ATE237603T1 - Verbindungen und verfahren zur herstellung substituierter 4-phenyl-4-cyanocyclohexansäuren - Google Patents

Verbindungen und verfahren zur herstellung substituierter 4-phenyl-4-cyanocyclohexansäuren

Info

Publication number: ATE237603T1
Authority: AT; Austria
Prior art keywords: cyanocyclohexanic; phenyl; acids; compounds; methods
Prior art date: 1997-02-12

Application number

AT98908534T

Other languages

English (en)

Inventor

Andrew Allen

Ann Marie Diederich

Li Liu

Wilford Mendelson

Original Assignee

Smithkline Beecham

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-12

Filing date

1998-02-12

Publication date

2003-05-15

1998-02-12 Application filed by Smithkline Beecham filed Critical Smithkline Beecham

2003-05-15 Application granted granted Critical

2003-05-15 Publication of ATE237603T1 publication Critical patent/ATE237603T1/de

Links

239000002253 acid Substances 0.000 title 1
150000007513 acids Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/21—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing rings other than six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pulmonology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Epoxy Compounds (AREA)
Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)

AT98908534T 1997-02-12 1998-02-12 Verbindungen und verfahren zur herstellung substituierter 4-phenyl-4-cyanocyclohexansäuren ATE237603T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3760897P	1997-02-12	1997-02-12
PCT/US1998/002749 WO1998034584A2 (en)	1997-02-12	1998-02-12	Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Publications (1)

Publication Number	Publication Date
ATE237603T1 true ATE237603T1 (de)	2003-05-15

Family

ID=21895265

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT98908534T ATE237603T1 (de)	1997-02-12	1998-02-12	Verbindungen und verfahren zur herstellung substituierter 4-phenyl-4-cyanocyclohexansäuren
AT02078056T ATE300517T1 (de)	1997-02-12	1998-02-12	Verbindungen und verfahren zur herstellung substituierter 4-phenyl-4-cyanocyclohexansäuren

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT02078056T ATE300517T1 (de)	1997-02-12	1998-02-12	Verbindungen und verfahren zur herstellung substituierter 4-phenyl-4-cyanocyclohexansäuren

Country Status (37)

Country	Link
US (1)	US6337408B1 (de)
EP (1)	EP1023279B8 (de)
JP (4)	JP3786971B2 (de)
KR (1)	KR100412008B1 (de)
CN (2)	CN1854131A (de)
AP (1)	AP1215A (de)
AR (2)	AR012550A1 (de)
AT (2)	ATE237603T1 (de)
AU (1)	AU725484B2 (de)
BG (1)	BG63541B1 (de)
BR (1)	BR9808637A (de)
CA (1)	CA2279951A1 (de)
CO (1)	CO4950534A1 (de)
CY (1)	CY2478B1 (de)
DE (3)	DE69836928T2 (de)
DK (2)	DK1023279T3 (de)
DZ (1)	DZ2423A1 (de)
EA (1)	EA001783B1 (de)
ES (3)	ES2280008T3 (de)
HU (1)	HUP0001801A3 (de)
ID (1)	ID23527A (de)
IL (7)	IL131270A (de)
MA (1)	MA24471A1 (de)
MY (1)	MY118813A (de)
NO (1)	NO993863D0 (de)
NZ (1)	NZ337084A (de)
OA (1)	OA11144A (de)
PL (1)	PL193366B1 (de)
PT (2)	PT1524268E (de)
SI (2)	SI1295869T1 (de)
SK (1)	SK108899A3 (de)
TR (1)	TR199901920T2 (de)
TW (1)	TW442455B (de)
UA (1)	UA58533C2 (de)
UY (2)	UY24882A1 (de)
WO (1)	WO1998034584A2 (de)
ZA (1)	ZA981125B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA67753C2 (uk) *	1997-10-10	2004-07-15	Смітклайн Бічам Корпорейшн	Спосіб отримання заміщених 4-феніл-4-ціанциклогексанових кислот
US6452022B1 (en) *	1997-10-10	2002-09-17	Smithkline Beecham Corporation	Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
UY26268A1 (es) *	1999-08-06	2001-01-31	Smithkline Beecham Corp	Procedimiento para preparar acidos a traves de alfa-cloroep xi- esteres ley 17164 art 127
US20040220424A1 (en) *	1999-08-06	2004-11-04	Smithkline Beecham Corporation	Process for preparing acids via alpha-chloroepoxy esters
GB9920152D0 (en)	1999-08-25	1999-10-27	Smithkline Beecham Plc	Novel process
US6555572B2 (en)	2000-03-16	2003-04-29	Inflazyme Pharmaceuticals Ltd.	Benzylated PDE4 inhibitors
CN102491959B (zh) *	2011-12-19	2015-03-25	江苏澄扬作物科技有限公司	一种环氧乙烷衍生物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8320943D0 (en) *	1983-08-03	1983-09-07	Lilly Industries Ltd	Organic compounds
CA2133439C (en) *	1992-04-02	2005-07-26	Siegfried Benjamin Christensen, Iv	Compounds useful for treating allergic and inflammatory diseases
US5602173A (en) *	1992-04-02	1997-02-11	Smithkline Beecham Corporation	Compounds useful for treating allergic and inflammatory diseases

