ATE249442T1 - Polyhydroxyalkylpyrazine derivate, deren herstellung,diese enthaltende arzneimitteln - Google Patents

Polyhydroxyalkylpyrazine derivate, deren herstellung,diese enthaltende arzneimitteln

Info

Publication number: ATE249442T1
Authority: AT; Austria
Prior art keywords: formula; ch2oh; choh; compound; production
Prior art date: 1997-07-17

Application number

AT98939678T

Other languages

English (en)

Inventor

Georges Bashiardes

Jean-Christophe Carry

Michel Evers

Bruno Filoche

Serge Mignani

Original Assignee

Aventis Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-17

Filing date

1998-07-15

Publication date

2003-09-15

1998-07-15 Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa

2003-09-15 Application granted granted Critical

2003-09-15 Publication of ATE249442T1 publication Critical patent/ATE249442T1/de

Links

229940126601 medicinal product Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 5
238000000034 method Methods 0.000 abstract 3
206010012601 diabetes mellitus Diseases 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
NPWQIVOYGNUVEB-JKCCIXDMSA-N (1r,2r,3r)-1-[5-[(1r,2r,3r)-1,2,3,4-tetrahydroxybutyl]pyrazin-2-yl]butane-1,2,3,4-tetrol Chemical compound OC[C@@H](O)[C@H](O)[C@H](O)C1=CN=C([C@@H](O)[C@@H](O)[C@H](O)CO)C=N1 NPWQIVOYGNUVEB-JKCCIXDMSA-N 0.000 abstract 1
FBDICDJCXVZLIP-VSSNEEPJSA-N (1r,2s,3r)-1-[5-[(2s,3r)-2,3,4-trihydroxybutyl]pyrazin-2-yl]butane-1,2,3,4-tetrol Chemical compound OC[C@@H](O)[C@@H](O)CC1=CN=C([C@@H](O)[C@H](O)[C@H](O)CO)C=N1 FBDICDJCXVZLIP-VSSNEEPJSA-N 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Hematology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Obesity (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicinal Preparation (AREA)

AT98939678T 1997-07-17 1998-07-15 Polyhydroxyalkylpyrazine derivate, deren herstellung,diese enthaltende arzneimitteln ATE249442T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9709060A FR2766184B1 (fr)	1997-07-17	1997-07-17	Medicaments contenant en tant que principe actif au moins un derive de polyhydroxylalkylpyrazine, les nouveaux derives de polyhydroxylalkylpyrazine et leur preparation
PCT/FR1998/001544 WO1999003842A1 (fr)	1997-07-17	1998-07-15	Derives de polyhydroxylalkylpyrazine, leur preparation, medicaments les contenant

Publications (1)

Publication Number	Publication Date
ATE249442T1 true ATE249442T1 (de)	2003-09-15

Family

ID=9509303

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98939678T ATE249442T1 (de)	1997-07-17	1998-07-15	Polyhydroxyalkylpyrazine derivate, deren herstellung,diese enthaltende arzneimitteln

Country Status (24)

Country	Link
US (2)	US6392042B1 (de)
EP (1)	EP0998465B1 (de)
JP (1)	JP4443034B2 (de)
KR (1)	KR20010021822A (de)
CN (1)	CN1264370A (de)
AT (1)	ATE249442T1 (de)
AU (1)	AU751090B2 (de)
BR (1)	BR9811013A (de)
CA (1)	CA2296739C (de)
CZ (1)	CZ290908B6 (de)
DE (1)	DE69818060T2 (de)
DK (1)	DK0998465T3 (de)
ES (1)	ES2206978T3 (de)
FR (1)	FR2766184B1 (de)
HU (1)	HUP0002821A3 (de)
IL (1)	IL134038A0 (de)
MX (1)	MXPA00000252A (de)
NO (1)	NO20000055L (de)
NZ (1)	NZ502276A (de)
PL (1)	PL338133A1 (de)
RU (1)	RU2192420C2 (de)
SK (1)	SK472000A3 (de)
WO (1)	WO1999003842A1 (de)
ZA (1)	ZA986334B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1704862A1 (de) *	2005-03-24	2006-09-27	Rottapharm S.p.A.	2,5-bis(tetrahydroxybutyl)pyrazin-Derivaten zur Behandlung von Osteoarthritis und rheumatoider Arthritis
CN100371330C (zh) *	2006-01-24	2008-02-27	湖南中烟工业公司	从糖氨反应液中分离提纯多羟基烷基吡嗪类化合物的方法
CN105294579B (zh) *	2015-11-27	2018-07-20	中国科学院山西煤炭化学研究所	一种利用甲壳素类生物质制备脱氧果糖嗪的方法
US11091446B2 (en) *	2017-03-24	2021-08-17	R.J. Reynolds Tobacco Company	Methods of selectively forming substituted pyrazines

