ES2196551T3 - Compuestos y procedimiento para la preparacion de acidos 4-fenil-4-cianociclohexanoicos sustituidos. - Google Patents

Compuestos y procedimiento para la preparacion de acidos 4-fenil-4-cianociclohexanoicos sustituidos.

Info

Publication number
ES2196551T3
ES2196551T3 ES98908534T ES98908534T ES2196551T3 ES 2196551 T3 ES2196551 T3 ES 2196551T3 ES 98908534 T ES98908534 T ES 98908534T ES 98908534 T ES98908534 T ES 98908534T ES 2196551 T3 ES2196551 T3 ES 2196551T3
Authority
ES
Spain
Prior art keywords
thiocyclopyl
thiocycloalkyl
cr4r5
aryl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98908534T
Other languages
English (en)
Inventor
Andrew Allen
Ann Marie Diederich
Li Liu
Wilford Mendelson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Application granted granted Critical
Publication of ES2196551T3 publication Critical patent/ES2196551T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/21—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un procedimiento para la preparación de un compuesto de fórmula I **fórmula** R1 es -(CR4R5)nC(O)O(CR4R5)mR6, -(CR4R5)nC(O)NR4(CR4R5)mR6, -(CR4R5)nO(CR4R5)mR6, o -(CR4R5)rR6, en la que las estructuras alquílicas pueden estar opcionalmente sustituidas con uno a más halógenos; m es 0 a 2; n es 1 a 4; r es 0 a 6; R4 y R5 son, independientemente, hidrógeno o un alquilo C1-2; R6 es hidrógeno, metilo, hidroxilo, arilo, arilo halosustituido, ariloxiC1-3alquilo, ariloxiC1-3alquilo halosustituido, indanilo, indenilo, C7- 11policicloalquilo, tetrahidrofuranilo, furalino, tetrahidropiranilo, piranilo, tetrahidrotienilo, tienilo, tetrahidrotiopiranilo, tiopiranilo, C3-6cicloalquilo o un C4-6cicloalquilo con uno o dos enlaces insaturados, en los que las estructuras cicloalquílicas y heterocíclicas pueden estar opcionalmente sustituidas por 1 a 3 grupos metilo o un grupo etilo.
ES98908534T 1997-02-12 1998-02-12 Compuestos y procedimiento para la preparacion de acidos 4-fenil-4-cianociclohexanoicos sustituidos. Expired - Lifetime ES2196551T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3760897P 1997-02-12 1997-02-12

Publications (1)

Publication Number Publication Date
ES2196551T3 true ES2196551T3 (es) 2003-12-16

Family

ID=21895265

Family Applications (3)

Application Number Title Priority Date Filing Date
ES04078092T Expired - Lifetime ES2280008T3 (es) 1997-02-12 1998-02-12 Composiciones y procedimientos de preparacion de acidos 4-fenil-4-cianociclohexanoicos sustituidos.
ES98908534T Expired - Lifetime ES2196551T3 (es) 1997-02-12 1998-02-12 Compuestos y procedimiento para la preparacion de acidos 4-fenil-4-cianociclohexanoicos sustituidos.
ES02078056T Expired - Lifetime ES2246373T3 (es) 1997-02-12 1998-02-12 Composiciones y procedimiento de preparacion de acidos 4-fenil-4-cianociclohexanoicos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES04078092T Expired - Lifetime ES2280008T3 (es) 1997-02-12 1998-02-12 Composiciones y procedimientos de preparacion de acidos 4-fenil-4-cianociclohexanoicos sustituidos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES02078056T Expired - Lifetime ES2246373T3 (es) 1997-02-12 1998-02-12 Composiciones y procedimiento de preparacion de acidos 4-fenil-4-cianociclohexanoicos.

Country Status (37)

Country Link
US (1) US6337408B1 (es)
EP (1) EP1023279B8 (es)
JP (4) JP3786971B2 (es)
KR (1) KR100412008B1 (es)
CN (2) CN1301982C (es)
AP (1) AP1215A (es)
AR (2) AR012550A1 (es)
AT (2) ATE237603T1 (es)
AU (1) AU725484B2 (es)
BG (1) BG63541B1 (es)
BR (1) BR9808637A (es)
CA (1) CA2279951A1 (es)
CO (1) CO4950534A1 (es)
CY (1) CY2478B1 (es)
DE (3) DE69836928T2 (es)
DK (2) DK1524268T3 (es)
DZ (1) DZ2423A1 (es)
EA (1) EA001783B1 (es)
ES (3) ES2280008T3 (es)
HU (1) HUP0001801A3 (es)
ID (1) ID23527A (es)
IL (7) IL131270A (es)
MA (1) MA24471A1 (es)
MY (1) MY118813A (es)
NO (1) NO993863L (es)
NZ (1) NZ337084A (es)
OA (1) OA11144A (es)
PL (1) PL193366B1 (es)
PT (2) PT1023279E (es)
SI (2) SI1524268T1 (es)
SK (1) SK108899A3 (es)
TR (1) TR199901920T2 (es)
TW (1) TW442455B (es)
UA (1) UA58533C2 (es)
UY (2) UY24882A1 (es)
WO (1) WO1998034584A2 (es)
ZA (1) ZA981125B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA67753C2 (uk) * 1997-10-10 2004-07-15 Смітклайн Бічам Корпорейшн Спосіб отримання заміщених 4-феніл-4-ціанциклогексанових кислот
US6452022B1 (en) * 1997-10-10 2002-09-17 Smithkline Beecham Corporation Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
US20040220424A1 (en) * 1999-08-06 2004-11-04 Smithkline Beecham Corporation Process for preparing acids via alpha-chloroepoxy esters
UY26268A1 (es) * 1999-08-06 2001-01-31 Smithkline Beecham Corp Procedimiento para preparar acidos a traves de alfa-cloroep xi- esteres ley 17164 art 127
GB9920152D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
WO2001068600A2 (en) 2000-03-16 2001-09-20 Inflazyme Pharmaceuticals Limited Benzylated pde4 inhibitors
CN102491959B (zh) * 2011-12-19 2015-03-25 江苏澄扬作物科技有限公司 一种环氧乙烷衍生物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8320943D0 (en) * 1983-08-03 1983-09-07 Lilly Industries Ltd Organic compounds
HU225869B1 (en) * 1992-04-02 2007-11-28 Smithkline Beecham Corp Compounds with antiallergic and antiinflammatory activity and pharmaceutical compns. contg. them
US5602173A (en) * 1992-04-02 1997-02-11 Smithkline Beecham Corporation Compounds useful for treating allergic and inflammatory diseases

Also Published As

Publication number Publication date
IL166188A0 (en) 2006-01-15
JP2001510482A (ja) 2001-07-31
IL166184A0 (en) 2006-01-15
IL166185A0 (en) 2006-01-15
BG63541B1 (bg) 2002-04-30
WO1998034584A2 (en) 1998-08-13
EP1023279A4 (en) 2000-10-04
DK1524268T3 (da) 2007-05-14
BG103651A (en) 2000-02-29
DE69836928D1 (de) 2007-03-08
NO993863D0 (no) 1999-08-11
CN1246855A (zh) 2000-03-08
UY25127A1 (es) 1998-11-27
AR050308A2 (es) 2006-10-18
TR199901920T2 (xx) 1999-11-22
KR20000070927A (ko) 2000-11-25
PL193366B1 (pl) 2007-02-28
SK108899A3 (en) 2000-01-18
IL166186A0 (en) 2006-01-15
JP2004292460A (ja) 2004-10-21
EP1023279B1 (en) 2003-04-16
DE69813596D1 (de) 2003-05-22
SI1524268T1 (sl) 2007-04-30
JP3786971B2 (ja) 2006-06-21
CO4950534A1 (es) 2000-09-01
ID23527A (id) 2000-04-27
NZ337084A (en) 2001-04-27
US6337408B1 (en) 2002-01-08
JP2004269546A (ja) 2004-09-30
TW442455B (en) 2001-06-23
WO1998034584A3 (en) 1998-11-19
ATE300517T1 (de) 2005-08-15
CA2279951A1 (en) 1998-08-13
EA001783B1 (ru) 2001-08-27
AU725484B2 (en) 2000-10-12
OA11144A (en) 2003-04-17
UA58533C2 (uk) 2003-08-15
JP2004149546A (ja) 2004-05-27
EA199900735A1 (ru) 2000-02-28
DK1023279T3 (da) 2003-07-21
PT1524268E (pt) 2007-03-30
JP4053023B2 (ja) 2008-02-27
MY118813A (en) 2005-01-31
DE69836928T2 (de) 2007-11-08
DE69831022D1 (de) 2005-09-01
AP1215A (en) 2003-10-14
HK1037613A1 (en) 2002-02-15
IL166187A0 (en) 2006-01-15
AR012550A1 (es) 2000-11-08
ES2280008T3 (es) 2007-09-01
NO993863L (no) 1999-08-11
PL335031A1 (en) 2000-03-27
BR9808637A (pt) 2000-07-04
MA24471A1 (fr) 1998-10-01
IL150955A (en) 2006-07-05
IL131270A0 (en) 2001-01-28
PT1023279E (pt) 2003-08-29
ES2246373T3 (es) 2006-02-16
KR100412008B1 (ko) 2003-12-24
AU6654498A (en) 1998-08-26
SI1295869T1 (sl) 2005-12-31
EP1023279A2 (en) 2000-08-02
HUP0001801A2 (hu) 2000-10-28
CN1301982C (zh) 2007-02-28
DZ2423A1 (fr) 2003-01-04
EP1023279B8 (en) 2003-08-13
UY24882A1 (es) 2001-08-27
ZA981125B (en) 1998-08-21
HUP0001801A3 (en) 2001-12-28
JP4053024B2 (ja) 2008-02-27
CN1854131A (zh) 2006-11-01
CY2478B1 (en) 2005-06-03
DE69831022T2 (de) 2006-04-20
ATE237603T1 (de) 2003-05-15
JP4093967B2 (ja) 2008-06-04
DE69813596T2 (de) 2004-02-12
IL131270A (en) 2005-05-17
AP9901618A0 (en) 1999-09-30

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