ATE442159T1 - Parathyroidhormon analoge - Google Patents

Parathyroidhormon analoge

Info

Publication number: ATE442159T1
Authority: AT; Austria
Prior art keywords: amino acid; analogue; parathyroid; hormon; acid residue
Prior art date: 1995-07-13

Application number

AT03077383T

Other languages

English (en)

Inventor

Zheng Xin Dong

Original Assignee

Ipsen Pharma Sas

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-07-13

Filing date

1996-07-03

Publication date

2009-09-15

1996-07-03 Application filed by Ipsen Pharma Sas filed Critical Ipsen Pharma Sas

2009-09-15 Application granted granted Critical

2009-09-15 Publication of ATE442159T1 publication Critical patent/ATE442159T1/de

Links

230000000849 parathyroid Effects 0.000 title 1
125000000539 amino acid group Chemical group 0.000 abstract 5
FUOOLUPWFVMBKG-UHFFFAOYSA-N 2-Aminoisobutyric acid Chemical compound CC(C)(N)C(O)=O FUOOLUPWFVMBKG-UHFFFAOYSA-N 0.000 abstract 2
PECYZEOJVXMISF-UHFFFAOYSA-N 3-aminoalanine Chemical compound [NH3+]CC(N)C([O-])=O PECYZEOJVXMISF-UHFFFAOYSA-N 0.000 abstract 2
BVAUMRCGVHUWOZ-ZETCQYMHSA-N (2s)-2-(cyclohexylazaniumyl)propanoate Chemical compound OC(=O)[C@H](C)NC1CCCCC1 BVAUMRCGVHUWOZ-ZETCQYMHSA-N 0.000 abstract 1
QUOGESRFPZDMMT-UHFFFAOYSA-N L-Homoarginine Natural products OC(=O)C(N)CCCCNC(N)=N QUOGESRFPZDMMT-UHFFFAOYSA-N 0.000 abstract 1
QUOGESRFPZDMMT-YFKPBYRVSA-N L-homoarginine Chemical compound OC(=O)[C@@H](N)CCCCNC(N)=N QUOGESRFPZDMMT-YFKPBYRVSA-N 0.000 abstract 1
LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 abstract 1
102000003982 Parathyroid hormone Human genes 0.000 abstract 1
108090000445 Parathyroid hormone Proteins 0.000 abstract 1
239000012634 fragment Substances 0.000 abstract 1
239000000199 parathyroid hormone Substances 0.000 abstract 1
229960001319 parathyroid hormone Drugs 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Physical Education & Sports Medicine (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Toxicology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Obesity (AREA)
Analytical Chemistry (AREA)
Immunology (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT03077383T 1995-07-13 1996-07-03 Parathyroidhormon analoge ATE442159T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US110595P	1995-07-13	1995-07-13
US330595P	1995-09-06	1995-09-06
US08/626,186 US5723577A (en)	1995-07-13	1996-03-29	Analogs of parathyroid hormone

Publications (1)

Publication Number	Publication Date
ATE442159T1 true ATE442159T1 (de)	2009-09-15

Family

ID=27356825

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT03077383T ATE442159T1 (de)	1995-07-13	1996-07-03	Parathyroidhormon analoge
AT96924355T ATE250425T1 (de)	1995-07-13	1996-07-03	Analoga des parathyroid-hormons

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT96924355T ATE250425T1 (de)	1995-07-13	1996-07-03	Analoga des parathyroid-hormons

Country Status (19)

Country	Link
US (1)	US5723577A (de)
EP (2)	EP1405861B1 (de)
JP (3)	JPH11509201A (de)
KR (5)	KR100500853B1 (de)
CN (3)	CN101851288A (de)
AT (2)	ATE442159T1 (de)
AU (1)	AU707094B2 (de)
DE (2)	DE69638025D1 (de)
DK (2)	DK0847278T3 (de)
ES (2)	ES2207680T3 (de)
HU (1)	HU226935B1 (de)
IL (1)	IL122837A (de)
MX (1)	MX9800418A (de)
NZ (1)	NZ312899A (de)
PL (1)	PL186710B1 (de)
PT (2)	PT847278E (de)
SK (1)	SK3198A3 (de)
TW (1)	TW482766B (de)
WO (1)	WO1997002834A1 (de)

