ATE294804T1 - Pharmazeutische zusammensetzung enthaltend ein farnesyl-transferase hemmenden 1,2-annellierten chinolin enantiomer - Google Patents

Pharmazeutische zusammensetzung enthaltend ein farnesyl-transferase hemmenden 1,2-annellierten chinolin enantiomer

Info

Publication number: ATE294804T1
Authority: AT; Austria
Prior art keywords: annellated; farnesyl; pharmaceutical composition; composition containing; transferase inhibiting
Prior art date: 2000-06-22

Application number

AT01938263T

Other languages

English (en)

Inventor

Marc Gaston Venet

Patrick Rene Angibaud

David William End

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-22

Filing date

2001-06-13

Publication date

2005-05-15

2001-06-13 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2005-05-15 Application granted granted Critical

2005-05-15 Publication of ATE294804T1 publication Critical patent/ATE294804T1/de

Links

102000007317 Farnesyltranstransferase Human genes 0.000 title 1
108010007508 Farnesyltranstransferase Proteins 0.000 title 1
SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Immunology (AREA)
Surgery (AREA)
Obesity (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT01938263T 2000-06-22 2001-06-13 Pharmazeutische zusammensetzung enthaltend ein farnesyl-transferase hemmenden 1,2-annellierten chinolin enantiomer ATE294804T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00202181		2000-06-22
PCT/EP2001/006747 WO2001098302A1 (en)	2000-06-22	2001-06-13	Farnesyl transferase inhibiting 1,2-annelated quinoline enantiomer

Publications (1)

Publication Number	Publication Date
ATE294804T1 true ATE294804T1 (de)	2005-05-15

Family

ID=8171675

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01938263T ATE294804T1 (de)	2000-06-22	2001-06-13	Pharmazeutische zusammensetzung enthaltend ein farnesyl-transferase hemmenden 1,2-annellierten chinolin enantiomer

Country Status (33)

Country	Link
US (3)	US20030114471A1 (de)
EP (1)	EP1296984B1 (de)
JP (1)	JP4919575B2 (de)
KR (2)	KR100846370B1 (de)
CN (1)	CN1207296C (de)
AR (1)	AR030704A1 (de)
AT (1)	ATE294804T1 (de)
AU (3)	AU6396201A (de)
BG (1)	BG65894B1 (de)
BR (1)	BRPI0111743B8 (de)
CA (1)	CA2410232C (de)
CZ (1)	CZ295278B6 (de)
DE (1)	DE60110592T2 (de)
EA (1)	EA005065B1 (de)
EE (1)	EE04966B1 (de)
EG (1)	EG24180A (de)
ES (1)	ES2241830T3 (de)
HR (1)	HRP20020989B1 (de)
HU (1)	HU229095B1 (de)
IL (2)	IL153560A0 (de)
IS (1)	IS2596B (de)
JO (1)	JO2361B1 (de)
MX (1)	MXPA02012845A (de)
MY (1)	MY127734A (de)
NO (1)	NO324494B1 (de)
NZ (1)	NZ522481A (de)
PA (1)	PA8519501A1 (de)
PL (1)	PL209521B1 (de)
SA (1)	SA01220349B1 (de)
SK (1)	SK285699B6 (de)
UA (1)	UA73572C2 (de)
WO (1)	WO2001098302A1 (de)
ZA (1)	ZA200210305B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003018135A1 (en) *	2001-08-24	2003-03-06	Wyeth Holdings Corporation	Method of using 5-(arylsulfonyl)-,5-(arylsulfinyl), and 5-(arylsulfanyl)-thiazolidine-2,4-diones for inhibition of farnesyl-protein transferase
ATE336496T1 (de)	2002-04-15	2006-09-15	Janssen Pharmaceutica Nv	Farnesyl transferase hemmende tricyclische quinazolinederivate substitutiert mit kohlenstoff-gebundenen imidazolen oder triazolen
US20050003422A1 (en)	2003-07-01	2005-01-06	Mitch Reponi	Methods for assessing and treating cancer
US11311519B2 (en)	2014-05-01	2022-04-26	Eiger Biopharmaceuticals, Inc.	Treatment of hepatitis delta virus infection
US10076512B2 (en)	2014-05-01	2018-09-18	Eiger Biopharmaceuticals, Inc.	Treatment of hepatitis delta virus infection
EP3226973A4 (de) *	2014-12-04	2018-05-30	Eiger Biopharmaceuticals, Inc.	Behandlung von hepatitis-delta-virusinfektion
US10835496B2 (en)	2015-04-21	2020-11-17	Eiger Biopharmaceuticals, Inc.	Pharmaceutical compositions comprising lonafarnib and ritonavir
EA201890512A1 (ru)	2015-08-17	2018-09-28	Кура Онколоджи, Инк.	Способы лечения пациентов со злокачественными опухолями с использованием ингибиторов фарнезилтрансферазы
RS61745B1 (sr)	2016-11-03	2021-05-31	Kura Oncology Inc	Inhibitori farneziltransferaze za upotrebu u tretiranju kancera

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1519765A (en) *	1974-09-05	1978-08-02	Ici Ltd	Pesticidal dihydrotetrazolo(1,5a) quinazolines compositions and processes
US4141979A (en) *	1976-12-23	1979-02-27	Pfizer Inc.	Tetrazolo[a]quinazol-5-ones antiallergy and antiulcer agents
GB9513577D0 (en) *	1995-07-04	1995-09-06	Brotherwood Rodney J	Improvements in passenger carrying vehicles
TW349948B (en) *	1995-10-31	1999-01-11	Janssen Pharmaceutica Nv	Farnesyl transferase inhibiting 2-quinolone derivatives
EE03484B1 (et) *	1995-12-08	2001-08-15	Janssen Pharmaceutica N.V.	Farnesüülproteiintransferaasi inhibeerivad (5-imidasolüül)metüül-2-kinolinooni derivaadid ja nende kasutamine
AU715658B2 (en)	1996-04-03	2000-02-10	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
TW591030B (en) *	1997-03-10	2004-06-11	Janssen Pharmaceutica Nv	Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
BR9809398A (pt) *	1997-04-25	2000-06-13	Janssen Pharmaceutica Nv	Quinazolinonas que inibem a farnesil transferase
ATE222104T1 (de)	1997-06-02	2002-08-15	Janssen Pharmaceutica Nv	(imidazol-5-yl)methyl-2-quinolinone derivativen als inhibitoren von proliferation der glatten muskelzellen
US6545020B1 (en) *	1998-07-06	2003-04-08	Janssen Pharmaceutica, N.V.	Farnesyl Protein transferase inhibitors with in vivo radiosensitizing properties
HRP20000904A2 (en)	1998-07-06	2001-12-31	Janssen Pharmaceutica Nv	Farnesyl protein transferase inhibitors for treating arthropathies
TR200101343T2 (tr) *	1998-08-27	2001-09-21	Pfizer Products Inc.	Kansere karşı kullanılan maddeler olarak alkinil-ikame edilmiş kinolin-2-on türevleri
ATE289602T1 (de) *	1998-08-27	2005-03-15	Pfizer Prod Inc	Quinolin-2-on-derivate verwendbar als antikrebsmittel
BR9916827A (pt) *	1998-12-23	2001-10-16	Janssen Pharmaceutica Nv	Derivados de quinolina 1,2-anelados
US6462201B1 (en) *	1998-12-29	2002-10-08	Isp Investments Inc.	Process for the production of N-vinyl-2-pyrrolidone by vinylation
KR20010102073A (ko) *	1999-02-11	2001-11-15	실버스타인 아써 에이.	항암제로 유용한 헤테로아릴-치환된 퀴놀린-2-온 유도체
HN2000000266A (es)	2000-01-21	2001-05-21	Pfizer Prod Inc	Compuesto anticanceroso y metodo de separacion de enantiomeros util para sintetizar dicho compuesto.
US6838467B2 (en) *	2000-02-24	2005-01-04	Janssen Pharmaceutica N. V.	Dosing regimen
WO2002024686A2 (en)	2000-09-25	2002-03-28	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives
JP4974439B2 (ja)	2000-09-25	2012-07-11	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	ファルネシルトランスフェラーゼを阻害する６−ヘテロシクリルメチルキノリノン誘導体

