ATE250425T1 - Analoga des parathyroid-hormons - Google Patents

Analoga des parathyroid-hormons

Info

Publication number: ATE250425T1
Authority: AT; Austria
Prior art keywords: amino acid; parathyroid hormone; analogues; acid residue; alpha
Prior art date: 1995-07-13

Application number

AT96924355T

Other languages

English (en)

Inventor

Zheng Xin Dong

Original Assignee

Sod Conseils Rech Applic

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-07-13

Filing date

1996-07-03

Publication date

2003-10-15

1996-07-03 Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic

2003-10-15 Application granted granted Critical

2003-10-15 Publication of ATE250425T1 publication Critical patent/ATE250425T1/de

Links

102000003982 Parathyroid hormone Human genes 0.000 title abstract 2
108090000445 Parathyroid hormone Proteins 0.000 title abstract 2
239000000199 parathyroid hormone Substances 0.000 title abstract 2
229960001319 parathyroid hormone Drugs 0.000 title abstract 2
125000000539 amino acid group Chemical group 0.000 abstract 5
FUOOLUPWFVMBKG-UHFFFAOYSA-N 2-Aminoisobutyric acid Chemical compound CC(C)(N)C(O)=O FUOOLUPWFVMBKG-UHFFFAOYSA-N 0.000 abstract 2
PECYZEOJVXMISF-UHFFFAOYSA-N 3-aminoalanine Chemical compound [NH3+]CC(N)C([O-])=O PECYZEOJVXMISF-UHFFFAOYSA-N 0.000 abstract 2
BVAUMRCGVHUWOZ-ZETCQYMHSA-N (2s)-2-(cyclohexylazaniumyl)propanoate Chemical compound OC(=O)[C@H](C)NC1CCCCC1 BVAUMRCGVHUWOZ-ZETCQYMHSA-N 0.000 abstract 1
QUOGESRFPZDMMT-UHFFFAOYSA-N L-Homoarginine Natural products OC(=O)C(N)CCCCNC(N)=N QUOGESRFPZDMMT-UHFFFAOYSA-N 0.000 abstract 1
QUOGESRFPZDMMT-YFKPBYRVSA-N L-homoarginine Chemical compound OC(=O)[C@@H](N)CCCCNC(N)=N QUOGESRFPZDMMT-YFKPBYRVSA-N 0.000 abstract 1
LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 abstract 1
239000012634 fragment Substances 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Physical Education & Sports Medicine (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
Orthopedic Medicine & Surgery (AREA)
Obesity (AREA)
Hematology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Analytical Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT96924355T 1995-07-13 1996-07-03 Analoga des parathyroid-hormons ATE250425T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US110595P	1995-07-13	1995-07-13
US330595P	1995-09-06	1995-09-06
US08/626,186 US5723577A (en)	1995-07-13	1996-03-29	Analogs of parathyroid hormone
PCT/US1996/011292 WO1997002834A1 (en)	1995-07-13	1996-07-03	Analogs of parathyroid hormone

Publications (1)

Publication Number	Publication Date
ATE250425T1 true ATE250425T1 (de)	2003-10-15

Family

ID=27356825

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT03077383T ATE442159T1 (de)	1995-07-13	1996-07-03	Parathyroidhormon analoge
AT96924355T ATE250425T1 (de)	1995-07-13	1996-07-03	Analoga des parathyroid-hormons

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT03077383T ATE442159T1 (de)	1995-07-13	1996-07-03	Parathyroidhormon analoge

Country Status (19)

Country	Link
US (1)	US5723577A (de)
EP (2)	EP1405861B1 (de)
JP (3)	JPH11509201A (de)
KR (5)	KR100500853B1 (de)
CN (3)	CN101851288A (de)
AT (2)	ATE442159T1 (de)
AU (1)	AU707094B2 (de)
DE (2)	DE69630133T2 (de)
DK (2)	DK0847278T3 (de)
ES (2)	ES2207680T3 (de)
HU (1)	HU226935B1 (de)
IL (1)	IL122837A (de)
MX (1)	MX9800418A (de)
NZ (1)	NZ312899A (de)
PL (1)	PL186710B1 (de)
PT (2)	PT1405861E (de)
SK (1)	SK3198A3 (de)
TW (1)	TW482766B (de)
WO (1)	WO1997002834A1 (de)