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL64267A (en) *	1980-12-09	1985-08-30	Erba Farmitalia	Ethers of hydroxymethylpyrazin-n-oxides,their preparation and pharmaceutical compositions containing them
WO1995030660A1 (fr) *	1994-05-10	1995-11-16	Firmenich S.A.	Procede pour la preparation de pyrazines substituees
DE19547543A1 (de)	1995-12-20	1997-06-26	Teves Gmbh Alfred	Teilbelagscheibenbremse mit einem Schwimmsattel
FR2744365B1 (fr) *	1996-02-06	1998-02-27	Inst Malgache Rech Appl	Melanges isolables a partir de graines d'eugenia jambolana lamarck, leur preparation et l'utilisation de ces melanges et certains de leurs constituants comme medicaments

1997
- 1997-07-17 FR FR9709060A patent/FR2766184B1/fr not_active Expired - Fee Related
1998
- 1998-07-15 AT AT98939678T patent/ATE249442T1/de not_active IP Right Cessation
- 1998-07-15 CN CN98807301A patent/CN1264370A/zh active Pending
- 1998-07-15 PL PL98338133A patent/PL338133A1/xx not_active Application Discontinuation
- 1998-07-15 WO PCT/FR1998/001544 patent/WO1999003842A1/fr not_active Ceased
- 1998-07-15 SK SK47-2000A patent/SK472000A3/sk unknown
- 1998-07-15 IL IL13403898A patent/IL134038A0/xx unknown
- 1998-07-15 HU HU0002821A patent/HUP0002821A3/hu unknown
- 1998-07-15 EP EP98939678A patent/EP0998465B1/de not_active Expired - Lifetime
- 1998-07-15 CA CA002296739A patent/CA2296739C/fr not_active Expired - Fee Related
- 1998-07-15 MX MXPA00000252A patent/MXPA00000252A/es not_active IP Right Cessation
- 1998-07-15 BR BR9811013-6A patent/BR9811013A/pt not_active IP Right Cessation
- 1998-07-15 ES ES98939678T patent/ES2206978T3/es not_active Expired - Lifetime
- 1998-07-15 NZ NZ502276A patent/NZ502276A/en unknown
- 1998-07-15 RU RU2000103581/04A patent/RU2192420C2/ru not_active IP Right Cessation
- 1998-07-15 AU AU88104/98A patent/AU751090B2/en not_active Ceased
- 1998-07-15 DK DK98939678T patent/DK0998465T3/da active
- 1998-07-15 KR KR1020007000386A patent/KR20010021822A/ko not_active Ceased
- 1998-07-15 JP JP2000503067A patent/JP4443034B2/ja not_active Expired - Fee Related
- 1998-07-15 CZ CZ2000122A patent/CZ290908B6/cs not_active IP Right Cessation
- 1998-07-15 DE DE69818060T patent/DE69818060T2/de not_active Expired - Lifetime
- 1998-07-16 ZA ZA986334A patent/ZA986334B/xx unknown
2000
- 2000-01-06 NO NO20000055A patent/NO20000055L/no not_active Application Discontinuation
- 2000-01-14 US US09/480,965 patent/US6392042B1/en not_active Expired - Fee Related
2001
- 2001-11-21 US US09/990,015 patent/US20040209890A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ES2206978T3 (es)	2004-05-16
US6392042B1 (en)	2002-05-21
DK0998465T3 (da)	2003-12-15
HUP0002821A3 (en)	2001-07-30
JP4443034B2 (ja)	2010-03-31
JP2001510186A (ja)	2001-07-31
AU8810498A (en)	1999-02-10
US20040209890A1 (en)	2004-10-21
RU2192420C2 (ru)	2002-11-10
CZ2000122A3 (cs)	2000-05-17
CN1264370A (zh)	2000-08-23
CZ290908B6 (cs)	2002-11-13
EP0998465B1 (de)	2003-09-10
PL338133A1 (en)	2000-09-25
WO1999003842A1 (fr)	1999-01-28
MXPA00000252A (es)	2002-04-24
IL134038A0 (en)	2001-04-30
HUP0002821A2 (hu)	2001-05-28
FR2766184A1 (fr)	1999-01-22
AU751090B2 (en)	2002-08-08
NO20000055D0 (no)	2000-01-06
CA2296739C (fr)	2008-09-23
ZA986334B (en)	1999-02-02
SK472000A3 (en)	2000-06-12
EP0998465A1 (de)	2000-05-10
DE69818060D1 (de)	2003-10-16
NO20000055L (no)	2000-01-06
NZ502276A (en)	2001-09-28
FR2766184B1 (fr)	2000-11-17
KR20010021822A (ko)	2001-03-15
DE69818060T2 (de)	2004-07-08
BR9811013A (pt)	2000-08-15
CA2296739A1 (fr)	1999-01-28

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Legal Events

Date	Code	Title	Description
2004-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties