ATE362471T1 - Substituierte benzopyrane als selektive agonisten am östrogenrezeptor-beta - Google Patents

Substituierte benzopyrane als selektive agonisten am östrogenrezeptor-beta

Info

Publication number
ATE362471T1
ATE362471T1 AT02793806T AT02793806T ATE362471T1 AT E362471 T1 ATE362471 T1 AT E362471T1 AT 02793806 T AT02793806 T AT 02793806T AT 02793806 T AT02793806 T AT 02793806T AT E362471 T1 ATE362471 T1 AT E362471T1
Authority
AT
Austria
Prior art keywords
estrogen receptor
receptor beta
selective agonists
agonists
substituted benzopyrans
Prior art date
Application number
AT02793806T
Other languages
English (en)
Inventor
Jeffrey Dodge
Venkatesh Krishnan
Charles Lugar
Blake Neubauer
Bryan Norman
Lance Pfeifer
Timothy Richardson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE362471T1 publication Critical patent/ATE362471T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
AT02793806T 2001-11-19 2002-11-07 Substituierte benzopyrane als selektive agonisten am östrogenrezeptor-beta ATE362471T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33276601P 2001-11-19 2001-11-19
US36362202P 2002-03-11 2002-03-11

Publications (1)

Publication Number Publication Date
ATE362471T1 true ATE362471T1 (de) 2007-06-15

Family

ID=26988373

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02793806T ATE362471T1 (de) 2001-11-19 2002-11-07 Substituierte benzopyrane als selektive agonisten am östrogenrezeptor-beta

Country Status (23)

Country Link
US (1) US7217734B2 (de)
EP (1) EP1448544B1 (de)
JP (1) JP4381810B2 (de)
KR (1) KR100950616B1 (de)
CN (1) CN1312147C (de)
AT (1) ATE362471T1 (de)
AU (1) AU2002359283B2 (de)
CA (1) CA2467013C (de)
CY (1) CY1106726T1 (de)
DE (1) DE60220179T2 (de)
DK (1) DK1448544T3 (de)
EA (1) EA007382B1 (de)
EC (1) ECSP045113A (de)
ES (1) ES2286322T3 (de)
HR (1) HRP20040439A2 (de)
HU (1) HU229351B1 (de)
IL (3) IL161325A0 (de)
MX (1) MXPA04004703A (de)
NO (1) NO328563B1 (de)
NZ (1) NZ531850A (de)
PL (1) PL205733B1 (de)
PT (1) PT1448544E (de)
WO (1) WO2003044006A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE406373T1 (de) * 2003-04-21 2008-09-15 Lilly Co Eli Substituierte benzopyrane als selektive antagonisten am östrogenrezeptor-beta
DE602004025460D1 (de) 2003-04-21 2010-03-25 Lilly Co Eli Substituierte benzopyrane als selektive antagonisten am östrogenrezeptor-beta
CN101052641A (zh) 2004-09-07 2007-10-10 惠氏公司 6H－[1]苯并吡喃并[4,3－b]喹啉及其作为雌激素药物的用途
CA2578300A1 (en) * 2004-10-18 2006-04-27 Eli Lilly And Company Substituted benzopyrans as selective estrogen receptor-beta agonists
CA2587669A1 (en) * 2004-11-18 2006-05-26 Janssen Pharmaceutica N.V. Novel 2h-chromene derivatives as selective estrogen receptor modulators
WO2006088716A1 (en) * 2005-02-15 2006-08-24 Eli Lilly And Company Substituted tetralins as selective estrogen receptor-beta agonists
US9623021B2 (en) 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
US9604931B2 (en) 2007-01-22 2017-03-28 Gtx, Inc. Nuclear receptor binding agents
US8063102B2 (en) 2009-03-13 2011-11-22 N.V. Organon Tetrahydronaphthalen-2-ol derivatives
TW201043595A (en) 2009-03-13 2010-12-16 Organon Nv Tetrahydronaphthalen-2-ol derivatives
US9974776B2 (en) 2013-12-05 2018-05-22 Karo Pharma Ab Estrogen receptor beta agonists for use in treating mesothelioma
CN108884124A (zh) 2015-09-17 2018-11-23 俄亥俄州创新基金会 碳硼烷化合物及其使用方法
WO2021183760A1 (en) * 2020-03-11 2021-09-16 Ohio State Innovation Foundation Methods of modulating t-cell activation using estrogen receptor beta (erβ) agonists

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3901926A (en) 1973-04-02 1975-08-26 Abbott Lab Alkylphenyl benzopyrans
KR100263137B1 (ko) 1995-09-08 2000-08-01 오테스코그 페르 오판 수용체
AU8102398A (en) * 1997-07-09 1999-02-08 Central Drug Research Institute (dl)-2,3-diaryl-2h-1-benzopyrans
US6593322B1 (en) 1999-03-17 2003-07-15 Signal Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors
AU766648B2 (en) 1999-03-17 2003-10-23 Axys Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors
JP2002542187A (ja) 1999-04-16 2002-12-10 アストラゼネカ・アクチエボラーグ エストロゲン−β受容体リガンド
IL150463A0 (en) 1999-12-30 2002-12-01 Signal Pharm Inc Compounds and methods for modulation of estrogen receptors
AU2001256164A1 (en) * 2000-03-01 2001-09-12 Akzo Nobel N.V. Chroman derivatives as estrogenic compounds
JP2003528858A (ja) 2000-03-27 2003-09-30 アクゾ・ノベル・エヌ・ベー エストロゲン関連治療用のノンステロイド系四環式化合物
GB2361642A (en) 2000-10-24 2001-10-31 Karobio Ab Estrogen receptor beta (ERbeta) agonists for use in cancer treatment
UA83620C2 (ru) 2001-12-05 2008-08-11 Уайт Замещенные бензоксазолы и их аналоги как эстрогенные агенты
US6914074B2 (en) 2001-12-13 2005-07-05 Wyeth Substituted phenyl naphthalenes as estrogenic agents
US6630508B1 (en) 2002-02-11 2003-10-07 Eli Lilly And Company Substituted benzopyrans as selective estrogen receptor β agonists

Also Published As

Publication number Publication date
MXPA04004703A (es) 2004-08-19
NO20042583L (no) 2004-06-18
DK1448544T3 (da) 2007-10-08
IL185867A (en) 2009-09-22
IL185867A0 (en) 2008-01-06
AU2002359283B8 (en) 2003-06-10
ES2286322T3 (es) 2007-12-01
CY1106726T1 (el) 2012-05-23
WO2003044006A1 (en) 2003-05-30
JP2005513027A (ja) 2005-05-12
CA2467013C (en) 2010-08-10
CN1589268A (zh) 2005-03-02
PL374510A1 (en) 2005-10-31
EA200400695A1 (ru) 2004-12-30
EA007382B1 (ru) 2006-10-27
HUP0402628A2 (hu) 2005-04-28
CA2467013A1 (en) 2003-05-30
DE60220179T2 (de) 2008-02-07
IL161325A (en) 2008-07-08
KR100950616B1 (ko) 2010-04-01
JP4381810B2 (ja) 2009-12-09
HRP20040439A2 (en) 2005-04-30
IL161325A0 (en) 2004-09-27
CN1312147C (zh) 2007-04-25
PT1448544E (pt) 2007-08-10
KR20040063963A (ko) 2004-07-15
NZ531850A (en) 2007-01-26
AU2002359283B2 (en) 2007-06-21
ECSP045113A (es) 2004-07-23
PL205733B1 (pl) 2010-05-31
NO328563B1 (no) 2010-03-22
DE60220179D1 (de) 2007-06-28
AU2002359283A1 (en) 2003-06-10
EP1448544B1 (de) 2007-05-16
US7217734B2 (en) 2007-05-15
HU229351B1 (en) 2013-11-28
EP1448544A1 (de) 2004-08-25
HK1068349A1 (en) 2005-04-29
US20040249167A1 (en) 2004-12-09

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