646A1 (de)	2018-10-18	2021-08-25	F. Hoffmann-La Roche AG	Diagnostische und therapeutische verfahren für sarkomatoiden nierenkrebs
MY195550A (en)	2018-10-29	2023-01-31	Hoffmann La Roche	Antibody Formulation
CN113365664A (zh)	2018-10-29	2021-09-07	梅尔莎纳医疗公司	具有含肽接头的半胱氨酸工程化的抗体-药物缀合物
BR112021008041A2 (pt)	2018-11-07	2021-08-10	Crispr Therapeutics Ag	terapia contra o câncer com células imunitárias anti-cd33
JP7699542B2 (ja)	2018-11-20	2025-06-27	コーネルユニバーシティー	放射線核種の大環状錯体およびがんの放射線療法におけるそれらの使用
BR112021010908A2 (pt)	2018-12-06	2021-08-31	Genentech, Inc.	Método para tratamento de linfoma difuso de grandes células b, kit e imunoconjugado
AR117453A1 (es)	2018-12-20	2021-08-04	Genentech Inc	Fc de anticuerpos modificados y métodos para utilizarlas
WO2020127968A1 (en)	2018-12-20	2020-06-25	Marino Stephen F	Protein-drug conjugate comprising a monomeric form of proteinase 3
CA3122773A1 (en)	2018-12-26	2020-07-02	Xilio Development, Inc.	Anti-ctla4 antibodies and methods of use thereof
CA3125484A1 (en)	2019-01-08	2020-07-16	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Cross-species single domain antibodies targeting mesothelin for treating solid tumors
US12122843B2 (en)	2019-01-22	2024-10-22	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	High affinity monoclonal antibodies targeting glypican-1 and methods of use
BR112021014276A2 (pt)	2019-01-22	2021-09-28	Genentech, Inc.	Anticorpos iga isolados, moléculas de fusão igg-iga isoladas, ácido nucleico isolado, célula hospedeira, método para produzir um anticorpo, para tratar um indivíduo, para aumentar a expressão de dímeros, trímeros ou tetrâmeros, para aumentar a produção de polímeros, para aumentar a produção de dímeros, para aumentar a produção de um polímero, para diminuir a produção de polímeros, para aumentar a expressão transitória de um anticorpo, para expressar dímeros de moléculas de fusão, para expressar dímeros, trímeros ou tetrâmeros, para purificar um anticorpo, para purificar um estado oligomérico de um anticorpo, composição farmacêutica e uso do anticorpo
WO2020153467A1 (ja)	2019-01-24	2020-07-30	中外製薬株式会社	新規がん抗原及びそれらの抗原に対する抗体
SG11202107976SA (en)	2019-01-29	2021-08-30	Juno Therapeutics Inc	Antibodies and chimeric antigen receptors specific for receptor tyrosine kinase like orphan receptor 1 (ror1)
CN119039441A (zh)	2019-02-21	2024-11-29	马伦戈治疗公司	与nkp30结合的抗体分子及其用途
GB2599228B (en)	2019-02-21	2024-02-07	Marengo Therapeutics Inc	Multifunctional molecules that bind to T cell related cancer cells and uses thereof
WO2020176748A1 (en)	2019-02-27	2020-09-03	Genentech, Inc.	Dosing for treatment with anti-tigit and anti-cd20 or anti-cd38 antibodies
CA3132185A1 (en)	2019-03-01	2020-09-10	Xencor, Inc.	Heterodimeric antibodies that bind enpp3 and cd3
EP3938403A1 (de)	2019-03-14	2022-01-19	F. Hoffmann-La Roche AG	Behandlung von krebs mit her2xcd3-bispezifischen antikörpern in kombination mit anti-her2-mab
CN113795264A (zh)	2019-03-19	2021-12-14	瓦尔希伯伦私人肿瘤研究基金会	采用Omomyc和结合PD-1或CTLA-4的抗体治疗癌症的联合疗法
BR112021020867A2 (pt)	2019-04-19	2022-01-04	Genentech Inc	Anticorpos, ácido nucleico, vetor, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica, usos do anticorpo, método de tratamento de um indivíduo com câncer e método para reduzir a depuração
US11591395B2 (en)	2019-04-19	2023-02-28	Janssen Biotech, Inc.	Methods of treating prostate cancer with an anti-PSMA/CD3 antibody
TW202110873A (zh)	2019-04-30	2021-03-16	美商聖堤生物科技股份有限公司	嵌合受體及其使用方法
AU2020275415B2 (en)	2019-05-14	2026-01-15	Genentech, Inc.	Methods of using anti-CD79B immunoconjugates to treat follicular lymphoma
EP3969035A4 (de)	2019-05-14	2023-06-21	Werewolf Therapeutics, Inc.	Trennungseinheiten und verfahren und ihre verwendung
EP4696320A2 (de)	2019-05-15	2026-02-18	Chugai Seiyaku Kabushiki Kaisha	Anti-c1s anitkörper
JP7680375B2 (ja)	2019-06-03	2025-05-20	ザ・ユニバーシティ・オブ・シカゴ	コラーゲン結合薬物担体を用いてがんを処置するための方法および組成物
US20220267281A1 (en) *	2019-06-12	2022-08-25	Ontario Institute For Cancer Research (Oicr)	Unsaturated heterocycloalkyl and heteroaromatic acyl hydrazone linkers, methods and uses thereof
DK3983363T3 (da)	2019-06-17	2024-06-24	Tagworks Pharmaceuticals B V	Forbindelser til hurtig og effektiv klikfrigivelse
IL289094A (en)	2019-06-17	2022-02-01	Tagworks Pharmaceuticals B V	Tetrazines for increasing the speed and yield of the "click release" reaction
MX2022000111A (es)	2019-07-10	2022-02-10	Chugai Pharmaceutical Co Ltd	Moleculas de union a claudina-6 y usos de las mismas.
