ATE328895T1 - Methoden zur reinigung von stark anionischen proteinen - Google Patents

Methoden zur reinigung von stark anionischen proteinen

Info

Publication number
ATE328895T1
ATE328895T1 AT01922750T AT01922750T ATE328895T1 AT E328895 T1 ATE328895 T1 AT E328895T1 AT 01922750 T AT01922750 T AT 01922750T AT 01922750 T AT01922750 T AT 01922750T AT E328895 T1 ATE328895 T1 AT E328895T1
Authority
AT
Austria
Prior art keywords
methods
proteins
sulfations
strong anionic
anionic proteins
Prior art date
Application number
AT01922750T
Other languages
English (en)
Inventor
Jonathan L Coffman
William Barry Foster
Bonnie J Germain
Shujun Sun
Jeffrey J Robinson
Original Assignee
Genetics Inst Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Inst Llc filed Critical Genetics Inst Llc
Application granted granted Critical
Publication of ATE328895T1 publication Critical patent/ATE328895T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
AT01922750T 2000-03-27 2001-03-27 Methoden zur reinigung von stark anionischen proteinen ATE328895T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19335100P 2000-03-27 2000-03-27

Publications (1)

Publication Number Publication Date
ATE328895T1 true ATE328895T1 (de) 2006-06-15

Family

ID=22713294

Family Applications (3)

Application Number Title Priority Date Filing Date
AT06006739T ATE461935T1 (de) 2000-03-27 2001-03-27 Verfahren zur reinigung von stark anionischen proteinen
AT01922750T ATE328895T1 (de) 2000-03-27 2001-03-27 Methoden zur reinigung von stark anionischen proteinen
AT06006740T ATE448241T1 (de) 2000-03-27 2001-03-27 Verfahren zur reinigung stark anionischer proteine

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT06006739T ATE461935T1 (de) 2000-03-27 2001-03-27 Verfahren zur reinigung von stark anionischen proteinen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT06006740T ATE448241T1 (de) 2000-03-27 2001-03-27 Verfahren zur reinigung stark anionischer proteine

Country Status (11)

Country Link
US (1) US6933370B2 (de)
EP (3) EP1681299B1 (de)
JP (2) JP5025874B2 (de)
AT (3) ATE461935T1 (de)
AU (2) AU4951501A (de)
CA (1) CA2404155C (de)
DE (3) DE60120374T2 (de)
DK (3) DK1681299T3 (de)
ES (3) ES2338687T3 (de)
NZ (1) NZ521578A (de)
WO (1) WO2001072769A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2321539T3 (es) 2001-06-05 2009-06-08 Genetics Institute, Llc Procedimientos relativos a la purificacion de proteinas altamente anionicas.
JP2005532793A (ja) * 2002-04-22 2005-11-04 レコファーマ アーベー 微生物付着を阻害するための融合ポリペプチドおよび方法
US7427659B2 (en) 2003-10-24 2008-09-23 Amgen Inc. Process for purifying proteins in a hydrophobic interaction chromatography flow-through fraction
RU2417093C2 (ru) * 2005-06-24 2011-04-27 Дезерт Лейк Текнолоджиз Очищенный компонент цианобактерий и способ применения
AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
DK1969007T3 (da) * 2005-12-20 2013-11-25 Bristol Myers Squibb Co Sammensætninger og fremgangsmåder til fremstilling af en sammensætning
EP2089429B1 (de) * 2006-10-19 2014-11-26 Janssen Biotech, Inc. Verfahren zur herstellung nicht aggregierter antikörper-fc-domänen
US20130116413A1 (en) * 2009-12-29 2013-05-09 Dr. Reddy's Laboratories, Inc. Purification of proteins
CN102762585B (zh) 2010-02-12 2016-01-20 DPx控股有限公司 单一单元抗体纯化
EP2619217B1 (de) * 2010-09-20 2016-11-09 Bio-Rad Laboratories, Inc. Dissoziation von produktkomplex-kontaminantien in der chromatographie
US12162938B2 (en) 2016-10-28 2024-12-10 Merck Sharp & Dohme Llc Purification process for removal of tyrosine sulfation antibody variants; purified compositions
US12516102B1 (en) * 2017-02-09 2026-01-06 Bracco Suisse Sa Process for the purification of soluble PSGL-1 protein variants
US11447547B1 (en) 2017-12-13 2022-09-20 Amgen Inc. Method of antigen-binding protein production
US20230331773A1 (en) * 2022-04-15 2023-10-19 Pall Corporation Chromatography device and method of use

