ATE237627T1 - S-substituierte 11beta-benzaldoxim-estra-4,9-dien-kohlensäureth olester, verfahren zu deren herstellung und diese verbindungen enthaltene pharmazeutische zubereitungen - Google Patents

S-substituierte 11beta-benzaldoxim-estra-4,9-dien-kohlensäureth olester, verfahren zu deren herstellung und diese verbindungen enthaltene pharmazeutische zubereitungen

Info

Publication number: ATE237627T1
Authority: AT; Austria
Prior art keywords: compounds; 11beta; estra; substituted; pharmaceutical preparations
Prior art date: 1998-03-03

Application number

AT99915475T

Other languages

German (de)

English (en)

Inventor

Gerd Schubert

Sven Ring

Guenther Kaufmann

Walter Elger

Birgit Schneider

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-03

Filing date

1999-02-10

Publication date

2003-05-15

1999-02-10 Application filed by Schering Ag filed Critical Schering Ag

2003-05-15 Application granted granted Critical

2003-05-15 Publication of ATE237627T1 publication Critical patent/ATE237627T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000003862 glucocorticoid Substances 0.000 abstract 1
102000003998 progesterone receptors Human genes 0.000 abstract 1
108090000468 progesterone receptors Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
150000007970 thio esters Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/006—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Gynecology & Obstetrics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT99915475T 1998-03-03 1999-02-10 S-substituierte 11beta-benzaldoxim-estra-4,9-dien-kohlensäureth olester, verfahren zu deren herstellung und diese verbindungen enthaltene pharmazeutische zubereitungen ATE237627T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19809845A DE19809845A1 (de)	1998-03-03	1998-03-03	S-substituierte 11beta-Benzaldoxim-estra-4,9-dien-kohlensäurethiolester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
PCT/DE1999/000408 WO1999045023A1 (de)	1998-03-03	1999-02-10	S-SUBSTITUIERTE 11β-BENZALDOXIM-ESTRA-4,9-DIEN-KOHLENSÄURETHIOLESTER, VERFAHREN ZU DEREN HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENE PHARMAZEUTISCHE ZUBEREITUNGEN

Publications (1)

Publication Number	Publication Date
ATE237627T1 true ATE237627T1 (de)	2003-05-15

Family

ID=7860080

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99915475T ATE237627T1 (de)	1998-03-03	1999-02-10	S-substituierte 11beta-benzaldoxim-estra-4,9-dien-kohlensäureth olester, verfahren zu deren herstellung und diese verbindungen enthaltene pharmazeutische zubereitungen

Country Status (28)