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US6110892A (en) *	1994-06-20	2000-08-29	National Research Council Of Canada	Parathyroid hormone analogues for the treatment of osteoporosis
US7410948B2 (en) *	1995-07-13	2008-08-12	Societe De Conseils De Recherches Et D'applications Scientifiques, Sas	Analogs of parathyroid hormone
US5969095A (en) *	1995-07-13	1999-10-19	Biomeasure, Inc.	Analogs of parathyroid hormone
US6544949B1 (en) *	1995-07-13	2003-04-08	Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S.	Analogs of parathyroid hormone
US5955574A (en) *	1995-07-13	1999-09-21	Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.	Analogs of parathyroid hormone
EA002819B1 (ru)	1997-05-14	2002-10-31	Авентис Фармасьютикалз Продактс Инк.	Циклическое пептидное соединение и его применение, бициклопептидное соединение, пептидное соединение и его применение, фармацевтическая композиция
BR9812068A (pt) *	1997-09-09	2000-09-26	Hoffmann La Roche	Processo para a cicatrização óssea e restauração de fraturas e utilização de um análogo de polipeptìdeo de peptìdeo (pthrp) relacionado com hormÈnios de paratireóide e seus sais
AU3673699A (en) *	1998-05-05	1999-11-23	Beth Israel Deaconess Medical Center	Pth2 receptor selective compounds
DE69941708D1 (de) *	1998-07-20	2010-01-07	Ipsen Pharma	Pacap-peptidanaloga
JP4486256B2 (ja) *	1998-10-22	2010-06-23	ザ・ジェネラル・ホスピタル・コーポレイション	副甲状腺ホルモン（ＰＴＨ）および副甲状腺ホルモン関連ペプチド（ＰＴＨｒＰ）の生物活性ペプチドおよびペプチド誘導体
US7169567B1 (en)	1998-12-31	2007-01-30	The General Hospital Corporation	Screening assay utilizing the PTH receptor
US7820393B2 (en) *	1999-01-14	2010-10-26	Scantibodies Laboratory, Inc.	Methods, kits and antibodies for detecting parathyroid hormone
US6689566B1 (en)	1999-01-14	2004-02-10	Scantibodies Laboratory, Inc.	Methods, kits, and antibodies for detecting parathyroid hormone
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US20080108086A1 (en) *	1999-06-02	2008-05-08	Cantor Thomas L	Parathyroid hormone antagonists and uses thereof
AU7734800A (en) *	1999-09-29	2001-04-30	General Hospital Corporation, The	Polypeptide derivatives of parathyroid hormone (pth)
ATE412670T1 (de)	1999-09-29	2008-11-15	Gen Hospital Corp	Parathyroid hormon (pth) polypeptidderivate
US7022815B1 (en)	1999-09-29	2006-04-04	The General Hospital Corporation	Polypeptide derivatives of parathyroid hormone (PTH)
US20050124537A1 (en) *	2000-04-27	2005-06-09	Amgen Inc.	Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US6756480B2 (en)	2000-04-27	2004-06-29	Amgen Inc.	Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
JP5073153B2 (ja)	2001-06-01	2012-11-14	ノバルティスアーゲー	副甲状腺ホルモンおよびカルシトニンの経口投与
KR100491737B1 (ko) *	2001-07-20	2005-05-27	주식회사 한국아이템개발	공기 정화 기능의 모기 퇴치기
US7572765B2 (en) *	2001-07-23	2009-08-11	The General Hospital Corporation	Conformationally constrained parathyroid hormone (PTH) analogs
US20040067526A1 (en) *	2002-10-03	2004-04-08	Cantor Thomas L.	Methods for diagnosing and guiding treatment of bone turnover disease
AU2003220380A1 (en) *	2003-03-19	2004-11-19	Bristol-Myers Squibb Company	CONFORMATIONALLY CONSTRAINED PARATHYROID HORMONES WITH Alpha-HELIX STABILIZERS
KR100540659B1 (ko) *	2003-07-02	2006-01-10	삼성전자주식회사	이미지 확대 인쇄 방법과 장치 및 컴퓨터 프로그램을저장하는 컴퓨터로 읽을 수 있는 기록 매체
EP1653985A4 (de)	2003-07-17	2009-08-05	Gen Hospital Corp	Zwangsform-parathormon (pth)-analoga