WO2021010326A1 (ja)	2019-07-12	2021-01-21	中外製薬株式会社	抗変異型ｆｇｆｒ３抗体およびその使用
KR20220070433A (ko)	2019-08-14	2022-05-31	코디악 바이오사이언시즈, 인크.	Stat6을 표적으로 하는 세포외 소포-aso 작제물
AU2020330133A1 (en)	2019-08-14	2022-03-17	Lonza Sales Ag	Extracellular vesicle-ASO constructs targeting CEBP/beta
CA3147365A1 (en)	2019-08-14	2021-02-18	Joanne LIM	Extracellular vesicle-nlrp3 antagonist
CA3147366A1 (en)	2019-08-14	2021-02-18	Adam T. BOUTIN	Extracellular vesicles with stat3-antisense oligonucleotides
US20220306736A1 (en)	2019-09-04	2022-09-29	Y-Biologics Inc.	Anti-vsig4 antibody or antigen binding fragment and uses thereof
JP2022548978A (ja)	2019-09-27	2022-11-22	ジェネンテック，インコーポレイテッド	薬抗ｔｉｇｉｔ及び抗ｐｄ－ｌ１アンタゴニスト抗体を用いた処置のための投薬
EP4017542A1 (de)	2019-10-04	2022-06-29	Tae Life Sciences	Antikörperzusammensetzungen mit fc-mutationen und ortsspezifischen konjugationseigenschaften
WO2021076196A1 (en)	2019-10-18	2021-04-22	Genentech, Inc.	Methods of using anti-cd79b immunoconjugates to treat diffuse large b-cell lymphoma
CA3156761A1 (en)	2019-10-22	2021-04-29	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	High affinity nanobodies targeting b7h3 (cd276) for treating multiple solid tumors
KR20220092580A (ko)	2019-11-06	2022-07-01	제넨테크, 인크.	혈액암의 치료를 위한 진단과 치료 방법
MX2022005666A (es)	2019-11-14	2022-10-07	Werewolf Therapeutics Inc	Polipeptidos de citocina activables y metodos de uso de los mismos.