1998
- 1998-02-10 UY UY24882A patent/UY24882A1/es not_active IP Right Cessation
- 1998-02-10 AR ARP980100587A patent/AR012550A1/es unknown
- 1998-02-10 MY MYPI98000536A patent/MY118813A/en unknown
- 1998-02-11 ZA ZA981125A patent/ZA981125B/xx unknown
- 1998-02-12 CN CNA2006100819583A patent/CN1854131A/zh active Pending
- 1998-02-12 CA CA002279951A patent/CA2279951A1/en not_active Abandoned
- 1998-02-12 PT PT04078092T patent/PT1524268E/pt unknown
- 1998-02-12 MA MA24962A patent/MA24471A1/fr unknown
- 1998-02-12 DZ DZ980033A patent/DZ2423A1/xx active
- 1998-02-12 DE DE69836928T patent/DE69836928T2/de not_active Expired - Lifetime
- 1998-02-12 AU AU66544/98A patent/AU725484B2/en not_active Ceased
- 1998-02-12 AT AT98908534T patent/ATE237603T1/de not_active IP Right Cessation
- 1998-02-12 EP EP98908534A patent/EP1023279B8/de not_active Expired - Lifetime
- 1998-02-12 SI SI9830794T patent/SI1295869T1/sl unknown
- 1998-02-12 BR BR9808637-5A patent/BR9808637A/pt not_active Application Discontinuation
- 1998-02-12 PL PL335031A patent/PL193366B1/pl not_active IP Right Cessation
- 1998-02-12 EA EA199900735A patent/EA001783B1/ru not_active IP Right Cessation
- 1998-02-12 DE DE69831022T patent/DE69831022T2/de not_active Expired - Lifetime
- 1998-02-12 AP APAP/P/1999/001618A patent/AP1215A/en active
- 1998-02-12 CO CO98007356A patent/CO4950534A1/es unknown
- 1998-02-12 HU HU0001801A patent/HUP0001801A3/hu unknown
- 1998-02-12 ES ES04078092T patent/ES2280008T3/es not_active Expired - Lifetime
- 1998-02-12 DK DK98908534T patent/DK1023279T3/da active
- 1998-02-12 TR TR1999/01920T patent/TR199901920T2/xx unknown
- 1998-02-12 PT PT98908534T patent/PT1023279E/pt unknown
- 1998-02-12 AT AT02078056T patent/ATE300517T1/de not_active IP Right Cessation
- 1998-02-12 ES ES02078056T patent/ES2246373T3/es not_active Expired - Lifetime
- 1998-02-12 ES ES98908534T patent/ES2196551T3/es not_active Expired - Lifetime
- 1998-02-12 JP JP53506598A patent/JP3786971B2/ja not_active Expired - Fee Related
- 1998-02-12 KR KR10-1999-7007192A patent/KR100412008B1/ko not_active Expired - Fee Related
- 1998-02-12 DK DK04078092T patent/DK1524268T3/da active
- 1998-02-12 SI SI9830872T patent/SI1524268T1/sl unknown
- 1998-02-12 SK SK1088-99A patent/SK108899A3/sk unknown
- 1998-02-12 CN CNB988023776A patent/CN1301982C/zh not_active Expired - Fee Related
- 1998-02-12 NZ NZ337084A patent/NZ337084A/en unknown
- 1998-02-12 DE DE69813596T patent/DE69813596T2/de not_active Expired - Lifetime
- 1998-02-12 IL IL13127098A patent/IL131270A/xx not_active IP Right Cessation
- 1998-02-12 WO PCT/US1998/002749 patent/WO1998034584A2/en not_active Ceased
- 1998-02-12 ID IDW990806A patent/ID23527A/id unknown
- 1998-07-20 TW TW087101889A patent/TW442455B/zh active
- 1998-08-06 UY UY25127A patent/UY25127A1/es not_active IP Right Cessation
- 1998-12-02 UA UA99084524A patent/UA58533C2/uk unknown
1999
- 1999-08-10 BG BG103651A patent/BG63541B1/bg unknown
- 1999-08-11 NO NO993863A patent/NO993863D0/no unknown
- 1999-08-12 OA OA9900176A patent/OA11144A/en unknown
2000
- 2000-03-22 US US09/533,368 patent/US6337408B1/en not_active Expired - Fee Related
2002
- 2002-07-29 IL IL150955A patent/IL150955A/en not_active IP Right Cessation
2004
- 2004-01-05 JP JP2004000418A patent/JP4093967B2/ja not_active Expired - Fee Related
- 2004-06-09 JP JP2004171348A patent/JP4053024B2/ja not_active Expired - Fee Related
- 2004-06-09 JP JP2004171346A patent/JP4053023B2/ja not_active Expired - Fee Related
- 2004-09-08 CY CY0400070A patent/CY2478B1/xx unknown
2005
- 2005-01-06 IL IL16618805A patent/IL166188A0/xx unknown
- 2005-01-06 IL IL16618405A patent/IL166184A0/xx unknown
- 2005-01-06 IL IL16618505A patent/IL166185A0/xx unknown
- 2005-01-06 IL IL16618705A patent/IL166187A0/xx unknown
- 2005-01-06 IL IL16618605A patent/IL166186A0/xx unknown
2006
- 2006-04-05 AR ARP060101344A patent/AR050308A2/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP4093967B2 (ja)	2008-06-04
PL335031A1 (en)	2000-03-27
KR100412008B1 (ko)	2003-12-24
EP1023279A2 (de)	2000-08-02
PT1524268E (pt)	2007-03-30
DE69836928D1 (de)	2007-03-08
ES2280008T3 (es)	2007-09-01
DE69836928T2 (de)	2007-11-08
JP4053024B2 (ja)	2008-02-27
CN1301982C (zh)	2007-02-28
IL166186A0 (en)	2006-01-15
AP9901618A0 (en)	1999-09-30
SI1295869T1 (sl)	2005-12-31
JP4053023B2 (ja)	2008-02-27
AU725484B2 (en)	2000-10-12
AR050308A2 (es)	2006-10-18
IL166188A0 (en)	2006-01-15
CN1854131A (zh)	2006-11-01
DE69813596D1 (de)	2003-05-22
PT1023279E (pt)	2003-08-29
NZ337084A (en)	2001-04-27
OA11144A (en)	2003-04-17
HUP0001801A3 (en)	2001-12-28
TR199901920T2 (xx)	1999-11-22
KR20000070927A (ko)	2000-11-25
JP2004292460A (ja)	2004-10-21
DE69831022D1 (de)	2005-09-01
ID23527A (id)	2000-04-27
NO993863L (no)	1999-08-11
TW442455B (en)	2001-06-23
BG103651A (en)	2000-02-29
DK1524268T3 (da)	2007-05-14
AP1215A (en)	2003-10-14
MY118813A (en)	2005-01-31
AU6654498A (en)	1998-08-26
SK108899A3 (en)	2000-01-18
JP2004149546A (ja)	2004-05-27
WO1998034584A2 (en)	1998-08-13
NO993863D0 (no)	1999-08-11
JP2004269546A (ja)	2004-09-30
ZA981125B (en)	1998-08-21
IL131270A0 (en)	2001-01-28
MA24471A1 (fr)	1998-10-01
DZ2423A1 (fr)	2003-01-04
EP1023279B8 (de)	2003-08-13
IL131270A (en)	2005-05-17
HUP0001801A2 (hu)	2000-10-28
JP3786971B2 (ja)	2006-06-21
IL150955A (en)	2006-07-05
CN1246855A (zh)	2000-03-08
US6337408B1 (en)	2002-01-08
DE69831022T2 (de)	2006-04-20
IL166187A0 (en)	2006-01-15
IL166185A0 (en)	2006-01-15
WO1998034584A3 (en)	1998-11-19
JP2001510482A (ja)	2001-07-31
SI1524268T1 (sl)	2007-04-30
UY25127A1 (es)	1998-11-27
DK1023279T3 (da)	2003-07-21
EP1023279B1 (de)	2003-04-16
BG63541B1 (bg)	2002-04-30
EP1023279A4 (de)	2000-10-04
ES2246373T3 (es)	2006-02-16
UA58533C2 (uk)	2003-08-15
EA199900735A1 (ru)	2000-02-28
IL166184A0 (en)	2006-01-15
EA001783B1 (ru)	2001-08-27
HK1037613A1 (en)	2002-02-15
BR9808637A (pt)	2000-07-04
CO4950534A1 (es)	2000-09-01
CY2478B1 (en)	2005-06-03
ES2196551T3 (es)	2003-12-16
DE69813596T2 (de)	2004-02-12
PL193366B1 (pl)	2007-02-28
UY24882A1 (es)	2001-08-27
AR012550A1 (es)	2000-11-08
CA2279951A1 (en)	1998-08-13
ATE300517T1 (de)	2005-08-15

Legal Events

Date

Code

Title

Description

2003-12-15

UEP

Publication of translation of european patent specification

Ref document number: 1023279

Country of ref document: EP

2011-11-15

REN

Ceased due to non-payment of the annual fee

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