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US6110892A (en) *	1994-06-20	2000-08-29	National Research Council Of Canada	Parathyroid hormone analogues for the treatment of osteoporosis
US5955425A (en) *	1996-08-02	1999-09-21	National Research Council Of Canada	Parathyroid hormone analogues for the treatment of osteoporosis
US5969095A (en) *	1995-07-13	1999-10-19	Biomeasure, Inc.	Analogs of parathyroid hormone
US5955574A (en) *	1995-07-13	1999-09-21	Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.	Analogs of parathyroid hormone
US7410948B2 (en) *	1995-07-13	2008-08-12	Societe De Conseils De Recherches Et D'applications Scientifiques, Sas	Analogs of parathyroid hormone
US6544949B1 (en) *	1995-07-13	2003-04-08	Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S.	Analogs of parathyroid hormone
SK151599A3 (en)	1997-05-14	2000-09-12	Rhone Poulenc Rorer Pharma	Peptide parathyroid hormone analogs
CA2302255C (en)	1997-09-09	2011-11-08	F. Hoffmann-La Roche Ag	Fracture healing using pthrp analogs
US7531621B1 (en) *	1998-05-05	2009-05-12	Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S.	PTH2 receptor selective compounds
PL345583A1 (en) *	1998-07-20	2001-12-17	Sod Conseils Rech Applic	Peptide analogues of pacap
WO2000023594A1 (en) *	1998-10-22	2000-04-27	The General Hospital Corporation	BIOACTIVE PEPTIDES AND PEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH) AND PARATHYROID HORMONE-RELATED PEPTIDE (PTHrP)
ATE308609T1 (de)	1998-12-31	2005-11-15	Gen Hospital Corp	Pth rezeptor und testverfahren unter verwendung desselben
US6689566B1 (en) *	1999-01-14	2004-02-10	Scantibodies Laboratory, Inc.	Methods, kits, and antibodies for detecting parathyroid hormone
US7820393B2 (en) *	1999-01-14	2010-10-26	Scantibodies Laboratory, Inc.	Methods, kits and antibodies for detecting parathyroid hormone
US20080108086A1 (en) *	1999-06-02	2008-05-08	Cantor Thomas L	Parathyroid hormone antagonists and uses thereof
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US7022815B1 (en)	1999-09-29	2006-04-04	The General Hospital Corporation	Polypeptide derivatives of parathyroid hormone (PTH)
WO2001023521A2 (en) *	1999-09-29	2001-04-05	The General Hospital Corporation	Polypeptide derivatives of parathyroid hormone (pth)
DE60040678D1 (en)	1999-09-29	2008-12-11	Gen Hospital Corp	Parathyroid hormon (pth) polypeptidderivate
US6756480B2 (en) *	2000-04-27	2004-06-29	Amgen Inc.	Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US20050124537A1 (en) *	2000-04-27	2005-06-09	Amgen Inc.	Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
KR101320817B1 (ko)	2001-06-01	2013-10-21	노파르티스 아게	부갑상선 호르몬 및 칼시토닌의 경구 투여
KR100491737B1 (ko) *	2001-07-20	2005-05-27	주식회사 한국아이템개발	공기 정화 기능의 모기 퇴치기
WO2003009804A2 (en)	2001-07-23	2003-02-06	The General Hospital Corporation	Conformationally constrained parathyroid hormone (pth) analogs
US20040067526A1 (en) *	2002-10-03	2004-04-08	Cantor Thomas L.	Methods for diagnosing and guiding treatment of bone turnover disease
WO2004093902A1 (en) *	2003-03-19	2004-11-04	The General Hospital Corporation	CONFORMATIONALLY CONSTRAINED PARATHYROID HORMONES WITH α-HELIX STABILIZERS
KR100540659B1 (ko) *	2003-07-02	2006-01-10	삼성전자주식회사	이미지 확대 인쇄 방법과 장치 및 컴퓨터 프로그램을저장하는 컴퓨터로 읽을 수 있는 기록 매체
US7910544B2 (en)	2003-07-17	2011-03-22	The General Hospital Corporation	Conformationally constrained parthyroid hormone (PTH) analogs
WO2005016265A2 (en) *	2003-08-06	2005-02-24	Rhodia Inc.	Method for promoting bone growth
US7465703B1 (en)	2003-10-01	2008-12-16	Scantibodies Laboratory, Inc.	Methods and kits useful for guiding osteoporosis related therapy
US7541140B2 (en) *	2004-06-03	2009-06-02	Scantibodies Laboratory, Inc.	Assessing risk for kidney stones using parathyroid hormone agonist and antagonist
BRPI0618469A2 (pt) *	2005-11-10	2011-08-30	Univ Michigan Tech	hormÈnio paratiróide de urso preto e métodos de uso de hormÈnio paratiróide de urso preto
JP2009545320A (ja) *	2006-08-04	2009-12-24	ザジェネラルホスピタルコーポレイション	副甲状腺ホルモン（ｐｔｈ）のポリペプチド誘導体
US7803770B2 (en) *	2006-10-03	2010-09-28	Radius Health, Inc.	Method of treating osteoporosis comprising administration of PTHrP analog
USRE49444E1 (en)	2006-10-03	2023-03-07	Radius Health, Inc.	Method of treating osteoporosis comprising administration of PTHrP analog
CA2664734C (en) *	2006-10-03	2023-08-01	Radius Health, Inc.	Method of drug delivery for bone anabolic protein
BRPI0719885B8 (pt)	2006-10-13	2021-05-25	Lilly Co Eli	peptídeos peguilados como moduladores de receptores de pth, seus usos, e composição.
EP1961765A1 (de) *	2006-12-08	2008-08-27	Zealand Pharma A/S	Verkürzte PTH-Peptide mit zyklischer Konformation
CN101784281B (zh)	2007-08-01	2014-07-02	总医院有限公司	确定g蛋白偶联受体激动剂的方法
EP2411038B1 (de)	2009-03-27	2016-12-28	Van Andel Research Institute	Parathryoidhormonpeptide und parathyroidhormonbezogene proteinpeptide sowie anwendungsverfahren dafür
CA2782640A1 (en)	2009-12-07	2011-06-16	Michigan Technological University	Black bear parathyroid hormone and methods of using black bear parathyroid hormone
PT2568806T (pt)	2010-05-12	2016-08-05	Radius Health Inc	Regimes terapêuticos
US9492508B2 (en)	2010-05-13	2016-11-15	The General Hospital Corporation	Parathyroid hormone analogs and uses thereof
ES2550319T3 (es)	2010-09-28	2015-11-06	Radius Health, Inc	Moduladores selectivos del receptor de andrógenos
WO2012111852A1 (ja) *	2011-02-17	2012-08-23	帝人ファーマ株式会社	椎体骨折治療剤及びその評価方法
RS67458B1 (sr)	2014-03-28	2025-12-31	Univ Duke	Lečenje kancera dojke pozitivnog na receptor estrogena upotrebom selektivnih modulatora receptora estrogena
KR102676629B1 (ko)	2015-04-29	2024-06-18	래디어스 파마슈티컬스, 인코포레이티드	암을 치료하는 방법
RS63311B1 (sr)	2016-06-22	2022-07-29	Ellipses Pharma Ltd	Ar+ metode lečenja raka dojke
KR102881465B1 (ko)	2017-01-05	2025-11-04	래디어스 파마슈티컬스, 인코포레이티드	Rad1901-2hcl의 다형 형태
US10996208B2 (en)	2017-04-28	2021-05-04	Radius Health, Inc.	Abaloparatide formulations and methods of testing, storing, modifying, and using same
EP3765488A1 (de)	2018-03-12	2021-01-20	Fresenius Kabi iPSUM S.r.l.	Verfahren zur herstellung von pthrp-analog
CN112423844B (zh)	2018-07-04	2024-08-13	雷迪厄斯制药公司	Rad1901-2hcl的多晶型形式
JOP20210218A1 (ar)	2019-02-12	2023-01-30	Radius Pharmaceuticals Inc	عمليات ومركبات
US11806387B1 (en) *	2022-05-20	2023-11-07	Radius Health, Inc.	Process of making abaloparatide