WO2022106869A1 (en)	2019-11-22	2022-05-27	Medimmune Limited	Fusion proteins comprising an e2 ubiquitin or ubiquitin-like conjugating domain and a targeting domain for specific protein degradation
CN115916817A (zh)	2019-12-06	2023-04-04	朱诺治疗学股份有限公司	针对bcma靶向结合结构域的抗独特型抗体及相关组合物和方法
EP4069742A1 (de)	2019-12-06	2022-10-12	Juno Therapeutics, Inc.	Anti-idiotypische antikörper gegen gprc5d-gerichtete bindungsdomänen und verwandte zusammensetzungen und verfahren
WO2021118968A1 (en)	2019-12-12	2021-06-17	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Antibody-drug conjugates specific for cd276 and uses thereof
WO2021119505A1 (en)	2019-12-13	2021-06-17	Genentech, Inc.	Anti-ly6g6d antibodies and methods of use
UA128549C2 (uk)	2019-12-27	2024-08-07	Чугаі Сейяку Кабусікі Кайся	Антитіло до ctla-4 та його застосування
AU2020416273A1 (en)	2020-01-03	2022-07-28	Marengo Therapeutics, Inc.	Anti-TCR antibody molecules and uses thereof
CN110818795B (zh)	2020-01-10	2020-04-24	上海复宏汉霖生物技术股份有限公司	抗tigit抗体和使用方法
JP7821733B2 (ja)	2020-01-22	2026-02-27	上海森輝医薬有限公司	エリブリン誘導体の薬物複合体、その調製方法及びその医薬的応用
WO2021194481A1 (en)	2020-03-24	2021-09-30	Genentech, Inc.	Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies
WO2022050954A1 (en)	2020-09-04	2022-03-10	Genentech, Inc.	Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies
TWI895351B (zh)	2020-02-12	2025-09-01	日商中外製藥股份有限公司	用於癌症之治療的抗cd137抗原結合分子
PE20230252A1 (es)	2020-03-13	2023-02-07	Genentech Inc	Anticuerpos anti-interleucina-33 y sus usos de estos
CN117551194A (zh)	2020-03-19	2024-02-13	基因泰克公司	同种型选择性抗TGF-β抗体及使用方法
CN115103858B (zh)	2020-03-25	2025-07-15	江苏恒瑞医药股份有限公司	一种抗体药物偶联物的制备方法
BR112022019073A2 (pt)	2020-03-25	2022-11-08	Jiangsu Hengrui Pharmaceuticals Co Ltd	Composição farmacêutica que compreende conjugado anticorpo-fármaco e uso da mesma
WO2021202959A1 (en)	2020-04-03	2021-10-07	Genentech, Inc.	Therapeutic and diagnostic methods for cancer
CN115916822A (zh)	2020-04-24	2023-04-04	基因泰克公司	使用抗CD79b免疫缀合物的方法
EP4143345A1 (de)	2020-04-28	2023-03-08	Genentech, Inc.	Verfahren und zusammensetzungen zur immuntherapie gegen nicht-kleinzelligen lungenkrebs
WO2021231976A1 (en)	2020-05-14	2021-11-18	Xencor, Inc.	Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3
US20230220068A1 (en)	2020-06-05	2023-07-13	Codiak Biosciences, Inc.	Anti-transferrin extracellular vesicles
MX2022015651A (es)	2020-06-11	2023-01-16	Genentech Inc	Conjugados de nanolipoproteina-polipeptido y composiciones, sistemas y procedimientos mediante el uso de los mismos.
JP2023529206A (ja)	2020-06-12	2023-07-07	ジェネンテック，インコーポレイテッド	がん免疫療法のための方法及び組成物
KR20230024368A (ko)	2020-06-18	2023-02-20	제넨테크, 인크.	항-tigit 항체 및 pd-1 축 결합 길항제를 사용한 치료
TW202204895A (zh)	2020-07-13	2022-02-01	美商建南德克公司	預測多肽免疫性的基於細胞之方法
JP7846667B2 (ja)	2020-07-16	2026-04-15	レジェンドバイオテックアイルランドリミテッド	Ｃｄ２０結合分子及びその使用
EP4190801A4 (de)	2020-07-29	2024-10-02	Chugai Seiyaku Kabushiki Kaisha	Verfahren zur messung der pharmakokinetik eines mit einer nichtradioaktiven substanz markierten arzneimittels
EP4192868A1 (de)	2020-08-05	2023-06-14	Juno Therapeutics, Inc.	Antiidiotypische antikörper gegen ror1-gerichtete bindungsdomänen und zugehörige zusammensetzungen und verfahren
EP4192942A1 (de)	2020-08-07	2023-06-14	Genentech, Inc.	Verfahren auf t-zellen-basis zur vorhersage der immunogenität von polypeptiden
BR112023002123A2 (pt)	2020-08-07	2023-03-07	Genentech Inc	Proteína de fusão fc, ácidos nucleicos isolados, método de produção da proteína de fusão fc, formulação farmacêutica, métodos para expandir o número de células dendríticas (dcs) em um indivíduo e para tratar um câncer, proteína fc sem efetora e anticorpo
EP4210832A1 (de)	2020-09-14	2023-07-19	Vor Biopharma, Inc.	Chimäre antigenrezeptoren zur behandlung von krebs
CN116406291A (zh)	2020-10-05	2023-07-07	基因泰克公司	用抗fcrh5/抗cd3双特异性抗体进行治疗的给药
US20230391852A1 (en)	2020-10-26	2023-12-07	The U.S.A., As Represented By The Secretary, Department Of Health And Human Services	Single domain antibodies targeting sars coronavirus spike protein and uses thereof
WO2022093983A1 (en)	2020-10-27	2022-05-05	Vor Biopharma, Inc.	Compositions and methods for treating hematopoietic malignancy
AU2021374594B2 (en)	2020-11-04	2026-03-05	Genentech, Inc.	Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies and anti-cd79b antibody drug conjugates
TWI874719B (zh)	2020-11-04	2025-03-01	美商建南德克公司	用抗cd20/抗cd3雙特異性抗體進行治療之給藥
JP7716473B2 (ja)	2020-11-04	2025-07-31	ジェネンテック，インコーポレイテッド	抗ｃｄ２０／抗ｃｄ３二重特異性抗体の皮下投薬
WO2022115865A2 (en)	2020-11-25	2022-06-02	Xilio Development, Inc.	Tumor-specific cleavable linkers
WO2022116877A1 (en)	2020-12-02	2022-06-09	Shanghai Henlius Biotech, Inc.	ANTI-GARP/TGFβ ANTIBODIES AND METHODS OF USE
MX2023007133A (es)	2020-12-17	2023-06-27	Hoffmann La Roche	Anticuerpos anti-hla-g y uso de estos.