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4723000A (en) * 1983-07-05 1988-02-02 Biospectrum, Inc. Human interferon gamma and interleukin-2
US5115101A (en) 1988-06-08 1992-05-19 Miles Inc. Removal of protein A from antibody preparations
US5464778A (en) * 1989-03-08 1995-11-07 Board Of Regents Of The University Of Oklahoma Glycoprotein ligand for P-selectin and methods of use thereof
US5378464A (en) * 1989-03-08 1995-01-03 Board Of Regents Of The University Of Oklahoma Modulation of inflammatory responses by administration of GMP-140 or antibody to GMP-140
US5034133A (en) * 1990-07-26 1991-07-23 Schering-Corporation Purification of human interleukin-4 from a CHO-cell line culture medium
US5530109A (en) * 1991-04-10 1996-06-25 Ludwig Institute For Cancer Research DNA encoding glial mitogenic factors
US6277975B1 (en) * 1992-10-23 2001-08-21 Genetics Institute, Inc. Fusions of P-selectin ligand protein and polynucleotides encoding same
US5843707A (en) 1992-10-23 1998-12-01 Genetics Institute, Inc. Nucleic acid encoding a novel P-selectin ligand protein
WO1994010309A1 (en) * 1992-10-23 1994-05-11 Genetics Institute, Inc. Novel p-selectin ligand protein
US5429746A (en) 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
ATE205256T1 (de) * 1994-04-09 2001-09-15 Hoffmann La Roche Verfahren zur herstellung von alpha-interferon
US6008328A (en) 1994-10-13 1999-12-28 Amgen Inc. Method for purifying keratinocyte growth factors
SE503424C2 (sv) 1994-11-14 1996-06-10 Pharmacia Ab Process för rening av rekombinant koagulationsfaktor VIII
FR2737730B1 (fr) 1995-08-10 1997-09-05 Pasteur Merieux Serums Vacc Procede de purification de virus par chromatographie
FR2738009B1 (fr) 1995-08-24 1997-10-31 Centre Nat Rech Scient Procede d'obtention de polysaccharides sulfates
AU729459B2 (en) * 1996-11-15 2001-02-01 Genentech Inc. Purification of neurotrophins
AU9695698A (en) * 1997-10-14 1999-05-03 Avant Immunotherapeutics, Inc. Method for purifying retroviral particles and soluble viral antigens

Also Published As

Publication number Publication date
EP1268514B1 (de) 2006-06-07
WO2001072769A3 (en) 2002-02-07
US6933370B2 (en) 2005-08-23
ES2266188T3 (es) 2007-03-01
JP5596078B2 (ja) 2014-09-24
DK1681299T3 (da) 2010-02-01
ATE461935T1 (de) 2010-04-15
AU4951501A (en) 2001-10-08
EP1681298A3 (de) 2006-12-20
JP5025874B2 (ja) 2012-09-12
DK1268514T3 (da) 2006-10-09
DK1681298T3 (da) 2010-06-14
US20020132991A1 (en) 2002-09-19
ES2343023T3 (es) 2010-07-21
EP1681298B1 (de) 2010-03-24
NZ521578A (en) 2004-08-27
WO2001072769A9 (en) 2003-04-03
CA2404155A1 (en) 2001-10-04
EP1268514A2 (de) 2003-01-02
AU2001249515B2 (en) 2006-10-05
DE60120374D1 (de) 2006-07-20
ES2338687T3 (es) 2010-05-11
JP2003528884A (ja) 2003-09-30
JP2012184245A (ja) 2012-09-27
EP1681299A3 (de) 2006-12-27
ATE448241T1 (de) 2009-11-15
EP1681298A2 (de) 2006-07-19
DE60120374T2 (de) 2007-06-06
EP1681299A2 (de) 2006-07-19
DE60141657D1 (de) 2010-05-06
CA2404155C (en) 2011-08-09
DE60140493D1 (de) 2009-12-24
WO2001072769A2 (en) 2001-10-04
EP1681299B1 (de) 2009-11-11

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