Country	Link
US (1)	US6365582B1 (cs)
EP (1)	EP1060187B1 (cs)
JP (1)	JP3796405B2 (cs)
KR (1)	KR100488823B1 (cs)
CN (1)	CN1208341C (cs)
AT (1)	ATE237627T1 (cs)
AU (1)	AU749163B2 (cs)
BG (1)	BG64735B1 (cs)
BR (1)	BR9908458A (cs)
CA (1)	CA2322471C (cs)
CZ (1)	CZ20003125A3 (cs)
DE (2)	DE19809845A1 (cs)
DK (1)	DK1060187T3 (cs)
EA (1)	EA002766B1 (cs)
EE (1)	EE04242B1 (cs)
ES (1)	ES2197634T3 (cs)
HU (1)	HUP0100962A3 (cs)
ID (1)	ID26972A (cs)
IL (1)	IL137851A (cs)
IS (1)	IS5579A (cs)
NO (1)	NO316977B1 (cs)
NZ (1)	NZ506048A (cs)
PL (1)	PL193687B1 (cs)
PT (1)	PT1060187E (cs)
SK (1)	SK284177B6 (cs)
TR (1)	TR200002506T2 (cs)
UA (1)	UA59437C2 (cs)
WO (1)	WO1999045023A1 (cs)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19906152B4 (de)	1999-02-10	2005-02-10	Jenapharm Gmbh & Co. Kg	Wirkstoffhaltige Laminate für Transdermalsysteme
US7629334B1 (en) *	1999-08-31	2009-12-08	Bayer Schering Pharma Aktiengesellschaft	Mesoprogrestins (progesterone receptor modulations) as a component of compositions for hormone replacement therapy (HRT)
EE200200102A (et) *	1999-08-31	2003-04-15	Jenapharm Gmbh & Co. Kg	Mesoprogestiinid (progesterooniretseptori modulaatorid) hormoonasendusravi (HAR) kompositsioonide komponendina
CO5200772A1 (es) *	1999-08-31	2002-09-27	Jenapharm Gmbh And Co Kg	Mesoprogestinas (moduladores de receptores de progesterona) para el trataiento y la prevencion de transtornos ginecolo- gicos benignos hormona-dependientes
YU13902A (sh) *	1999-08-31	2006-01-16	Schering Ag.	Mezoprogestini (progesteron receptor modulatori) kao komponente kontraceptivnih sredstava za žene
US8193252B1 (en)	1999-08-31	2012-06-05	Bayer Pharma AG	Mesoprogestins (progesterone receptor modulators) for the treatment and prevention of benign hormone dependent gynecological disorders
EP1285927A3 (de) *	2001-08-16	2005-06-29	Schering Aktiengesellschaft	Verwendung von Glucocorticoid-Rezeptorantagonisten zur Vorbeugung und Behandlung von Erkrankungen des männlichen Reproduktionssystems
DE10221034A1 (de)	2002-05-03	2003-11-20	Schering Ag	17alpha-Fluoralkyl-11ß-benzaldoxim-Steroide, Verfahren zu deren Herstellung, diese Steroide enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
DE10236405A1 (de) *	2002-08-02	2004-02-19	Schering Ag	Progesteronrezeptormodulatoren mit erhöhter antigonadotroper Aktivität für die weibliche Fertilitätskontrolle und Hormonersatztherapie
ES2273061T3 (es) *	2002-08-02	2007-05-01	Schering Aktiengesellschaft	Agentes moduladores de receptores de progesterona con actividad antigonadotropa elevada para el control de fertilidad femenina y para la terapia por reemplazo hormonal.
DE102005059222B4 (de) *	2005-12-08	2007-10-11	Bayer Schering Pharma Ag	11ß-Benzaldoximderivate von D-Homoestra-4,9-dien-3-onen
AU2007327707B2 (en)	2006-10-24	2012-07-12	Allergan pharmaceuticals International Ltd.	Compositions and methods for suppressing endometrial proliferation
WO2008109719A2 (en) *	2007-03-07	2008-09-12	Janssen Pharmaceutica N.V.	Steroids derivatives as selective progesterone receptor modulators
TWI539953B (zh)	2008-04-28	2016-07-01	瑞波若斯治療學公司	用於治療乳癌之組成物和方法
DE102009034525A1 (de) *	2009-07-21	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
CN107260745A (zh)	2010-03-22	2017-10-20	利普生物药剂公司	用于抗孕酮的非毒性递送的组合物和方法
EP2664325A1 (en) *	2012-05-16	2013-11-20	PregLem S.A.	Methods for preventing or treating androgen mediated diseases

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4039677A (en) *	1976-03-01	1977-08-02	Syntex (U.S.A.) Inc.	Novel 1-phenethylimidazoles
ZA8231B (en) *	1981-01-09	1982-11-24	Roussel Uclaf	New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
DE3504421A1 (de) *	1985-02-07	1986-08-07	Schering AG, 1000 Berlin und 4709 Bergkamen	Neue 11ss-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate
DE4332283A1 (de) *	1993-09-20	1995-04-13	Jenapharm Gmbh	Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE4332284C2 (de) *	1993-09-20	1997-05-28	Jenapharm Gmbh	11-Benzaldoxim-17beta-methoxy-17alpha-methoxymethyl-estradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5576310A (en) *	1994-09-20	1996-11-19	Jenapharm Gmbh	11-benzaldoxime-17β-methoxy-17α-methoxymethyl-estrasdiene derivatives, methods for their production and pharmaceuticals containing such compounds
CA2203541A1 (en)	1994-10-24	1996-05-02	Kristof Chwalisz	Competitive progesterone antagonists for demand-oriented female birth control
ZA9510926B (en) *	1994-12-23	1996-07-03	Schering Ag	Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception
CN1151781C (zh)	1995-03-14	2004-06-02	舍林股份公司	一氧化氮的供体或者一氧化氮的抑制剂调节子宫颈扩张和伸展的用途