AR124681A1 (es)	2021-01-20	2023-04-26	Abbvie Inc	Conjugados anticuerpo-fármaco anti-egfr
EP4284838A2 (de)	2021-01-28	2023-12-06	Janssen Biotech, Inc.	Psma-bindende proteine und verwendungen davon
CA3209364A1 (en)	2021-03-01	2022-09-09	Jennifer O'neil	Combination of masked ctla4 and pd1/pdl1 antibodies for treating cancer
EP4301467A1 (de)	2021-03-01	2024-01-10	Xilio Development, Inc.	Kombination von ctla4 und pd1/pdl1-antikörpern zur behandlung von krebs
US20240158503A1 (en)	2021-03-03	2024-05-16	Pierre Fabre Medicament	Anti-vsig4 antibody or antigen binding fragment and uses thereof
US11739144B2 (en)	2021-03-09	2023-08-29	Xencor, Inc.	Heterodimeric antibodies that bind CD3 and CLDN6
EP4305065A1 (de)	2021-03-10	2024-01-17	Xencor, Inc.	Cd3 und gpc3 bindende heterodimere antikörper
AR125344A1 (es)	2021-04-15	2023-07-05	Chugai Pharmaceutical Co Ltd	Anticuerpo anti-c1s
WO2022232612A1 (en)	2021-04-29	2022-11-03	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Lassa virus-specific nanobodies and methods of their use
US20240209094A1 (en)	2021-04-30	2024-06-27	Pierre Fabre Medicament	New stable anti-vista antibody
TW202244059A (zh)	2021-04-30	2022-11-16	瑞士商赫孚孟拉羅股份公司	用抗ｃｄ２０／抗ｃｄ３雙特異性抗體進行治療之給藥
CA3213632A1 (en)	2021-04-30	2022-11-03	F. Hoffmann-La Roche Ag	Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate
IL308351A (en)	2021-05-12	2024-01-01	Genentech Inc	Methods for using anti-CD79B immunoconjugates to treat diffuse large B-cell lymphoma
US20250076283A1 (en)	2021-05-19	2025-03-06	Chugai Seiyaku Kabushiki Kaisha	Method for predicting in vivo pharmacokinetics of molecule
CN117396513A (zh)	2021-05-28	2024-01-12	葛兰素史密斯克莱知识产权发展有限公司	治疗癌症的联合疗法
TW202306994A (zh)	2021-06-04	2023-02-16	日商中外製藥股份有限公司	抗ddr2抗體及其用途
US20240270851A1 (en)	2021-06-09	2024-08-15	The U.S.A., As Represented By The Secretary, Department Of Health And Human Services	Cross species single domain antibodies targeting pd-l1 for treating solid tumors
TWI879694B (zh)	2021-06-25	2025-04-01	日商中外製藥股份有限公司	抗ctla-4抗體的用途
AR126220A1 (es)	2021-06-25	2023-09-27	Chugai Pharmaceutical Co Ltd	Anticuerpo anti-ctla-4
US11807685B2 (en)	2021-08-05	2023-11-07	The Uab Research Foundation	Anti-CD47 antibody and uses thereof
US20240336697A1 (en)	2021-08-07	2024-10-10	Genentech, Inc.	Methods of using anti-cd79b immunoconjugates to treat diffuse large b-cell lymphoma
US20240342282A1 (en)	2021-08-13	2024-10-17	Ludwig-Maximilians-Universität München	Anti-csf1r car expressing lymphocytes for targeted tumor therapy
AU2022333321A1 (en)	2021-08-27	2024-04-11	Janssen Biotech, Inc.	Anti-psma antibodies and uses thereof
US20250327057A1 (en)	2021-09-06	2025-10-23	Veraxa Biotech Gmbh	Novel aminoacyl-trna synthetase variants for genetic code expansion in eukaryotes
WO2023056403A1 (en)	2021-09-30	2023-04-06	Genentech, Inc.	Methods for treatment of hematologic cancers using anti-tigit antibodies, anti-cd38 antibodies, and pd-1 axis binding antagonists
CA3233953A1 (en)	2021-10-05	2023-04-13	Matthew Bruce	Combination therapies for treating cancer
EP4413998A4 (de)	2021-10-08	2026-02-25	Chugai Pharmaceutical Co Ltd	Verfahren zur herstellung einer vorgefüllten spritzenformulierung
EP4426727A2 (de)	2021-11-03	2024-09-11	Hangzhou Dac Biotech Co., Ltd.	Spezifische konjugation eines antikörpers
TW202337494A (zh)	2021-11-16	2023-10-01	美商建南德克公司	用莫蘇妥珠單抗治療全身性紅斑狼瘡（ｓｌｅ）之方法及組成物
