ATE310740T1 - Imidazotriazin-derivate als liganden für gaba- rezeptoren - Google Patents

Imidazotriazin-derivate als liganden für gaba- rezeptoren

Info

Publication number
ATE310740T1
ATE310740T1 AT01980742T AT01980742T ATE310740T1 AT E310740 T1 ATE310740 T1 AT E310740T1 AT 01980742 T AT01980742 T AT 01980742T AT 01980742 T AT01980742 T AT 01980742T AT E310740 T1 ATE310740 T1 AT E310740T1
Authority
AT
Austria
Prior art keywords
ligands
sub
gaba receptors
gaba
receptors
Prior art date
Application number
AT01980742T
Other languages
English (en)
Inventor
Michela Bettati
Peter Blurton
William Robert Carling
Mark Stuart Chambers
David James Hallett
Andrew Jennings
Richard Thomas Lewis
Michael Geoffrey Neil Russell
Leslie Joseph Street
Helen Jane Szekeres
Niel Monique Bodil Van
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0027562A external-priority patent/GB0027562D0/en
Priority claimed from GBGB0117277.4A external-priority patent/GB0117277D0/en
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE310740T1 publication Critical patent/ATE310740T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT01980742T 2000-11-10 2001-11-08 Imidazotriazin-derivate als liganden für gaba- rezeptoren ATE310740T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0027562A GB0027562D0 (en) 2000-11-10 2000-11-10 Therapeutic agents
GBGB0117277.4A GB0117277D0 (en) 2001-07-16 2001-07-16 Therapeutic agents
PCT/GB2001/004948 WO2002038568A1 (en) 2000-11-10 2001-11-08 Imidazo-triazine derivatives as ligands for gaba receptors

Publications (1)

Publication Number Publication Date
ATE310740T1 true ATE310740T1 (de) 2005-12-15

Family

ID=26245271

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01980742T ATE310740T1 (de) 2000-11-10 2001-11-08 Imidazotriazin-derivate als liganden für gaba- rezeptoren

Country Status (9)

Country Link
US (1) US6936608B2 (de)
EP (1) EP1343788B1 (de)
JP (1) JP4302980B2 (de)
AT (1) ATE310740T1 (de)
AU (2) AU1253002A (de)
CA (1) CA2427779A1 (de)
DE (1) DE60115282T2 (de)
ES (1) ES2251518T3 (de)
WO (1) WO2002038568A1 (de)