2001
- 2001-05-29 JO JO200183A patent/JO2361B1/en active
- 2001-06-13 EP EP01938263A patent/EP1296984B1/de not_active Expired - Lifetime
- 2001-06-13 BR BRPI0111743-2 patent/BRPI0111743B8/pt not_active IP Right Cessation
- 2001-06-13 AU AU6396201A patent/AU6396201A/xx active Pending
- 2001-06-13 US US10/312,301 patent/US20030114471A1/en not_active Abandoned
- 2001-06-13 AU AU2001263962A patent/AU2001263962B2/en not_active Expired
- 2001-06-13 ES ES01938263T patent/ES2241830T3/es not_active Expired - Lifetime
- 2001-06-13 WO PCT/EP2001/006747 patent/WO2001098302A1/en not_active Ceased
- 2001-06-13 EE EEP200200695A patent/EE04966B1/xx unknown
- 2001-06-13 IL IL15356001A patent/IL153560A0/xx unknown
- 2001-06-13 SK SK50-2003A patent/SK285699B6/sk not_active IP Right Cessation
- 2001-06-13 HU HU0300872A patent/HU229095B1/hu unknown
- 2001-06-13 DE DE60110592T patent/DE60110592T2/de not_active Expired - Lifetime
- 2001-06-13 KR KR1020077026608A patent/KR100846370B1/ko not_active Expired - Lifetime
- 2001-06-13 JP JP2002504258A patent/JP4919575B2/ja not_active Expired - Lifetime
- 2001-06-13 NZ NZ522481A patent/NZ522481A/en not_active IP Right Cessation
- 2001-06-13 KR KR1020027014678A patent/KR100831940B1/ko not_active Expired - Lifetime
- 2001-06-13 CN CNB018113788A patent/CN1207296C/zh not_active Expired - Lifetime
- 2001-06-13 HR HR20020989A patent/HRP20020989B1/xx not_active IP Right Cessation
- 2001-06-13 MX MXPA02012845A patent/MXPA02012845A/es active IP Right Grant
- 2001-06-13 AT AT01938263T patent/ATE294804T1/de active
- 2001-06-13 EA EA200300048A patent/EA005065B1/ru not_active IP Right Cessation
- 2001-06-13 CA CA002410232A patent/CA2410232C/en not_active Expired - Lifetime
- 2001-06-13 CZ CZ2003114A patent/CZ295278B6/cs not_active IP Right Cessation
- 2001-06-13 PL PL358918A patent/PL209521B1/pl unknown
- 2001-06-13 UA UA20021210152A patent/UA73572C2/uk unknown
- 2001-06-14 PA PA20018519501A patent/PA8519501A1/es unknown
- 2001-06-20 MY MYPI20012896A patent/MY127734A/en unknown
- 2001-06-20 EG EG20010660A patent/EG24180A/xx active
- 2001-06-21 AR ARP010102954A patent/AR030704A1/es not_active Application Discontinuation
- 2001-09-10 SA SA01220349A patent/SA01220349B1/ar unknown
2002
- 2002-10-25 IS IS6590A patent/IS2596B/is unknown
- 2002-11-25 BG BG107310A patent/BG65894B1/bg unknown
- 2002-12-16 NO NO20026032A patent/NO324494B1/no not_active IP Right Cessation
- 2002-12-19 IL IL153560A patent/IL153560A/en not_active IP Right Cessation
- 2002-12-19 ZA ZA200210305A patent/ZA200210305B/en unknown
2006
- 2006-09-20 AU AU2006220405A patent/AU2006220405B2/en not_active Expired
2007
- 2007-01-31 US US11/669,587 patent/US8329714B2/en not_active Expired - Lifetime
- 2007-10-29 US US11/926,741 patent/US8318753B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP2004501153A (ja)	2004-01-15
MY127734A (en)	2006-12-29
HU229095B1 (en)	2013-07-29
US8318753B2 (en)	2012-11-27
SK502003A3 (en)	2003-05-02
WO2001098302A1 (en)	2001-12-27
US20080114009A1 (en)	2008-05-15
CA2410232C (en)	2008-10-07
PL209521B1 (pl)	2011-09-30
DE60110592T2 (de)	2006-01-19
BG65894B1 (bg)	2010-04-30
KR100831940B1 (ko)	2008-05-23
HUP0300872A3 (en)	2004-11-29
HRP20020989A2 (en)	2005-02-28
AR030704A1 (es)	2003-09-03
UA73572C2 (en)	2005-08-15
EA005065B1 (ru)	2004-10-28
AU2001263962B2 (en)	2006-07-20
EE04966B1 (et)	2008-02-15
IS6590A (is)	2002-10-25
SA01220349B1 (ar)	2007-01-23
PL358918A1 (en)	2004-08-23
AU2006220405A1 (en)	2006-10-12
JP4919575B2 (ja)	2012-04-18
NO324494B1 (no)	2007-10-29
EP1296984A1 (de)	2003-04-02
BR0111743A (pt)	2003-07-08
IL153560A0 (en)	2003-07-06
US20030114471A1 (en)	2003-06-19
EG24180A (en)	2008-09-28
US8329714B2 (en)	2012-12-11
CA2410232A1 (en)	2001-12-27
AU2006220405B2 (en)	2009-05-21
PA8519501A1 (es)	2002-08-29
CZ295278B6 (cs)	2005-06-15
JO2361B1 (en)	2006-12-12
CZ2003114A3 (cs)	2003-05-14
DE60110592D1 (de)	2005-06-09
CN1437601A (zh)	2003-08-20
BRPI0111743B8 (pt)	2021-05-25
BG107310A (bg)	2003-07-31
HK1058363A1 (en)	2004-05-14
NO20026032D0 (no)	2002-12-16
BRPI0111743B1 (pt)	2019-03-26
EE200200695A (et)	2004-06-15
ES2241830T3 (es)	2005-11-01
AU6396201A (en)	2002-01-02
IS2596B (is)	2010-03-15
KR100846370B1 (ko)	2008-07-15
HUP0300872A2 (hu)	2003-07-28
EA200300048A1 (ru)	2003-04-24
NZ522481A (en)	2004-09-24
ZA200210305B (en)	2004-03-19
HRP20020989B1 (hr)	2011-05-31
EP1296984B1 (de)	2005-05-04
CN1207296C (zh)	2005-06-22
SK285699B6 (sk)	2007-06-07
US20070259902A1 (en)	2007-11-08
MXPA02012845A (es)	2003-05-15
KR20030009463A (ko)	2003-01-29
KR20070121847A (ko)	2007-12-27
NO20026032L (no)	2002-12-16
IL153560A (en)	2011-06-30

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2006-01-15

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NO20026032L (no)	2002-12-16	Farnesyltransferasehemmende 1,2-annelert kinolinenantiomer
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GB0019272D0 (en)	2000-09-27	Pharmaceutical compounds
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GB0024318D0 (en)	2000-11-15	Pharmaceutical compounds