DK4186529T3 (da)	2021-11-25	2025-08-25	Veraxa Biotech Gmbh	Forbedrede antistof-payload-konjugater (apc) fremstillet ved stedspecifik konjugering ved hjælp af genetisk kodeudvidelse
WO2023094525A1 (en)	2021-11-25	2023-06-01	Veraxa Biotech Gmbh	Improved antibody-payload conjugates (apcs) prepared by site-specific conjugation utilizing genetic code expansion
US20250135011A1 (en)	2021-12-08	2025-05-01	European Molecular Biology Laboratory	Hydrophilic tetrazine-functionalized payloads for preparation of targeting conjugates
KR20240122784A (ko)	2021-12-17	2024-08-13	상하이 헨리우스 바이오테크, 인크.	항-ox40 항체 및 사용 방법
KR20240116755A (ko)	2021-12-17	2024-07-30	상하이 헨리우스 바이오테크, 인크.	항-ox40 항체, 다중 특이적 항체 및 이의 사용 방법
UY40097A (es)	2022-01-07	2023-07-14	Johnson & Johnson Entpr Innovation Inc	Materiales y métodos de proteínas de unión a il-1b
US20250114489A1 (en)	2022-02-15	2025-04-10	Tagworks Pharmaceuticals B.V.	Masked il12 protein
MX2024011468A (es)	2022-03-23	2024-09-25	Hoffmann La Roche	Tratamiento conjunto de un anticuerpo biespecifico anti-cd20/anti-cd3 y quimioterapia.
CA3245762A1 (en)	2022-03-25	2023-09-28	Shanghai Henlius Biologics Co., Ltd.	ANTI-MSLN ANTIBODIES AND METHODS OF USE
IL315770A (en)	2022-04-01	2024-11-01	Genentech Inc	Dosage for treatment with bispecific anti-FCRH5/anti-CD3 antibodies
WO2023198727A1 (en)	2022-04-13	2023-10-19	F. Hoffmann-La Roche Ag	Pharmaceutical compositions of anti-cd20/anti-cd3 bispecific antibodies and methods of use
WO2023201299A1 (en)	2022-04-13	2023-10-19	Genentech, Inc.	Pharmaceutical compositions of therapeutic proteins and methods of use
US20230346862A1 (en)	2022-05-02	2023-11-02	Athanor Biosciences, Inc.	Cancer eradicating - bio-nanoparticles (ce-bnp)
JP2025517650A (ja)	2022-05-11	2025-06-10	ジェネンテック，インコーポレイテッド	抗ＦｃＲＨ５／抗ＣＤ３二重特異性抗体による処置のための投与
KR20250022049A (ko)	2022-06-07	2025-02-14	제넨테크, 인크.	항-pd-l1 길항제 및 항-tigit 길항제 항체를 포함하는, 폐암 치료의 효율을 결정하는 방법
AU2023305619A1 (en)	2022-07-13	2025-01-23	F. Hoffmann-La Roche Ag	Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
KR20250040020A (ko)	2022-07-19	2025-03-21	제넨테크, 인크.	항-fcrh5/항-cd3 이중특이성 항체로 치료하기 위한 투약법
TW202417504A (zh)	2022-07-22	2024-05-01	美商建南德克公司	抗ｓｔｅａｐ１抗原結合分子及其用途
EP4581366A1 (de)	2022-09-01	2025-07-09	Genentech, Inc.	Therapeutische und diagnostische verfahren für blasenkrebs
WO2024073751A1 (en)	2022-09-29	2024-04-04	Vor Biopharma Inc.	Methods and compositions for gene modification and enrichment
WO2024080872A1 (en)	2022-10-12	2024-04-18	Tagworks Pharmaceuticals B.V.	Strained bicyclononenes
KR20250093336A (ko)	2022-10-25	2025-06-24	제넨테크, 인크.	다발성 골수종에 대한 치료 및 진단 방법
EP4608429A1 (de)	2022-10-25	2025-09-03	Peptomyc, S.L.	Kombinationstherapie zur behandlung von krebs
WO2024102948A1 (en)	2022-11-11	2024-05-16	Celgene Corporation	Fc receptor-homolog 5 (fcrh5) specific binding molecules and bispecific t-cell engaging antibodies including same and related methods
KR20250135354A (ko)	2022-12-13	2025-09-12	주노 쎄러퓨티크스 인코퍼레이티드	Baff-r 및 cd19에 특이적인 키메라 항원 수용체 및 그의 방법 및 용도
GB202219154D0 (en)	2022-12-19	2023-02-01	Metacurum Biotech Ab	Antibodies and uses thereof
WO2024153789A1 (en)	2023-01-20	2024-07-25	Basf Se	Stabilized biopolymer composition, their manufacture and use
WO2024168312A1 (en)	2023-02-09	2024-08-15	Vor Biopharma Inc.	Methods for treating hematopoietic malignancy
WO2024191293A1 (en)	2023-03-10	2024-09-19	Tagworks Pharmaceuticals B.V.	Trans-cyclooctene with improved t-linker