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GB0117277D0 (en) 2001-07-16 2001-09-05 Merck Sharp & Dohme Therapeutic agents
GB0128499D0 (en) * 2001-11-28 2002-01-23 Merck Sharp & Dohme Therapeutic agents
GB0210127D0 (en) 2002-05-02 2002-06-12 Merck Sharp & Dohme Therapeutic agents
GB0212048D0 (en) * 2002-05-24 2002-07-03 Merck Sharp & Dohme Therapeutic agents
ATE420867T1 (de) * 2002-08-13 2009-01-15 Merck Sharp & Dohme Phenylpyridazin derivative als liganden für gaba- rezeptoren
US7485640B2 (en) 2002-11-06 2009-02-03 Merck Sharp & Dohme Limited Imidazopyrazinones as GABA-A receptor anxiolytics
US7365174B2 (en) 2003-08-22 2008-04-29 Meiji Seika Kaisha, Ltd. Azalide and azalactam derivatives and method for producing the same
WO2007025177A2 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258359A3 (de) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin
EP2377530A3 (de) 2005-10-21 2012-06-20 Braincells, Inc. Modulation von Neurogenese durch PDE-Hemmung
EP1942879A1 (de) 2005-10-31 2008-07-16 Braincells, Inc. Gaba-rezeptor-vermittelte modulation von neurogenese
US7465795B2 (en) 2005-12-20 2008-12-16 Astrazeneca Ab Compounds and uses thereof
WO2007073283A1 (en) 2005-12-20 2007-06-28 Astrazeneca Ab Substituted cinnoline derivatives as gabaa-receptor modulators and method for their synthesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2021000A2 (de) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenese mittels angiotensin-modulation
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
BRPI0716604A2 (pt) 2006-09-08 2013-04-09 Braincells Inc combinaÇÕes contendo um derivado de 4-acilaminopiridina
GEP20125658B (en) 2006-11-22 2012-10-10 Incyte Corp Imidazotriazines and imidazo pyrimidines as kinase inhibitors
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US20110082147A1 (en) * 2009-07-24 2011-04-07 Concert Pharmaceuticals, Inc. Substituted imidazotriazines
CN102030770B (zh) * 2009-09-25 2012-10-31 北京大学 一种芳香硼酸酯化合物的制备方法
EP2468726B1 (de) * 2010-12-06 2013-08-28 Siena Biotech S.p.A. Verbindung zur Behandlung von Tumoren und Tumormetastasen
CN102898315B (zh) * 2012-11-05 2015-01-28 上海毕得医药科技有限公司 3-乙炔基-4-氟苯胺的制备方法
UA112028C2 (uk) 2012-12-14 2016-07-11 Пфайзер Лімітед Похідні імідазопіридазину як модулятори гамка-рецептора
CN104177304A (zh) * 2013-05-28 2014-12-03 海洋王照明科技股份有限公司 双极性蓝光磷光主体材料及其制备方法和有机电致发光器件
GB201321732D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
BR112016018555B1 (pt) 2014-02-13 2024-01-23 Incyte Holdings Corporation Ciclopropilaminas como inibidores de lsd1, seu uso, composição farmacêutica que os compreende e método de inibição de lsd1
CN106164066B (zh) 2014-02-13 2020-01-17 因赛特公司 作为lsd1抑制剂的环丙胺
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
CA2951497C (en) 2014-06-12 2019-04-09 Pfizer Limited Imidazopyridazine derivatives as modulators of the gabaa receptor activity
TWI687419B (zh) 2014-07-10 2020-03-11 美商英塞特公司 作為ｌｓｄ１抑制劑之咪唑并吡啶及咪唑并吡嗪
US9695167B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted triazolo[1,5-a]pyridines and triazolo[1,5-a]pyrazines as LSD1 inhibitors
TW201613925A (en) 2014-07-10 2016-04-16 Incyte Corp Imidazopyrazines as LSD1 inhibitors
ES2757948T3 (es) 2015-04-03 2020-04-30 Incyte Corp Compuestos heterocíclicos como inhibidores LSD1
CN110402244B (zh) 2015-08-12 2023-02-03 因赛特公司 Lsd1抑制剂的盐
JP7115746B2 (ja) 2016-01-27 2022-08-09 ウニヴェルズィテート・ツューリヒ 掻痒の処置のためのｇａｂａａ受容体モジュレーターの使用
CN110799267B (zh) 2017-03-21 2023-05-26 密西西比州立大学 不对称盐、ccc-nhc钳形金属配合物及其制备方法
CN112384513A (zh) * 2018-04-18 2021-02-19 纽罗塞克医疗公司 Gabaa正变构调节剂化合物、其制备方法和用途
US10968200B2 (en) 2018-08-31 2021-04-06 Incyte Corporation Salts of an LSD1 inhibitor and processes for preparing the same
IL292340A (en) * 2019-10-22 2022-06-01 Neurocycle Therapeutics Inc Gabaa positive allosteric modulator compounds, methods of preparation and uses thereof
BR112022007648A2 (pt) * 2019-10-23 2022-10-11 Neurocycle Therapeutics Inc Tratamento de condições epilépticas com moduladores do receptor gabaa
KR102537615B1 (ko) * 2020-02-25 2023-05-30 주식회사 종근당 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물
CN120865250A (zh) 2022-02-25 2025-10-31 上海赛默罗生物科技有限公司 咪唑并哒嗪类衍生物、其制备方法、药物组合物和用途
CN117069725A (zh) 2022-05-10 2023-11-17 上海赛默罗生物科技有限公司 咪唑并哒嗪取代苯环类衍生物、制备方法、药物组合物及用途

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* Cited by examiner, † Cited by third party
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DE1581125B1 (de) * 1966-03-26 1970-08-27 Maierform Trust Reg Bug fuer Verdraengungsschiffe
US3422194A (en) * 1967-08-15 1969-01-14 Smithkline Corp The treatment of depression with imidazo(1,2-b)-as-triazines and compositions thereof
BR0011823A (pt) 1999-06-22 2002-03-19 Neurosearch As Derivado de benzimidazol, composto, composição farmacêutica, uso de um derivado de benzimidazol, e, método para tratamento, prevenção ou alìvio de uma doença ou de um distúrbio ou de uma condição de um corpo animal vivo
GB0117277D0 (en) * 2001-07-16 2001-09-05 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
JP4302980B2 (ja) 2009-07-29
US6936608B2 (en) 2005-08-30
DE60115282T2 (de) 2006-08-10
CA2427779A1 (en) 2002-05-16
ES2251518T3 (es) 2006-05-01
JP2004513171A (ja) 2004-04-30
EP1343788A1 (de) 2003-09-17
US20040023964A1 (en) 2004-02-05
WO2002038568A1 (en) 2002-05-16
AU2002212530B2 (en) 2006-08-17
EP1343788B1 (de) 2005-11-23
AU1253002A (en) 2002-05-21
DE60115282D1 (de) 2005-12-29

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