JP2007501241A (ja) *	2003-08-06	2007-01-25	ローディアインコーポレイティド	骨成長を促進する方法
US7465703B1 (en)	2003-10-01	2008-12-16	Scantibodies Laboratory, Inc.	Methods and kits useful for guiding osteoporosis related therapy
US7541140B2 (en) *	2004-06-03	2009-06-02	Scantibodies Laboratory, Inc.	Assessing risk for kidney stones using parathyroid hormone agonist and antagonist
WO2007059470A2 (en) *	2005-11-10	2007-05-24	Board Of Control Of Michigan Technological University	Black bear parathyroid hormone and methods of using black bear parathyroid hormone
WO2008019062A2 (en) *	2006-08-04	2008-02-14	The General Hospital Corporation	Polypeptide derivatives of parathyroid hormone (pth)
US7803770B2 (en) *	2006-10-03	2010-09-28	Radius Health, Inc.	Method of treating osteoporosis comprising administration of PTHrP analog
DK2073789T3 (da) *	2006-10-03	2019-08-05	Radius Health Inc	Stabil sammensætning omfattende et knogle-anabolisk protein, nemlig en pthrp-analog, og anvendelser deraf
USRE49444E1 (en)	2006-10-03	2023-03-07	Radius Health, Inc.	Method of treating osteoporosis comprising administration of PTHrP analog
SI2084183T1 (sl)	2006-10-13	2010-09-30	Lilly Co Eli	Pegilirani pth kot modulatorji pth receptorja in njihove uporabe
EP1961765A1 (de) *	2006-12-08	2008-08-27	Zealand Pharma A/S	Verkürzte PTH-Peptide mit zyklischer Konformation
BRPI0814962B8 (pt) *	2007-08-01	2021-05-25	Chugai Pharmaceutical Co Ltd	métodos in vitro para determinar se um composto candidato é um agonista de longa duração ou de curta duração de um receptor acoplado à proteína g, polipeptídeo, seu uso e composição farmacêutica
WO2010111617A2 (en)	2009-03-27	2010-09-30	Van Andel Research Institute	Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use
WO2011071480A1 (en)	2009-12-07	2011-06-16	Michigan Technological University	Black bear parathyroid hormone and methods of using black bear parathyroid hormone
PL2568806T3 (pl)	2010-05-12	2017-03-31	Radius Health, Inc.	Schematy lecznicze
CN103002906B (zh)	2010-05-13	2017-12-29	总医院有限公司	甲状旁腺激素类似物及其应用
AU2011312490B2 (en)	2010-09-28	2015-06-25	Radius Pharmaceuticals, Inc.	Selective androgen receptor modulators
WO2012111852A1 (ja) *	2011-02-17	2012-08-23	帝人ファーマ株式会社	椎体骨折治療剤及びその評価方法
ES2939940T3 (es)	2014-03-28	2023-04-28	Univ Duke	Tratamiento del cáncer de mama utilizando moduladores selectivos de los receptores de estrógenos
MX384605B (es)	2015-04-29	2025-03-14	Radius Pharmaceuticals Inc	Combinación de palbociclib y rad1901 para usarse en el tratamiento de cáncer de mama en un sujeto con cáncer positivo a receptor de estrógeno.
WO2017223115A1 (en)	2016-06-22	2017-12-28	Radius Health, Inc.	Ar+ breast cancer treatment methods
EP3565542B1 (de)	2017-01-05	2024-04-10	Radius Pharmaceuticals, Inc.	Polymorphe formen von rad1901-2hcl
US10996208B2 (en)	2017-04-28	2021-05-04	Radius Health, Inc.	Abaloparatide formulations and methods of testing, storing, modifying, and using same
EP3765488A1 (de)	2018-03-12	2021-01-20	Fresenius Kabi iPSUM S.r.l.	Verfahren zur herstellung von pthrp-analog
SG11202013177WA (en)	2018-07-04	2021-01-28	Radius Pharmaceuticals Inc	Polymorphic forms of rad 1901-2hcl
US12441745B2 (en)	2019-02-12	2025-10-14	Radius Pharmaceuticals, Inc.	Processes and compounds
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FR2550204B1 (fr) *	1983-08-05	1987-11-13	Toyo Jozo Kk	Derives peptidiques de (nle8,nle1b, tyr34)-h-pth