WO2024218345A1 (en)	2023-04-21	2024-10-24	Glaxosmithkline Intellectual Property Development Limited	Cytotoxicity targeting chimeras for antibody-drug conjugates and bispecific antibodies
AU2024270495A1 (en)	2023-05-05	2025-10-09	Genentech, Inc.	Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
IL325025A (en)	2023-06-07	2026-01-01	Fundaci? Privada Inst Dinvestigaci? Oncol?Gica De Vall Hebron	Combination therapy with BRAF inhibitors for cancer treatment
IL324909A (en)	2023-06-07	2026-01-01	Fundaci? Privada Inst Dinvestigaci? Oncol?Gica De Vall Hebron	Combination therapy with mek inhibitors for the treatment of cancer
EP4473974A1 (de)	2023-06-07	2024-12-11	Peptomyc, S.L.	Omomyc und kras-hemmern kombinationstherapie zur behandlung von krebs
KR20260021689A (ko)	2023-06-08	2026-02-13	제넨테크, 인크.	림프종 진단 및 치료 방법을 위한 대식세포 시그니처
AU2024304180A1 (en)	2023-06-13	2026-01-08	Adcentrx Therapeutics, Inc.	Methods and compositions related to antibodies and antibody drug conjugates (adcs) that bind nectin-4 proteins
US12319747B2 (en)	2023-07-03	2025-06-03	Medicovestor, Inc.	Methods of using anti-SP17 immunotherapeutics
AU2024295016A1 (en)	2023-07-20	2026-02-05	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Fully human monoclonal antibodies and chimeric antigen receptors against cd276 for the treatment of solid tumors
KR20260046464A (ko)	2023-07-27	2026-04-07	베락사 바이오테크 게엠베하	친수성 트랜스-시클로옥텐(hyTCO) 화합물, 이를 포함하는 구조체 및 접합체
EP4509142A1 (de)	2023-08-16	2025-02-19	Ona Therapeutics S.L.	Fgfr4 als target in der krebsbehandlung
WO2025056807A1 (en)	2023-09-15	2025-03-20	Basf Se	Stabilized biopolymer composition, their manufacture and use
US12364777B2 (en)	2023-10-20	2025-07-22	Medicovestor, Inc.	Homodimeric antibodies for use in treating cancers and methods of use
WO2025106474A1 (en)	2023-11-14	2025-05-22	Genentech, Inc.	Therapeutic and diagnostic methods for treating cancer with anti-fcrh5/anti-cd3 bispecific antibodies
US12600795B2 (en)	2023-12-26	2026-04-14	Medicovestor, Inc.	Oligomeric IgG for immunotherapeutics and diagnostics
US12116410B1 (en)	2023-12-26	2024-10-15	Medicovestor, Inc.	Methods of manufacturing dimeric antibodies
US12378314B1 (en)	2024-02-02	2025-08-05	Medicovestor, Inc.	Proteins that bind folate receptor alpha including fully-human antibodies
US12258396B1 (en)	2024-02-02	2025-03-25	Medicovestor, Inc.	Methods of using immunotherapeutics that bind folate receptor alpha
US12240900B1 (en)	2024-02-02	2025-03-04	Medicovestor, Inc.	Nucleic acids, vectors, and cells that encode antibodies and other proteins that bind folate receptor alpha
WO2025171238A1 (en)	2024-02-07	2025-08-14	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Monoclonal antibodies that bind the juxta-membrane region of mesothelin and uses thereof
WO2025174248A1 (en)	2024-02-16	2025-08-21	Tagworks Pharmaceuticals B.V.	Trans-cyclooctenes with "or gate" release
WO2025264533A1 (en)	2024-06-17	2025-12-26	Adcentrx Therapeutics Inc.	Methods and compositions related to antibody drug conjugates (adcs) that bind steap-1 proteins
WO2026030464A1 (en)	2024-07-30	2026-02-05	Genentech, Inc.	Dosage regimen for reducing cytokine release syndrome (crs) with anti-fcrh5/anti-cd3 bispecific antibodies in multiple myeloma therapy
WO2026043376A1 (en)	2024-08-22	2026-02-26	Tagworks Pharmaceuticals B.V.	Trans-cyclooctene formulations