1998
- 1998-03-03 DE DE19809845A patent/DE19809845A1/de not_active Ceased
1999
- 1999-02-10 ID IDW20001706A patent/ID26972A/id unknown
- 1999-02-10 PL PL99342449A patent/PL193687B1/pl unknown
- 1999-02-10 NZ NZ506048A patent/NZ506048A/en unknown
- 1999-02-10 EP EP99915475A patent/EP1060187B1/de not_active Expired - Lifetime
- 1999-02-10 IL IL13785199A patent/IL137851A/xx not_active IP Right Cessation
- 1999-02-10 SK SK1305-2000A patent/SK284177B6/sk unknown
- 1999-02-10 TR TR2000/02506T patent/TR200002506T2/xx unknown
- 1999-02-10 ES ES99915475T patent/ES2197634T3/es not_active Expired - Lifetime
- 1999-02-10 JP JP2000534565A patent/JP3796405B2/ja not_active Expired - Fee Related
- 1999-02-10 KR KR10-2000-7009712A patent/KR100488823B1/ko not_active Expired - Fee Related
- 1999-02-10 DE DE59905075T patent/DE59905075D1/de not_active Expired - Fee Related
- 1999-02-10 CN CNB998036080A patent/CN1208341C/zh not_active Expired - Fee Related
- 1999-02-10 AU AU34067/99A patent/AU749163B2/en not_active Ceased
- 1999-02-10 EA EA200000896A patent/EA002766B1/ru not_active IP Right Cessation
- 1999-02-10 BR BR9908458-9A patent/BR9908458A/pt not_active Application Discontinuation
- 1999-02-10 HU HU0100962A patent/HUP0100962A3/hu unknown
- 1999-02-10 DK DK99915475T patent/DK1060187T3/da active
- 1999-02-10 AT AT99915475T patent/ATE237627T1/de not_active IP Right Cessation
- 1999-02-10 CA CA002322471A patent/CA2322471C/en not_active Expired - Fee Related
- 1999-02-10 WO PCT/DE1999/000408 patent/WO1999045023A1/de not_active Ceased
- 1999-02-10 EE EEP200000500A patent/EE04242B1/xx not_active IP Right Cessation
- 1999-02-10 US US09/622,803 patent/US6365582B1/en not_active Expired - Fee Related
- 1999-02-10 PT PT99915475T patent/PT1060187E/pt unknown
- 1999-02-10 CZ CZ20003125A patent/CZ20003125A3/cs unknown
- 1999-10-02 UA UA2000105635A patent/UA59437C2/uk unknown
2000
- 2000-07-28 IS IS5579A patent/IS5579A/is unknown
- 2000-08-28 BG BG104712A patent/BG64735B1/bg unknown
- 2000-09-01 NO NO20004362A patent/NO316977B1/no unknown

Also Published As

Publication number	Publication date
IL137851A0 (en)	2001-10-31
AU3406799A (en)	1999-09-20
DK1060187T3 (da)	2003-08-11
PL342449A1 (en)	2001-06-04
KR100488823B1 (ko)	2005-05-12
NO316977B1 (no)	2004-07-12
BG64735B1 (bg)	2006-01-31
EP1060187B1 (de)	2003-04-16
KR20010041536A (ko)	2001-05-25
ID26972A (id)	2001-02-22
CA2322471C (en)	2007-04-24
CN1291990A (zh)	2001-04-18
SK284177B6 (sk)	2004-10-05
CA2322471A1 (en)	1999-09-10
JP2002505335A (ja)	2002-02-19
EA002766B1 (ru)	2002-08-29
NO20004362D0 (no)	2000-09-01
TR200002506T2 (tr)	2000-12-21
DE59905075D1 (de)	2003-05-22
EE200000500A (et)	2002-02-15
CZ20003125A3 (cs)	2002-01-16
NZ506048A (en)	2003-05-30
WO1999045023A1 (de)	1999-09-10
PL193687B1 (pl)	2007-03-30
EP1060187A1 (de)	2000-12-20
HUP0100962A3 (en)	2002-07-29
CN1208341C (zh)	2005-06-29
NO20004362L (no)	2000-10-31
HUP0100962A2 (hu)	2001-09-28
UA59437C2 (uk)	2003-09-15
AU749163B2 (en)	2002-06-20
SK13052000A3 (sk)	2001-11-06
IS5579A (is)	2000-07-28
BR9908458A (pt)	2000-11-14
IL137851A (en)	2005-06-19
ES2197634T3 (es)	2004-01-01
EE04242B1 (et)	2004-02-16
DE19809845A1 (de)	1999-09-09
JP3796405B2 (ja)	2006-07-12
PT1060187E (pt)	2003-09-30
US6365582B1 (en)	2002-04-02
EA200000896A1 (ru)	2001-04-23
BG104712A (en)	2001-02-28

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Legal Events

Date	Code	Title	Description
2008-11-15	REN	Ceased due to non-payment of the annual fee