EP0293158A3 (de) *	1987-05-26	1990-05-09	Merck & Co. Inc.	Parathyroide Hormon-Antagonisten
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1996
- 1996-03-29 US US08/626,186 patent/US5723577A/en not_active Expired - Lifetime
- 1996-07-03 KR KR10-1998-0700249A patent/KR100500853B1/ko not_active Expired - Fee Related
- 1996-07-03 HU HU9901718A patent/HU226935B1/hu unknown
- 1996-07-03 JP JP9505897A patent/JPH11509201A/ja active Pending
- 1996-07-03 AU AU64834/96A patent/AU707094B2/en not_active Expired
- 1996-07-03 CN CN201010150544A patent/CN101851288A/zh active Pending
- 1996-07-03 SK SK31-98A patent/SK3198A3/sk unknown
- 1996-07-03 KR KR1020047006340A patent/KR100563602B1/ko not_active Expired - Fee Related
- 1996-07-03 PT PT03077383T patent/PT1405861E/pt unknown
- 1996-07-03 EP EP03077383A patent/EP1405861B1/de not_active Expired - Lifetime
- 1996-07-03 CN CNB2004100054277A patent/CN100412091C/zh not_active Expired - Fee Related
- 1996-07-03 ES ES96924355T patent/ES2207680T3/es not_active Expired - Lifetime
- 1996-07-03 KR KR1020047006338A patent/KR100563600B1/ko not_active Expired - Fee Related
- 1996-07-03 DK DK96924355T patent/DK0847278T3/da active
- 1996-07-03 PT PT96924355T patent/PT847278E/pt unknown
- 1996-07-03 DE DE69630133T patent/DE69630133T2/de not_active Expired - Lifetime
- 1996-07-03 AT AT03077383T patent/ATE442159T1/de active
- 1996-07-03 NZ NZ312899A patent/NZ312899A/en not_active IP Right Cessation
- 1996-07-03 KR KR1020047006341A patent/KR100563112B1/ko not_active Expired - Lifetime
- 1996-07-03 CN CNB961969261A patent/CN1247260C/zh not_active Expired - Fee Related
- 1996-07-03 DK DK03077383T patent/DK1405861T3/da active
- 1996-07-03 KR KR1020047006339A patent/KR100563601B1/ko not_active Expired - Fee Related
- 1996-07-03 AT AT96924355T patent/ATE250425T1/de active
- 1996-07-03 EP EP96924355A patent/EP0847278B1/de not_active Expired - Lifetime
- 1996-07-03 WO PCT/US1996/011292 patent/WO1997002834A1/en not_active Ceased
- 1996-07-03 ES ES03077383T patent/ES2329233T3/es not_active Expired - Lifetime
- 1996-07-03 IL IL12283796A patent/IL122837A/en not_active IP Right Cessation
- 1996-07-03 DE DE69638025T patent/DE69638025D1/de not_active Expired - Lifetime
- 1996-07-03 PL PL96325905A patent/PL186710B1/pl unknown
- 1996-07-11 TW TW085108390A patent/TW482766B/zh not_active IP Right Cessation
1998
- 1998-01-13 MX MX9800418A patent/MX9800418A/es active IP Right Grant
2003
- 2003-01-16 JP JP2003008027A patent/JP4008825B2/ja not_active Expired - Fee Related
2007
- 2007-07-02 JP JP2007174291A patent/JP2007302682A/ja active Pending

Also Published As

Publication number	Publication date
AU707094B2 (en)	1999-07-01
DE69630133D1 (de)	2003-10-30
TW482766B (en)	2002-04-11
HU226935B1 (en)	2010-03-29
JP2007302682A (ja)	2007-11-22
PL325905A1 (en)	1998-08-17
CN1521189A (zh)	2004-08-18
HK1014876A1 (en)	1999-10-08
ES2207680T3 (es)	2004-06-01
PT847278E (pt)	2004-02-27
HUP9901718A3 (en)	2000-10-30
KR100500853B1 (ko)	2005-10-24
EP0847278A4 (de)	1999-01-13
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CN1247260C (zh)	2006-03-29
IL122837A0 (en)	1998-08-16
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CN1199340A (zh)	1998-11-18
JP2003238595A (ja)	2003-08-27
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