WO2026078060A1 (en)	2024-10-08	2026-04-16	Basf Se	Tocopherol alkoxylates for biopolymer stabilization

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5053394A (en) *	1988-09-21	1991-10-01	American Cyanamid Company	Targeted forms of methyltrithio antitumor agents
EP0329184A3 (de) *	1988-02-19	1990-05-23	Neorx Corporation	Antimere und antimere Konjugation
US5006652A (en) *	1988-08-08	1991-04-09	Eli Lilly And Company	Intermediates for antibody-vinca drug conjugates
US5144012A (en) *	1988-08-08	1992-09-01	Eli Lilly And Company	Cytotoxic drug conjugates
US5028697A (en) *	1988-08-08	1991-07-02	Eli Lilly And Company	Cytotoxic antibody conjugates of hydrazide derivatized methotrexate analogs via simple organic linkers
US5094849A (en) *	1988-08-08	1992-03-10	Eli Lilly And Company	Cytotoxic antibody conjugates of hydrazide derivatized vinca analogs via simple organic linkers
US5045451A (en) *	1988-10-26	1991-09-03	Board Of Regents	Methods for screening antibodies for use as immunotoxins
IL93733A (en) *	1989-04-14	1996-01-19	American Cyanamid Co	Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group and targeted forms thereof
GB8928874D0 (en) *	1989-12-21	1990-02-28	Celltech Ltd	Humanised antibodies
GB9120467D0 (en) *	1991-09-26	1991-11-06	Celltech Ltd	Anti-hmfg antibodies and process for their production
US5773001A (en) *	1994-06-03	1998-06-30	American Cyanamid Company	Conjugates of methyltrithio antitumor agents and intermediates for their synthesis

1994
- 1994-06-03 US US08/253,877 patent/US5773001A/en not_active Expired - Lifetime
- 1994-10-12 TW TW083109420A patent/TW394778B/zh not_active IP Right Cessation
1995
- 1995-05-26 US US08/452,164 patent/US5877296A/en not_active Expired - Lifetime
- 1995-05-31 JP JP15564495A patent/JP3650165B2/ja not_active Expired - Lifetime
- 1995-06-01 ES ES95303746T patent/ES2181752T3/es not_active Expired - Lifetime
- 1995-06-01 AT AT95303746T patent/ATE223234T1/de active
- 1995-06-01 DE DE69528016T patent/DE69528016T2/de not_active Expired - Lifetime
- 1995-06-01 IL IL11398495A patent/IL113984A/xx not_active IP Right Cessation
- 1995-06-01 PT PT95303746T patent/PT689845E/pt unknown
- 1995-06-01 SI SI9530554T patent/SI0689845T1/xx unknown
- 1995-06-01 EP EP95303746A patent/EP0689845B1/de not_active Expired - Lifetime
- 1995-06-01 DK DK95303746T patent/DK0689845T3/da active
- 1995-06-01 CA CA2150785A patent/CA2150785C/en not_active Expired - Lifetime
- 1995-06-02 FI FI952720A patent/FI117690B/fi not_active IP Right Cessation
- 1995-06-02 NZ NZ272274A patent/NZ272274A/en not_active IP Right Cessation
- 1995-06-02 ZA ZA954570A patent/ZA954570B/xx unknown
- 1995-06-02 NO NO19952206A patent/NO313617B1/no not_active IP Right Cessation
- 1995-06-02 NZ NZ536440A patent/NZ536440A/en not_active IP Right Cessation
- 1995-06-02 AU AU20449/95A patent/AU697280B2/en not_active Expired
- 1995-06-03 KR KR1019950014699A patent/KR100408376B1/ko not_active Expired - Lifetime
- 1995-06-05 US US08/462,939 patent/US5767285A/en not_active Expired - Lifetime
- 1995-06-05 US US08/461,284 patent/US5739116A/en not_active Expired - Lifetime
1997
- 1997-05-14 BR BR1100990-0A patent/BR1100990A/pt active IP Right Grant
- 1997-05-14 BR BR1101078-9A patent/BR1101078A/pt active IP Right Grant
- 1997-09-17 NZ NZ328762A patent/NZ328762A/xx not_active IP Right Cessation
2003
- 2003-01-27 CY CY0300005A patent/CY2334B1/xx unknown
2005
- 2005-01-12 JP JP2005004986A patent/JP2005139200A/ja active Pending

Also Published As

Publication number	Publication date
BR1101078A (pt)	1999-10-26
JP2005139200A (ja)	2005-06-02
NZ272274A (en)	1997-11-24
KR100408376B1 (ko)	2004-03-09
JP3650165B2 (ja)	2005-05-18
PT689845E (pt)	2002-12-31
NZ536440A (en)	2007-08-31
ZA954570B (en)	1996-05-22
NO952206L (no)	1995-12-04
EP0689845A2 (de)	1996-01-03
JPH0848637A (ja)	1996-02-20
CY2334B1 (en)	2004-02-06
NZ328762A (en)	2000-08-25
IL113984A (en)	2000-09-28
CA2150785A1 (en)	1995-12-04
IL113984A0 (en)	1995-10-31
AU2044995A (en)	1995-12-14
FI117690B (fi)	2007-01-31
TW394778B (en)	2000-06-21
US5767285A (en)	1998-06-16
DE69528016D1 (de)	2002-10-10
ES2181752T3 (es)	2003-03-01
EP0689845B1 (de)	2002-09-04
KR960000234A (ko)	1996-01-25
DE69528016T2 (de)	2003-01-02
SI0689845T1 (en)	2002-12-31
DK0689845T3 (da)	2003-01-06
NO313617B1 (no)	2002-11-04
FI952720A0 (fi)	1995-06-02
FI952720L (fi)	1995-12-04
NO952206D0 (no)	1995-06-02
EP0689845A3 (de)	1999-08-25
US5877296A (en)	1999-03-02
BR1100990A (pt)	2002-04-02
US5773001A (en)	1998-06-30
US5739116A (en)	1998-04-14
CA2150785C (en)	2010-07-06
AU697280B2 (en)	1998-10-01

Legal Events

Date	Code	Title	Description
2002-12-15	UEP	Publication of translation of european patent specification
2003-11-15	EEFA	Change of the company name

Publication	Publication Date	Title
ATE223234T1 (de)	2002-09-15	Konjugate von methyltrithio-antitumormitteln und zwischenprodukte für deren herstellung
UY23541A1 (es)	1993-06-28	Procedimiento para la preparacion de conjugados de tioeter
DE50014571D1 (de)	2007-09-27	Träger-pharmaka-konjugate
IL189629A0 (en)	2008-06-05	Compositions containing human ctla-4 antibodies
TR200003117T2 (tr)	2001-03-21	Hastalıkların tedavisi için arsenik sülfür bileşikleri ve bunların türevleri
HU9302330D0 (en)	1993-10-28	7-(substituted)-9-\|(substituted glycyl)-amino¨-6-desmethyl-6-desoxy-tetracyclines, pharmaceutical preparatives containing them and methods for producing them
HU9302329D0 (en)	1993-10-28	7-(substituted)-9-\|(substituted glycyl)-amino¨-6-desmethyl-6-desoxy-tetracyclines, pharmaceutical preparatives containing them and methods for producing them
WO1996039193A3 (en)	1997-06-05	Drug mitochondrial targeting agents
DE69533564D1 (de)	2004-11-04	Effektor-Proteine für Rapamycin
GR1000118B (el)	1991-06-28	Συνθεσις 1,2-διοξετανων & ενδιαμεσαι ουσιαι δι αυτην.
ES2123582T3 (es)	1999-01-16	Proteina con capacidad de formacion de huesos y procedimiento para su produccion.
AU1125192A (en)	1993-01-28	Fusion proteins for prodrug activation, the preparation and use thereof
IL93733A0 (en)	1990-12-23	Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group,and targeted forms thereof
ATE173504T1 (de)	1998-12-15	Granulozytenbindende antikörperkonstrukte, ihre herstellung und verwendung
WO2000001729A3 (en)	2000-02-10	Synthetic peptides and pharmaceutical compositions comprising them for diagnosis and treatment of anti-phospholipid syndrome
EA200000705A1 (ru)	2000-12-25	Промежуточные соединения и способ синтеза 17-замещенных 16.бета.-арилокси 4-азастероидов
KR970025416A (ko)	1997-06-24	항생제와 조단백질이 포함된 사료용 항생제 조성물 및 그의 제조방법
IT1264495B1 (it)	1996-09-24	Complessi solubili in acqua di glicosaminoglicani, loro procedimento di preparazione e composizioni farmaceutiche che li contengono