ATE358181T1 - Methoden und zusammensetzungen für die sekretion von heterologen polypeptiden - Google Patents

Methoden und zusammensetzungen für die sekretion von heterologen polypeptiden

Info

Publication number
ATE358181T1
ATE358181T1 AT96906659T AT96906659T ATE358181T1 AT E358181 T1 ATE358181 T1 AT E358181T1 AT 96906659 T AT96906659 T AT 96906659T AT 96906659 T AT96906659 T AT 96906659T AT E358181 T1 ATE358181 T1 AT E358181T1
Authority
AT
Austria
Prior art keywords
secretion
polypeptide
interest
heterologue
polypeptides
Prior art date
Application number
AT96906659T
Other languages
English (en)
Inventor
Laura C Simmons
Daniel G Yansura
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE358181T1 publication Critical patent/ATE358181T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Electrotherapy Devices (AREA)
  • External Artificial Organs (AREA)
AT96906659T 1995-03-01 1996-02-27 Methoden und zusammensetzungen für die sekretion von heterologen polypeptiden ATE358181T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/398,615 US5840523A (en) 1995-03-01 1995-03-01 Methods and compositions for secretion of heterologous polypeptides

Publications (1)

Publication Number Publication Date
ATE358181T1 true ATE358181T1 (de) 2007-04-15

Family

ID=23576066

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96906659T ATE358181T1 (de) 1995-03-01 1996-02-27 Methoden und zusammensetzungen für die sekretion von heterologen polypeptiden

Country Status (18)

Country Link
US (1) US5840523A (de)
EP (1) EP0815246B1 (de)
JP (1) JP3375970B2 (de)
CN (1) CN1154736C (de)
AT (1) ATE358181T1 (de)
AU (1) AU701476B2 (de)
BR (1) BR9607464B1 (de)
CA (1) CA2213813C (de)
DE (1) DE69636996T2 (de)
DK (1) DK0815246T3 (de)
ES (1) ES2285711T3 (de)
FI (1) FI120357B (de)
IL (1) IL117314A0 (de)
NO (1) NO324920B1 (de)
NZ (1) NZ303619A (de)
RU (1) RU2208639C2 (de)
WO (1) WO1996027016A1 (de)
ZA (1) ZA961688B (de)

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NO324920B1 (no) 2008-01-07
EP0815246B1 (de) 2007-03-28
RU2208639C2 (ru) 2003-07-20
CN1180379A (zh) 1998-04-29
CN1154736C (zh) 2004-06-23
US5840523A (en) 1998-11-24
WO1996027016A1 (en) 1996-09-06
NZ303619A (en) 2000-02-28
CA2213813C (en) 2008-05-27
CA2213813A1 (en) 1996-09-06
BR9607464A (pt) 1997-12-23
NO973985L (no) 1997-10-29
DE69636996D1 (de) 2007-05-10
FI120357B (fi) 2009-09-30
JP3375970B2 (ja) 2003-02-10
BR9607464B1 (pt) 2009-01-13
DE69636996T2 (de) 2007-12-06
IL117314A0 (en) 1996-06-18
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FI973559L (fi) 1997-10-29
ES2285711T3 (es) 2007-11-16
MX9706607A (es) 1997-11-29
AU701476B2 (en) 1999-01-28
JPH10507368A (ja) 1998-07-21
DK0815246T3 (da) 2007-08-06
ZA961688B (en) 1997-09-01
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