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FR2550204B1 (fr) *	1983-08-05	1987-11-13	Toyo Jozo Kk	Derives peptidiques de (nle8,nle1b, tyr34)-h-pth
EP0293158A3 (de) *	1987-05-26	1990-05-09	Merck & Co. Inc.	Parathyroide Hormon-Antagonisten
JPH03504201A (ja) *	1989-02-23	1991-09-19	ゲゼルシャフト・フュア・ビオテクノロギッシェ・フォルシュンク・ミット・ベシュレンクテル・ハフツング　（ゲー・ベー・エフ）	Ｐｔｈ変種をコードするｄｎａ配列、ｐｔｈ変種、発現ベクター、細菌宿主、利用と治療用組成物
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1996
- 1996-03-29 US US08/626,186 patent/US5723577A/en not_active Expired - Lifetime
- 1996-07-03 AU AU64834/96A patent/AU707094B2/en not_active Expired
- 1996-07-03 JP JP9505897A patent/JPH11509201A/ja active Pending
- 1996-07-03 NZ NZ312899A patent/NZ312899A/en not_active IP Right Cessation
- 1996-07-03 KR KR10-1998-0700249A patent/KR100500853B1/ko not_active Expired - Fee Related
- 1996-07-03 WO PCT/US1996/011292 patent/WO1997002834A1/en not_active Ceased
- 1996-07-03 HU HU9901718A patent/HU226935B1/hu unknown
- 1996-07-03 CN CN201010150544A patent/CN101851288A/zh active Pending
- 1996-07-03 KR KR1020047006338A patent/KR100563600B1/ko not_active Expired - Fee Related
- 1996-07-03 AT AT03077383T patent/ATE442159T1/de active
- 1996-07-03 PT PT96924355T patent/PT847278E/pt unknown
- 1996-07-03 CN CNB961969261A patent/CN1247260C/zh not_active Expired - Fee Related
- 1996-07-03 EP EP03077383A patent/EP1405861B1/de not_active Expired - Lifetime
- 1996-07-03 EP EP96924355A patent/EP0847278B1/de not_active Expired - Lifetime
- 1996-07-03 PT PT03077383T patent/PT1405861E/pt unknown
- 1996-07-03 KR KR1020047006340A patent/KR100563602B1/ko not_active Expired - Fee Related
- 1996-07-03 DK DK96924355T patent/DK0847278T3/da active
- 1996-07-03 CN CNB2004100054277A patent/CN100412091C/zh not_active Expired - Fee Related
- 1996-07-03 SK SK31-98A patent/SK3198A3/sk unknown
- 1996-07-03 IL IL12283796A patent/IL122837A/en not_active IP Right Cessation
- 1996-07-03 KR KR1020047006339A patent/KR100563601B1/ko not_active Expired - Fee Related
- 1996-07-03 ES ES96924355T patent/ES2207680T3/es not_active Expired - Lifetime
- 1996-07-03 DK DK03077383T patent/DK1405861T3/da active
- 1996-07-03 ES ES03077383T patent/ES2329233T3/es not_active Expired - Lifetime
- 1996-07-03 DE DE69638025T patent/DE69638025D1/de not_active Expired - Lifetime
- 1996-07-03 PL PL96325905A patent/PL186710B1/pl unknown
- 1996-07-03 DE DE69630133T patent/DE69630133T2/de not_active Expired - Lifetime
- 1996-07-03 KR KR1020047006341A patent/KR100563112B1/ko not_active Expired - Lifetime
- 1996-07-03 AT AT96924355T patent/ATE250425T1/de active
- 1996-07-11 TW TW085108390A patent/TW482766B/zh not_active IP Right Cessation
1998
- 1998-01-13 MX MX9800418A patent/MX9800418A/es active IP Right Grant
2003
- 2003-01-16 JP JP2003008027A patent/JP4008825B2/ja not_active Expired - Fee Related
2007
- 2007-07-02 JP JP2007174291A patent/JP2007302682A/ja active Pending

Also Published As

Publication number	Publication date
CN1521189A (zh)	2004-08-18
CN101851288A (zh)	2010-10-06
EP0847278A4 (de)	1999-01-13
CN1199340A (zh)	1998-11-18
KR20040053216A (ko)	2004-06-23
CN1247260C (zh)	2006-03-29
IL122837A0 (en)	1998-08-16
SK3198A3 (en)	1998-07-08
PL325905A1 (en)	1998-08-17
DK0847278T3 (da)	2003-12-22
AU6483496A (en)	1997-02-10
AU707094B2 (en)	1999-07-01
EP1405861A2 (de)	2004-04-07
DE69630133D1 (de)	2003-10-30
HUP9901718A3 (en)	2000-10-30
EP0847278A1 (de)	1998-06-17
WO1997002834A1 (en)	1997-01-30
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